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TQAGIETASENAEVTGLSLPPGADPVDFVAELARALPERDGEEYVVYERDRQWTLAAGVRAVIELDSDEI RVISDDVVQSQPWTGRPGAALGEAVDRLLLETEQLFGWVAFEFGTYRFGLQEHLKPGTPLARVLAPRTRI VVADGRVELIGADERQVEAVRRLLAGTIGPAPVSTAVDVRADGSRYRDRVATAIGEITGGRYQKVILSRR LELPFAVDFPATYRVGRRNNTPARSFLLRLSGIRALGFSPELVAAVHADGTVITEPLAGTRAFGRGADDD RAAREDLVSNPKEIVEHAISVKTSISEIEEVAEAGTAVVLDFMTVRERGSVQHLGSTVGGRLKGSMDRMH ALEALFPAVTASGIPKAESMDAILRLDEAPRGLYSGAVVTFSADGAMDAALTLRSAYEAHGATWLRAGAG IIAESTPEREFEETCEKLTTLAPHLVPRV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4524 | - | - | 100% (450) | salicylate synthase MbtI |
| M. smegmatis MC2 155 | MSMEG_3217 | trpE | 4e-32 | 31.02% (332) | anthranilate synthase component I |
| M. smegmatis MC2 155 | MSMEG_5446 | pabB | 6e-15 | 27.01% (211) | para-aminobenzoate synthase component I |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2407c | mbtI | 1e-165 | 65.26% (449) | salicylate synthase MbtI |
| M. gilvum PYR-GCK | Mflv_3602 | - | 6e-32 | 31.14% (334) | anthranilate synthase component I |
| M. tuberculosis H37Rv | Rv2386c | mbtI | 1e-165 | 65.26% (449) | salicylate synthase MbtI |
| M. leprae Br4923 | MLBr_01269 | trpE | 9e-33 | 31.42% (331) | anthranilate synthase component I |
| M. abscessus ATCC 19977 | MAB_2245 | - | 1e-155 | 63.26% (430) | salicylate synthase MbtI |
| M. marinum M | MMAR_3706 | mbtI | 1e-165 | 66.22% (450) | isochorismate synthase MbtI |
| M. avium 104 | MAV_1792 | - | 1e-169 | 67.48% (449) | salicylate synthase MbtI |
| M. thermoresistible (build 8) | TH_2725 | - | 1e-30 | 29.82% (332) | PUTATIVE anthranilate synthase component I |
| M. ulcerans Agy99 | MUL_3648 | mbtI | 1e-165 | 65.71% (452) | salicylate synthase MbtI |
| M. vanbaalenii PYR-1 | Mvan_2814 | - | 6e-30 | 31.40% (258) | anthranilate synthase component I |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2407c|M.bovis_AF2122/97 --MSELSVATGAVSTASSSIP----MPAGVNPADLAAELAAVVTESVDED
Rv2386c|M.tuberculosis_H37Rv --MSELSVATGAVSTASSSIP----MPAGVNPADLAAELAAVVTESVDED
MMAR_3706|M.marinum_M ---MEVSVEASAVSTAEPSIP----MPADIDPADLAAELAVVLCEAVRPE
MUL_3648|M.ulcerans_Agy99 --MVEVSVEASAVSTAEPSIP----MPADIDPADLAAELAVVLCDAVRPE
