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KIVLAPDSFKESMTASQAVTAMREGVHSVFPDAECVGVPMADGGEGTVDAVVDALAGERVRVDVSDPLGR PVRADYGYIPERKLAVIEMATASGLELVAPADRDVLSASTFGVGQLIASALDRGAVDLLIGLGGSATNDG GTGMLTALGAVLLDAAGNPLPPGGGALAQLDRIDLSGLDKRLADIQIRIASDVTAPLLGPGGASAVFGPQ KGATPFDVETLEAALTRLAVVTEETLGRARPELPGAGAAGGLGFALLDFLGAECRPGVEVIAETVGLAQA VVGADWVFTGEGSVDAQTVLGKTPFGVAQVARTAGARVVIFAGRVGDDAGVLLEHGVDRLVAITVPGTPI EQALREGPQSLARATAEVCRALS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2528 | - | - | 100% (374) | glycerate kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2228c | - | 2e-51 | 35.47% (375) | hypothetical protein Mb2228c |
| M. gilvum PYR-GCK | Mflv_2944 | - | 2e-51 | 38.92% (370) | glycerate kinase |
| M. tuberculosis H37Rv | Rv2205c | - | 2e-51 | 35.47% (375) | hypothetical protein Rv2205c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1956 | - | 1e-54 | 37.30% (370) | glycerate kinase |
| M. marinum M | MMAR_3249 | - | 6e-53 | 36.27% (375) | glycerate kinase |
| M. avium 104 | MAV_2286 | - | 4e-49 | 37.80% (336) | glycerate kinase subfamily protein |
| M. thermoresistible (build 8) | TH_2724 | - | 6e-11 | 33.33% (186) | PUTATIVE ftsk/spoiiie family protein |
| M. ulcerans Agy99 | MUL_3562 | - | 7e-52 | 35.73% (375) | glycerate kinase |
| M. vanbaalenii PYR-1 | Mvan_3569 | - | 2e-50 | 38.92% (370) | glycerate kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2228c|M.bovis_AF2122/97 -----------------------MRVLVAPDCYGDSLSAVEAAAAIATGW
Rv2205c|M.tuberculosis_H37Rv -----------------------MRVLVAPDCYGDSLSAVEAAAAIATGW
MMAR_3249|M.marinum_M MNGSLASDAAADGLGPGRIQLPAMRVLVAPDCYGESLSAVEAAAVIATGW
MUL_3562|M.ulcerans_Agy99 -----------------------MRVLVAPVCYGESLSAVEAAAVIATGW
MAV_2286|M.avium_104 ---------------------------MAPDCYADSMSALEASAAIATGW
Mflv_2944|M.gilvum_PYR-GCK ---------------MTATESPGATVLIAPDCFGDSLTAVQAAESIARGW
Mvan_3569|M.vanbaalenii_PYR-1 ---------------MVAA------ILIAPDCFGDSLTAVQAAQSIAAGW
MAB_1956|M.abscessus_ATCC_1997 ---------------------------MAPDSFGDTLTATEAAGVIADGW
MSMEG_2528|M.smegmatis_MC2_155 -----------------------MKIVLAPDSFKESMTASQAVTAMREGV
TH_2724|M.thermoresistible__bu -------------MVGRQPDSAARHVLIAPDSFGGTLTAVRAAEAIAAGW
:** .: :::* .* : *
Mb2228c|M.bovis_AF2122/97 TRSRPGDSFIVAPQSDGGPGFVEVLGSRLGETR--RLRVCGPLNTV----
Rv2205c|M.tuberculosis_H37Rv TRSRPGDSFIVAPQSDGGPGFVEVLGSRLGETR--RLRVCGPLNTV----
MMAR_3249|M.marinum_M TRSRPNDSFIVAPQSDGGPGFIDVLRSRLGGVR--KLQVSGPLDTA----
MUL_3562|M.ulcerans_Agy99 TRSRPNDSFIVAPQSDGGPGFIDVLRSRLGGVR--KLQVSGPLDTA----
MAV_2286|M.avium_104 TRSRPGDRFIVAPQSDGGPGFVEVLASRLGETR--RLRVSGPLKAM----
Mflv_2944|M.gilvum_PYR-GCK SASRPADTVRLAPQSDGGPGFVEVLASRLGEVR--TLTVSGPLDAE----
Mvan_3569|M.vanbaalenii_PYR-1 RRARPQDVLTLAPQSDGGPGFVEVLASRLGEVR--TTSVSGPLDTD----
