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LLPALERILAGRAPATVAVGSRPDPTMVSALRVGDQIDDDVALVVTTSGTTGAPKGALLTAAALIASASA THHRLGGAGNWLLAVPAIHIAGLQVLVRSALAGTVPVELDVSAGFDITELPRAVDKLGSGRRYTSLVAAQ LAKVLGDPAATAALAELDAVLIGGGPAPRPVLDAGAAAGIRIVRTYGMSETCGGCVYDGVALDGVQLRVA ADGRIMIGGATLAKGYRNPVQPDPFAEPGWFRTDDLGALDDSGVLSVLGRADDAISTGGLTVLPQLVESA LATHAAVSDCAVFGLDDDRLGQRVAAAIVVRAHCPTPTLDQLRAHVAGTLAITAAPRELHVVDELPRRGI GKIDRRALVRRFAAATDQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0641 | menE | - | 100% (369) | O-succinylbenzoic acid--CoA ligase |
| M. ulcerans Agy99 | MUL_0943 | fadD36 | 6e-32 | 32.11% (355) | acyl-CoA synthetase |
| M. ulcerans Agy99 | MUL_4827 | fadD12_2 | 3e-27 | 29.89% (368) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0556c | menE | 1e-157 | 78.51% (363) | O-succinylbenzoic acid--CoA ligase |
| M. gilvum PYR-GCK | Mflv_0033 | - | 1e-123 | 65.55% (357) | O-succinylbenzoic acid--CoA ligase |
| M. tuberculosis H37Rv | Rv0542c | menE | 1e-157 | 78.51% (363) | O-succinylbenzoic acid--CoA ligase |
| M. leprae Br4923 | MLBr_02257 | menE | 1e-150 | 73.70% (365) | O-succinylbenzoic acid--CoA ligase |
| M. abscessus ATCC 19977 | MAB_3952 | - | 1e-116 | 60.38% (366) | O-succinylbenzoic acid--CoA ligase |
| M. marinum M | MMAR_0888 | menE | 0.0 | 99.46% (369) | O-succinylbenzoic acid-CoA ligase, MenE |
| M. avium 104 | MAV_4602 | - | 1e-145 | 72.80% (364) | O-succinylbenzoic acid--CoA ligase |
| M. smegmatis MC2 155 | MSMEG_1062 | - | 1e-132 | 68.99% (345) | O-succinylbenzoic acid--CoA ligase |
| M. thermoresistible (build 8) | TH_4370 | - | 1e-126 | 63.59% (368) | PUTATIVE AMP-dependent synthetase and ligase |
| M. vanbaalenii PYR-1 | Mvan_0937 | - | 1e-128 | 69.14% (337) | O-succinylbenzoic acid--CoA ligase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0033|M.gilvum_PYR-GCK ---------------------MIADVLDGR-AAVLPVPADDPHQSAALAT
Mvan_0937|M.vanbaalenii_PYR-1 ------------------------------------MPAHDPVQTAALTT
MSMEG_1062|M.smegmatis_MC2_155 ------------------------------------MPAADRRQTALLTS
TH_4370|M.thermoresistible__bu -MSVLRPISVAAGAEALAILPALADALEDRSPALLPVPADDARDRALLTT
MUL_0641|M.ulcerans_Agy99 -----------------MLLPALERILAGRAPATVAVGS--RPDPT-MVS
MMAR_0888|M.marinum_M -----------------MLLPALERILAGRAPATVAVGS--RPDPT-VVS
Mb0556c|M.bovis_AF2122/97 -------------------------MLGGSDPALVAVPT--QHES--LLG
Rv0542c|M.tuberculosis_H37Rv -------------------------MLGGSDPALVAVPT--QHES--LLG
MLBr_02257|M.leprae_Br4923 -----------------MLLPTLERILDGRAPAMVVVPA--QHEPIAALR
MAV_4602|M.avium_104 -------------------------MLDGRDSALVVLGPPGDRESATLRA
MAB_3952|M.abscessus_ATCC_1997 MTRLLRALPVPSGQTVLGLLPRLAELLDGRGDAVLPVPADDADHAHFLAS
: . .
