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VTELTLTTGAPANGGSCVARHDGRVVFVRYALPGETVRVRVVDERGSFWRAEVVEVIDPSPDRVDSLCPI AGVDGAGCCDLAFATPDASRRIKGAVVANQLSRLGGYHWRDEDSATAEPVGSGAATGWRTRVRLDTTADG RPGFHRYHSADLVTDLGCAQLPSGMVDGLDDLRVPGGAQLHLALDSEGTRHVVQSGPKNGRKSPTRVVDG QYEAVQRIGSRVWRVPVTAFWQAHREAAALYSDLVAGWAQLEPGMTAWDLYGGAGVFAASLAEQVGESGH VVTVDTSRGSSRSARAALADLKSVSVITDSVRRALATQHQRADVAVLDPPRTGANREVIDQIAAADVPRI IHIGCEAASFARDVGLYLRHGYHVEEIRVFDSFPLTHHIECVAVLNR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2773 | - | - | 100% (397) | RNA methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2708c | - | 1e-155 | 68.01% (397) | hypothetical protein Mb2708c |
| M. gilvum PYR-GCK | Mflv_3925 | - | 1e-166 | 72.91% (395) | (Uracil-5)-methyltransferase |
| M. tuberculosis H37Rv | Rv2689c | - | 1e-155 | 68.01% (397) | hypothetical protein Rv2689c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2992c | - | 1e-133 | 59.85% (396) | hypothetical protein MAB_2992c |
| M. marinum M | MMAR_2025 | - | 1e-150 | 65.16% (399) | SAM-dependent methyltransferase |
| M. avium 104 | MAV_3580 | - | 1e-161 | 69.25% (400) | RNA methyltransferase |
| M. thermoresistible (build 8) | TH_2210 | - | 1e-171 | 73.23% (396) | CONSERVED HYPOTHETICAL ALANINE AND VALINE AND GLYCINE RICH |
| M. ulcerans Agy99 | MUL_3327 | - | 1e-149 | 64.91% (399) | SAM-dependent methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_2475 | - | 1e-171 | 73.67% (395) | (Uracil-5)-methyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2708c|M.bovis_AF2122/97 --MTRAGDDAVNLTLVTGAPANGGSCVAHHEGRVVFVRYALPGERVRARV
Rv2689c|M.tuberculosis_H37Rv --MTRAGDDAVNLTLVTGAPANGGSCVAHHEGRVVFVRYALPGERVRARV
MMAR_2025|M.marinum_M --MN--PNQALELNLVTGAAANGGSCVARHEGRVVFVRHALPGERVLARV
MUL_3327|M.ulcerans_Agy99 --MN--PNQALELNLVTGAAANGGSCVARHEGRVVFVRHALPGERVLARV
MAV_3580|M.avium_104 --MG-------ELTLTTGSPANGGSCVAHHEGRVVFVRYALPGERVRVRV
Mflv_3925|M.gilvum_PYR-GCK MSADDSA---EELTLTTVAPANGGSCIARHDARVVFVRYALPGETVRARL
Mvan_2475|M.vanbaalenii_PYR-1 MSTD-------ELVLTTVAAANGGSCIARHDGRVVFVRYALPGETVRARL
MSMEG_2773|M.smegmatis_MC2_155 ------M---TELTLTTGAPANGGSCVARHDGRVVFVRYALPGETVRVRV
TH_2210|M.thermoresistible__bu MTSDSVLSSDTVVTLTVGAPANGGSCVARHDGRVVFVRYALPGETVRARI
MAB_2992c|M.abscessus_ATCC_199 MTIG------DILEVHTGGAANGGSVVARHDGRVIFVRDALPGERVRVQI
: : . ..***** :*:*:.**:*** ***** * .::
