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NATQYDHYDDFDRERLVPEPAKSAALPGTDTEHRTDFARDRARVLHCAALRRLADKTQVVGPRHGDNPRT RLTHSLEVAQIGRGMAIGLGCDPDLVDLAGLAHDIGHPPYGHNGERALNEIAKAFGGFEGNAQNFRILTR LEPKVLDADGRSAGLNLTRASLDAVTKYPWRRTEERRKFGFYVGFPDDDGPAADWVRDGAPVDRPCLEAQ VMDWADDVAYSVHDVEDGVISGRIDLRVLADADAAESLAQLGAAAFPSLAHDDLLAAAQRLSEMPVVAAV GKYDGTLAASVALKRLTSELVGRFANAAITETRAVAGDRPLKRFDSDLVVPDLVRAEVAVLKMLALQFIM SDHQHLQVQADQRTRIHEVALALWAQAPGSLDPQFAPEFAAAGDDGARLRVVIDQIASYTETRLERVHEA RSPRPLE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4483 | - | - | 100% (428) | deoxyguanosinetriphosphate triphosphohydrolase-like protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2373c | dgt | 1e-172 | 73.70% (422) | deoxyguanosinetriphosphate triphosphohydrolase-like protein |
| M. gilvum PYR-GCK | Mflv_2721 | - | 0.0 | 83.61% (421) | deoxyguanosinetriphosphate triphosphohydrolase-like protein |
| M. tuberculosis H37Rv | Rv2344c | dgt | 1e-172 | 73.70% (422) | deoxyguanosinetriphosphate triphosphohydrolase-like protein |
| M. leprae Br4923 | MLBr_00831 | dgt | 1e-165 | 70.78% (421) | deoxyguanosinetriphosphate triphosphohydrolase-like protein |
| M. abscessus ATCC 19977 | MAB_1707 | - | 1e-157 | 70.67% (416) | deoxyguanosinetriphosphate triphosphohydrolase-like protein |
| M. marinum M | MMAR_3651 | dgt | 1e-173 | 74.41% (422) | deoxyguanosine triphosphate triphosphohydrolase Dgt |
| M. avium 104 | MAV_2042 | - | 1e-174 | 74.07% (428) | deoxyguanosinetriphosphate triphosphohydrolase-like protein |
| M. thermoresistible (build 8) | TH_0430 | dgt | 1e-170 | 76.17% (407) | PROBABLE DEOXYGUANOSINE TRIPHOSPHATE TRIPHOSPHOHYDROLASE DGT |
| M. ulcerans Agy99 | MUL_1458 | dgt | 1e-173 | 74.41% (422) | deoxyguanosinetriphosphate triphosphohydrolase-like protein |
| M. vanbaalenii PYR-1 | Mvan_3815 | - | 0.0 | 84.60% (422) | deoxyguanosinetriphosphate triphosphohydrolase-like protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2721|M.gilvum_PYR-GCK -------------MRRTHTAALKGASALADCASVRP---RQDSYDAFDRQ
Mvan_3815|M.vanbaalenii_PYR-1 -------------------------------MSPR----LQDSYDEFDRQ