MAB_1956|M.abscessus_ATCC_1997 GSARPGDTVILSPQSDGGPGFVEVLATQLSSARRHTARVRGPLDED----
MSMEG_2528|M.smegmatis_MC2_155 HSVFPDAECVGVPMADGGEGTVDAVVDALAGER-VRVDVSDPLGRP----
TH_2724|M.thermoresistible__bu RRGRPHDEITPAPQSDGGPGFVDVLATRLGEVR--TTRVDGPLSAESSAD
* * :*** * ::.: *. * * .**
Mb2228c|M.bovis_AF2122/97 VNAAWVFDPGS-ATAYLECAQACGLGLLGGPPTPETALAAHSKGVGQLIA
Rv2205c|M.tuberculosis_H37Rv VNAAWVFDPGS-ATAYLECAQACGLGLLGGPPTPETALAAHSKGVGQLIA
MMAR_3249|M.marinum_M VSAEWVFERSS-ATAYLECAQACGLSLLGGPPSPETALAAHSRGVGQLID
MUL_3562|M.ulcerans_Agy99 VSAEWVFERSS-ATAYLECAQACGLSLLGGPPSPETALAAHSRGVGQLID
MAV_2286|M.avium_104 VEAEWVFDRGS-ATAYLECAQACGLALLGGPPTPETAMAAHSKGVGQLIA
Mflv_2944|M.gilvum_PYR-GCK VAARWVLDADPPVTAYIECAQACGLTLLGGPPTVRTAVDAHSGGVGQLIA
Mvan_3569|M.vanbaalenii_PYR-1 VDAQWVLDSSPPVTAYIECAQACGLTLLGGPPTVRTALDAHSRGVGQLIA
MAB_1956|M.abscessus_ATCC_1997 VDAAWLLDTPT---AYVECAQACGLPLLRRPPSVDTAWRAHSTGVGQLIA
MSMEG_2528|M.smegmatis_MC2_155 VRADYGYIPER-KLAVIEMATASGLELVA--PADRDVLSASTFGVGQLIA
TH_2724|M.thermoresistible__bu VSADWLFDPADPATAYLECAQACGLTLLPRPPDPTTAEAAHSRGVGQLVA
* * : * :* * *.** *: * . * : *****:
Mb2228c|M.bovis_AF2122/97 AALRAG----------------------------AARIVVGLGGSACTDG
Rv2205c|M.tuberculosis_H37Rv AALRAG----------------------------AARIVVGLGGSACTDG
MMAR_3249|M.marinum_M AALAAG----------------------------ARRIVVGLGGSACTDG
MUL_3562|M.ulcerans_Agy99 AALAAG----------------------------ARRIVVGLGGSACTDG
MAV_2286|M.avium_104 EALRVG----------------------------ATRIVVGLGGSACTDG
Mflv_2944|M.gilvum_PYR-GCK AARAAG----------------------------AGRIVVGLGGSSCTDG
Mvan_3569|M.vanbaalenii_PYR-1 AARAAG----------------------------ARRIVVGLGGSSCTDG
MAB_1956|M.abscessus_ATCC_1997 AALDAG----------------------------AARIVVGLGGSSCTDG
MSMEG_2528|M.smegmatis_MC2_155 SALDRG----------------------------AVDLLIGLGGSATNDG
TH_2724|M.thermoresistible__bu AALAAXXXGGPKSGKTTALQTFILSAAALHSPREVTFYCLDYGGGQLRDL
* . :. **. *
Mb2228c|M.bovis_AF2122/97 GKGMIAELGG--LDAAR---------------------------------
Rv2205c|M.tuberculosis_H37Rv GKGMIAELGG--LDAAR---------------------------------
MMAR_3249|M.marinum_M GHGMITELGG--LDAAR---------------------------------
MUL_3562|M.ulcerans_Agy99 GHGMITELGG--LDAAR---------------------------------
MAV_2286|M.avium_104 GQGMIAELGG--LDTAR---------------------------------
Mflv_2944|M.gilvum_PYR-GCK GRGMVEALGG--LDAAR---------------------------------
Mvan_3569|M.vanbaalenii_PYR-1 GRGMVEALGG--PAAAR---------------------------------
MAB_1956|M.abscessus_ATCC_1997 GAGLIEGLGG--IEQAQ---------------------------------
MSMEG_2528|M.smegmatis_MC2_155 GTGMLTALGAVLLDAAGNPLPP----------------------------
TH_2724|M.thermoresistible__bu ADLAHVGSVASPLEPERIRRTFGELEQLLLQRQARGPQSRGDGDSPDGFG
. .
