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MTTATESEAPRIHKGLAGVVVDTTAISKVVPETNSLTYRGYPVQDLAAQCSFEQVAYLLWHGELPTDQQL ALFSQRERASRRIDRSMQALLAKLPDNCHPMDVVRTAISYLGAEDPEEDVDTAEANYAKSLRMFAVLPTI VATDIRRRQGLTPIPPHSQLGYAQNFLNMCFGEVPEPVVVRAFEQSMVLYAEHSFNASTFAARVVTSTQS DIYSAVTAAIGALKGSLHGGANEAVMHDMLEIGSAEKAPEWLHGKLSRKEKVMGFGHRVYKNGDSRVPTM KVALEQVAQVRDGQRWLDIYNTLESAMFAATRIKPNLDFPTGPAYYLMDFPIESFTPLFVMSRITGWTAH IMEQAASNALIRPLSEYSGQPQRSLV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6647 | - | - | 100% (376) | methylcitrate synthase |
| M. smegmatis MC2 155 | MSMEG_5672 | gltA | 5e-55 | 33.78% (376) | type II citrate synthase |
| M. smegmatis MC2 155 | MSMEG_5676 | - | 3e-30 | 29.44% (377) | citrate synthase 2 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1162 | gltA1 | 1e-171 | 80.00% (375) | citrate synthase |
| M. gilvum PYR-GCK | Mflv_1729 | gltA | 6e-54 | 33.51% (376) | type II citrate synthase |
| M. tuberculosis H37Rv | Rv1131 | gltA1 | 1e-171 | 80.00% (375) | citrate synthase |
| M. leprae Br4923 | MLBr_02130 | gltA | 1e-51 | 33.16% (380) | type II citrate synthase |
| M. abscessus ATCC 19977 | MAB_4619 | - | 0.0 | 82.93% (375) | citrate synthase |
| M. marinum M | MMAR_1381 | gltA1 | 1e-172 | 80.38% (372) | citrate synthase I GltA1 |
| M. avium 104 | MAV_0344 | - | 1e-175 | 81.62% (370) | methylcitrate synthase |
| M. thermoresistible (build 8) | TH_3084 | - | 6e-53 | 33.95% (377) | PUTATIVE citrate synthase I |
| M. ulcerans Agy99 | MUL_2494 | gltA1 | 1e-172 | 79.84% (372) | citrate synthase |
| M. vanbaalenii PYR-1 | Mvan_5022 | gltA | 1e-53 | 33.51% (376) | type II citrate synthase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_6647|M.smegmatis_MC2_155 ------------------------------------MTTATESEA-PRIH
MAB_4619|M.abscessus_ATCC_1997 ------------------------------------MTIAT-----PTIH
MMAR_1381|M.marinum_M --------------------------------------MSTLDDT-PRIC
MUL_2494|M.ulcerans_Agy99 --------------------------------------MSTLDDT-PRVC
MAV_0344|M.avium_104 --------------------------------------MSTLEDNQPRIH
Mb1162|M.bovis_AF2122/97 --------------------MTGPLAAARSVAATKSMTAPTVDER-PDIK
Rv1131|M.tuberculosis_H37Rv --------------------MTGPLAAARSVAATKSMTAPTVDER-PDIK
Mflv_1729|M.gilvum_PYR-GCK MADNAEAGQEHATLSYPGGELELDIVKASEGSDGIALGSLLAKTGYTTFD
Mvan_5022|M.vanbaalenii_PYR-1 MADNADAGQEHATLVYPGGELELDIVKASEGADGIALGSLLAKSGYTTFD
TH_3084|M.thermoresistible__bu VAENASSGDKHATLIYPGGQIDLEIVRATEGADGIALGSMLAETGYTTFD
MLBr_02130|M.leprae_Br4923 MADTDDT----VTLKYPGGEIDLQIVRATEGNDGIAIVPVLAKTGYTTFD
. .