Mb2708c|M.bovis_AF2122/97 TAQR-GSYWHAEAFEVIDPSPDRIGSLCSIAG-ADGAGCCDLAFAAPEAA
Rv2689c|M.tuberculosis_H37Rv TAQR-GSYWHAEAFEVIDPSPDRIGSLCSIAG-ADGAGCCDLAFAAPEAA
MMAR_2025|M.marinum_M TAQR-GSYWNAEVIEVIDPSPDRIGSLCPIAG-VDGAGCCDLAFAAPDAA
MUL_3327|M.ulcerans_Agy99 TAQR-GSYWNAEVIEVIDPSPDRIGSLCPIAG-VDGAGCCDLAFAAPDAA
MAV_3580|M.avium_104 TADR-GSYWHAEVLDVIEAAYGRIESLCPIAG-VDGAGCCDLAFVRPEAA
Mflv_3925|M.gilvum_PYR-GCK VGDR-GSYLNAEAVEVLESSADRIDPLCPIAG-ADGAGCCDLAFAEPAAV
Mvan_2475|M.vanbaalenii_PYR-1 VGDR-GAYWNADTVEVLESAAERIDSLCPIAG-VDGSGCCDLAFAEPSAV
MSMEG_2773|M.smegmatis_MC2_155 VDER-GSFWRAEVVEVIDPSPDRVDSLCPIAG-VDGAGCCDLAFATPDAS
TH_2210|M.thermoresistible__bu TRDR-GSYWHAETVEVIDPSPDRIAPLCAIAG-VDGAGCCDLAFATPEAV
MAB_2992c|M.abscessus_ATCC_199 TDDRQASFWHGAAVEVLDPSPHRIEPLCPIAHSAVGSGCCDLSFADPVYV
. :* .:: .. ..:*::.: *: .**.** . *:*****:*. *
Mb2708c|M.bovis_AF2122/97 RTLKAQVVANQLERLGRHSWQG----EAQPLSDAGPTGWRIRVRLDVGAD
Rv2689c|M.tuberculosis_H37Rv RTLKAQVVANQLERLGRHSWQG----EAQPLSDAGPTGWRIRVRLDVGAD
MMAR_2025|M.marinum_M RAIKSSVVGEQLQRLGGFSWSG----AAEPLSDAGPTGWRTRVRLEVGAD
MUL_3327|M.ulcerans_Agy99 RAIKSSVVGEQLQRLGGFSWSG----AAEPLSDAGPTGWRTRVRLEAGAD
MAV_3580|M.avium_104 RALKAAVVANQLERLGGHRWAG----EAEPLGNTGPTGWRTRVRLDVGAD
Mflv_3925|M.gilvum_PYR-GCK RRIKGEVVANQLARLGGLQWRDEAEATAEPVGDGAATGWRTRVRLDTSDD
Mvan_2475|M.vanbaalenii_PYR-1 RRIKGAVVANQLARLGNYRWCDESEATAEPVGDGGATGWRTRVRLDTSAD
MSMEG_2773|M.smegmatis_MC2_155 RRIKGAVVANQLSRLGGYHWRDEDSATAEPVGSGAATGWRTRVRLDTTAD
TH_2210|M.thermoresistible__bu RRLKGEVVANQLARLGGFRWRDEAEAAAEPLGAGEPTGWRTRVRLGTTAD
MAB_2992c|M.abscessus_ATCC_199 RELKGDVVSQQLARLGKYEWQG----VAQPLGAGDPTGWRTRVRLDVNAL
* :*. **.:** *** * . *:*:. .**** **** .
Mb2708c|M.bovis_AF2122/97 RRPGFHRYHSGELVTDLDCGQLPVGMLDGLVA----ADWPPEAQLYVALD
Rv2689c|M.tuberculosis_H37Rv RRPGFHRYHSGELVTDLDCGQLPVGMLDGLVA----ADWPPEAQLYVALD
MMAR_2025|M.marinum_M HCVGFHRYHSNELVTDLRCGQLPDGMLDGLAQRSAKAGWPAGAQLHVALG
MUL_3327|M.ulcerans_Agy99 HCVGFHRYHSNELVTDLSCGQLPDGMLDGLAQRSAKAGWPAGAQLHVALG
MAV_3580|M.avium_104 RRPGFHRYHSEELVTDLRCAQLPPGMLDGIAE----TQWPSAAQLHVAVD
Mflv_3925|M.gilvum_PYR-GCK GRVGFHRYHSGELVHRLDCAQLPAGMVDGLAD----MRWAPGSAVHVVLD
Mvan_2475|M.vanbaalenii_PYR-1 GRAGFHRYHSAELVHRLDCAQLPAGLLDGLAD----TQWPAGSVVHVVVD
MSMEG_2773|M.smegmatis_MC2_155 GRPGFHRYHSADLVTDLGCAQLPSGMVDGLDD----LRVPGGAQLHLALD
TH_2210|M.thermoresistible__bu GYAGFHRYRSNEVVTDLRCGQLAPGMLTGLDQ----GGWTPGAQVHVAVD