MSMEG_4483|M.smegmatis_MC2_155 -------------------------------MNAT----QYDHYDDFDRE
TH_0430|M.thermoresistible__bu --------------------------------------------------
MMAR_3651|M.marinum_M MSGRFAAGGKQCRRERRPWVPAAICLADCGAVST----KQQEPYGDFDRQ
MUL_1458|M.ulcerans_Agy99 -------------------------------MST----KQQEPYGDFDRQ
Mb2373c|M.bovis_AF2122/97 -------------------------------MSA----SEHDPYDDFDRQ
Rv2344c|M.tuberculosis_H37Rv -------------------------------MSA----SEHDPYDDFDRQ
MLBr_00831|M.leprae_Br4923 -------------------------------MTTKANTNQHDPYDDFDRQ
MAV_2042|M.avium_104 -------------------------------MTR----NQHDPYDDFDRQ
MAB_1707|M.abscessus_ATCC_1997 -------------------------------MRK------KDAYTDSDRE
Mflv_2721|M.gilvum_PYR-GCK RLVAEPAKSAGLP----GTDTERRSDFARDRARVLHCAALRRLADKTQVV
Mvan_3815|M.vanbaalenii_PYR-1 RLVAEPAKSAGLP----GTDTEHRSDFARDRARVLHCAALRRLADKTQVV
MSMEG_4483|M.smegmatis_MC2_155 RLVPEPAKSAALP----GTDTEHRTDFARDRARVLHCAALRRLADKTQVV
TH_0430|M.thermoresistible__bu -MVAEEPKRAGLP----GTEVQHRTDFARDRARVLHSAALRRLADKTQVV
MMAR_3651|M.marinum_M RRVVEAPKTAGLP----GTEGQHRTDFARDRARVLHCAALRRLADKTQVV
MUL_1458|M.ulcerans_Agy99 RRVVEAPKTAGLP----GTEGQHRTDFARDRARVLHCAALRRLADKTQVV
Mb2373c|M.bovis_AF2122/97 RRVAEAPKTAGLP----GTEGQYRSDFARDRARVLHSAALRRLADKTQVV
Rv2344c|M.tuberculosis_H37Rv RRVAEAPKTAGLP----GTEGQYRSDFARDRARVLHSAALRRLADKTQVV
MLBr_00831|M.leprae_Br4923 RRAHEAPKTAVLP----GSEGQHRTEFARDRARVLHSAALRRLSDKTQVV
MAV_2042|M.avium_104 RRVAEAPKTAGLP----GTEGQHRTDFARDRARVLHSAALRRLADKTQVV
MAB_1707|M.abscessus_ATCC_1997 RVVTESPKTAAVVDIPAASLTEYRTDFARDRARVLHSAAFRRLADKTQVV
. * .* * : .: : *::**********.**:***:******
Mflv_2721|M.gilvum_PYR-GCK GPRDGETPRTRLTHSLEVAQIGRGMAIGLGCDPDLVDLAGLAHDIGHPPY
Mvan_3815|M.vanbaalenii_PYR-1 GPRDGETPRTRLTHSLEVAQIGRGMAIGLGCDPDLVDLAGLAHDIGHPPY
MSMEG_4483|M.smegmatis_MC2_155 GPRHGDNPRTRLTHSLEVAQIGRGMAIGLGCDPDLVDLAGLAHDIGHPPY
TH_0430|M.thermoresistible__bu GPRQSETPRTRLTHSLEVAQIGRGMAIELGCDPDLVDLAGLAHDIGHPPY
MMAR_3651|M.marinum_M GPREGDTPRTRLTHSLEVAQIGRGMAIGLGCDLDLVELAGLAHDIGHPPY
