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PQTGPWTGDPVWLADVLRAEGVNLVEYPGWRTRGHGDFKDIRGVMVHHTGSDTATAASIANGRPDLPGPL SQLHIARDGTVTIVAVGVAWHAGVGMYPWIPANMGNWHLIGIECANTGTSPTAPHRQNWPDAQYFAMVRC CAAINRRLAQTSARTIGHKEYAGRAQGKWDPGAINMDILRADIQNQIGVLEAPAPTPRPRVPVGEYIDVL LYRPMEGAEVAELQRRLNALGADLVVDGIFGPLTEAAVRDFQRRTPGLKVDGIVGPATAAALNL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5315 | - | - | 100% (275) | gp35 protein |
| M. smegmatis MC2 155 | MSMEG_0533 | - | 6e-36 | 46.24% (173) | gp236 protein |
| M. smegmatis MC2 155 | MSMEG_6935 | - | 3e-05 | 48.33% (60) | N-acetylmuramoyl-L-alanine amidase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3625 | - | 2e-59 | 52.36% (212) | hypothetical protein Mb3625 |
| M. gilvum PYR-GCK | Mflv_3152 | - | 1e-124 | 74.91% (279) | peptidoglycan binding domain-containing protein |
| M. tuberculosis H37Rv | Rv3594 | - | 2e-59 | 52.36% (212) | hypothetical protein Rv3594 |
| M. leprae Br4923 | MLBr_02704 | - | 1e-05 | 46.67% (60) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_4807 | - | 1e-140 | 83.27% (275) | bacteriophage protein |
| M. marinum M | MMAR_5479 | - | 4e-05 | 45.00% (60) | hydrolase |
| M. avium 104 | MAV_5303 | - | 2e-05 | 46.67% (60) | putative N-acetylmuramoyl-L-alanine amidase |
| M. thermoresistible (build 8) | TH_0851 | - | 1e-125 | 75.27% (279) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_5068 | - | 3e-05 | 45.00% (60) | hydrolase |
| M. vanbaalenii PYR-1 | Mvan_3376 | - | 1e-126 | 76.34% (279) | peptidoglycan binding domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3625|M.bovis_AF2122/97 --------------------------------------------------
Rv3594|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_5315|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4807|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_3152|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3376|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_0851|M.thermoresistible__bu --------------------------------------------------
MMAR_5479|M.marinum_M MPSPRREDGDTLRCGDRSAAVAEIRAALAALGMLDNPDEDLSTGRHIALE
MUL_5068|M.ulcerans_Agy99 MPSPRREDGDTLRCGDRSAAVAEIRAALAALGMLDNPDEDLSTGRHIALE
MAV_5303|M.avium_104 MSSPRREYGDALRCGDRSAAVTEIRATLASLGLLASADEDLSTGRHVALE
MLBr_02704|M.leprae_Br4923 MSSPRCEDGDTLRCGDRNAAVTEIRSALAALGLLHSPGDDLTTSKYIALD
Mb3625|M.bovis_AF2122/97 ---------------------------------------------MGWIG
Rv3594|M.tuberculosis_H37Rv ---------------------------------------------MGWIG