MAB_2992c|M.abscessus_ATCC_199 GQPGFHRYHSDELVTDLRCAQVVPGLLDGLDQ----PELGSEGPLHAVMD
*****:* ::* * *.*: *:: *: . :: .:.
Mb2708c|M.bovis_AF2122/97 DDGERHVVCSVRQGPRNRTRTVTNVVEGAYHAHQRVHRRSWRVPVTAFWQ
Rv2689c|M.tuberculosis_H37Rv DDGERHVVCSVRQGPRNRTRTVTNVVEGAYHAHQRVHRRSWRVPVTAFWQ
MMAR_2025|M.marinum_M DDGARHVVLTVRRG----RRTDAKVVEGDPRVLQRVGERSWRIPATAFWQ
MUL_3327|M.ulcerans_Agy99 DDGARHVVLTVRRG----RRTDAKVVEGDPRVLQRVGERSWRIPATAFWQ
MAV_3580|M.avium_104 DDGARHVVRTLRQG----RRTATKVIEGRYEAVQRVSGRRWRVPVTAFWQ
Mflv_3925|M.gilvum_PYR-GCK GDGNRHVVVAAGRD----RGVRTTVVEGDYETVQRVAGRSWRVPATAFWQ
Mvan_2475|M.vanbaalenii_PYR-1 DDGNRHVAHTG-------KGQRTAVVEGGYEAVQRVAGRTWRVPVTAFWQ
MSMEG_2773|M.smegmatis_MC2_155 SEGTRHVVQSGPKNG---RKSPTRVVDGQYEAVQRIGSRVWRVPVTAFWQ
TH_2210|M.thermoresistible__bu DNDDRHVVQVGPRRG---RRNPTQVRFGRYEAVQRVGGREWRVPVTAFWQ
MAB_2992c|M.abscessus_ATCC_199 DQGRRHVLRGS------------TIVEGEDVAVQKVGDRHWLVPVTAFWQ
.:. *** : * . *:: * * :*.*****
Mb2708c|M.bovis_AF2122/97 AHRDAAAVYSDLIADWAQPAPGMTAWDLYGGAGVFAAVLGEAVGESGRVL
Rv2689c|M.tuberculosis_H37Rv AHRDAAAVYSDLIADWAQPAPGMTAWDLYGGAGVFAAVLGEAVGESGRVL
MMAR_2025|M.marinum_M SHRDAAKVYSGLVADWAQPGAGMTAWDLYGGAGVFAAVLGDAVGESGRVL
MUL_3327|M.ulcerans_Agy99 SHRDAAKVCSGLVADWAQPGAGMTAWDLYGGAGVFAAVLGDAVGESGRVL
MAV_3580|M.avium_104 AHRDAAATYRALVLDWAQPGAGMTAWDLYGGAGVFAAALGEAVGESGRVL
Mflv_3925|M.gilvum_PYR-GCK AHRAAPELYSALVTRWAQLELGMSAWDLYGGAGVFAAALAAGVGPDGSVL
Mvan_2475|M.vanbaalenii_PYR-1 AHRDAPALYSALVAQWAQLEAGMTAWDLYGGAGVFAAALARGVGDTGAVT
MSMEG_2773|M.smegmatis_MC2_155 AHREAAALYSDLVAGWAQLEPGMTAWDLYGGAGVFAASLAEQVGESGHVV
TH_2210|M.thermoresistible__bu AHRDAAHSYSALVAEWAQLSPGMTAWDLYGGAGLFAAVLAEAVGAHGRVL
MAB_2992c|M.abscessus_ATCC_199 AHRDAAGTYSRLVSDWAELEPGMSAWDLYGGVGVFAAALGEAVGRTGHVV
:** *. *: **: **:*******.*:*** *. ** * *
Mb2708c|M.bovis_AF2122/97 TVDTSRLASGAARAALVDLPQVEVVTGSVRRVLAVQPA---GADLAVLDP
Rv2689c|M.tuberculosis_H37Rv TVDTSRLASGAARAALVDLPQVEVVTGSVRRVLAVQPA---GADLAVLDP
MMAR_2025|M.marinum_M SVDTARAASAAARVALADLPQVEVVTDSVRRVLAAQDG---GADIAVLDP
