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TDLWQIAGWALACSVPVVLAGAVIIHLARSWSLAVSMVALVLIPVVATFTGVIGASGFMITATFERIAVV LVIVSVVTIPAAIMLARYQARRTVWEQEIRDAERAAEHSRRRLVAFVSHDLRTPLAGIRAVAEAIADGVV TDDEVRVHAKQIEQESIRLAEMVDDLFEMSKINAGAIAPTRDQVALDEVVDDVLSAHRLPAQRAGVTLRA ELPTGPVRVIGSDRSLLRVLSNLVANAIAHTPDGGSVTLAVGSDTDGAWIRVDDTGVGIDEADLPKVFDV AYRGSNGRVPRADSSLPSGSGLGLAIAAGLVAAHGGSLTASNLDTGARFEVRLPAA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0993 | - | - | 100% (337) | histidine kinase |
| M. smegmatis MC2 155 | MSMEG_0936 | senX3 | 2e-33 | 35.37% (229) | sensor histidine kinase SenX3 |
| M. smegmatis MC2 155 | MSMEG_5870 | - | 7e-31 | 35.43% (254) | sensor histidine kinase PhoR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0500 | senX3 | 3e-32 | 35.22% (230) | putative two component sensor histidine kinase SENX3 |
| M. gilvum PYR-GCK | Mflv_0036 | - | 1e-153 | 81.49% (335) | integral membrane sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv0490 | senX3 | 3e-32 | 35.22% (230) | putative two component sensor histidine kinase SENX3 |
| M. leprae Br4923 | MLBr_02440 | - | 4e-32 | 35.06% (231) | putative two-component system sensor histidine kinase |
| M. abscessus ATCC 19977 | MAB_0674 | - | 5e-31 | 36.22% (254) | putative sensor histidine kinase PhoR |
| M. marinum M | MMAR_0815 | senX3 | 1e-30 | 34.63% (231) | two-component sensor histidine kinase SenX3 |
| M. avium 104 | MAV_4661 | - | 7e-34 | 35.93% (231) | hisitidine protein kinase SenX3 |
| M. thermoresistible (build 8) | TH_2898 | - | 3e-32 | 35.65% (230) | PUTATIVE sensor histidine kinase SenX3 |
| M. ulcerans Agy99 | MUL_4559 | senX3 | 2e-30 | 34.20% (231) | two component sensor histidine kinase SenX3 |
| M. vanbaalenii PYR-1 | Mvan_0884 | - | 1e-149 | 81.46% (329) | integral membrane sensor signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0815|M.marinum_M --------------------------------------------------
MUL_4559|M.ulcerans_Agy99 --------------------------------------------------
MAV_4661|M.avium_104 --------------------------------------------------
Mb0500|M.bovis_AF2122/97 --------------------------------------------------
Rv0490|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02440|M.leprae_Br4923 --------------------------------------------------
TH_2898|M.thermoresistible__bu --------------------------------------------------