MSMEG_5315|M.smegmatis_MC2_155 -----------------------------------------MPQTGPWTG
MAB_4807|M.abscessus_ATCC_1997 -----------------------------------------MPQTGPWTG
Mflv_3152|M.gilvum_PYR-GCK -----------------------------------------MPQPGGWRG
Mvan_3376|M.vanbaalenii_PYR-1 -----------------------------------------MPQVPGWRG
TH_0851|M.thermoresistible__bu -----------------------------------------VPAVRTWTG
MMAR_5479|M.marinum_M LFDPELDHAVRAFQQHRGLLVDGIVGEATYRALREASYRLGARTLYHQFG
MUL_5068|M.ulcerans_Agy99 LFDPELDHAVRAFQQHRGLLVDGIVGEATYRALREASYRLGARTLYHQFG
MAV_5303|M.avium_104 LFDAELDQAVRAFQQHRGLLVDGIVGEATYRALKEASYRLGARTLYHQFG
MLBr_02704|M.leprae_Br4923 LFDPQLEHAVRAFQQHRGLLVDGVVGEATHRALKEASYRLGARTLYHRFG
*
Mb3625|M.bovis_AF2122/97 DPIWLEEVLRPALGERLRVLDGWRERGHGDFRDIRGVMWHHTGN------
Rv3594|M.tuberculosis_H37Rv DPIWLEEVLRPALGERLRVLDGWRERGHGDFRDIRGVMWHHTGN------
MSMEG_5315|M.smegmatis_MC2_155 DPVWLADVLR-AEGVNLVEYPGWRTRGHGDFKDIRGVMVHHTGS------
MAB_4807|M.abscessus_ATCC_1997 DPVWIVDILR-AEGVNPVEYPGWRGRGHGDFKDIRGVMVHHTGS------
Mflv_3152|M.gilvum_PYR-GCK DPVWLAEVLR-AEGLDVVEFPGWRNRGHGDFKDIRGVMVHHTGS------
Mvan_3376|M.vanbaalenii_PYR-1 DPVWLADVLR-AEGLDVVEFPGWRQRGHGDFKDIRGVMVHHTGS------
TH_0851|M.thermoresistible__bu DPVWLADVLV-AEGLDAVEFPGWRNRGHGDFRDIRGVMVHHTGS------
MMAR_5479|M.marinum_M APLYGDDVATLQARLQDLGFYTGLVDGYFGLQTHNALMSYQREYGMSADG
MUL_5068|M.ulcerans_Agy99 APLYGDDVATLQARLQDLGFYTGLVDGYFGLQTHNALMSYQREYGMSADG
MAV_5303|M.avium_104 APLYGDDVATLQARLQDLGFYTGLVDGYFGLQTHNALMSYQREYGLSADG
MLBr_02704|M.leprae_Br4923 APLSGDDVATLQARLQDLGFYTGMVDGHFGLQTHNALISYQREYGLTADG
*: :: *: .:: ..:: ::
Mb3625|M.bovis_AF2122/97 --------------SRETAKS---------IARGRPDLPGPLANLHIAHS
Rv3594|M.tuberculosis_H37Rv --------------SRETAKS---------IARGRPDLPGPLANLHIAHS
MSMEG_5315|M.smegmatis_MC2_155 --------------DTATAAS---------IANGRPDLPGPLSQLHIARD
MAB_4807|M.abscessus_ATCC_1997 --------------DSASAAS---------IAEGRPDLAGPLSQLHIARN
Mflv_3152|M.gilvum_PYR-GCK --------------DTASAES---------IARGRPDLAGPLSQLHIARD
Mvan_3376|M.vanbaalenii_PYR-1 --------------NSATAAS---------IAFGRPDLAGPLSQLHIARD
TH_0851|M.thermoresistible__bu --------------DHATAAS---------IAHGRPDLPGPLSQLHIARD
MMAR_5479|M.marinum_M ICGPETLRSLYFLSSRVSGGSPHAIREEELVRRSGPKLSGKRIIIDPGRG
MUL_5068|M.ulcerans_Agy99 ICGPETLRSLYFLSSRVSGGSPHAIREEELVRRSGPKLSGKRIIIDPGRG
MAV_5303|M.avium_104 ICGPETLRSLYFLSSRVTGGSPHALREEELVRRSGPKLSGKRIIIDPGRG
MLBr_02704|M.leprae_Br4923 ICGPETLRSLYFLSSRVTGGSPHAIREEELVRRSGPKLSGKRIIIDPGRG
. :. * : . *.*.* :. .:.