MUL_3327|M.ulcerans_Agy99 SVDTARAASAAARVALADLPQVEVVTDSVRRVLAAQDG---GADIAVLDP
MAV_3580|M.avium_104 SVDTSRASTRAARAALADLPQVQVVTDSVRRALAAQRTPALQADVAVLDP
Mflv_3925|M.gilvum_PYR-GCK TVDTSRGASRSARAALGDLGNVTVVTDSVRRALGAQRE---RADVAVLDP
Mvan_2475|M.vanbaalenii_PYR-1 TVDTSRGASRAARAALADLGNVSVVTDSVRRALTGQRT---RADVAVLDP
MSMEG_2773|M.smegmatis_MC2_155 TVDTSRGSSRSARAALADLKSVSVITDSVRRALATQHQ---RADVAVLDP
TH_2210|M.thermoresistible__bu TVDTAPGASRAARTALADLGCVSVVTDPVRRALSAEPD---RADVAVLDP
MAB_2992c|M.abscessus_ATCC_199 SVDTSRPAFRSAKSALGDLRQVTMICGSVRHAIRDLGE----ADVAVLDP
:***: : :*: ** ** * :: ..**:.: **:*****
Mb2708c|M.bovis_AF2122/97 PRSGAGREVVDLLAGAGVPRLIHIGCEAASFARDIGLYRGHGYAVEKIKV
Rv2689c|M.tuberculosis_H37Rv PRSGAGREVVDLLAGAGVPRLIHIGCEAASFARDIGLYRGHGYAVEKIKV
MMAR_2025|M.marinum_M PRSGAGREVIDLLADAGVRRVVHIGCEAASFARDLGLYRGHGYGVDAIKV
MUL_3327|M.ulcerans_Agy99 PRSGAGREVIDLLADAGVRRVVHIGCEAASFARDLGLYRGHGYGVHAIKV
MAV_3580|M.avium_104 PRAGAGREVIDSLSAAGVPRIVHIGCEAASFARDMGIYLGHGYTVEKIRV
Mflv_3925|M.gilvum_PYR-GCK PRTGAGREVIDLLAGAGVPRIIHIGCEAASFARDVGLYRTHGYAVEELQV
Mvan_2475|M.vanbaalenii_PYR-1 PRTGAGREVVDLLAAAEVPRIIHIGCEAASFARDVGLYLGHGYAVEELRV
MSMEG_2773|M.smegmatis_MC2_155 PRTGANREVIDQIAAADVPRIIHIGCEAASFARDVGLYLRHGYHVEEIRV
TH_2210|M.thermoresistible__bu PRTGAGREVIDLLAAAEVPRIIHIGCEAASFARDIGLYRGHGYTVEDLRV
MAB_2992c|M.abscessus_ATCC_199 PRAGAGREVIGKVAAANVSRVIHIGCEAAAFARDVGLYLERGYRVRELRV
**:**.***:. :: * * *::*******:****:*:* :** * ::*
Mb2708c|M.bovis_AF2122/97 FDAFPLTHYVECVALLTRKV
Rv2689c|M.tuberculosis_H37Rv FDAFPLTHYVECVALLTRKV
MMAR_2025|M.marinum_M FDAFPLTHHVECVALLTR--
MUL_3327|M.ulcerans_Agy99 FDAFPLTHHVECVALLTR--
MAV_3580|M.avium_104 FDAFPLTHHSECVALLTR--
Mflv_3925|M.gilvum_PYR-GCK YDSFPLTHHVECVAVLSR--
Mvan_2475|M.vanbaalenii_PYR-1 FDSFPLTHHVECVAVLTR--
MSMEG_2773|M.smegmatis_MC2_155 FDSFPLTHHIECVAVLNR--
TH_2210|M.thermoresistible__bu FDSFPLTHHVECVAVLTR--
MAB_2992c|M.abscessus_ATCC_199 FDAFPLTHHIESFALLTR--
:*:*****: *..*:*.*