Mflv_0033|M.gilvum_PYR-GCK ALRAGEDIDDAVGAVLSTSGTTGTPKGALLTAAALRAGAEATHERLGGPG
Mvan_0937|M.vanbaalenii_PYR-1 ALRAGEPIDDAIGVVLSTSGTTGTPKGAMLTVAALTASAEATHARLGGPG
MSMEG_1062|M.smegmatis_MC2_155 TLRAGESIDDDVAVVVSTSGTTGAPKGALLTRSALVSSAEATYERLGGAG
TH_4370|M.thermoresistible__bu ALRAGEPIDDDVAVVVATSGTTGTPKGAMLTAVALRASAEATHNRLGGPG
MUL_0641|M.ulcerans_Agy99 ALRVGDQIDDDVALVVTTSGTTGAPKGALLTAAALIASASATHHRLGGAG
MMAR_0888|M.marinum_M ALRVGDQIDDDVALVVTTSGTTGAPKGALLTAAALIASASATHHRLGGAG
Mb0556c|M.bovis_AF2122/97 ALRVGEQIDDDVALVVTTSGTTGPPKGAMLTAAALTASASAAHDRLGGPG
Rv0542c|M.tuberculosis_H37Rv ALRVGEQIDDDVALVVTTSGTTGPPKGAMLTAAALTASASAAHDRLGGPG
MLBr_02257|M.leprae_Br4923 ALRVGEEIDDDVALVATTSGTTGVPKGALLTAAALTASASATHDRLGGPG
MAV_4602|M.avium_104 GLRVGEPVDDDVALVAATSGTTGAPKGAMLTAAALRASATATHARLGGPG
MAB_3952|M.abscessus_ATCC_1997 ELSADEPIADDVAVVISTSGTTGKPKGAMLTGQALTASGTATATRLGGPG
* ..: : * :. * :****** ****:** ** :.. *: ****.*
Mflv_0033|M.gilvum_PYR-GCK QWLLALPAHHVAGFQVLVRSVVAGTRPVA--VPASFEPEALTSAIAGMEP
Mvan_0937|M.vanbaalenii_PYR-1 RWLLALPAYHVAGFQVLVRSVIAGAAPTA--VPASFEPSALAAATDAMGS
MSMEG_1062|M.smegmatis_MC2_155 RWLLALPAHHIAGLQVLVRSTVAGTTPVT--IPAGFEPGELPSAIARLGP
TH_4370|M.thermoresistible__bu QWLLALPAEHIAGLQVLVRSLIAGTTPVA--IAPNFAPADLVAAIDQMDP
MUL_0641|M.ulcerans_Agy99 NWLLAVPAIHIAGLQVLVRSALAGTVPVELDVSAGFDITELPRAVDKLGS
MMAR_0888|M.marinum_M NWLLAVPAIHIAGLQVLVRSALAGTVPVELDVSAGFDITELPRAVDKLGS
Mb0556c|M.bovis_AF2122/97 SWLLAVPPYHIAGLAVLVRSVIAGSVPVELNVSAGFDVTELPNAIKRLGS
Rv0542c|M.tuberculosis_H37Rv SWLLAVPPYHIAGLAVLVRSVIAGSVPVELNVSAGFDVTELPNAIKRLGS
MLBr_02257|M.leprae_Br4923 SWLLALPPYHIGGLQVLVRSVLAGSVPIELDISAGFDLAKLPDAVGRLGT
MAV_4602|M.avium_104 SWLLALPAHHIAGVQVLVRSLLAGSTPVELDVSRGFDVTQLPAATRALGT
MAB_3952|M.abscessus_ATCC_1997 QWLLALPPHHIAGMQVLLRSIQAGSDPVVLDVSTGFSVPDFVRAVAEMTG
****:*. *:.*. **:** **: * :. .* : * :
Mflv_0033|M.gilvum_PYR-GCK G-RRYASLVAVQLDKALGDVAATRALASLDAVLIGGGPMPAGVAEKASAA
Mvan_0937|M.vanbaalenii_PYR-1 G-RRYASLVAAQLDKALRDPRATESLAGLDAVLIGGGPMPAKVAEQASAA
MSMEG_1062|M.smegmatis_MC2_155 G-RKYASMVAIQLDKALRDPAATTALAELDAVLIGGGPMPAGMAERAAAG
TH_4370|M.thermoresistible__bu GTRRYTAMVAAQLAKVLHHDEATAALARLDAVLIGGGPIPAAVAEPAVAA
MUL_0641|M.ulcerans_Agy99 G-RRYTSLVAAQLAKVLGDPAATAALAELDAVLIGGGPAPRPVLDAGAAA
MMAR_0888|M.marinum_M G-RRYTSLVAAQLAKVLGDPAATAALAELDAVLIGGGPAPRPVLDAAAAA
Mb0556c|M.bovis_AF2122/97 G-RRYTSLVAAQLAKALTDPAATAALAELDAVLIGGGPAPRPILDAAAAA
Rv0542c|M.tuberculosis_H37Rv G-RRYTSLVAAQLAKALTDPAATAALAELDAVLIGGGPAPRPILDAAAAA
MLBr_02257|M.leprae_Br4923 G-RRYTSLVATQLAKALTDSTATAVLAELDAVLVGGGPAPRPILDAATSA
MAV_4602|M.avium_104 G-RRYASLVAVQLAKALGDPAATAALAELDAVLLGGGPAPRPVLQAAAAA
MAB_3952|M.abscessus_ATCC_1997 S-RRYISLVATQLVKALGDAEASEALASFDAVLLGGGPLPATVAIRAAQA
. *:* ::** ** *.* . *: ** :****:**** * : . .