MAV_1792|M.avium_104 --MTEVSVETTSAGSESPSIP----LPVHIDPADLAAELAVVLSERAGEE
MSMEG_4524|M.smegmatis_MC2_155 --MTQAGIETASENAEVTGLS----LPPGADPVDFVAELARALPERDGEE
MAB_2245|M.abscessus_ATCC_1997 --MSKMSAVVDPDTGARTWVSVQEGLPDGFAPADLAGALAQEIPERHGDE
Mflv_3602|M.gilvum_PYR-GCK MQTTADLSVTTSREDFRTLAAEHRVVPVTRKVLADSETPLSAYRKLAANR
Mvan_2814|M.vanbaalenii_PYR-1 MQMTATLSATTTREDFRALAAEHRVVPVTRKVLADSETPLSAYRKLAANR
TH_2725|M.thermoresistible__bu --------------------------------------------------
MLBr_01269|M.leprae_Br4923 --MHAHLAATTSREDFRQLAVDHRVVPVTRKVLADSETPLSAYRKLAANR
Mb2407c|M.bovis_AF2122/97 ---YLLYECD-----GQWVLAAGVQAMVELDSDELRVIRDGVTRRQQWSG
Rv2386c|M.tuberculosis_H37Rv ---YLLYECD-----GQWVLAAGVQAMVELDSDELRVIRDGVTRRQQWSG
MMAR_3706|M.marinum_M GTQYLLYERD-----GQWVLASGVQAMVELDSDEVRVIRDGVTQRQQWSG
MUL_3648|M.ulcerans_Agy99 GTQYLLYERD-----GQWVLASGVQAMVELDSDEVRVMRDGVTQRQQWSG
MAV_1792|M.avium_104 ---YLLYERG-----GEWVLATGVRAMIELDSDELRVIRDGVTQRQHWSG
MSMEG_4524|M.smegmatis_MC2_155 ---YVVYERD-----RQWTLAAGVRAVIELDSDEIRVISDDVVQSQPWTG
MAB_2245|M.abscessus_ATCC_1997 ---YLIYERD-----GEWVLAIGARASVELDSDGLRIVRDGTIEKRDWSG
Mflv_3602|M.gilvum_PYR-GCK PGTFLLESAENGRSWSRWSFIGAGAPSALTVRDGEAVWLGVIPQDAPAGG
Mvan_2814|M.vanbaalenii_PYR-1 PGTFLLESAENGRSWSRWSFIGAGAPSALTVRDGEAVWLGVIPQDAPSGG
TH_2725|M.thermoresistible__bu ---------------VXX--------------------------------
MLBr_01269|M.leprae_Br4923 PSTFLLESAENGRSWSQWSFIGVGAPSALTIRDGEAVWLGTVPQDAPTGG
Mb2407c|M.bovis_AF2122/97 RPGAALGEAVDRLLLETDQAFG-WVAFEFGVHRYGLQQRLAPH-------
Rv2386c|M.tuberculosis_H37Rv RPGAALGEAVDRLLLETDQAFG-WVAFEFGVHRYGLQQRLAPH-------
MMAR_3706|M.marinum_M RPGEVLGEAIDRLLLETDQVFG-WVAFEFGLYRYGLQARLAPG-------
MUL_3648|M.ulcerans_Agy99 RPGEVLGEAIDRLLLETDQVFG-WVAFEFGLYRYGLQARLAPG-------
MAV_1792|M.avium_104 RPGPVLGEAIDRLLLETDQLFG-WIAFEFGVYRYGLQQRLAPG-------
MSMEG_4524|M.smegmatis_MC2_155 RPGAALGEAVDRLLLETEQLFG-WVAFEFGTYRFGLQEHLKPG-------
MAB_2245|M.abscessus_ATCC_1997 HPGAALEQAVNEISDGTHRVFG-WVAFEFGTYRFNLQHRLAPG-------
Mflv_3602|M.gilvum_PYR-GCK DPLQALRTTLTLLETAALPGLPPLSSGLVGFFAYDLVRRLERLPELTVDD
Mvan_2814|M.vanbaalenii_PYR-1 DPLQALRATLTLLETAPLPGLPPLSSGLVGFFAYDLVRRLERLPELTVDD
TH_2725|M.thermoresistible__bu ---XALRATLELLKTEPLPGLPPLSSGLVGFFAYDLVRRLERLPELAVDD