Mb3625|M.bovis_AF2122/97 G-VVTIVAVGVCWHAGRGSYPWLPTD--NANWHMIGVECAWPTIRRDGSY
Rv3594|M.tuberculosis_H37Rv G-VVTIVAVGVCWHAGRGSYPWLPTD--NANWHMIGVECAWPTIRRDGSY
MSMEG_5315|M.smegmatis_MC2_155 G-TVTIVAVGVAWHAGVGMYPWIPAN--MGNWHLIGIECANTGTSPTAPH
MAB_4807|M.abscessus_ATCC_1997 G-AVTVVAVGVAWHAGVGMYPWLPTN--MGNWHLIGIECANTGTSPTAPH
Mflv_3152|M.gilvum_PYR-GCK G-TVTVVAAGVAWHAGVGMYPWLPAN--MGNWHTIGIECANSGTSPTAPH
Mvan_3376|M.vanbaalenii_PYR-1 G-TVTVVAAGVAWHAGVGMYPWLPAN--MGNWHTIGIECANSGTSPTAPH
TH_0851|M.thermoresistible__bu G-TVTVVAAGVAWHAGVGQYPWLPTN--MANWHMIGIECANSGTSPTAPH
MMAR_5479|M.marinum_M GSDRGLIAHGEAGPVSEADVLWDLASRLEGRMSAIGMETFLSRPANTSPS
MUL_5068|M.ulcerans_Agy99 GSDRGVIAHGEAGPISEADVLWDLASRLEGRMSAIGMETFFSRPANTSPS
MAV_5303|M.avium_104 GADHGMIMQGPSGPISEADVLWDLASRLEGRMTAIGMETFLSRPVNRSPL
MLBr_02704|M.leprae_Br4923 GADRGLITQGPTGPISEADVLWDLASRLEGRMAAIGIETFLSRTTNGSPS
* :: * . . * :. .. **:* . ..
Mb3625|M.bovis_AF2122/97 DAGERWPDAQIVSMRDVAAALTLKLGYGPERNIGHKEYAGAAQGKWDPGN
Rv3594|M.tuberculosis_H37Rv DAGERWPDAQIVSMRDVAAALTLKLGYGPERNIGHKEYAGAAQGKWDPGN
MSMEG_5315|M.smegmatis_MC2_155 RQ--NWPDAQYFAMVRCCAAINRRLAQTSARTIGHKEYAGRAQGKWDPGA
MAB_4807|M.abscessus_ATCC_1997 RQ--NWPDAQYSTLINCCAAINRRLAQTSARTIGHKEYAGRAQGKWDPGA
Mflv_3152|M.gilvum_PYR-GCK RR--NWPDAQYAALIGCCAAICRRLGVPATRTIGHKEYAGRAQGKWDPGG
Mvan_3376|M.vanbaalenii_PYR-1 RR--NWPDAQYFALVGSCAAINRHLGQPAGRTIGHKEYAGRAQGKWDPGA
TH_0851|M.thermoresistible__bu RT--NWPDAQYDALVASCAAINRRLGQPADRTIGHKEYAGRAQGKWDPGA
MMAR_5479|M.marinum_M DA-ERAATANAVGADLMISLRCETQTTVSANGVASFHFGNSHGSVSTIGR
MUL_5068|M.ulcerans_Agy99 DA-ERAATANAVGADLMISLRCETQTSVSANGVASFHFGNSHGSVSTIGR
MAV_5303|M.avium_104 DA-ERAATANNVGADLMISLRCEAQKSPAANGVASFHFGNSHGSVSTIGR
MLBr_02704|M.leprae_Br4923 DS-ERAAIANNVGAELMISLRCETQTSPAANGVASFHFGNSHGSVSTIGR
. . *: : . . :. .:.. . *
Mb3625|M.bovis_AF2122/97 LSMDWFRAEVAKDTRGEFDHPL-TPPPAV-IARPPILPKPRNPRDDRILL
Rv3594|M.tuberculosis_H37Rv LSMDWFRAEVAKDTRGEFDHPL-TPPPAV-IARPPILPKPRNPRDDRILL
MSMEG_5315|M.smegmatis_MC2_155 INMDILRADIQNQIGVLEAPAP-TPRPRVPVGEYIDVLLYRPMEGA--EV