MSMEG_6647|M.smegmatis_MC2_155 KGLAGVVVDTTAISKVVPETNSLTYRGYPVQDLAAQCSFEQVAYLLWHGE
MAB_4619|M.abscessus_ATCC_1997 KGLAGVVVDTTAISKVVPETNSLTYRGYPVQDLAVQCSFEQVAYLLWHGE
MMAR_1381|M.marinum_M KGLAGVVVDNTAISKVVAETNSLTYRGYPVEDLAAHCSFEQVAYLLWHGE
MUL_2494|M.ulcerans_Agy99 KGLAGVVVDNTAISKVVAETNSLTYRGYPVEDLAAHCSFEQVAYLLWHGE
MAV_0344|M.avium_104 KGLAGVVVDTTAISKVVPETNSLTYRGYAVQDLAAHCSFEQVAYLLWYGE
Mb1162|M.bovis_AF2122/97 KGLAGVVVDTTAISKVVPQTNSLTYRGYPVQDLAARCSFEQVAFLLWRGE
Rv1131|M.tuberculosis_H37Rv KGLAGVVVDTTAISKVVPQTNSLTYRGYPVQDLAARCSFEQVAFLLWRGE
Mflv_1729|M.gilvum_PYR-GCK GGFVNTASTKSAITYIDGDAGILRYRGYPIEQLAEKSTFIEVSYLLIYGE
Mvan_5022|M.vanbaalenii_PYR-1 GGFVNTASTKSAITYIDGDAGILRYRGYPIEQLAEKSNFIEVSYLLIYGE
TH_3084|M.thermoresistible__bu SGFVNTASTKSSITYIDGEAGILRYRGYPIEQLAEKSTFIEVCFLLIYGE
MLBr_02130|M.leprae_Br4923 VGYGNTASTKSSITYIDGDAGILRYRGYPIEQLAEKSTFIEVCYLLIYGE
* ... .::*: : ::. * ****.:::** :..* :*.:** **
MSMEG_6647|M.smegmatis_MC2_155 LPTDQQLALFSQRERASRRIDRSMQALLAKLPDNCHPMDVVRTAISYLGA
MAB_4619|M.abscessus_ATCC_1997 LPNDGELALFNQRERAQRRLDRSLMALLAKLPETCHPMDVVRTAISYLGA
MMAR_1381|M.marinum_M LPDDQQLALFMQRERAARRLNRSMLSLLAKLPDTCHPMDVVRTLISYLGA
MUL_2494|M.ulcerans_Agy99 LPDDQQLALFMQRERAARRLNRSMLSLLAKLPDTCHPMDVVRTLISYLGA
MAV_0344|M.avium_104 LPDDQQLALFSQRERAARRLNRSQLSLLHKLPDTCHPMDVVRTFISSMGA
Mb1162|M.bovis_AF2122/97 LPTDAELALFSQRERASRRVDRSMLSLLAKLPDNCHPMDVVRTAISYLGA
Rv1131|M.tuberculosis_H37Rv LPTDAELALFSQRERASRRVDRSMLSLLAKLPDNCHPMDVVRTAISYLGA
Mflv_1729|M.gilvum_PYR-GCK LPTAEQLEDFTTKIQRHTLLHEDLKRFFDGFPRNAHPMPVLSSAVNALSA
Mvan_5022|M.vanbaalenii_PYR-1 LPTADQLEDFTTKIQRHTLLHEDLKRFFDGFPRNAHPMPVLSSAVNALSA
TH_3084|M.thermoresistible__bu LPNTDQLAEFTTRIQRHTLLHEDLKRFFDGFPREAHPMPVLSSAVNALSA
MLBr_02130|M.leprae_Br4923 LPATDQLAEFTHRIQRHTMLHEDLKRFYDGFPRNAHPMPVLSSVVNALSA
** :* * : : :... : :* .*** *: : :. :.*
MSMEG_6647|M.smegmatis_MC2_155 EDPE-EDVDTAEANYAKSLRMFAVLPTIVATDIRRRQGLTPIPPHSQLGY
MAB_4619|M.abscessus_ATCC_1997 EDPS-EDDSTPDANYAKSLRMFAVLPTIVASDMRRRRGLDPIQPHSHLGY
MMAR_1381|M.marinum_M EDPD-EDDSSPRSNYTKSLRMFAVLPTIVAADMRRRRGLAPIAPHSHMSY
MUL_2494|M.ulcerans_Agy99 EDPD-EDDSSPRSNYAKSLRMFAVLPTIVAADMRRRRGLAPVAPHSHMSY
MAV_0344|M.avium_104 EDPD-EDDNSASANHAKALRMFAVLPTIVAADMRRRRGLEPIAPHSHMSY
Mb1162|M.bovis_AF2122/97 EDPD-EDD--AAANRAKAMRMMAVLPTIVAIDMRRRRGLPPIAPHSGLGY
Rv1131|M.tuberculosis_H37Rv EDPD-EDD--AAANRAKAMRMMAVLPTIVAIDMRRRRGLPPIAPHSGLGY