Mflv_0036|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0884|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0993|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0674|M.abscessus_ATCC_1997 MAWDTYCASRDERLREEQLALLVAVPGVRRGVPLRVSLVVGTLVLVALGL
MMAR_0815|M.marinum_M --------MTVFSALLLAGVLSALALAAGVAVGARLSQRLVRRRQQASTE
MUL_4559|M.ulcerans_Agy99 ----------MFSALLLAGVLSALALAAGVAVGARLSQRLVRRRQQASTE
MAV_4661|M.avium_104 ----------MFSALLLAGVLSVLALAAGVAVGTRLSPRAAQRRQRISTE
Mb0500|M.bovis_AF2122/97 --------MTVFSALLLAGVLSALALAVGGAVGMRLTSRVVEQRQRVATE
Rv0490|M.tuberculosis_H37Rv --------MTVFSALLLAGVLSALALAVGGAVGMRLTSRVVEQRQRVATE
MLBr_02440|M.leprae_Br4923 ----------MFSALLLAGVLSGLAFVVGIVAGIRLSPRLIERRQRLANE
TH_2898|M.thermoresistible__bu --------------------------------------------------
Mflv_0036|M.gilvum_PYR-GCK ----------------------------------------------MLPA
Mvan_0884|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0993|M.smegmatis_MC2_155 ------------------------------------------------MT
MAB_0674|M.abscessus_ATCC_1997 VASGIAVTTTMQRTMMNRADRELIDAANGWANRPPPPPPAFETTRHRPPS
MMAR_0815|M.marinum_M WTGITVAQMLQRIVALM---------------------------------
MUL_4559|M.ulcerans_Agy99 WTGITVAQMLQRIVALM---------------------------------
MAV_4661|M.avium_104 WTGITVAQMLERIVALM---------------------------------
Mb0500|M.bovis_AF2122/97 WSGITVSQMLQCIVTLM---------------------------------
Rv0490|M.tuberculosis_H37Rv WSGITVSQMLQCIVTLM---------------------------------
MLBr_02440|M.leprae_Br4923 WAGITVLQMLQRIIALM---------------------------------
TH_2898|M.thermoresistible__bu --------------------------------------------------
Mflv_0036|M.gilvum_PYR-GCK EYWEIIGWALACSVPVV---------------------------------
Mvan_0884|M.vanbaalenii_PYR-1 -----MGWALACSVPVV---------------------------------
MSMEG_0993|M.smegmatis_MC2_155 DLWQIAGWALACSVPVV---------------------------------
MAB_0674|M.abscessus_ATCC_1997 LFFIRTTDDRGRVVIMLNDRARADPDLPFDNDVGGRPVTVRSSDGGTEWR
MMAR_0815|M.marinum_M ------------PMGVAVVDSHRDVVYLNDRAKELGLVRDRQLDDQAWEA
MUL_4559|M.ulcerans_Agy99 ------------PMGVAVVDSHRDVVYLNDRAKELGLVRDRQLDDQAWEA
MAV_4661|M.avium_104 ------------PLGAAVVDAHRDVVYLNDRAKELGLVRDRQLDDQAWEA
Mb0500|M.bovis_AF2122/97 ------------PLGAAVVDTHRDVVYLNERAKELGLVRDRQLDDQAWRA
Rv0490|M.tuberculosis_H37Rv ------------PLGAAVVDTHRDVVYLNERAKELGLVRDRQLDDQAWRA
MLBr_02440|M.leprae_Br4923 ------------PLGAAVVDTYRDVVYLNEQAKELGLVRDRQLDDQAWRA
TH_2898|M.thermoresistible__bu -------------VGIIVVDTFRDVVYSNEQARQLNLVRDGLIDDKTWEA