MUL_1458|M.ulcerans_Agy99 GPREGDTPRTRLTHSLEVAQIGRGMAIGLGCDLDLVELAGLAHDIGHPPY
Mb2373c|M.bovis_AF2122/97 GPREGDTPRTRLTHSLEVAQIGRGMAIGLGCDLDLVELAGLAHDIGHPPY
Rv2344c|M.tuberculosis_H37Rv GPREGDTPRTRLTHSLEVAQIGRGMAIGLGCDLDLVELAGLAHDIGHPPY
MLBr_00831|M.leprae_Br4923 GPHEGDTPRTRLTHSLEVAQIGRSMAVGLGCDLDLVELAGLAHDIGHPPY
MAV_2042|M.avium_104 GPREGDTPRTRLTHSLEVAQIGRGMAVGLGCDLDLVELAGLAHDIGHPPY
MAB_1707|M.abscessus_ATCC_1997 GPREGDTPRTRLTHSVEVAQIGRGIATGLGADPDLVDLAGLAHDIGHPPY
**:..:.********:*******.:* **.* ***:*************
Mflv_2721|M.gilvum_PYR-GCK GHNGERALDEIIKGFGGFEGNAQNFRILTRLEPKVLDEHGRSAGLNLTRA
Mvan_3815|M.vanbaalenii_PYR-1 GHNGERALDEIIKGFGGFEGNAQNFRILTRLEPKVLDEHGRSAGLNLTRA
MSMEG_4483|M.smegmatis_MC2_155 GHNGERALNEIAKAFGGFEGNAQNFRILTRLEPKVLDADGRSAGLNLTRA
TH_0430|M.thermoresistible__bu GHNGERALNELVADHGGFEGNAQNFRILTRLEPKVLDPQGNSAGLNLTRA
MMAR_3651|M.marinum_M GHNGERALDEVATGCGGFEGNAQNFRILTSLEPKVLDEHGLSVGLNLTRA
MUL_1458|M.ulcerans_Agy99 GHNGERALDEVAIGCGGFEGNAQNFRILTSLEPKVLDEHGLSVGLNLTRA
Mb2373c|M.bovis_AF2122/97 GHNGERALDEVAASHGGFEGNAQNFRILTSLEPKVVDAQGLSAGLNLTRA
Rv2344c|M.tuberculosis_H37Rv GHNGERALDEVAASHGGFEGNAQNFRILTSLEPKVVDAQGLSAGLNLTRA
MLBr_00831|M.leprae_Br4923 GHNGERALDEVAVGYGGFEGNAQNFRILTSLEPKVIDEQGCSVGLNLTRA
MAV_2042|M.avium_104 GHNGERALDEVAAAYGGFEGNAQNFRILTSLEPKVLDAQGNSAGLNLTRA
MAB_1707|M.abscessus_ATCC_1997 GHNGERALDEVAVDCGGFEGNAQNLRILTRLEPKVVDAAGNSAGLNLTRA
********:*: *********:**** *****:* * *.*******
Mflv_2721|M.gilvum_PYR-GCK SLDAVAKYPWPR----EEGRRKFGFYG----DDAAAAQWVRDGAPAGRPC
Mvan_3815|M.vanbaalenii_PYR-1 SLDAVAKYPWPR----QEGRRKFGFYG----DDMAAAQWVRHGAPAARPC
MSMEG_4483|M.smegmatis_MC2_155 SLDAVTKYPWRR----TEERRKFGFYVGFPDDDGPAADWVRDGAPVDRPC
TH_0430|M.thermoresistible__bu ALDAVTKYPWHR----GPQGGKFGFYVGFPGDDAAAAEWMRTGAPPGRRC
MMAR_3651|M.marinum_M ALDAVTKYPWPR----GRARRKFGFYD----QDLQPALWVRQGAPQRRPC
MUL_1458|M.ulcerans_Agy99 ALDAVTKYPWPR----GRARRKFGFYD----QDLQPALWVRQGAPQRRPC
Mb2373c|M.bovis_AF2122/97 SLDAVTKYPWMRGDGLGSQRRKFGFYD----DDRESAVWVRQGAPPERAC
Rv2344c|M.tuberculosis_H37Rv SLDAVTKYPWMRGDGLGSQRRKFGFYD----DDRESAVWVRQGAPPERAC
