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VNALGAMVDLDDGDGLLAADRGGLLRAAAMAGAQVRATAAALDEGLFDPLRADDPARTVIWVAGRGTAEH AGAVLAATLGPSAAAPVVLASEAPPWIGALDVLIVAGDDPGDPALVNAAAMGVRRGARVVVAAPYEGPLR DVSAGRAVVIEPRLWVPDDFAFVRYLAVGLAALHTVNRDRSRDPHADLTALADELDAEALRNSAARDLFT NAAKTLVERMSGADVVLAGDTAATLALARHGATMMLRIAGEVVSAVGLADVLAALRSGARGDAGTRSLFH DEEIDGPLPDRMRTLVLTTDVERAAVAARIAGYDDISAIGADDVPDSTETTLPAGRPEQQVAILAVRLEM AAVYSKLVRG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1835 | - | - | 100% (360) | TobH protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3284c | - | 1e-119 | 64.51% (355) | hypothetical protein Mb3284c |
| M. gilvum PYR-GCK | Mflv_4725 | - | 1e-123 | 63.14% (369) | hypothetical protein Mflv_4725 |
| M. tuberculosis H37Rv | Rv3256c | - | 1e-119 | 64.51% (355) | hypothetical protein Rv3256c |
| M. leprae Br4923 | MLBr_00764 | - | 1e-114 | 61.48% (366) | hypothetical protein MLBr_00764 |
| M. abscessus ATCC 19977 | MAB_3602c | - | 2e-87 | 48.75% (361) | hypothetical protein MAB_3602c |
| M. marinum M | MMAR_1286 | - | 1e-117 | 62.06% (369) | hypothetical protein MMAR_1286 |
| M. avium 104 | MAV_4219 | - | 1e-117 | 60.65% (371) | hypothetical protein MAV_4219 |
| M. thermoresistible (build 8) | TH_0474 | - | 2e-68 | 59.58% (240) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_2601 | - | 1e-116 | 61.85% (367) | hypothetical protein MUL_2601 |
| M. vanbaalenii PYR-1 | Mvan_1738 | - | 1e-121 | 63.22% (367) | hypothetical protein Mvan_1738 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4725|M.gilvum_PYR-GCK MT-SPASAAEVDLDDGEGLLAADRHGLLRAASMAGAQVRATAAALTEGDL
Mvan_1738|M.vanbaalenii_PYR-1 MSPSPLSAADVDLDDTDGLLAADRQGLLRAASMAGAQVRATAAALDEGDL
TH_0474|M.thermoresistible__bu --------------------------------------------------
MSMEG_1835|M.smegmatis_MC2_155 ---MNALGAMVDLDDGDGLLAADRGGLLRAAAMAGAQVRATAAALDEGLF
Mb3284c|M.bovis_AF2122/97 ----MNVARAIDLEDTEGLIAADRGALLRAASMAGAQVRAIAAAADEGEL
Rv3256c|M.tuberculosis_H37Rv ----MNVARAIDLEDTEGLIAADRGALLRAASMAGAQVRAIAAAADEGEL
MLBr_00764|M.leprae_Br4923 ----MNATRLIDLEDTKGLIAADRDGLLRAASSAGAQVRAIAAAAEEGAL
MAV_4219|M.avium_104 ----MNATRAIDLEDTEGLLSADRDGLLRAASSAGAQVRAIATAVEEGAL
MMAR_1286|M.marinum_M ----MKATQAIDLEDADGLIAADRDGLLRAASTAGAQVRAIAAASDEGEL
MUL_2601|M.ulcerans_Agy99 ----MKATQAIDLEDADGLIAADRDGLLRAASTAGAQVRAIAAASDEGEL