Mflv_0036|M.gilvum_PYR-GCK ------------LVGAAVVRLAR------AWSLAVSMVALVLIPVLATLA
Mvan_0884|M.vanbaalenii_PYR-1 ------------LVGAAVVRLAR------AWSLAVSMVALVLIPVLATLA
MSMEG_0993|M.smegmatis_MC2_155 ------------LAGAVIIHLAR------SWSLAVSMVALVLIPVVATFT
MAB_0674|M.abscessus_ATCC_1997 AVSRHDALGGYTTVARDITDVRTTVRDLLWLQVAIGIAVLTVLGVAGYWL
. : :.:. :
MMAR_0815|M.marinum_M AQQALR-GSDVEFDLSPGKRPG-GRSGLSVH----------GQARLLSEE
MUL_4559|M.ulcerans_Agy99 AQQALR-GSDVEFDLSPGKRPG-GRSGLSVH----------GQARLLSEE
MAV_4661|M.avium_104 AQQALT-GVDVEFDLRPAKRSG-GRSGLSVH----------GQARLLSEE
Mb0500|M.bovis_AF2122/97 ARQALG-GEDVEFDLSPRKRSATGRSGLSVH----------GHARLLSEE
Rv0490|M.tuberculosis_H37Rv ARQALG-GEDVEFDLSPRKRSATGRSGLSVH----------GHARLLSEE
MLBr_02440|M.leprae_Br4923 AQQALG-GDDVEFDLLPGKRPAAGRSGLSVH----------GHARLLSEK
TH_2898|M.thermoresistible__bu VQQTLITGADGDVDLSEVRTPSWGWPGRSANRSTPR--SIRGHVRLLTDE
Mflv_0036|M.gilvum_PYR-GCK GVLGAS-GFMISGTFERTAVVLVIVSIVTIP-----------AAVMLARY
Mvan_0884|M.vanbaalenii_PYR-1 GVLGAS-GFMITETFERTAVVLLIVSIVTIP-----------AAVMLARY
MSMEG_0993|M.smegmatis_MC2_155 GVIGAS-GFMITATFERIAVVLVIVSVVTIP-----------AAIMLARY
MAB_0674|M.abscessus_ATCC_1997 VHRSLRPLAEVEATAADIAAGHLDRRVPERDPRTEVGRLSLALNGMLAQI
:*:
MMAR_0815|M.marinum_M DRRFTVVFAYDQSDYARMEATRRDFVANVSHELKTPVGAMALLAEALLAS
MUL_4559|M.ulcerans_Agy99 DRRFTVVFAYDQSDYARMEATRRDFVANVSHELKTPVGAMALLAEALLAS
MAV_4661|M.avium_104 DRRFAVVFAHDQSDYARMEATRRDFVANVSHELKTPVGAMALLAEALLAS
Mb0500|M.bovis_AF2122/97 DRRFAVVFVHDQSDYARMEAARRDFVANVSHELKTPVGAMALLAEALLAS
Rv0490|M.tuberculosis_H37Rv DRRFAVVFVHDQSDYARMEAARRDFVANVSHELKTPVGAMALLAEALLAS
MLBr_02440|M.leprae_Br4923 DRRFAVVFVHDQSDYVRMEAARRDFVANVSHELKTPVGAMALLAEALLAS
TH_2898|M.thermoresistible__bu DRRFAVVYINDESEHARMEATRRDFVANVSHELKTPVGALKVLAEALLAS
Mflv_0036|M.gilvum_PYR-GCK QARRMVWEAEIRDSEAAAEHSRRRLVAFVSHDLRTPLAGIRAVAEAIADG
Mvan_0884|M.vanbaalenii_PYR-1 QARRMVWEAEIRDSEAAAEQSRRRLVAFVSHDLRTPLAGIRALSEAIADG
MSMEG_0993|M.smegmatis_MC2_155 QARRTVWEQEIRDAERAAEHSRRRLVAFVSHDLRTPLAGIRAVAEAIADG
MAB_0674|M.abscessus_ATCC_1997 QRAVADSEKSAKAARTSEERMRR-FITDASHELRTPLTTIRGYAELYRQG
: . * ** ::: .**:*:**: : :* .
MMAR_0815|M.marinum_M ADDSDTVRRFAEKVLIEANRLGDMVAELIELSRLQGAERLHNVTDVDVDT
MUL_4559|M.ulcerans_Agy99 ADDSDTVRRFAEKVLIEANRLGDMVAELIELSRLQGAERLHNVTDVDVDT
MAV_4661|M.avium_104 ADDSETVRRFAEKVLVEANRLGDMVAELIELSRLQGAERLTNVTEVDVDS
Mb0500|M.bovis_AF2122/97 ADDSETVRRFAEKVLIEANRLGDMVAELIELSRLQGAERLPNMTDVDVDT