MLBr_00831|M.leprae_Br4923 SLDAVTKYPWTRVGGLGHGRSKYGFYE----EDRDPADWVRVYAPANRAC
MAV_2042|M.avium_104 SLDAVIKYPWRR--GEGPGTSKFGFYD----DDREAAAWVRAGAPAGRMC
MAB_1707|M.abscessus_ATCC_1997 ALDAATKYPWLR----PPGGGKFGAYD----DEVEALTWVRAGAPPRRRC
:***. **** * *:* * :: . *:* ** * *
Mflv_2721|M.gilvum_PYR-GCK LEAQVMDWADDVAYSVHDVEDGVISGRIDLRVLADSDAAASLARVGARSF
Mvan_3815|M.vanbaalenii_PYR-1 LEAQVMDWADDVAYSVHDVEDGVISGRIDLRVLADADAAASLAHVGAQSF
MSMEG_4483|M.smegmatis_MC2_155 LEAQVMDWADDVAYSVHDVEDGVISGRIDLRVLADADAAESLAQLGAAAF
TH_0430|M.thermoresistible__bu LEAQVMDWADDVAYSVHDVEDGVISGRIDLRVLADDDAASALAKLGEESF
MMAR_3651|M.marinum_M LEAQVMDWADDVAYSVHDVEDGVVSERIDLRVLADHDEAAALAKLGESEF
MUL_1458|M.ulcerans_Agy99 LEAQVMDWADDVAYSVHDVEDGVVSERIDLRVLADHDEAAALAKLGESEF
Mb2373c|M.bovis_AF2122/97 LEAQVMDWADDVAYSVHDVEDGVVSERIDLRVLAAEEDAAALARLGEREF
Rv2344c|M.tuberculosis_H37Rv LEAQVMDWADDVAYSVHDVEDGVVSERIDLRVLAAEEDAAALARLGEREF
MLBr_00831|M.leprae_Br4923 LEAQVMDWADDVAYSVHDVEDGVVSQRIDLRVLADEYETAALAKLGEGEF
MAV_2042|M.avium_104 LEAQVMDWADDVAYSVHDVEDGVVSQRIDLRVLADDDEAAALAKLGESEF
MAB_1707|M.abscessus_ATCC_1997 LEAQIMDWSDDVAYSVHDVEDGVISGRIDLRVLASRGEAQVLAELGVRSF
****:***:**************:* ******** : **.:* *
Mflv_2721|M.gilvum_PYR-GCK PSLTPDDLVEAAARLSQVPVVAAVGKFDGTLSASVALKTLTSELVGRFAN
Mvan_3815|M.vanbaalenii_PYR-1 PTLTPDDLVAAAERLSQVPVVAAVGKFDGTLSASVALKTLTSELVGRFAN
MSMEG_4483|M.smegmatis_MC2_155 PSLAHDDLLAAAQRLSEMPVVAAVGKYDGTLAASVALKRLTSELVGRFAN
TH_0430|M.thermoresistible__bu G-ANRDDLLAAADRLSRMPVVAAVGKYDGTLAASVALKRLTSELVGRFAN
MMAR_3651|M.marinum_M SRVSADELMEAAGRLSGLPVVAAVGKYDATLAASVALKQLTSELVGRFAS
MUL_1458|M.ulcerans_Agy99 SRVSADELMEAAGRLSGLPVVAAVGKYDATLAASVALKQLTSELVGRFAS
Mb2373c|M.bovis_AF2122/97 SRVSADELMAAARRLSRLPVVAAVGKYDATLSASVALKRLTSELVGRFAS
Rv2344c|M.tuberculosis_H37Rv SRVSADELMAAARRLSRLPVVAAVGKYDATLSASVALKRLTSELVGRFAS
MLBr_00831|M.leprae_Br4923 SWVTADELMAAAHRLSELPVVAAVGKYDATLASSVALKRLTSELVGRFAS
MAV_2042|M.avium_104 SRVGADDFMAAARRLSALPVVAAVGKYDATLASSVALKRLTSELVGRFAS
MAB_1707|M.abscessus_ATCC_1997 GGLQQGALEEAAARLAMLPVVAAVGPYDGTLSASTDLKRLTSELVGRFAS
. : ** **: :******* :*.**::*. ** **********.