MLBr_01269|M.leprae_Br4923 DPLHVLQATLELLATAAMPGLPPLSSGMVGFFAYDMVRRLERLPELALND
.* :: : . : : .* . :.: :*
Mb2407c|M.bovis_AF2122/97 -----------TPLARVFSPRTRIMVSEKEIRLFDAGIRHREAIDRLLA-
Rv2386c|M.tuberculosis_H37Rv -----------TPLARVFSPRTRIMVSEKEIRLFDAGIRHREAIDRLLA-
MMAR_3706|M.marinum_M -----------TPLARVFWPRTRIVVTRDDVSLFGAEPHEREAVLRLLR-
MUL_3648|M.ulcerans_Agy99 -----------TPLARVFWPRTRIVVTRDDVSLFGAERHEREAVLRLLR-
MAV_1792|M.avium_104 -----------TALARVFWPNGRVVVTREAIQLFGTSTGRRDDVLGVLG-
MSMEG_4524|M.smegmatis_MC2_155 -----------TPLARVLAPRTRIVVADGRVELIGADERQVEAVRRLLA-
MAB_2245|M.abscessus_ATCC_1997 -----------TPLARVFAPRAEVVITADGVSVSDES--YVEDISRLIE-
Mflv_3602|M.gilvum_PYR-GCK LGLPDMMLLLATDIAAVDHHEGTITLIANAVNWNGTDERVDEAYDDAVAR
Mvan_2814|M.vanbaalenii_PYR-1 LALPDMMLLLATDVAAVDHHEGTITLIANAVNWNGTDERVDWAYDDAVAR
TH_2725|M.thermoresistible__bu LGLPDMVLLLATDIAAVDHHEGTITLIANAVNWNGTDERVDWAYDDAVAR
MLBr_01269|M.leprae_Br4923 LQLPDMLLLLATDVAAVDHHEGTITLIANAVNWNGTDERVDQAYDDAIAR
* :* * . : : : . :
Mb2407c|M.bovis_AF2122/97 ----TGVREVPQSRSVDVSDDP----------SGFRRRVAVAVDEIAAGR
Rv2386c|M.tuberculosis_H37Rv ----TGVREVPQSRSVDVSDDP----------SGFRRRVAVAVDEIAAGR
MMAR_3706|M.marinum_M ----DGLPTVPRSRTIDLSADP----------SGYRDRVAVAVREIASGA
MUL_3648|M.ulcerans_Agy99 ----DGLPTVPRSRTIDLSADP----------SGYRDRVAVAVREIASGA
MAV_1792|M.avium_104 ----DGVPGLRDASAVDVVTDP----------SNYRDRVASAVAEIAAGR
MSMEG_4524|M.smegmatis_MC2_155 ----GTIGPAPVSTAVDVRADG----------SRYRDRVATAIGEITGGR
MAB_2245|M.abscessus_ATCC_1997 ----QGVPAIPAPASIDLAPDP----------SDYRGRVGIATAEIRSGL
Mflv_3602|M.gilvum_PYR-GCK LDVMTAALAEPLASTVATFRRPAPQPRAQLSVDEYTAIVDKLVGDIEAGE
Mvan_2814|M.vanbaalenii_PYR-1 LDVMTAALAEPLASTVATFSRPVPEHRSQRTVEEYTAIVDKLVGDIEAGE
TH_2725|M.thermoresistible__bu LDVMTAALGEPLPSAVATFSRPEPRYRAQRTVEEYTAIVEKLVGDIEAGE
MLBr_01269|M.leprae_Br4923 LDVMTAALGQPLPSTIATFSRPDPRRRAQCTIEEYGAIVDHLVDQIAAGE
. :: . : * :* .*
Mb2407c|M.bovis_AF2122/97 YHKVILSRCVEVPFAIDFPLTYRLGRRHNTPVRSFLLQLG------GIRA
Rv2386c|M.tuberculosis_H37Rv YHKVILSRCVEVPFAIDFPLTYRLGRRHNTPVRSFLLQLG------GIRA
MMAR_3706|M.marinum_M YHKVILSRCVEVPFRLDFPSTYRRGRERNTPVRSFLLRLG------GIRA
MUL_3648|M.ulcerans_Agy99 YHKVILSRCVEVPFRLDFPSTYRRGRERNTPVRSFLLRLG------GIRA
MAV_1792|M.avium_104 YHKVILSRCLQVPFALDFPSTYRLARRHNTPVRSFLLRLG------GIRA