Mflv_0033|M.gilvum_PYR-GCK GISVIRTYGMSETAGGCVYDGVPLRGVEVRIAEDGRIELGGPTVAVGYRN
Mvan_0937|M.vanbaalenii_PYR-1 GISVVRTYGMSETAGGCVYDGVPLDGVGVRVDDDGRIWLGGPTVAAGYRN
MSMEG_1062|M.smegmatis_MC2_155 GVRVVRTYGMSETAGGCVYDGVPLAGVTIRIE-DSRISLGGATVAKGYRN
TH_4370|M.thermoresistible__bu GINVVRTYGMSETAGGCVYDGFPLDGVRVRLD-DSRILLGGPVLAKGYRN
MUL_0641|M.ulcerans_Agy99 GIRIVRTYGMSETCGGCVYDGVALDGVQLRVAADGRIMIGGATLAKGYRN
MMAR_0888|M.marinum_M GIRIVRTYGMSETCGGCVYDGVALDGVQLRVAADGRIMIGGATLAKGYRN
Mb0556c|M.bovis_AF2122/97 GITVVRTYGMSETSGGCVYDGVPLDGVRLRVLAGGRIAIGGATLAKGYRN
Rv0542c|M.tuberculosis_H37Rv GITVVRTYGMSETSGGCVYDGVPLDGVRLRVLAGGRIAIGGATLAKGYRN
MLBr_02257|M.leprae_Br4923 GIMVVGTYGMSETAGGCVYDGVPLDGVCIRVLVNGHVAIGGATLAKGYRN
MAV_4602|M.avium_104 GITVVRSYGMSETAGGCVYDGVPLDGVRVRVS-DGRIALSGATLAKGYRN
MAB_3952|M.abscessus_ATCC_1997 RVPVVRTYGMSETCGGCVYDGVALDGVEVRIGPEGRISLGGATVATGYRN
: :: :******.*******..* ** :*: .:: :.*..:* ****
Mflv_0033|M.gilvum_PYR-GCK PVTPDPFAEPGWFRTDDIGVLD---AGVLRVLGRADDAISTGGLTVLPGM
Mvan_0937|M.vanbaalenii_PYR-1 PVTPDPFAEPGWFRTDDLGVIDD--SGVLRVLGRVDDAISTGGLTVLPGL
MSMEG_1062|M.smegmatis_MC2_155 PVEPDPFSEPGWFRTDDLGVLDD--SGALRVLGRIDDAVSTGGLTVLPQL
TH_4370|M.thermoresistible__bu PVWPDPFAEPGWFRTDDYGLIDE--SGALRVLGRVDDAISTGGLTVLPQV
MUL_0641|M.ulcerans_Agy99 PVQPDPFAEPGWFRTDDLGALD--DSGVLSVLGRADDAISTGGLTVLPQL
MMAR_0888|M.marinum_M PVQPDPFAEPGWFRTDDLGALD--DSGVLSVLGRADDAISTGGLTVLPQL
Mb0556c|M.bovis_AF2122/97 PVSPDPFAEPGWFHTDDLGALESGDSGVLTVLGRADEAISTGGFTVLPQP
Rv0542c|M.tuberculosis_H37Rv PVSPDPFAEPGWFHTDDLGALESGDSGVLTVLGRADEAISTGGFTVLPQP
MLBr_02257|M.leprae_Br4923 PIVPDPFAESGWFHTDDLGTVD--GSGVLTVLGRADDAISTGGLTVLPGP
MAV_4602|M.avium_104 PVDPDPFADPGWFLTDDLGAVD--DDGVLTVFGRADDAISTGGLTVLPQP
MAB_3952|M.abscessus_ATCC_1997 IPEHKAFAEHGWFHTDDFGELD---EGRLRVLGRLDEAISTGGLTVVPQV