Rv0490|M.tuberculosis_H37Rv ADDSETVRRFAEKVLIEANRLGDMVAELIELSRLQGAERLPNMTDVDVDT
MLBr_02440|M.leprae_Br4923 ADDAETVSRFAEKVLIEANRLGYMVAELIELSRLQGAERLPNVTDIDVDI
TH_2898|M.thermoresistible__bu ADDEETVRRFADRMVAESTRLADMIGELIDLSRLQGGEPLPDLTAVDVDT
Mflv_0036|M.gilvum_PYR-GCK VVPDEEVRVHAKHIENESIRLSEMVDDLFEMSKINAGALTPTFDMVALDE
Mvan_0884|M.vanbaalenii_PYR-1 VVPDDEIRVSAKHIEHESIRLSEMVDDLFEMSKINAGALTPSFDKVALDE
MSMEG_0993|M.smegmatis_MC2_155 VVTDDEVRVHAKQIEQESIRLAEMVDDLFEMSKINAGAIAPTRDQVALDE
MAB_0674|M.abscessus_ATCC_1997 AATDT--ELVLGRIEGESTRMGQLVEDLLLLARLDAHRPMEQR-LVDLLV
. :: *: *:. :: :*: :::::. : :
MMAR_0815|M.marinum_M IVSEAISRHKVAADNAEIEVRTDSSSG-LHVLGDQTLLVTALANLVSNAI
MUL_4559|M.ulcerans_Agy99 IVSEAISRHKVAADNAEIEVRTDSSSG-LHVLGDQTLLVTALANLVSNAI
MAV_4661|M.avium_104 VVNEAISRHKVAADNANIEVRTDAPSG-LRVLGDETLLVTALANLVSNAI
Mb0500|M.bovis_AF2122/97 IVSEAISRHKVAADNADIEVRTDAPSN-LRVLGDQTLLVTALANLVSNAI
Rv0490|M.tuberculosis_H37Rv IVSEAISRHKVAADNADIEVRTDAPSN-LRVLGDQTLLVTALANLVSNAI
MLBr_02440|M.leprae_Br4923 IVSEAIARHKVAADTAAIEVRTDPPSG-LRVLGDQTLLVTALANLVSNAI
TH_2898|M.thermoresistible__bu VVAEALSRHKVAADNADITIITDPPSG-YRVRGDLGLLVTAVANLVSNAI
Mflv_0036|M.gilvum_PYR-GCK VVDDVIAAHRMPAERAGVRLRASLPEQPVQVVGSDRALVRVLSNLVANAI
Mvan_0884|M.vanbaalenii_PYR-1 VVDDVLAAHRITAERAGVHLRAVLPEQPVRVVGSDRALVRVLSNLVANAI
MSMEG_0993|M.smegmatis_MC2_155 VVDDVLSAHRLPAQRAGVTLRAELPTGPVRVIGSDRSLLRVLSNLVANAI
MAB_0674|M.abscessus_ATCC_1997 LATDAVHDAKATAPERDVELEVFDGPGTPEVIGDELRLRQVLGNLVSNAL
:. :.: : .* : : . .* *. * .:.***:**:
MMAR_0815|M.marinum_M AYSSPGSPVSISRRKRGDNVEIAVTDRGIGIALEDQERVFERFFRGD---
MUL_4559|M.ulcerans_Agy99 AYSSPGSPVSISRRKRGDNVEIAVTDRGIGIALEDQERVFERFFRGD---
MAV_4661|M.avium_104 AYSPPGSPVSISRRRRGDNIEIAVTDRGIGIALEDQERVFERFFRGD---
Mb0500|M.bovis_AF2122/97 AYSPRGSLVSISRRRRGANIEIAVTDRGIGIAPEDQERVFERFFRGD---
Rv0490|M.tuberculosis_H37Rv AYSPRGSLVSISRRRRGANIEIAVTDRGIGIAPEDQERVFERFFRGD---
MLBr_02440|M.leprae_Br4923 AYSPGGSLVSISRRRRGDNIEIAVTDRGIGIALEDQERVFERFFRGD---
TH_2898|M.thermoresistible__bu AYSPNGSTVSISRQRRGGFVEISVTDRGIGIAPEDQERVFERFFRVD---
Mflv_0036|M.gilvum_PYR-GCK AHTPPGGTVELALGADEISAWARVDDTGVGIDEADLPRVFDVAYRGSNSR
Mvan_0884|M.vanbaalenii_PYR-1 AHTPAGGSVELSLGADATGAWARVDDTGVGIDEADLPRVFDVAYRGSNSR
MSMEG_0993|M.smegmatis_MC2_155 AHTPDGGSVTLAVGSDTDGAWIRVDDTGVGIDEADLPKVFDVAYRGSNGR
MAB_0674|M.abscessus_ATCC_1997 GHTT--AAVRVRVGTEGDDAVLEVIDRGPGMTKTDAERVFERFYRAD---
.::. . * : * * * *: * :**: :* .
