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M. smegmatis MC2 155 MSMEG_3748 (-)

annotation: thiamin pyrophosphokinase catalytic subunit
coordinates: 3812765 - 3813961
length: 398

KMSALLTRNASSRPGITGTARVDRDIDRLLRRIGPGDIVVMDVLDLDRITADALVEANIAGVVNASPSIS
GRYPNLGPEVLVGNGIVLIDEAGPEVFKKIKDGARVRLHNGGVYSGDRRIALGTERTDQDIHELMHEAKS
GLVAHLEAFAGNTIEFIRSESPLLIDGIGIPNIDVDVHRRHVVIVAEEPSAAEDLKALKPFIKEYQPVLV
GVGAGADVLRKAGYRPALIVGDPDKMSVEVLRSGAQVVLPADADGHAAGLERIQDLGVGAMTFPAAGSAA
DLALLLCDHHGASLIVTAGHTATIEEFFDRSRQASNPSTFLTRLKVGEKLVDAKAVATLYRSRVSGGAIA
MLVLAMLVAVIVALWVSRADTAVVDWVVSYWHQFTAWVQSIIGSLGG*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. smegmatis MC2 155MSMEG_3748--100% (398)thiamin pyrophosphokinase catalytic subunit

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1723-1e-18078.88% (393) hypothetical protein Mb1723
M. gilvum PYR-GCKMflv_3504-0.085.24% (393) hypothetical protein Mflv_3504
M. tuberculosis H37RvRv1697-1e-18078.88% (393) hypothetical protein Rv1697
M. leprae Br4923MLBr_01361-1e-18079.64% (393) hypothetical protein MLBr_01361
M. abscessus ATCC 19977MAB_2362-1e-17574.81% (393) hypothetical protein MAB_2362
M. marinum MMMAR_2502-1e-18079.13% (393) hypothetical protein MMAR_2502
M. avium 104MAV_3074-1e-17778.21% (390) hypothetical protein MAV_3074
M. thermoresistible (build 8)TH_1546-0.088.24% (391) CONSERVED HYPOTHETICAL PROTEIN
M. ulcerans Agy99MUL_1686-1e-18078.88% (393) hypothetical protein MUL_1686
M. vanbaalenii PYR-1Mvan_3285-0.086.51% (393) hypothetical protein Mvan_3285

CLUSTAL 2.0.9 multiple sequence alignment


MSMEG_3748|M.smegmatis_MC2_155      ----MKMSALLTRNASSRPGITGTARVDRDIDRLLRRIGPGDIVVMDVLD
TH_1546|M.thermoresistible__bu      ------MTALLSRNAAARPGITGTARVDRDINRLLRRVAPGDIVVIDALD
Mflv_3504|M.gilvum_PYR-GCK          ----MKMSALLSRNASSRPGITGTARVDRDIDRLLRRVTPGDIVVLDALD
Mvan_3285|M.vanbaalenii_PYR-1       ----MKMSALLSRNASSRPGITGTARVDRDIDRLLRRVTPGDIVVLDALD
Mb1723|M.bovis_AF2122/97            ----MRMSALLSRNTS-RPGLIGIARVDRNIDRLLRRVCPGDIVVLDVLD
Rv1697|M.tuberculosis_H37Rv         ----MRMSALLSRNTS-RPGLIGIARVDRNIDRLLRRVCPGDIVVLDVLD
MMAR_2502|M.marinum_M               ----MKMSALLSRNTA-RPGLIGTARVDRNIDRLLRRVCPGDIVVLDALD
MUL_1686|M.ulcerans_Agy99           ----MKMSALLSRNTA-RPGLIGTARVDRNIDRLLRRVCPGDIVVLDALD
MAV_3074|M.avium_104                ----MKMSGLLSRNTD-RPGIVGTARVDRNIDRLLRRVCPGDIVVLDVLD
MLBr_01361|M.leprae_Br4923          ----MRMSALLSRNNS-RPGLVGTARVDRNIDRLLRRICPGDIVVLDVLD
MAB_2362|M.abscessus_ATCC_1997      MITPMNLTTMLTRSSSSRPGIVGTVRTDRDINRLLQRLNPGDIAVIDILD
                                          :: :*:*.   ***: * .*.**:*:***:*: ****.*:* **

MSMEG_3748|M.smegmatis_MC2_155      LDRITADALVEANIAGVVNASPSISGRYPNLGPEVLVGNGIVLIDEAGPE
TH_1546|M.thermoresistible__bu      LDRITADALVEANVAGVVNASPSISGRYPNLGPEVLVANGIALIDETGPE
Mflv_3504|M.gilvum_PYR-GCK          LDRVTADALVDAGVSAVVNASPSISGRYPNLGPEVLVANGITLVDETGPE
Mvan_3285|M.vanbaalenii_PYR-1       LDRVTADALVEAGVAAVVNASPSISGRYPNLGPEVLVANGITLVDETGPE
Mb1723|M.bovis_AF2122/97            LDRITADALVEAEIAAVVNASSSVSGRYPNLGPEVLVTNGVTLIDETGPE
Rv1697|M.tuberculosis_H37Rv         LDRITADALVEAEIAAVVNASSSVSGRYPNLGPEVLVTNGVTLIDETGPE
MMAR_2502|M.marinum_M               LDRITADALVESGVAAVVNASSSVSGRYPNLGPEVLVNNGVTLIDETGPE
MUL_1686|M.ulcerans_Agy99           LDRITADALVESGVAAVVNASSSVSGRYPNLGPEVLVNNGVTLIDETGPE
MAV_3074|M.avium_104                LDRITADALVEADIAAVVNASPSVSGRYPNLGPEVLVNNGVTLIDEAGPD
MLBr_01361|M.leprae_Br4923          LDRITADALVEADIVAVVNASPSVSGRYPNLGPEVLVNNGVTLIDETGPE
MAB_2362|M.abscessus_ATCC_1997      LDRITADALVDARVSAVVNASPSISGRYPNLGPEVLVANGITLIDSIGPE
                                    ***:******:: : .*****.*:************* **:.*:*. **:

MSMEG_3748|M.smegmatis_MC2_155      VFKKIKDGARVRLHNGGVYSGDRRIALGTERTDQDIHELMHEAKSGLVAH
TH_1546|M.thermoresistible__bu      VFKKVKDGAKIRLHNGGIYSGDRRLALGVERTDHDIHELMHEAKSGLVAH
Mflv_3504|M.gilvum_PYR-GCK          IFKKVKDGARIRINEGGIYSGDRRLSLGTERTDADIHELMQEAKGGLVAH
Mvan_3285|M.vanbaalenii_PYR-1       VFKKVKDGARVRINEGGVYSGDRRLVLGTERTDADIHELMQEAKGGLVAH
Mb1723|M.bovis_AF2122/97            IFKKVKDGAKVRLYEGGVYAGDRRLIRGTERTDHDIADLMREAKSGLVAH
Rv1697|M.tuberculosis_H37Rv         IFKKVKDGAKVRLYEGGVYAGDRRLIRGTERTDHDIADLMREAKSGLVAH
MMAR_2502|M.marinum_M               IFKKVKDGSKVRLYEGGVYSGDRRLIRGTERTDHDIADLMREAKSGLAAH
MUL_1686|M.ulcerans_Agy99           IFKKVKDGSKVRLYEGGVYSGDRRLIRGTERTDHDIADLMREAKSGLAAH
MAV_3074|M.avium_104                IFKKVKDGAKIRLYDGGVYAGDRRLVRGTERTEHDIADLMREAKSGLAAH
MLBr_01361|M.leprae_Br4923          VFKKIKDGAKIRLHEGGVYSGDRRLICGTERTDHDIADLMREAKSGLATH
MAB_2362|M.abscessus_ATCC_1997      VFKKVKDGSTVRVHNGGIYNGDRRLIAGTPRTDADVHDLMTEAKTGLVAH
                                    :***:***: :*: :**:* ****:  *. **: *: :** *** **.:*

MSMEG_3748|M.smegmatis_MC2_155      LEAFAGNTIEFIRSESPLLIDGIGIPNIDVDVHRRHVVIVAEEPSAAEDL
TH_1546|M.thermoresistible__bu      LEAFAGNTIEFIRSESPLLIDGIGIPDIDVDLHRRHVVVVAEEPGAADDL
Mflv_3504|M.gilvum_PYR-GCK          LEAFAGNTIEFIRSESPLLIDGIGIPDIDVDLNRRHVVIVAEEDNAAADL
Mvan_3285|M.vanbaalenii_PYR-1       LEAFAGNTIEFIRSESPLLIDGIGIPDIDVDMNRRHVVIVAEEDHAAADL
Mb1723|M.bovis_AF2122/97            LEAFAGNTIEFIRSESPLLIDGIGIPDVDVDLRRRHVVIVADEPSGPDDL
Rv1697|M.tuberculosis_H37Rv         LEAFAGNTIEFIRSESPLLIDGIGIPDVDVDLRRRHVVIVADEPSGPDDL
MMAR_2502|M.marinum_M               LEAFAGNTIEFIRSESPLLIDGIGIPDIDVDMRRRHVVIVAEEPSAADDL
MUL_1686|M.ulcerans_Agy99           LEAFAGNTIEFIRSESPLLIDGIGIPDIDVDMRRRHVVIVAEEPSAADDL
MAV_3074|M.avium_104                LEAFAGNTIEFIKSESPLLIDGIGIPDIDVDLRRRHVVIVADEPSAEEDL
MLBr_01361|M.leprae_Br4923          LEAFAGNTIEFIKSESPLLIDGIGIPDIDVDLRRRHVVIVADEPSAADDL
MAB_2362|M.abscessus_ATCC_1997      LEAFSGNTIEFIRSESPLLIDGIGIPDVDIDLRNRHVVVVSDGVGAAHDL
                                    ****:*******:*************::*:*:..****:*::   .  **

MSMEG_3748|M.smegmatis_MC2_155      KALKPFIKEYQPVLVGVGAGADVLRKAGYRPALIVGDPDKMSVEVLRSGA
TH_1546|M.thermoresistible__bu      KALKPFIKEYQPVLVGVGTGADILRKAGYRPALIVGDPDKMSAEVLRSGA
Mflv_3504|M.gilvum_PYR-GCK          KALKPFIKEYQPVLVGVGLGADTLRKAGYRPALIVGDPDKISTEVLRCGA
Mvan_3285|M.vanbaalenii_PYR-1       KALKPFIKEYQPVLVGVGAGADILRKAGYRPQLIVGDPDKISTEVLRCGA
Mb1723|M.bovis_AF2122/97            KSLKPFIKEYQPVLVGVGTGADVLRKAGYRPQLIVGDPDQISTEVLKCGA
Rv1697|M.tuberculosis_H37Rv         KSLKPFIKEYQPVLVGVGTGADVLRKAGYRPQLIVGDPDQISTEVLKCGA
MMAR_2502|M.marinum_M               KSLKPFIKEYQPVLVGVGTGADVLRKAGYRPQLIVGDPDQISTEVLKCGA
MUL_1686|M.ulcerans_Agy99           KSLKPFITEYQPVLVGVGTGADVLRKAGYRPQLIVGDPDQISTEVLKCGA
MAV_3074|M.avium_104                KSLKPFIKEYQPALIGVGTGADVLRKAGYRPQIIVGDPDQISADALKCGA
MLBr_01361|M.leprae_Br4923          KSLKPFIKEYQPVLVGVSGGADVLRKAGYRPQLIVGDPEQISTEALRCGA
MAB_2362|M.abscessus_ATCC_1997      KNLKPFIKEYQPVLIGVGTGADTLRKAGYRPLIVVGDPLLMSNDVLKSGA
                                    * *****.****.*:**. *** ******** ::****  :* :.*:.**

MSMEG_3748|M.smegmatis_MC2_155      QVVLPADADGHAAGLERIQDLGVGAMTFPAAGSAADLALLLCDHHGASLI
TH_1546|M.thermoresistible__bu      QVILPADADGHAAGLERIQDLGVGAMTFPAAGSAADLALLLCDHHGASLI
Mflv_3504|M.gilvum_PYR-GCK          QVVLPADADGHAAGLERIQDLGVGAMTFPAAGSAADLALLLCDHHGASLI
Mvan_3285|M.vanbaalenii_PYR-1       QVVLPADADGHAAGLERIQDLGVGAMTFPAAGSAADLALLLCDHHGAALI
Mb1723|M.bovis_AF2122/97            QVVLPADADGHAPGLERIQDLGVGAMTFPAAGSATDLALLLADHHGAALL
Rv1697|M.tuberculosis_H37Rv         QVVLPADADGHAPGLERIQDLGVGAMTFPAAGSATDLALLLADHHGAALL
MMAR_2502|M.marinum_M               QVVLPADADGHAPGLERIQDLGVGAMTFPAAGSATDLALLLADHHGAALL
MUL_1686|M.ulcerans_Agy99           QVVLPADADGHAPGLERIQDLGVGAMTFPAAGSATDLALLLADHHGAALL
MAV_3074|M.avium_104                QVVLPADADGHAPGLERIQDLGVGAMTFPAAGSAIDLALLLADHHGAALL
MLBr_01361|M.leprae_Br4923          HVVLPADADGHAPGLERIQDLGVGAMTFPAAGSATDLALLLADHHGAALL
MAB_2362|M.abscessus_ATCC_1997      QVVLPADADGHAAGLERIQDLGVGAVTFPAAGSAADLALLLADHHGASLI
                                    :*:*********.************:******** ******.*****:*:

MSMEG_3748|M.smegmatis_MC2_155      VTAGHTATIEEFFDRSRQASNPSTFLTRLKVGEKLVDAKAVATLYRSRVS
TH_1546|M.thermoresistible__bu      VTCGHTATIEEFFDRSRQQSNPSTFLTRLKVGEKLVDAKAVATLYRSRVS
Mflv_3504|M.gilvum_PYR-GCK          VTVGHTASIEEFFDRTRQQSNPSTFLTRMKVGEKLVDAKAVATLYRSRVS
Mvan_3285|M.vanbaalenii_PYR-1       VTVGHTASIEEFFDRNRQRSNPSTFLTRLKVGEKLVDAKAVATLYRSRVS
Mb1723|M.bovis_AF2122/97            VTAGHAANIETFFDRTRVQSNPSTFLTRLRVGEKLVDAKAVATLYRNHIS
Rv1697|M.tuberculosis_H37Rv         VTAGHAANIETFFDRTRVQSNPSTFLTRLRVGEKLVDAKAVATLYRNHIS
MMAR_2502|M.marinum_M               VTAGHNANIETFFDRTRVQSNPSTFLTRLRVGEKLVDAKAVATLYRNHIS
MUL_1686|M.ulcerans_Agy99           VTAGHNANIETFFDRTRVQSNPSTFLTRLRVGEKLVDAKAVATLYRNHIS
MAV_3074|M.avium_104                VTAGHTANIETFFDRTRAHSNPSTFLTRLRVGEKVVDAKAVATLYRNHIS
MLBr_01361|M.leprae_Br4923          VTAGHTANIETFFDRTRTQSNPSTFLTRLRVGEKLVDAKAVATLYRNHIS
MAB_2362|M.abscessus_ATCC_1997      VTVGHTASIEEFFDRERQQSNPSTFLTRLKVGAKLVDAKAVATLYRNRFS
                                    ** ** *.** **** *  *********::** *:***********.:.*

MSMEG_3748|M.smegmatis_MC2_155      GGAIAMLVLAMLVAVIVALWVSRADTAVVDWVVSYWHQFTAWVQSIIGSL
TH_1546|M.thermoresistible__bu      AGAIALLVLAMLIAVIVALWVARVDTVVVDWVIDYWNRFSLWVQGLVS--
Mflv_3504|M.gilvum_PYR-GCK          GGAIALLVLAMLIAVIAALWVSRADAAVLEWVTQYWNQFLLWAQGLVS--
Mvan_3285|M.vanbaalenii_PYR-1       GGAIALLVLAMLIAVIAALWVSRADAAVIEWVSQYWNQFLLWAQGLVS--
Mb1723|M.bovis_AF2122/97            GGAIALLALTMLIAIIVALWVSRTDGVVLHWIIDYWNRFSLWVQHLVS--
Rv1697|M.tuberculosis_H37Rv         GGAIALLALTMLIAIIVALWVSRTDGVVLHWIIDYWNRFSLWVQHLVS--
MMAR_2502|M.marinum_M               AGAIALLALTMLIAIIVVLWVSRTDGVVVHWIVDYWNRFSLWVQHLVT--
MUL_1686|M.ulcerans_Agy99           AGAIALLALTMLIAIIVVLWVSRTDGVVVHWIVDYWNRFSLWVQHLVT--
MAV_3074|M.avium_104                AGAIALLALTMLIAVIVALWVSRTDGVVLHWITDYWNHFSLMVQKWVT--
MLBr_01361|M.leprae_Br4923          FGAIALLALIMLIAVIVALWVSRTDGVVLHGVIDYWNRFSLWIQRLIA--
MAB_2362|M.abscessus_ATCC_1997      GGAIALLILAVLVAVITMLWVTSAGDSAAEWLLAYWNRMTVWVQNLVS--
                                     ****:* * :*:*:*. ***: ..  . . :  **:::    *  :   

MSMEG_3748|M.smegmatis_MC2_155      GG
TH_1546|M.thermoresistible__bu      --
Mflv_3504|M.gilvum_PYR-GCK          --
Mvan_3285|M.vanbaalenii_PYR-1       --
Mb1723|M.bovis_AF2122/97            --
Rv1697|M.tuberculosis_H37Rv         --
MMAR_2502|M.marinum_M               --
MUL_1686|M.ulcerans_Agy99           --
MAV_3074|M.avium_104                --
MLBr_01361|M.leprae_Br4923          --
MAB_2362|M.abscessus_ATCC_1997      --