MAB_3602c|M.abscessus_ATCC_199 ------MNATIDLDDAEALLAADLDGSLQAASMAGSQVRAVGTAIAEGAL
Mflv_4725|M.gilvum_PYR-GCK DAVRSDSPPRTVVWVAGPGTAEAAGMMLAAILGGSVGAPIVVAAEAPPWI
Mvan_1738|M.vanbaalenii_PYR-1 DAVRSDAPPRTIVWVAGHGNAETAGSMLAALLGGSIGTPIVVVAEAPPWI
TH_0474|M.thermoresistible__bu --------------------------------------------------
MSMEG_1835|M.smegmatis_MC2_155 DPLRADDPARTVIWVAGRGTAEHAGAVLAATLGPSAAAPVVLASEAPPWI
Mb3284c|M.bovis_AF2122/97 DLLRGSDRPRSVIWVTGRGTAETAGTILASTLGAGAAEPIVLASAAPPWV
Rv3256c|M.tuberculosis_H37Rv DLLRGSDRPRSVIWVTGRGTAETAGTILASTLGAGAAEPIVLASAAPPWV
MLBr_00764|M.leprae_Br4923 ETLRAHDRPRTVIWVAGRGTAETAGAMLAATSGGATTEPIVVASEAPPWV
MAV_4219|M.avium_104 EPLRVEDRPRSVIWVAGRGTAETAGVMLSATLGGVASQPFALAGEAPPWV
MMAR_1286|M.marinum_M DSLNIDDRPRTVIWVAGRGTAQTAGDMLAATLGATVGAPITIATEAPPWV
MUL_2601|M.ulcerans_Agy99 DSLNIDDRPRTVIWVPGRGTAQTAGDMLAATLGATVGAPITIATEAPPWV
MAB_3602c|M.abscessus_ATCC_199 EPLRSEDRSRAVVWVSGRGTAATAGAILAGALSDTVSLPFVTATRAPVWV
Mflv_4725|M.gilvum_PYR-GCK GALDVVVLAGDDPARPELVTAAATAVRRGARIVVVAPYEGPLRDATAGRS
Mvan_1738|M.vanbaalenii_PYR-1 GTLDVVILAGDDAGDAVLVSAAATAVRRGARVIVVAPQEGPLRDATAGRS
TH_0474|M.thermoresistible__bu ----------------------------------VAPYEGPLRDAAAGRS
MSMEG_1835|M.smegmatis_MC2_155 GALDVLIVAGDDPGDPALVNAAAMGVRRGARVVVAAPYEGPLRDVSAGRA
Mb3284c|M.bovis_AF2122/97 GPLDVLIVAGDDPGDPALVGAAAIGVRRGARVVVVAPYEGPLRDSTAGRV
Rv3256c|M.tuberculosis_H37Rv GPLDVLIVAGDDPGDPALVGAAAIGVRRGARVVVVAPYEGPLRDSTAGRV
MLBr_00764|M.leprae_Br4923 GPLDVLIVAGDDPGDPALVGAAATAVGRGARVVVVAPYEGPLRDATAGRV
MAV_4219|M.avium_104 GPLDVLVVAGDDPGDPALVAAAATGVRRGARVVVVAPYEGPLRDSTAGRA
MMAR_1286|M.marinum_M GPLDVMVVAGDDPGDPALVGAAAMGVRRGARVVIAAPNEGPLRDCAAGRA
MUL_2601|M.ulcerans_Agy99 GPLDVMVVAGDDPGDPALVGAAAMGVRRGARVVVAAPNEGPLRDCAAGRA
MAB_3602c|M.abscessus_ATCC_199 GPLDVMVIAGDDAGDPALSAAVTLGTRRGARVVIAAPDEGPLADSGAGRA
.** **** * ***
Mflv_4725|M.gilvum_PYR-GCK VSIPPRLPVPDDFALVRYFAAGLAVLHVVLPGFS----VDLPAIADALDE
Mvan_1738|M.vanbaalenii_PYR-1 LALPPRMPVPDHFTFARYLAAGLAVLQAVAPGYS----VDLTALADALDA
TH_0474|M.thermoresistible__bu VVLAPRVQVPDDFALCRYLAAGLAIMDCVDPRMR----TDLSALADDLDA
MSMEG_1835|M.smegmatis_MC2_155 VVIEPRLWVPDDFAFVRYLAVGLAALHTVNRDRSRDPHADLTALADELDA
Mb3284c|M.bovis_AF2122/97 AVLEPRLRVPDEFGLSRYLAAGLAALQTVDPKLR----IDLASLADELDA