MMAR_0815|M.marinum_M --KARSRATGGSGLGLAIVKHVAANHNGSIGVWSKPGTGSTFTLSIPASS
MUL_4559|M.ulcerans_Agy99 --KARSRATGGSGLGLAIVKHVAANHNGSIGVWSKPGTGSTFTLSIPTSS
MAV_4661|M.avium_104 --KARSRATGGSGLGLAIVKHVAANHNGTIGVWSKPGTGSTFTLSIPAAV
Mb0500|M.bovis_AF2122/97 --KARSRATGGSGLGLAIVKHVAANHDGTIRVWSKPGTGSTFTLALPALI
Rv0490|M.tuberculosis_H37Rv --KARSRATGGSGLGLAIVKHVAANHDGTIRVWSKPGTGSTFTLALPALI
MLBr_02440|M.leprae_Br4923 --KARSRATGGSGLGLAIVKHVAANHNGSIGVWSKPGTGSTFTLSIPAAM
TH_2898|M.thermoresistible__bu --KARSRATGGTGLGLAIVKHVAANHNGTIRLWSQPGTGSTFTLSIPAYP
Mflv_0036|M.gilvum_PYR-GCK VPRSDSSLPSGSGLGLAIAAGLVQAHRGTLTAHNLP-TGARFEVRLPLAE
Mvan_0884|M.vanbaalenii_PYR-1 VPRADSSLPSGSGLGLAIAAGLVQAHRGTLSAHNLP-TGARFEVRLPLAD
MSMEG_0993|M.smegmatis_MC2_155 VPRADSSLPSGSGLGLAIAAGLVAAHGGSLTASNLD-TGARFEVRLPAA-
MAB_0674|M.abscessus_ATCC_1997 --SSRTRSSGGTGLGLSIVDALTAAHGGTVTVHTAPGAGCRFEVRLPRAD
: : ..*:****:*. :. * *:: . :*. * : :*
MMAR_0815|M.marinum_M APD-DSD-QPDQPRARDARPNRSQREEE---------------LSR----
MUL_4559|M.ulcerans_Agy99 APD-DSD-QPDQPRGRDARPNRSQREEE---------------LSR----
MAV_4661|M.avium_104 ASH-RGDGESEQPQGREVRPNRSQREEE---------------LSR----
Mb0500|M.bovis_AF2122/97 EAY-HDDERPEQAREPELRSNRSQREEE---------------LSR----
Rv0490|M.tuberculosis_H37Rv EAY-HDDERPEQAREPELRSNRSQREEE---------------LSR----
MLBr_02440|M.leprae_Br4923 PLYQDNDEQSGQPRGCDMWLNRPQREEEEFKSMTPAQAMMQSEVTRGNVN
TH_2898|M.thermoresistible__bu DSDVASDEREDQKQS-----------------------------------
Mflv_0036|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0884|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0993|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0674|M.abscessus_ATCC_1997 MTDDDADVDEPESATPDAAASEPKIVRASRSESAQP--------------
MMAR_0815|M.marinum_M -------------
MUL_4559|M.ulcerans_Agy99 -------------
MAV_4661|M.avium_104 -------------
Mb0500|M.bovis_AF2122/97 -------------
Rv0490|M.tuberculosis_H37Rv -------------
MLBr_02440|M.leprae_Br4923 DKCPDCGGRGIAG
TH_2898|M.thermoresistible__bu -------------
Mflv_0036|M.gilvum_PYR-GCK -------------
Mvan_0884|M.vanbaalenii_PYR-1 -------------
MSMEG_0993|M.smegmatis_MC2_155 -------------
MAB_0674|M.abscessus_ATCC_1997 -------------