MSMEG_4524|M.smegmatis_MC2_155 YQKVILSRRLELPFAVDFPATYRVGRRNNTPARSFLLRLS------GIRA
MAB_2245|M.abscessus_ATCC_1997 YHKVILSRRVEVPFAMDFPSTYRLGRHNNTPVRSFLLRLG------GIRA
Mflv_3602|M.gilvum_PYR-GCK AFQVVPSQRFEMDTAADPLDVYRMLRVTNPSPYMYLLNVPDHDGGLDFSI
Mvan_2814|M.vanbaalenii_PYR-1 AFQVVPSQRFEMDTDADPLDVYRMLRVTNPSPYMYLLNVPNADGGLDFSI
TH_2725|M.thermoresistible__bu AFQVVPSQRFEMDTDADPLDVYRMLRVSNPSPYMYLLHVPDDAGGLDFSI
MLBr_01269|M.leprae_Br4923 AFQVVPSQRFEVDTDVDPIDVYRMLRVTNPSPYMYLLHVPNSDGATGFSI
:*: *: .:: * .** * *.. :**.: .:
Mb2407c|M.bovis_AF2122/97 LGYSPELVTAVRADGVVITEPLAGTRALGRGPAIDRLARDDLESNSKEIV
Rv2386c|M.tuberculosis_H37Rv LGYSPELVTAVRADGVVITEPLAGTRALGRGPAIDRLARDDLESNSKEIV
MMAR_3706|M.marinum_M LGFSPELVTAVSPSGVVVTEPLAGTRALGRGAAHDRLARGDLESNAKEIV
MUL_3648|M.ulcerans_Agy99 LGFSPELVTAVSPSGVVVTEPLAGTRALGRGAAHDRLARGDLESNAKEIV
MAV_1792|M.avium_104 VGYSPELVAAVRHDGVVVTEPLAGTRAFGRGALHDRQARDDLESNSKEIV
MSMEG_4524|M.smegmatis_MC2_155 LGFSPELVAAVHADGTVITEPLAGTRAFGRGADDDRAAREDLVSNPKEIV
MAB_2245|M.abscessus_ATCC_1997 LGYSPELVTAVEADGTVVTQPLAGTRAFGRGEDADRVARDDLESNAKEIV
Mflv_3602|M.gilvum_PYR-GCK VGSSPEALVTVK-DGRATTHPIAGTRWRGDTEEEDILLEKELLSDEKERA
Mvan_2814|M.vanbaalenii_PYR-1 VGSSPEALVTVK-DGRATTHPIAGTRWRGDTEEEDLLLEKELLCDEKERA
TH_2725|M.thermoresistible__bu VGSSPEALVTVK-DGRATTHPIAGTRWRGATEEEDVLLEKELLADEKERA
MLBr_01269|M.leprae_Br4923 VGSSPEALVTVK-DGRVTTHPIAGTRWRGQTEEEDQLLEKELLADEKERA
:* *** :.:* .* . *.*:**** * * . :* .: ** .
Mb2407c|M.bovis_AF2122/97 EHAISVRSSLEEITDIAEPGSAAVIDFMTVRERGSVQHLGSTIRARLDPS
Rv2386c|M.tuberculosis_H37Rv EHAISVRSSLEEITDIAEPGSAAVIDFMTVRERGSVQHLGSTIRARLDPS
MMAR_3706|M.marinum_M EHAISVRTSLHEITEVAEPGTAAVIDFMSVRERGSVQHLGSTISARLDAA
MUL_3648|M.ulcerans_Agy99 EHAISVRTSLHEITEVAEPGTAAVIDFMSVRERGSVQHLGSTISARLDAA
MAV_1792|M.avium_104 EHAISVRSSLQEMAEIAEPGTAVVTDFMTVRERGSVQHLGSTVSGRLGTS
MSMEG_4524|M.smegmatis_MC2_155 EHAISVKTSISEIEEVAEAGTAVVLDFMTVRERGSVQHLGSTVGGRLKGS
MAB_2245|M.abscessus_ATCC_1997 EHAISVRSSLAEIAEVVDPSSTKVTDFMTVRERGSVQHLGSTVSGELSAG
Mflv_3602|M.gilvum_PYR-GCK EHLMLVDLGRNDLGRVCRPGTVKVEDYSHIERYSHVMHLVSTVTGLLADG
Mvan_2814|M.vanbaalenii_PYR-1 EHLMLVDLGRNDLGRVCRPGTVKVEDYSHIERYSHVMHLVSTVTGLLADG
TH_2725|M.thermoresistible__bu EHLMLVDLGRNDLGRVCRPGTVRVEDYSHIERYSHVMHLVSTVTGELAEG