Mflv_1729|M.gilvum_PYR-GCK YYQDSLDPFDPHQVELSTIRLLAKLPTIAAYAYKKSEGQPFLYPDNSLTL
Mvan_5022|M.vanbaalenii_PYR-1 YYQDSLDPFDPKQVELSTIRLLAKLPTIAAYAYKKSEGQPFLYPDNSLTL
TH_3084|M.thermoresistible__bu YYPDSLDPNDTRQVELSTIRLLAKLPTIAAYAYKKSEGQPFLYPDNSLTL
MLBr_02130|M.leprae_Br4923 YYQDALDPMDNGQVELSTIRLLAKLPTIAAYAYKKSVGQPFLYPDNAFSL
. * .::*::* ****.* :: * : *.. :
MSMEG_6647|M.smegmatis_MC2_155 AQNFLNMCFG-----EVPEPVVVRAFEQSMVLYAEHSFNASTFAARVVTS
MAB_4619|M.abscessus_ATCC_1997 SANFLRMCFG-----EIPDPVIVKAFEQSMILYAEHSFNASTFAARVVTS
MMAR_1381|M.marinum_M AQNFLHMCFG-----DVPESAVVDTFEQSLVLYAEHSFNASTFAARVVTS
MUL_2494|M.ulcerans_Agy99 AQNFLHMCFG-----DVPESAVVDAFEQSLVLYAEHSFNASTFVARVVTS
MAV_0344|M.avium_104 AQNFLHMCFG-----DVPEQVIVDAFEQSMILYAEHSFNASTFAARVVTS
Mb1162|M.bovis_AF2122/97 AQNFLHMCFG-----EVPETAVVSAFEQSMILYAEHGFNASTFAARVVTS
Rv1131|M.tuberculosis_H37Rv AQNFLHMCFG-----EVPETAVVSAFEQSMILYAEHGFNASTFAARVVTS
Mflv_1729|M.gilvum_PYR-GCK VENFLRMTFGFPAEPYEVDPEIVRALDMLFILHADHEQNCSTSTVRLVGS
Mvan_5022|M.vanbaalenii_PYR-1 VENFLRMTFGFPAEPYEVDPEIVRALDMLFILHADHEQNCSTSTVRLVGS
TH_3084|M.thermoresistible__bu VENFLRMTFGFPAEPYQVDPEVVRALDMLLILHADHEQNCSTSTVRLVGS
MLBr_02130|M.leprae_Br4923 VENFLRMTFGLPAEPYEPDPEVVRALDMLFILHADHEQNCSTSTVRLVGS
***.* ** : :* ::: ::*:*:* *.** ..*:* *
MSMEG_6647|M.smegmatis_MC2_155 TQSDIYSAVTAAIGALKGSLHGGANEAVMHDMLEIGSAEKAPEWLHGKLS
MAB_4619|M.abscessus_ATCC_1997 TQSDIYSAVTAAIGALKGSLHGGANEAVMHDMIEIGDASKASEWLQSKRS
MMAR_1381|M.marinum_M TQSDIYSAVAAAIGALKGTLHGGANEAVMRDMLEIGSADRASEWLRRKLA
MUL_2494|M.ulcerans_Agy99 TQSDIYSAVAAAIGALKGTLHGGANEAVMRDMLEIGSADQASEWLRRKLA
MAV_0344|M.avium_104 TQSDIYSAVTAAIGALKGSLHGGANEAVMHDMLEIGTPDRAAEWLQGKLS
Mb1162|M.bovis_AF2122/97 TQSDIYSAVTGAIGALKGRLHGGANEAVMHDMIEIGDPANAREWLRAKLA
Rv1131|M.tuberculosis_H37Rv TQSDIYSAVTGAIGALKGRLHGGANEAVMHDMIEIGDPANAREWLRAKLA
Mflv_1729|M.gilvum_PYR-GCK SQANLFTSISGGINALWGPLHGGANQAVLEMLSKIRDGDDDVATFVKKVK
Mvan_5022|M.vanbaalenii_PYR-1 SQANLFTSISGGINALWGPLHGGANQAVLEMLSKIRAEGGDVKEFVRKVK
TH_3084|M.thermoresistible__bu SQANLFTSISGGINALWGPLHGGANQAVLEMLEKIRVEGGDVRDFVRRVK
MLBr_02130|M.leprae_Br4923 SRANLFTSISGGINALWGPLHGGANQAVLEMLEGIRESGDDVGGFVQKVK
::::::::::..*.** * ******:**:. : * : :
MSMEG_6647|M.smegmatis_MC2_155 RKE---KVMGFGHRVYKNGDSRVPTMKVALEQVAQVRDGQR-WLDIYNTL
MAB_4619|M.abscessus_ATCC_1997 RKE---KIMGFGHRVYKNGDSRVPTMRAALEDVARVRDGGQ-WLEIYKVL