..*:: *** *** * :: * * *:** *:*:****:**:*
Mflv_0033|M.gilvum_PYR-GCK VEAALATHPAVAECAVFGVADARLGQRVAAAVVTTPESSV-TLAQLRSHV
Mvan_0937|M.vanbaalenii_PYR-1 VEAALSTHPAVAECAVFGVPDERLGQRVVAAVVVAAGSSV-TLAQLRSHV
MSMEG_1062|M.smegmatis_MC2_155 VEAALVTHPAIAEAAVFGVADERLGQRVVAAVVLAAGSPLPELAELRSHV
TH_4370|M.thermoresistible__bu VEAAVNTHPAVAESVVFGVPDDRLGQRVVAALVLKPGAEAPSVDDLRTHV
MUL_0641|M.ulcerans_Agy99 VESALATHAAVSDCAVFGLDDDRLGQRVAAAIVVRAHCPTPTLDQLRAHV
MMAR_0888|M.marinum_M VESALATHAAVSDCAVFGLDDDRLGQRVAAAIVVRAHCPTPTLDQLRAHV
Mb0556c|M.bovis_AF2122/97 VEAALGTHPAVRDCAVFGLADDRLGQRVVAAIVVGDGCPPPTLEALRAHV
Rv0542c|M.tuberculosis_H37Rv VEAALGTHPAVRDCAVFGLADDRLGQRVVAAIVVGDGCPPPTLEALRAHV
MLBr_02257|M.leprae_Br4923 VEAALCTHPAVSDCAVFGLTDDRLGQRVVAAVVLTDGYATPTLSMLRAHV
MAV_4602|M.avium_104 VEAALCTHPAVADSAVFGLPDDRLGQRVVAAIVLRDGRAAPSPDALRAHL
MAB_3952|M.abscessus_ATCC_1997 VEAALGAHPLVADCAVFGVPDDRLGQRVAAAVVP-SAAGAPTLEDLREHV
**:*: :*. : :..***: * ******.**:* ** *:
Mflv_0033|M.gilvum_PYR-GCK TETLPSSAAPRQLHLVDELPRLGIGKIDRRELVRRFGESD--
Mvan_0937|M.vanbaalenii_PYR-1 ADTLPATAAPRQLHLVDELPRRGIGKVDRRELSRRFA-----
MSMEG_1062|M.smegmatis_MC2_155 ALTLDATAAPREVHVVDELPRHGIGKLDRRALVARFGG----
TH_4370|M.thermoresistible__bu ARILDRTAAPREIHILTRLPRRGIGKVDRRALAQRFAS----
MUL_0641|M.ulcerans_Agy99 AGTLAITAAPRELHVVDELPRRGIGKIDRRALVRRFAAATDQ
MMAR_0888|M.marinum_M AGTLAITAAPRELHVVDELPRRGIGKIDRRALVRRFAAATDQ
Mb0556c|M.bovis_AF2122/97 ARTLDVTAAPRELHVVNVLPRRGIGKVDRAALVRRFAGEADQ
Rv0542c|M.tuberculosis_H37Rv ARTLDVTAAPRELHVVNVLPRRGIGKVDRAALVRRFAGEADQ
MLBr_02257|M.leprae_Br4923 TRRLDAMAAPRELHIVDTLPRRGIGKVDRTALVRRFAKSG--
MAV_4602|M.avium_104 SRTLDATAAPREVHVVAALPRRGIGKVDRAALVRRFAGGGEQ
MAB_3952|M.abscessus_ATCC_1997 TAALDGTAAPRELHLLDELPRRGIGKLDRRALVKRFS-----
: * ****::*:: *** ****:** * **.