Mb2228c|M.bovis_AF2122/97 ------------------------RQLADVEVIAAS--------------
Rv2205c|M.tuberculosis_H37Rv ------------------------RQLADVEVIAAS--------------
MMAR_3249|M.marinum_M ------------------------DRLAGIELIAAS--------------
MUL_3562|M.ulcerans_Agy99 ------------------------DRLAGIELIAAS--------------
MAV_2286|M.avium_104 ------------------------RQLGNVELIAAS--------------
Mflv_2944|M.gilvum_PYR-GCK ------------------------DLLADVELIAAT--------------
Mvan_3569|M.vanbaalenii_PYR-1 ------------------------DLLAGVELIAAS--------------
MAB_1956|M.abscessus_ATCC_1997 ------------------------RRLATTELVVAS--------------
MSMEG_2528|M.smegmatis_MC2_155 -------GGGALAQLDRIDLSGLDKRLADIQIRIAS--------------
TH_2724|M.thermoresistible__bu EVFLVIDNLYAFSRDNTDMFNTRNPLLAKVTELVNTGLSYGIHVVITTPN
*. :
Mb2228c|M.bovis_AF2122/97 ----------------------------DVEYPLLGPWGTARVFAPQKGA
Rv2205c|M.tuberculosis_H37Rv ----------------------------DVEYPLLGPWGTARVFAPQKGA
MMAR_3249|M.marinum_M ----------------------------DAEYPLLGPWGSARVFSPQKGA
MUL_3562|M.ulcerans_Agy99 ----------------------------DAEYPLLGPWGSARVFSPQKGA
MAV_2286|M.avium_104 ----------------------------DTEYPLLGPWGAARVFGPQKGA
Mflv_2944|M.gilvum_PYR-GCK ----------------------------DVEHPLLGQMGAARVFGPQKGA
Mvan_3569|M.vanbaalenii_PYR-1 ----------------------------DVEHPLLGPTGAAAVFGPQKGA
MAB_1956|M.abscessus_ATCC_1997 ----------------------------DVEHPLLGPTGAAAVFGPQKGA
MSMEG_2528|M.smegmatis_MC2_155 ----------------------------DVTAPLLGPGGASAVFGPQKGA
TH_2724|M.thermoresistible__bu WIEVPLAMRDGLGLRLELKLHDPQDSNVRVAGALRRPAESVPADQPGRGL
. .* : . * :*
Mb2228c|M.bovis_AF2122/97 DMATVAVLEGRLAAWAIELDAAAGRGVSAEPG------------------
Rv2205c|M.tuberculosis_H37Rv DMATVAVLEGRLAAWAIELDAAAGRGVSAEPG------------------
MMAR_3249|M.marinum_M DAATISVLEGRLAAWAVELDAAAGRAVSAEPG------------------
MUL_3562|M.ulcerans_Agy99 DAATISVLEGRLAAWAVELDAAAGRAVSAEPG------------------
MAV_2286|M.avium_104 DTATVAALEVRLQAWALILEAVAGRDVSAEPG------------------
Mflv_2944|M.gilvum_PYR-GCK DPDTVDLLESRLAAWADDLDTAAGRMVSDDPG------------------
Mvan_3569|M.vanbaalenii_PYR-1 DPDTVAVLEARLTAWAQELNAAAGRDIRDDPG------------------
MAB_1956|M.abscessus_ATCC_1997 DPDTVRRLEARLAQWAAALEAGTGRGVRDLAG------------------
MSMEG_2528|M.smegmatis_MC2_155 TPFDVETLEAALTRLAVVTEETLGRARPELPG------------------
TH_2724|M.thermoresistible__bu TMAAEHFLFAKPDLSAIPAINARHPGVSAPPVRLLPTQLAPEDLGPLYPA
* * .