Rv3256c|M.tuberculosis_H37Rv AVLEPRLRVPDEFGLSRYLAAGLAALQTVDPKLR----IDLASLADELDA
MLBr_00764|M.leprae_Br4923 AVLEPRLRIPNEFGLCRYLAAGLAALQTVDPRLR----LDLAMLADELDS
MAV_4219|M.avium_104 AVLAPRLWVPDEFGLCRYLAAGLAVVHAVDPRPS----VDLGLLADELDA
MMAR_1286|M.marinum_M AVLAPRLSVPDEFGLCRYLAAGLAVLRTVDPKLR----IDLAALADDLDA
MUL_2601|M.ulcerans_Agy99 AVLAPRLSVPDEFGLCRYLAAGLAVLRTVAPKLR----IDLAALADDLDA
MAB_3602c|M.abscessus_ATCC_199 ISLAPRLRVPDTFSLAHHLAVGAAVLGVLDKSVA----PDVMTIADEVDG
: **: :*: * : :::*.* * : : *: :** :*
Mflv_4725|M.gilvum_PYR-GCK EAFRNSAGRELFTNPAKVLAERMRDHDVVLAGDSAATISLARHACTVMLR
Mvan_1738|M.vanbaalenii_PYR-1 EALRNSAARELFTNPAKGLADRMQNRDVVVAGDSAATVALARHASVVMLR
TH_0474|M.thermoresistible__bu EALRNSVGRESFVNPAKTLADRMLGRAVVLAGDNAATLALARHGAAIMLR
MSMEG_1835|M.smegmatis_MC2_155 EALRNSAARDLFTNAAKTLVERMSGADVVLAGDTAATLALARHGATMMLR
Mb3284c|M.bovis_AF2122/97 EALRNSAGREVFTNPAKALAARVSGCQLALAGDNAATLALARHGSSVMLR
Rv3256c|M.tuberculosis_H37Rv EALRNSAGREVFTNPAKALAARVSGCQLALAGDNAATLALARHGSSVMLR
MLBr_00764|M.leprae_Br4923 EALHNSVGYEVFTNPAKTLAASVSGHRVALAGDCAATLALARHGSSVLLR
MAV_4219|M.avium_104 EALRNSAGRELFTNPAKLLAARIADRQVALAGDSAATLALARHGSSVLLR
MMAR_1286|M.marinum_M ETLCNSAGREVFTNPAKALAARISGRRIVLAADGAATLALARHGSSVLLR
MUL_2601|M.ulcerans_Agy99 ETLCNSAGREVFTNPAKALAARISGRRIVLAADGAATLALARHGSSALLR
MAB_3602c|M.abscessus_ATCC_199 EVSRNTVGREVFTNAAKAIAARLTSGPTVLCGDRSATLTLAGHAAATLLR
*. *:.. : *.*.** :. : . .:..* :**::** *.. :**
Mflv_4725|M.gilvum_PYR-GCK VGHQVVASAGLSDALVAIGTGWG--RAG-GGEASIFHDEELDGPLPQQG-
Mvan_1738|M.vanbaalenii_PYR-1 VAQRTVAAAELADALVALGSGWG--RGGDTGAASIFHDEEIDGPLPQRT-
TH_0474|M.thermoresistible__bu VAHQPVAATCLADVLVALHGGLGV-SSGARSQSSIFHDEQIDGPLPPRV-
MSMEG_1835|M.smegmatis_MC2_155 IAGEVVSAVGLADVLAALRSGAR----GDAGTRSLFHDEEIDGPLPDRM-
Mb3284c|M.bovis_AF2122/97 IANQVVAATRLSDAVVALR--------AGTPPDALFHDEEIDGPAPQRL-
Rv3256c|M.tuberculosis_H37Rv IANQVVAATRLSDAVVALR--------AGTPPDALFHDEEIDGPAPQRL-
MLBr_00764|M.leprae_Br4923 IAHQVTSATGLSDAVVAVRSSVDVADYAPTSVDVLFHDEEIDGSLPERL-
MAV_4219|M.avium_104 VANQVTPATGLADAVVAMRAAVPR--ALEDPDAALFHDDQIDGPLPPRL-
MMAR_1286|M.marinum_M IAHQVTAATWLADAVVALRAGAASG--YDDGVDALFHDEEIDGPRPEQM-
MUL_2601|M.ulcerans_Agy99 IAHQVTAATWLADAVVALRAGAASG--YDDGVDALFHDEEIDGPRPEQM-
MAB_3602c|M.abscessus_ATCC_199 LTQRTATACGLAQALAAMRDALAS---KSSGESSLFHDEFIDGPRAEAPP
: . ..: *::.:.*: :***: :**. .