MAB_4807|M.abscessus_ATCC_1997 IDMDVLRRDIQDQIGRVAIPAP-TPRPSVPVGEYADVLLFRGSKGP--QV
Mflv_3152|M.gilvum_PYR-GCK IDMDRLRRDVAARIGSVGGGP--RPRPTVPVGEYAEVLLYRGSRGP--QV
Mvan_3376|M.vanbaalenii_PYR-1 IDMDQLRRDVGERIGAVAGGG--TPRPPVPVGEYADVLLYRGVRGP--QV
TH_0851|M.thermoresistible__bu IDMDLLRADIQTRIGDLDSRVR-TPRPPVPVGQYAHILLFRGSQGP--LV
MMAR_5479|M.marinum_M NLADFIQREVVARTGLQDCRTHGRTWDLLRLTRMPTVQVDIGYITNPLDR
MUL_5068|M.ulcerans_Agy99 NLADFIQREVVARTGLQDCRTHGRTWDLLRLTRMPTVQVDIGYITNPLDR
MAV_5303|M.avium_104 NLADFIQREVVARTGLRDCRTHGRTWDLLRLTRMPTVQVDVGYVTNPHDR
MLBr_02704|M.leprae_Br4923 NLADFIQREIVARTGLRDCRTHGRTWDLLRLTRMPTVQIDIGYITNPRDR
* :: :: . : : . :
Mb3625|M.bovis_AF2122/97 EEVWDQLR----------GIEGRGWPVLGDKTIVDYLAELG-NKVDALAA
Rv3594|M.tuberculosis_H37Rv EEVWDQLR----------GIEGRGWPVLGDKTIVDYLAELG-NKVDALAA
MSMEG_5315|M.smegmatis_MC2_155 AELQRRLN----ALGADLVVDGIFGPLTEAAVRDFQRRTPG-LKVDGIVG
MAB_4807|M.abscessus_ATCC_1997 SQLQRRLN----EHGADLVVDGIFGPNTEASVREFQRRARG-LKVDGIVG
Mflv_3152|M.gilvum_PYR-GCK AELQRRLKHAYAAYAGDLRIDGVYGPDTEAAVREFQRRTAG-LKVDGVVG
Mvan_3376|M.vanbaalenii_PYR-1 AELQRRLRYAYASYAGGLEIDGVFGPETESAVREFQRRTPG-LKVDGVVG
TH_0851|M.thermoresistible__bu AEVQRRLRSDHPDIAGDLAVDGIFGPRTEEAVRRFQRKTRG-LKVDGIVG
MMAR_5479|M.marinum_M ELLVSTQT-------RDAIAEGILAAVKRLYLLGKNDRPTGTFTFAELLA
MUL_5068|M.ulcerans_Agy99 ELLVSTQT-------RDAIAEGILAAVKRLYLLGKNDRPTGTFTFAELLA
MAV_5303|M.avium_104 AMLVSTQT-------RDAIAEGILAAVKRLYLLGKNDRPTGTFTFAELLA
MLBr_02704|M.leprae_Br4923 GVLIGTQN-------RDAIAEGILAAVKRLYLLGKNDQPTGTFTFAELLA
: :* . * .. : .
Mb3625|M.bovis_AF2122/97 KLDAREGLDRPSDTR----
Rv3594|M.tuberculosis_H37Rv KLDAREGLDRPSDTR----
MSMEG_5315|M.smegmatis_MC2_155 PATAAALNL----------
MAB_4807|M.abscessus_ATCC_1997 PATAAALRLKAEPALE---
Mflv_3152|M.gilvum_PYR-GCK PATAAALRLRLVDPDPDAG
Mvan_3376|M.vanbaalenii_PYR-1 PATAAALRLRLVDG-----
TH_0851|M.thermoresistible__bu PATAAALRLQTV-------
MMAR_5479|M.marinum_M HELSVERASRLSGS-----
MUL_5068|M.ulcerans_Agy99 HELSVERASRLSGS-----
MAV_5303|M.avium_104 HELSVERTSQMGGS-----
MLBr_02704|M.leprae_Br4923 HELSVERASRLGGS-----
: