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KMSALLTRNASSRPGITGTARVDRDIDRLLRRIGPGDIVVMDVLDLDRITADALVEANIAGVVNASPSIS GRYPNLGPEVLVGNGIVLIDEAGPEVFKKIKDGARVRLHNGGVYSGDRRIALGTERTDQDIHELMHEAKS GLVAHLEAFAGNTIEFIRSESPLLIDGIGIPNIDVDVHRRHVVIVAEEPSAAEDLKALKPFIKEYQPVLV GVGAGADVLRKAGYRPALIVGDPDKMSVEVLRSGAQVVLPADADGHAAGLERIQDLGVGAMTFPAAGSAA DLALLLCDHHGASLIVTAGHTATIEEFFDRSRQASNPSTFLTRLKVGEKLVDAKAVATLYRSRVSGGAIA MLVLAMLVAVIVALWVSRADTAVVDWVVSYWHQFTAWVQSIIGSLGG*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. smegmatis MC2 155 | MSMEG_3748 | - | - | 100% (398) | thiamin pyrophosphokinase catalytic subunit |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1723 | - | 1e-180 | 78.88% (393) | hypothetical protein Mb1723 |
M. gilvum PYR-GCK | Mflv_3504 | - | 0.0 | 85.24% (393) | hypothetical protein Mflv_3504 |
M. tuberculosis H37Rv | Rv1697 | - | 1e-180 | 78.88% (393) | hypothetical protein Rv1697 |
M. leprae Br4923 | MLBr_01361 | - | 1e-180 | 79.64% (393) | hypothetical protein MLBr_01361 |
M. abscessus ATCC 19977 | MAB_2362 | - | 1e-175 | 74.81% (393) | hypothetical protein MAB_2362 |
M. marinum M | MMAR_2502 | - | 1e-180 | 79.13% (393) | hypothetical protein MMAR_2502 |
M. avium 104 | MAV_3074 | - | 1e-177 | 78.21% (390) | hypothetical protein MAV_3074 |
M. thermoresistible (build 8) | TH_1546 | - | 0.0 | 88.24% (391) | CONSERVED HYPOTHETICAL PROTEIN |
M. ulcerans Agy99 | MUL_1686 | - | 1e-180 | 78.88% (393) | hypothetical protein MUL_1686 |
M. vanbaalenii PYR-1 | Mvan_3285 | - | 0.0 | 86.51% (393) | hypothetical protein Mvan_3285 |
CLUSTAL 2.0.9 multiple sequence alignment MSMEG_3748|M.smegmatis_MC2_155 ----MKMSALLTRNASSRPGITGTARVDRDIDRLLRRIGPGDIVVMDVLD TH_1546|M.thermoresistible__bu ------MTALLSRNAAARPGITGTARVDRDINRLLRRVAPGDIVVIDALD Mflv_3504|M.gilvum_PYR-GCK ----MKMSALLSRNASSRPGITGTARVDRDIDRLLRRVTPGDIVVLDALD Mvan_3285|M.vanbaalenii_PYR-1 ----MKMSALLSRNASSRPGITGTARVDRDIDRLLRRVTPGDIVVLDALD Mb1723|M.bovis_AF2122/97 ----MRMSALLSRNTS-RPGLIGIARVDRNIDRLLRRVCPGDIVVLDVLD Rv1697|M.tuberculosis_H37Rv ----MRMSALLSRNTS-RPGLIGIARVDRNIDRLLRRVCPGDIVVLDVLD MMAR_2502|M.marinum_M ----MKMSALLSRNTA-RPGLIGTARVDRNIDRLLRRVCPGDIVVLDALD MUL_1686|M.ulcerans_Agy99 ----MKMSALLSRNTA-RPGLIGTARVDRNIDRLLRRVCPGDIVVLDALD MAV_3074|M.avium_104 ----MKMSGLLSRNTD-RPGIVGTARVDRNIDRLLRRVCPGDIVVLDVLD MLBr_01361|M.leprae_Br4923 ----MRMSALLSRNNS-RPGLVGTARVDRNIDRLLRRICPGDIVVLDVLD MAB_2362|M.abscessus_ATCC_1997 MITPMNLTTMLTRSSSSRPGIVGTVRTDRDINRLLQRLNPGDIAVIDILD :: :*:*. ***: * .*.**:*:***:*: ****.*:* ** MSMEG_3748|M.smegmatis_MC2_155 LDRITADALVEANIAGVVNASPSISGRYPNLGPEVLVGNGIVLIDEAGPE TH_1546|M.thermoresistible__bu LDRITADALVEANVAGVVNASPSISGRYPNLGPEVLVANGIALIDETGPE Mflv_3504|M.gilvum_PYR-GCK LDRVTADALVDAGVSAVVNASPSISGRYPNLGPEVLVANGITLVDETGPE Mvan_3285|M.vanbaalenii_PYR-1 LDRVTADALVEAGVAAVVNASPSISGRYPNLGPEVLVANGITLVDETGPE Mb1723|M.bovis_AF2122/97 LDRITADALVEAEIAAVVNASSSVSGRYPNLGPEVLVTNGVTLIDETGPE Rv1697|M.tuberculosis_H37Rv LDRITADALVEAEIAAVVNASSSVSGRYPNLGPEVLVTNGVTLIDETGPE MMAR_2502|M.marinum_M LDRITADALVESGVAAVVNASSSVSGRYPNLGPEVLVNNGVTLIDETGPE MUL_1686|M.ulcerans_Agy99 LDRITADALVESGVAAVVNASSSVSGRYPNLGPEVLVNNGVTLIDETGPE MAV_3074|M.avium_104 LDRITADALVEADIAAVVNASPSVSGRYPNLGPEVLVNNGVTLIDEAGPD MLBr_01361|M.leprae_Br4923 LDRITADALVEADIVAVVNASPSVSGRYPNLGPEVLVNNGVTLIDETGPE MAB_2362|M.abscessus_ATCC_1997 LDRITADALVDARVSAVVNASPSISGRYPNLGPEVLVANGITLIDSIGPE ***:******:: : .*****.*:************* **:.*:*. **: MSMEG_3748|M.smegmatis_MC2_155 VFKKIKDGARVRLHNGGVYSGDRRIALGTERTDQDIHELMHEAKSGLVAH TH_1546|M.thermoresistible__bu VFKKVKDGAKIRLHNGGIYSGDRRLALGVERTDHDIHELMHEAKSGLVAH Mflv_3504|M.gilvum_PYR-GCK IFKKVKDGARIRINEGGIYSGDRRLSLGTERTDADIHELMQEAKGGLVAH Mvan_3285|M.vanbaalenii_PYR-1 VFKKVKDGARVRINEGGVYSGDRRLVLGTERTDADIHELMQEAKGGLVAH Mb1723|M.bovis_AF2122/97 IFKKVKDGAKVRLYEGGVYAGDRRLIRGTERTDHDIADLMREAKSGLVAH Rv1697|M.tuberculosis_H37Rv IFKKVKDGAKVRLYEGGVYAGDRRLIRGTERTDHDIADLMREAKSGLVAH MMAR_2502|M.marinum_M IFKKVKDGSKVRLYEGGVYSGDRRLIRGTERTDHDIADLMREAKSGLAAH MUL_1686|M.ulcerans_Agy99 IFKKVKDGSKVRLYEGGVYSGDRRLIRGTERTDHDIADLMREAKSGLAAH MAV_3074|M.avium_104 IFKKVKDGAKIRLYDGGVYAGDRRLVRGTERTEHDIADLMREAKSGLAAH MLBr_01361|M.leprae_Br4923 VFKKIKDGAKIRLHEGGVYSGDRRLICGTERTDHDIADLMREAKSGLATH MAB_2362|M.abscessus_ATCC_1997 VFKKVKDGSTVRVHNGGIYNGDRRLIAGTPRTDADVHDLMTEAKTGLVAH :***:***: :*: :**:* ****: *. **: *: :** *** **.:* MSMEG_3748|M.smegmatis_MC2_155 LEAFAGNTIEFIRSESPLLIDGIGIPNIDVDVHRRHVVIVAEEPSAAEDL TH_1546|M.thermoresistible__bu LEAFAGNTIEFIRSESPLLIDGIGIPDIDVDLHRRHVVVVAEEPGAADDL Mflv_3504|M.gilvum_PYR-GCK LEAFAGNTIEFIRSESPLLIDGIGIPDIDVDLNRRHVVIVAEEDNAAADL Mvan_3285|M.vanbaalenii_PYR-1 LEAFAGNTIEFIRSESPLLIDGIGIPDIDVDMNRRHVVIVAEEDHAAADL Mb1723|M.bovis_AF2122/97 LEAFAGNTIEFIRSESPLLIDGIGIPDVDVDLRRRHVVIVADEPSGPDDL Rv1697|M.tuberculosis_H37Rv LEAFAGNTIEFIRSESPLLIDGIGIPDVDVDLRRRHVVIVADEPSGPDDL MMAR_2502|M.marinum_M LEAFAGNTIEFIRSESPLLIDGIGIPDIDVDMRRRHVVIVAEEPSAADDL MUL_1686|M.ulcerans_Agy99 LEAFAGNTIEFIRSESPLLIDGIGIPDIDVDMRRRHVVIVAEEPSAADDL MAV_3074|M.avium_104 LEAFAGNTIEFIKSESPLLIDGIGIPDIDVDLRRRHVVIVADEPSAEEDL MLBr_01361|M.leprae_Br4923 LEAFAGNTIEFIKSESPLLIDGIGIPDIDVDLRRRHVVIVADEPSAADDL MAB_2362|M.abscessus_ATCC_1997 LEAFSGNTIEFIRSESPLLIDGIGIPDVDIDLRNRHVVVVSDGVGAAHDL ****:*******:*************::*:*:..****:*:: . ** MSMEG_3748|M.smegmatis_MC2_155 KALKPFIKEYQPVLVGVGAGADVLRKAGYRPALIVGDPDKMSVEVLRSGA TH_1546|M.thermoresistible__bu KALKPFIKEYQPVLVGVGTGADILRKAGYRPALIVGDPDKMSAEVLRSGA Mflv_3504|M.gilvum_PYR-GCK KALKPFIKEYQPVLVGVGLGADTLRKAGYRPALIVGDPDKISTEVLRCGA Mvan_3285|M.vanbaalenii_PYR-1 KALKPFIKEYQPVLVGVGAGADILRKAGYRPQLIVGDPDKISTEVLRCGA Mb1723|M.bovis_AF2122/97 KSLKPFIKEYQPVLVGVGTGADVLRKAGYRPQLIVGDPDQISTEVLKCGA Rv1697|M.tuberculosis_H37Rv KSLKPFIKEYQPVLVGVGTGADVLRKAGYRPQLIVGDPDQISTEVLKCGA MMAR_2502|M.marinum_M KSLKPFIKEYQPVLVGVGTGADVLRKAGYRPQLIVGDPDQISTEVLKCGA MUL_1686|M.ulcerans_Agy99 KSLKPFITEYQPVLVGVGTGADVLRKAGYRPQLIVGDPDQISTEVLKCGA MAV_3074|M.avium_104 KSLKPFIKEYQPALIGVGTGADVLRKAGYRPQIIVGDPDQISADALKCGA MLBr_01361|M.leprae_Br4923 KSLKPFIKEYQPVLVGVSGGADVLRKAGYRPQLIVGDPEQISTEALRCGA MAB_2362|M.abscessus_ATCC_1997 KNLKPFIKEYQPVLIGVGTGADTLRKAGYRPLIVVGDPLLMSNDVLKSGA * *****.****.*:**. *** ******** ::**** :* :.*:.** MSMEG_3748|M.smegmatis_MC2_155 QVVLPADADGHAAGLERIQDLGVGAMTFPAAGSAADLALLLCDHHGASLI TH_1546|M.thermoresistible__bu QVILPADADGHAAGLERIQDLGVGAMTFPAAGSAADLALLLCDHHGASLI Mflv_3504|M.gilvum_PYR-GCK QVVLPADADGHAAGLERIQDLGVGAMTFPAAGSAADLALLLCDHHGASLI Mvan_3285|M.vanbaalenii_PYR-1 QVVLPADADGHAAGLERIQDLGVGAMTFPAAGSAADLALLLCDHHGAALI Mb1723|M.bovis_AF2122/97 QVVLPADADGHAPGLERIQDLGVGAMTFPAAGSATDLALLLADHHGAALL Rv1697|M.tuberculosis_H37Rv QVVLPADADGHAPGLERIQDLGVGAMTFPAAGSATDLALLLADHHGAALL MMAR_2502|M.marinum_M QVVLPADADGHAPGLERIQDLGVGAMTFPAAGSATDLALLLADHHGAALL MUL_1686|M.ulcerans_Agy99 QVVLPADADGHAPGLERIQDLGVGAMTFPAAGSATDLALLLADHHGAALL MAV_3074|M.avium_104 QVVLPADADGHAPGLERIQDLGVGAMTFPAAGSAIDLALLLADHHGAALL MLBr_01361|M.leprae_Br4923 HVVLPADADGHAPGLERIQDLGVGAMTFPAAGSATDLALLLADHHGAALL MAB_2362|M.abscessus_ATCC_1997 QVVLPADADGHAAGLERIQDLGVGAVTFPAAGSAADLALLLADHHGASLI :*:*********.************:******** ******.*****:*: MSMEG_3748|M.smegmatis_MC2_155 VTAGHTATIEEFFDRSRQASNPSTFLTRLKVGEKLVDAKAVATLYRSRVS TH_1546|M.thermoresistible__bu VTCGHTATIEEFFDRSRQQSNPSTFLTRLKVGEKLVDAKAVATLYRSRVS Mflv_3504|M.gilvum_PYR-GCK VTVGHTASIEEFFDRTRQQSNPSTFLTRMKVGEKLVDAKAVATLYRSRVS Mvan_3285|M.vanbaalenii_PYR-1 VTVGHTASIEEFFDRNRQRSNPSTFLTRLKVGEKLVDAKAVATLYRSRVS Mb1723|M.bovis_AF2122/97 VTAGHAANIETFFDRTRVQSNPSTFLTRLRVGEKLVDAKAVATLYRNHIS Rv1697|M.tuberculosis_H37Rv VTAGHAANIETFFDRTRVQSNPSTFLTRLRVGEKLVDAKAVATLYRNHIS MMAR_2502|M.marinum_M VTAGHNANIETFFDRTRVQSNPSTFLTRLRVGEKLVDAKAVATLYRNHIS MUL_1686|M.ulcerans_Agy99 VTAGHNANIETFFDRTRVQSNPSTFLTRLRVGEKLVDAKAVATLYRNHIS MAV_3074|M.avium_104 VTAGHTANIETFFDRTRAHSNPSTFLTRLRVGEKVVDAKAVATLYRNHIS MLBr_01361|M.leprae_Br4923 VTAGHTANIETFFDRTRTQSNPSTFLTRLRVGEKLVDAKAVATLYRNHIS MAB_2362|M.abscessus_ATCC_1997 VTVGHTASIEEFFDRERQQSNPSTFLTRLKVGAKLVDAKAVATLYRNRFS ** ** *.** **** * *********::** *:***********.:.* MSMEG_3748|M.smegmatis_MC2_155 GGAIAMLVLAMLVAVIVALWVSRADTAVVDWVVSYWHQFTAWVQSIIGSL TH_1546|M.thermoresistible__bu AGAIALLVLAMLIAVIVALWVARVDTVVVDWVIDYWNRFSLWVQGLVS-- Mflv_3504|M.gilvum_PYR-GCK GGAIALLVLAMLIAVIAALWVSRADAAVLEWVTQYWNQFLLWAQGLVS-- Mvan_3285|M.vanbaalenii_PYR-1 GGAIALLVLAMLIAVIAALWVSRADAAVIEWVSQYWNQFLLWAQGLVS-- Mb1723|M.bovis_AF2122/97 GGAIALLALTMLIAIIVALWVSRTDGVVLHWIIDYWNRFSLWVQHLVS-- Rv1697|M.tuberculosis_H37Rv GGAIALLALTMLIAIIVALWVSRTDGVVLHWIIDYWNRFSLWVQHLVS-- MMAR_2502|M.marinum_M AGAIALLALTMLIAIIVVLWVSRTDGVVVHWIVDYWNRFSLWVQHLVT-- MUL_1686|M.ulcerans_Agy99 AGAIALLALTMLIAIIVVLWVSRTDGVVVHWIVDYWNRFSLWVQHLVT-- MAV_3074|M.avium_104 AGAIALLALTMLIAVIVALWVSRTDGVVLHWITDYWNHFSLMVQKWVT-- MLBr_01361|M.leprae_Br4923 FGAIALLALIMLIAVIVALWVSRTDGVVLHGVIDYWNRFSLWIQRLIA-- MAB_2362|M.abscessus_ATCC_1997 GGAIALLILAVLVAVITMLWVTSAGDSAAEWLLAYWNRMTVWVQNLVS-- ****:* * :*:*:*. ***: .. . . : **::: * : MSMEG_3748|M.smegmatis_MC2_155 GG TH_1546|M.thermoresistible__bu -- Mflv_3504|M.gilvum_PYR-GCK -- Mvan_3285|M.vanbaalenii_PYR-1 -- Mb1723|M.bovis_AF2122/97 -- Rv1697|M.tuberculosis_H37Rv -- MMAR_2502|M.marinum_M -- MUL_1686|M.ulcerans_Agy99 -- MAV_3074|M.avium_104 -- MLBr_01361|M.leprae_Br4923 -- MAB_2362|M.abscessus_ATCC_1997 --