Mb2228c|M.bovis_AF2122/97 --------------------------------------------------
Rv2205c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3249|M.marinum_M --------------------------------------------------
MUL_3562|M.ulcerans_Agy99 --------------------------------------------------
MAV_2286|M.avium_104 --------------------------------------------------
Mflv_2944|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3569|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1956|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_2528|M.smegmatis_MC2_155 --------------------------------------------------
TH_2724|M.thermoresistible__bu PEQVVIGQREEDLAPVSIDFAENPLLMVFGDNRSGKTTLLRHLIRTIREN
Mb2228c|M.bovis_AF2122/97 --------------------------------------------------
Rv2205c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3249|M.marinum_M --------------------------------------------------
MUL_3562|M.ulcerans_Agy99 --------------------------------------------------
MAV_2286|M.avium_104 --------------------------------------------------
Mflv_2944|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3569|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1956|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_2528|M.smegmatis_MC2_155 --------------------------------------------------
TH_2724|M.thermoresistible__bu STPDQIAFTVIDRRLQLVDEPLFPDNEYTANIDRVIPAMLGLSALIEKRR
Mb2228c|M.bovis_AF2122/97 --------------------------------------------------
Rv2205c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3249|M.marinum_M --------------------------------------------------
MUL_3562|M.ulcerans_Agy99 --------------------------------------------------
MAV_2286|M.avium_104 --------------------------------------------------
Mflv_2944|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3569|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1956|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_2528|M.smegmatis_MC2_155 --------------------------------------------------
TH_2724|M.thermoresistible__bu PPAGLTARELSGWRYEGHTHYLIVDDVDQIPDSPAVSGPFVGQRPWANLI
Mb2228c|M.bovis_AF2122/97 --AGAAGGIGAGLLA-VGGRYQSGAAIIAEHTHFADDLADAELIVTGE--
Rv2205c|M.tuberculosis_H37Rv --AGAAGGIGAGLLA-VGGRYQSGAAIIAEHTHFADDLADAELIVTGE--
MMAR_3249|M.marinum_M --AGAAGGIGAGLLA-LRGRCESGAAIIAELTHLADDLADAELIVTGE--
MUL_3562|M.ulcerans_Agy99 --AGAAGGIGAGLIA-LRGRCESGAAIIAELTHLADDLADAELIVTGE--
MAV_2286|M.avium_104 --AGAAGGIGAGLLA-LGGRCESGAAIIAEHTRLSDDLDTAELIVTGE--