MLBr_01269|M.leprae_Br4923 EHLMLVDLGRNDLGRVCTPGTVRVEDYSHVERYSHVMHMVSTVTGLLGEG
** : * . :: : ..:. * *: :.. . * *: **: . * .
Mb2407c|M.bovis_AF2122/97 SDRMAALEALFPAVTASGIPKAAGVEAIFRLDECPRGLYSGAVVMLSADG
Rv2386c|M.tuberculosis_H37Rv SDRMAALEALFPAVTASGIPKAAGVEAIFRLDECPRGLYSGAVVMLSADG
MMAR_3706|M.marinum_M SDRMNALEALFPAVTASGIPKADGVDAILRLDEGPRGLYSGAVVMLSADG
MUL_3648|M.ulcerans_Agy99 SDRMNALEALFPAVTASGIPKADGVDAILRLDEGPRGLYSGAVVMLSADG
MAV_1792|M.avium_104 NDRMDALEALFPAVTASGIPKAGGVEAILRLDEGPRGLYSGAVVMVSADG
MSMEG_4524|M.smegmatis_MC2_155 MDRMHALEALFPAVTASGIPKAESMDAILRLDEAPRGLYSGAVVTFSADG
MAB_2245|M.abscessus_ATCC_1997 MTRMDALEALFPAVTASGIPKAEGVDAILRLDDHPRGLYSGAVVMLSPNG
Mflv_3602|M.gilvum_PYR-GCK RSALDAVTACFPAGTLSGAPKVRAMELIEEVEKTRRGLYGGVLGYLDFAG
Mvan_2814|M.vanbaalenii_PYR-1 KTALDAVTACFPAGTLSGAPKVRAMELIEEVEKTRRGLYGGVLGYLDFAG
TH_2725|M.thermoresistible__bu KTALDPITACFPAGTLSGAPKVRAMELIEEVEKTRRGLYGGVLGYLDFAG
MLBr_01269|M.leprae_Br4923 RTALDAVTACFPAGTLSGAPKVRSMELIEEVEKTRRGLYGGVVGYLDFAG
: .: * *** * ** **. .:: * .::. ****.*.: .. *
Mb2407c|M.bovis_AF2122/97 GLDAALTLRAAYQVGGRTWLRAGAGIIEESEPEREFEETCEKLSTLTPYL
Rv2386c|M.tuberculosis_H37Rv GLDAALTLRAAYQVGGRTWLRAGAGIIEESEPEREFEETCEKLSTLTPYL
MMAR_3706|M.marinum_M GLDAALTLRAAYERDGRTWLRAGAGIIEASQPEREFEETCEKLSTLAPYL
MUL_3648|M.ulcerans_Agy99 GLDAALTLRAAYERDGRTWLRAGAGIIEASQPEREFEETCEKLFTLAPYL
MAV_1792|M.avium_104 ALDAALTLRAAYEHDGKTWLRAGAGIIEESTPEREFEETCEKLSTLAPYL
MSMEG_4524|M.smegmatis_MC2_155 AMDAALTLRSAYEAHGATWLRAGAGIIAESTPEREFEETCEKLTTLAPHL
MAB_2245|M.abscessus_ATCC_1997 GLDAALTLRSAYEQDGHTWLRAGAGIIEASTPEREFEETCEKLGSIAPYV
Mflv_3602|M.gilvum_PYR-GCK NADFAIAIRTALMRDGTAYVQAGGGVVADSNGPYEYNESANKARAVLAAI
Mvan_2814|M.vanbaalenii_PYR-1 NADFAIAIRTALIRNGTAYVQAGGGVVADSNGPYEYNEASNKARAVLAAI
TH_2725|M.thermoresistible__bu NADFAIAIRTALIRNGTAYVQSGGGVVADSNGPYEYNEAANKARAVLHAI
MLBr_01269|M.leprae_Br4923 NADFAIAIRTALMRDGIAYVQAGGGVVADSNGPYEYIEASNKARAVLNAI
* *:::*:* * :::::*.*:: * *: *:.:* :: :
Mb2407c|M.bovis_AF2122/97 VARQ----------------------------
Rv2386c|M.tuberculosis_H37Rv VARQ----------------------------
MMAR_3706|M.marinum_M VERQ----------------------------
MUL_3648|M.ulcerans_Agy99 VERQ----------------------------
MAV_1792|M.avium_104 IARQ----------------------------
MSMEG_4524|M.smegmatis_MC2_155 VPRV----------------------------
MAB_2245|M.abscessus_ATCC_1997 IKREA---------------------------
Mflv_3602|M.gilvum_PYR-GCK AAAETLSEP-----------------------
Mvan_2814|M.vanbaalenii_PYR-1 AAAETLSEP-----------------------
TH_2725|M.thermoresistible__bu AAAETLSEP-----------------------
MLBr_01269|M.leprae_Br4923 AAAETLTSLDFGVALAPGRVAARGEAGNQGRL