Mflv_4725|M.gilvum_PYR-GCK RTVVLTTDAERHNVSARLRGFDDVYVVNAN---DVPDVAAPGGNSEPGSA
Mvan_1738|M.vanbaalenii_PYR-1 RTIVLTSDAERSAVAARLQGFDDTQIVTAN---DVPDVAATGGDGEPGSA
TH_0474|M.thermoresistible__bu RSFVLTTGADRPVVAARVGGFDDVDIIDAE---DVPDAVAAA-DEVPAGA
MSMEG_1835|M.smegmatis_MC2_155 RTLVLTTDVERAAVAARIAGYDDISAIGAD---DVPDS----------TE
Mb3284c|M.bovis_AF2122/97 RVLALALAGERTVVAARVAGLDDAYLVAAE---DVP----ELLDA-PVG-
Rv3256c|M.tuberculosis_H37Rv RVLALALAGERTVVAARVAGLDDAYLVAAE---DVP----ELLDA-PVG-
MLBr_00764|M.leprae_Br4923 RVLALTLASERTVVAARVVGLDDVYLVAAE---DVPDGPSGLAGL-PVS-
MAV_4219|M.avium_104 RVLAVVLAAEQTVVAARTAGLDDVYLLAAE---DVPDGPGGSAGS-GVSP
MMAR_1286|M.marinum_M RVLALTLAAERTVVGARVAGLDNIDLIAAEDAAQVPGGPGGPAGS-DRAP
MUL_2601|M.ulcerans_Agy99 RVLALTLAAERTVVGARVAGLDNIDLIAAEDAAQVPGGPGGPAGS-DRAP
MAB_3602c|M.abscessus_ATCC_199 RILALATDSDYQSVAARIEGLDDAELVSTT---DLG--------------
* ..:. : *.** * *: : : ::
Mflv_4725|M.gilvum_PYR-GCK TTPGSARPEQQLALLAVRLEMAAVYRRLVRG----
Mvan_1738|M.vanbaalenii_PYR-1 TTPGSTRPEQQLALLALRLEMAAVYQRLVRG----
TH_0474|M.thermoresistible__bu PTPSAGRLEQQLARLAVRLEMTAVYLRLVRG----
MSMEG_1835|M.smegmatis_MC2_155 TTLPAGRPEQQVAILAVRLEMAAVYSKLVRG----
Mb3284c|M.bovis_AF2122/97 --SGG-------AVLAVRLEMAAVYLRLVRG----
Rv3256c|M.tuberculosis_H37Rv --SGG-------AVLAVRLEMAAVYLRLVRG----
MLBr_00764|M.leprae_Br4923 --GGADRAEQELAMLAVRLEMAAVYLRLVRG----
MAV_4219|M.avium_104 ALGGPGRTEQQLAVLAVRLEMAAVYMRLVRG----
MMAR_1286|M.marinum_M APTAAPRAEQQLAVLAVRLEMAAVYLRLVRG----
MUL_2601|M.ulcerans_Agy99 APTAAPRAEQQLAVLAVRLEMAAVYLRLVRG----
MAB_3602c|M.abscessus_ATCC_199 PVAARPSELAQLMMLSTRLEMASVYARLGGGRSGL
*: ****::** :* *