MMAR_1381|M.marinum_M RKE---KVMGFGHRVYRNGDSRVPTMKRALDRVAAVRDGQR-WLDIYQVL
MUL_2494|M.ulcerans_Agy99 RKE---KVMGFGHRVYRNGDSRVPTMKRALDRVAAVRDGQR-WLDIYQVL
MAV_0344|M.avium_104 RKE---KVMGFGHRVYKNGDSRVPTMKQALQRVAAVRDGQK-WLDIYQIL
Mb1162|M.bovis_AF2122/97 RKE---KIMGFGHRVYRHGDSRVPTMKRALERVGTVRDGQR-WLDIYQVL
Rv1131|M.tuberculosis_H37Rv RKE---KIMGFGHRVYRHGDSRVPTMKRALERVGTVRDGQR-WLDIYQVL
Mflv_1729|M.gilvum_PYR-GCK NREDNVKLMGFGHRVYKNYDPRARIVKEQADKILGKIGVHDPLLDIAKEL
Mvan_5022|M.vanbaalenii_PYR-1 NREDGVKLMGFGHRVYKNYDPRARIVKEQADKILGKIGVQDDLLDIAKSL
TH_3084|M.thermoresistible__bu NREDNVRLMGFGHRVYKNYDPRARIVKEQADKILGKLGGDDELLNIAKEL
MLBr_02130|M.leprae_Br4923 NCQAGVKLMGFGHRVYKNYDPRARIVKEQADKILVKLGGDDDLLNIAKGL
. : ::********:: *.*. :: : : . *:* : *
MSMEG_6647|M.smegmatis_MC2_155 ESAMFA-----ATRIKPNLDFPTGPAYYLMDFPIESFTPLFVMSRITGWT
MAB_4619|M.abscessus_ATCC_1997 ESEMDA-----ATGIKPNLDFPTGPAYYLMGFDIPCFTPIFVMSRITGWT
MMAR_1381|M.marinum_M EREMLA-----ATGIRPNLDFPTGPAYHLMGFDIGSFTPIFVMSRITGWT
MUL_2494|M.ulcerans_Agy99 EREMLA-----ATGIRPNLDFPTGPAYHLMGFDIGSFTPIFVMSRITGWT
MAV_0344|M.avium_104 ERGMAR-----ANGIKPNLDFPTGPAYYLMGFDIGAFTPIFVMSRITGWT
Mb1162|M.bovis_AF2122/97 AAEMAS-----ATGILPNLDFPTGPAYYLMGFDIASFTPIFVMSRITGWT
Rv1131|M.tuberculosis_H37Rv AAEMAS-----ATGILPNLDFPTGPAYYLMGFDIASFTPIFVMSRITGWT
Mflv_1729|M.gilvum_PYR-GCK EEIALTDDFFVERKLYPNVDYYTGVIYRAMGFPTRMFTVLFALGRLPGWI
Mvan_5022|M.vanbaalenii_PYR-1 EEIALTDDFFVERKLYPNVDYYTGVIYRAMGFPTRMFTVLFALGRLPGWI
TH_3084|M.thermoresistible__bu EETALTDEFFIERKLYPNVDFYTGLIYRAMGFPTRMFTVLFALGRLPGWI
MLBr_02130|M.leprae_Br4923 EEAALTDDYFIERKLYPNVDFYTGLIYRALGFPTRMFTVLFALGRLPGWI
: **:*: ** * :.* ** :*.:.*:.**
MSMEG_6647|M.smegmatis_MC2_155 AHIMEQAAS--NALIRPLSEYSGQPQRSLV-----
MAB_4619|M.abscessus_ATCC_1997 AHIMEQAAA--NALIRPLSEYSGKPQRTLAC----
MMAR_1381|M.marinum_M AHIMEQTAS--NALIRPLSEYVGPAQRTLKFAR--
MUL_2494|M.ulcerans_Agy99 AHIMEQTAS--NELIRPLSEYVGPAQRTLKFAR--
MAV_0344|M.avium_104 AHIIEQTAS--NALIRPLSEYVGPPQRALS-----
Mb1162|M.bovis_AF2122/97 AHIMEQATA--NALIRPLSAYCGHEQRVLPGTF--
Rv1131|M.tuberculosis_H37Rv AHIMEQATA--NALIRPLSAYCGHEQRVLPGTF--
Mflv_1729|M.gilvum_PYR-GCK AHWREMHGE-PNKIGRPRQIYTGYTERDYAGIDTR
Mvan_5022|M.vanbaalenii_PYR-1 AHWREMHGE-PNKIGRPRQIYTGYTERDYAGFDSR
TH_3084|M.thermoresistible__bu AHWREMHNEGNNKIGRPRQIYTGYGERDYTPLSER
MLBr_02130|M.leprae_Br4923 AHWREMHDEGDSKIGRPRQIYTGYTERDYTAIETR
** * . : ** . * * :*