Mflv_2944|M.gilvum_PYR-GCK --AGAAGGLGAALLA-LGGRREPGAAVIAEHTGLADDVASADVVITGE--
Mvan_3569|M.vanbaalenii_PYR-1 --AGAAGGIGAALLA-LGGRRESGAAIIAEHTALDADIAAADLVITGE--
MAB_1956|M.abscessus_ATCC_1997 --AGAAGGIGAALLA-LGGRRESGARIVAEHTGLKEAIERADLVITGE--
MSMEG_2528|M.smegmatis_MC2_155 --AGAAGGLGFALLDFLGAECRPGVEVIAETVGLAQAVVGADWVFTGE--
TH_2724|M.thermoresistible__bu GLLAEAGDLGLRVIVTARATGSAHAVMTAPLLRRLNELQATTLMLSGNPQ
. **.:* :: . . . : * : : :.:*:
Mb2228c|M.bovis_AF2122/97 --GRFDEQSLHGKVVGAIAAAARPLAIPVIVLAGQVSLDKSALRSAGIMA
Rv2205c|M.tuberculosis_H37Rv --GRFDEQSLHGKVVGAIAAAARPLAIPVIVLAGQVSLDKSALRSAGIMA
MMAR_3249|M.marinum_M --GRFDEQSLHGKVVGEIAAAARPLGIPVIVLAGQVDLDKSTIRLAGIMS
MUL_3562|M.ulcerans_Agy99 --GRFDEQSLHGKVVGEIAAAARPLGIPVIVLAGQVDLDKSTIRLAGIMS
MAV_2286|M.avium_104 --GRFDEQSLHGKVVGFLADAARPRGIPVIVLAGQVDLDTATVRSAGIMA
Mflv_2944|M.gilvum_PYR-GCK --GRFDDQSLHGKVVSALAGAARARGIPVLVLAGQVTLPQQALQAAGIAA
Mvan_3569|M.vanbaalenii_PYR-1 --GRFDDQSLHGKVVSALAAGARSRRIPVLVLAGQVTLDRAALQTAGIAS
MAB_1956|M.abscessus_ATCC_1997 --GKFDDQTLHGKVAGAVAAQAAASGTPVLVLAGQVTLAVSAYEQVGIAR
MSMEG_2528|M.smegmatis_MC2_155 --GSVDAQTVLGKTPFGVAQVARTAGARVVIFAGRVGDDAGVLLEHGVDR
TH_2724|M.thermoresistible__bu DSGKIRGHRFSRLPAGRAMLLDPDSDTPVFVQLVNXXXPPAPASAPVCAR
* . : . *.: .
Mb2228c|M.bovis_AF2122/97 ALSIAEYAGSVRLALADAANQLMGLASQVAARLGNSGPSGYR--------
Rv2205c|M.tuberculosis_H37Rv ALSIAEYAGSVRLALADAANQLMGLASQVAARLGNSGPSGYR--------
MMAR_3249|M.marinum_M ALSIADYAGSVRLALADAANQLMGLSSEVAARLGNRGPAGYR--------
MUL_3562|M.ulcerans_Agy99 ALSIADYAGSVRLALADAANQLMGLSSEVAARLGNRGPAGYR--------
MAV_2286|M.avium_104 ALSMAEHAGSARLAQADAANQLMGLASVAAARLGNSGPSRYR--------
Mflv_2944|M.gilvum_PYR-GCK AHSLTDRAGSVQKAIDDAADLLTAVAAEVAAGWHGGGDS-----------
Mvan_3569|M.vanbaalenii_PYR-1 AHSVTDHAGSVQRAIEDAANQLTGLACEVAAGWG----------------
MAB_1956|M.abscessus_ATCC_1997 AESIAQFAGSVQRAMRDAAGQLAGLAAHVAQEWAPR--------------
MSMEG_2528|M.smegmatis_MC2_155 LVAITVPGTPIEQALREGPQSLARATAEVCRALS----------------
TH_2724|M.thermoresistible__bu PVTAVAPSSSTAARLSGVRPSARTSWPASTSRRTIGAPIRPAPTKPTFIA
: . . .
Mb2228c|M.bovis_AF2122/97 -------------
Rv2205c|M.tuberculosis_H37Rv -------------
MMAR_3249|M.marinum_M -------------
MUL_3562|M.ulcerans_Agy99 -------------
MAV_2286|M.avium_104 -------------
Mflv_2944|M.gilvum_PYR-GCK -------------
Mvan_3569|M.vanbaalenii_PYR-1 -------------
MAB_1956|M.abscessus_ATCC_1997 -------------
MSMEG_2528|M.smegmatis_MC2_155 -------------
TH_2724|M.thermoresistible__bu GRDPSPSGRCRPR