Mflv_2721|M.gilvum_PYR-GCK AALSATREVAGPGPLRRFDVELTVPSLVRAEVVLLKTLALEFIMSDHRHL
Mvan_3815|M.vanbaalenii_PYR-1 AALTATRDVAGPGPLRRFDAELTVPSLVRAEVVLLKTLALQFIMSDHRHL
MSMEG_4483|M.smegmatis_MC2_155 AAITETRAVAGDRPLKRFDSDLVVPDLVRAEVAVLKMLALQFIMSDHQHL
TH_0430|M.thermoresistible__bu AAIAHTRESAGGGRLARFAADLAVPPTVTAEVAILKILALQFIMSDPKHL
MMAR_3651|M.marinum_M AAIATTRAAAGPGPLVRYQADLHVPELVRAEVAVLKILALQFIMSDPRHL
MUL_1458|M.ulcerans_Agy99 AAIATTRAAAGPGPLVRYQADLHVPELVRAEVAVLKILALQFIMSDPRHL
Mb2373c|M.bovis_AF2122/97 AAIATTRAAAGPGPLVRFRADLQVPDLVRAEVAVLKILALQFIMSDPRHL
Rv2344c|M.tuberculosis_H37Rv AAIATTRAAAGPGPLVRFRADLQVPDLVRAEVAVLKILALQFIMSDPRHL
MLBr_00831|M.leprae_Br4923 VAIATTRAVAGPGPLVRYQADLQVPDLVRAEVAVLKILALQFIMSDPRHL
MAV_2042|M.avium_104 AAIATTRAAAGPGPLVRYRAELAVPDLVRAEVALLKILALQFIMSDPRHQ
MAB_1707|M.abscessus_ATCC_1997 AAIGATRDVAGAGPLIRFEAELTVPEVVAAEVAVLKMLALQFIMSDPKHI
.*: ** ** * *: :* ** * ***.:** ***:***** :*
Mflv_2721|M.gilvum_PYR-GCK QIQTDQRHRIHEVALALWGQAPGSLDPQFAAEFAQASDDGARLRVVIDQI
Mvan_3815|M.vanbaalenii_PYR-1 QIQADQRNRIHEVALALWGQAPGSLDPQFAAEFAAAPDDGARLRVVIDQI
MSMEG_4483|M.smegmatis_MC2_155 QVQADQRTRIHEVALALWAQAPGSLDPQFAPEFAAAGDDGARLRVVIDQI
TH_0430|M.thermoresistible__bu LVQSEQRDQIKAVAEFLFAGAPATLDPVFVPYFNAAEDDQARWRVVIDQI
MMAR_3651|M.marinum_M ETQARQRERIHRVAQLLYAGAPRTLDPIFAAAFNAAGDDGARMRVVVDQI
MUL_1458|M.ulcerans_Agy99 ETQARQRERIHRVAQLLYAGAPRTLDPIFAAAFNAAGDDGARMRVVVDQI
Mb2373c|M.bovis_AF2122/97 ETQARQRERIHRVAHRLYSGAPQTLDPVYAAAFNTAADDAARLRVVVDQI
Rv2344c|M.tuberculosis_H37Rv ETQARQRERIHRVAHRLYSGAPQTLDPVYAAAFNTAADDAARLRVVVDQI
MLBr_00831|M.leprae_Br4923 EGQARQRERIHRVANWLYSGAPSTLDPVFVTAFTTAVDDNARWRVIVDQI
MAV_2042|M.avium_104 QTQAGQRERIHRVAHWLYAGAPRTLDPVFAAAFNTAADDGARWRVIVDQI
MAB_1707|M.abscessus_ATCC_1997 AVQARQRERIHRVARWLAEGAPATLDPVFLPAFESAADDAARTRVVVDQI
*: ** :*: ** * ** :*** : . * * ** ** **::***
Mflv_2721|M.gilvum_PYR-GCK ASYTESRLERVHEARS---PRPLN----
Mvan_3815|M.vanbaalenii_PYR-1 ASYTESRLERVHEARS---PRPLD----
MSMEG_4483|M.smegmatis_MC2_155 ASYTETRLERVHEARS---PRPLE----
TH_0430|M.thermoresistible__bu ASFTETQLERLFPAASRLIPGQLEVDFS
MMAR_3651|M.marinum_M ASYTEGRLERIDAAQLG--DGRVG----
MUL_1458|M.ulcerans_Agy99 ASYTEGRLERIDAAQLG--DGRVG----
Mb2373c|M.bovis_AF2122/97 ASYTEGRLERIDADQLG--VSRNALD--
Rv2344c|M.tuberculosis_H37Rv ASYTEGRLERIDADQLG--VSRNALD--
MLBr_00831|M.leprae_Br4923 ASYTEGRLERIDAGQAS--P--------
MAV_2042|M.avium_104 ASYTEGRLERIDARQAG--P--------
MAB_1707|M.abscessus_ATCC_1997 ASYTESRLERVDRDSLG-VQASWG----
**:** :***: