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MNSNITWHSHSVTRVERERLNGHRGCVIWFTGLSASGKSTIANLVDQKLCEREVRTYLLDGDNVRYGLNA SPDTLQQRHGREFASRFGLGFSAEDREENIRRIGAVAKLFSEAGVVALTAFISPYRRDRDGVRATLADGD FLEIFIDTPIEICEQRDPKGLYKKVRAGEIKGFTGIDDPYEAPVAPELRLEGGTKDAETLADEVISYLEK VGVIPALARCGTAREGSVEVQQVS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4259 | - | - | 100% (234) | bifunctional enzyme CysN/CysC-like: sulfate adenyltransferase (subunit 1) + adenylylsulfate kinase |
| M. marinum M | MMAR_4132 | cysN | 4e-41 | 45.67% (208) | bifunctional enzyme CysN/CysC: sulfate adenyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1317 | cysN | 6e-42 | 46.15% (208) | bifunctional sulfate adenylyltransferase subunit |
| M. gilvum PYR-GCK | Mflv_2272 | - | 1e-39 | 48.40% (188) | bifunctional sulfate adenylyltransferase subunit |
| M. tuberculosis H37Rv | Rv1286 | cysN | 6e-42 | 46.15% (208) | bifunctional sulfate adenylyltransferase subunit |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4182 | - | 3e-51 | 50.72% (207) | bifunctional sulfate adenylyltransferase subunit |
| M. avium 104 | MAV_1325 | cysC | 1e-101 | 79.91% (214) | adenylylsulfate kinase |
| M. smegmatis MC2 155 | MSMEG_4978 | cysNC | 4e-41 | 45.67% (208) | bifunctional sulfate adenylyltransferase subunit |
| M. thermoresistible (build 8) | TH_2244 | cysN | 3e-40 | 47.03% (185) | PROBABLE BIFUNCTIONAL ENZYME CYSN/CYSC: SULFATE |
| M. ulcerans Agy99 | MUL_3995 | cysN | 3e-41 | 45.67% (208) | bifunctional sulfate adenylyltransferase subunit |
| M. vanbaalenii PYR-1 | Mvan_4422 | - | 4e-41 | 48.40% (188) | bifunctional sulfate adenylyltransferase subunit |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1317|M.bovis_AF2122/97 ----------MTTLLRLATAGSVDDGKSTLIGRLLYDSKAVMEDQWASVE
Rv1286|M.tuberculosis_H37Rv ----------MTTLLRLATAGSVDDGKSTLIGRLLYDSKAVMEDQWASVE
MUL_3995|M.ulcerans_Agy99 -------MSASTTLLRLATAGSVDDGKSTLIGRLLYDSKAVMEDQWASVE
Mflv_2272|M.gilvum_PYR-GCK -------MSGSTTLLRIATAGSVDDGKSTLIGRLLFDSKAVMEDQLAAVE
Mvan_4422|M.vanbaalenii_PYR-1 -------MSASTTLLRIATAGSVDDGKSTLIGRLLYDSKAVMEDQLAAVE
MSMEG_4978|M.smegmatis_MC2_155 -------MSANTTLLRLATAGSVDDGKSTLIGRLLYDSKAVMEDQLAAVE
TH_2244|M.thermoresistible__bu ---MTQVLNQPTTLLRLATAGSVDDGKSTLIGRLLFDSKAVMEDQLAAVE
MAB_4182|M.abscessus_ATCC_1997 MSTVMHTAEPAQELIRIATAGSVDDGKSTLIGRLLYDSKSIFADQLAAVE
MMAR_4259|M.marinum_M --------------------------------------------------
MAV_1325|M.avium_104 --------------------------------------------------
Mb1317|M.bovis_AF2122/97 QTSKDRGHDYTDLALVTDGLRAEREQGITIDVAYRYFATPKRKFIIADTP
Rv1286|M.tuberculosis_H37Rv QTSKDRGHDYTDLALVTDGLRAEREQGITIDVAYRYFATPKRKFIIADTP
MUL_3995|M.ulcerans_Agy99 QTSKERGHEYTDLALVTDGLRAEREQGITIDVAYRYFATPKRKFIIADTP
Mflv_2272|M.gilvum_PYR-GCK RTSKERGNDYTDLALVTDGLRAEREQGITIDVAYRYFATAKRKFIIADTP
Mvan_4422|M.vanbaalenii_PYR-1 RTSKERGHDYTDLALVTDGLRAEREQGITIDVAYRYFATAKRKFIIADTP
MSMEG_4978|M.smegmatis_MC2_155 RTSKERGHDYTDLALVTDGLRAEREQGITIDVAYRYFATAKRKFIIADTP
TH_2244|M.thermoresistible__bu RTSQERGHDYTDLALVTDGLRAEREQGITIDVAYRYFATAKRKFIIADTP
MAB_4182|M.abscessus_ATCC_1997 ASSKAKGETQTNLALLTDGLRAEREQGITIDVAHRYFSTPARKFIIADTP
MMAR_4259|M.marinum_M --------------------------------------------------
MAV_1325|M.avium_104 --------------------------------------------------
Mb1317|M.bovis_AF2122/97 GHIQYTRNMVTGASTAQLVIVLVDARHGLLEQSRRHAFLASLLGIRHLVL
Rv1286|M.tuberculosis_H37Rv GHIQYTRNMVTGASTAQLVIVLVDARHGLLEQSRRHAFLASLLGIRHLVL
MUL_3995|M.ulcerans_Agy99 GHIQYTRNMVTGASTAQLVIVLVDARHGLLEQSRRHAFLASLLGIRHLVL
Mflv_2272|M.gilvum_PYR-GCK GHIQYTRNMVTGTSTAQLAIVLVDARHGLLEQSRRHAFLASLLGIRHIVL
Mvan_4422|M.vanbaalenii_PYR-1 GHIQYTRNMVTGTSTAQLAIVLVDARHGLLEQSRRHAFLASLLGIRHIVL
MSMEG_4978|M.smegmatis_MC2_155 GHIQYTRNMVTGTSTAQLAIVLVDARNGLLEQSRRHAFLASLLGIRHIVL
TH_2244|M.thermoresistible__bu GHLQYTRNMVTGASTAHLVIVLVDARNGLLEQSRRHAFLASLLGVRHVVL
MAB_4182|M.abscessus_ATCC_1997 GHEQYTRNMVTGASTADLAIILVDARNGLTQQTRRHAFITSLLGVEHVVL
MMAR_4259|M.marinum_M --------------------------------------------------
MAV_1325|M.avium_104 --------------------------------------------------
Mb1317|M.bovis_AF2122/97 AVNKMDLLGWDQEKFDAIRDEFHAFAARLDVQDVTSIPISALHGDNVVTK
Rv1286|M.tuberculosis_H37Rv AVNKMDLLGWDQEKFDAIRDEFHAFAARLDVQDVTSIPISALHGDNVVTK
MUL_3995|M.ulcerans_Agy99 AVNKMDLIGWDKAKFEAIRDEFHAFAARLDVQDVTSIPMSALHGDTVVTK
Mflv_2272|M.gilvum_PYR-GCK AVNKMDLIGWDQATFEKIRDDFHDFAARLDVHDVTTIPLSALTGDNVVTK
Mvan_4422|M.vanbaalenii_PYR-1 AVNKMDLIDWDRERFEKIRDDFHDFAARLDVHDVTTIPLSALNGDNVVTK
MSMEG_4978|M.smegmatis_MC2_155 AVNKMDLIGWDQERFEAIRDEFHTFAARLDVHDVTAIPLSALQGDNVVTK
TH_2244|M.thermoresistible__bu AVNKMDLIDWDRERFDAIREEFEAFATRLDLHDVRAIPLSALHGDNVVTK
MAB_4182|M.abscessus_ATCC_1997 CINKMDLVDWSPQRFDEIKEEFRRFATKLELHDLTVIPVSALLGDNIVTR
MMAR_4259|M.marinum_M --------------------------------------------------
MAV_1325|M.avium_104 --------------------------------------------------
Mb1317|M.bovis_AF2122/97 SDQTPWYEGPSLLSHLEDVYIAGDRNMVDVRFPVQYVIRPHT--------
Rv1286|M.tuberculosis_H37Rv SDQTPWYEGPSLLSHLEDVYIAGDRNMVDVRFPVQYVIRPHT--------
MUL_3995|M.ulcerans_Agy99 SDQTPWYEGPSLLSHLEEVYIAGDRNLVDVRFPVQYVIRPHT--------
Mflv_2272|M.gilvum_PYR-GCK SDVTPWYEGPSLLSHLEEVYIAGDRNLVDVRFPVQYVIRPQT--------
Mvan_4422|M.vanbaalenii_PYR-1 SAATPWYEGPSLLAHLEEVYIAGDRNLVDVRFPVQYVIRPQT--------
MSMEG_4978|M.smegmatis_MC2_155 SDKTPWYEGPALLAHLEDVYIAGDRNLVDVRFPVQYVIRPQT--------
TH_2244|M.thermoresistible__bu SDRAPWYEGPALLEHLESIDVAGDRNLVDVRFPVQYVIRPHT--------
MAB_4182|M.abscessus_ATCC_1997 STNTPWYEGPSLLHHLEQVHISSDRNLIDARFPIQYVIRPQGGAAAPGAE
MMAR_4259|M.marinum_M --------------------------------------------------
MAV_1325|M.avium_104 --------------------------------------------------
Mb1317|M.bovis_AF2122/97 --LEHQDHRSYAGTLASGVMRSGDEVVVLPIGKTTRITAIDGPNG-PVAE
Rv1286|M.tuberculosis_H37Rv --LEHQDHRSYAGTVASGVMRSGDEVVVLPIGKTTRITAIDGPNG-PVAE
MUL_3995|M.ulcerans_Agy99 --LEHQDHRSYAGTVASGVMRPGDEVVVLPIGKATRIIAIDGPNG-PVPE
Mflv_2272|M.gilvum_PYR-GCK --HEHADHRSYAGTVASGVMRPGDEIVVLPSGKTSRITSIEGPGG-PVQE
Mvan_4422|M.vanbaalenii_PYR-1 --REHADHRSYAGTVASGVMRPGDEIVVLPTGKTSRITEIEGPSG-AVQE
MSMEG_4978|M.smegmatis_MC2_155 --LDHADHRSYAGTVASGVMRPGDEIVVLPSGKSSRITEIAGPGG-PVDE
TH_2244|M.thermoresistible__bu --REHQDHRSYAGTVASGVLRTGDEIVVLPSGKTSRITGIEGPSG-PVTE
MAB_4182|M.abscessus_ATCC_1997 RITDLHDFRAVAGTVASGVFKPGDEIVALPSGFTSSVAAIWGPGGSVVDE
MMAR_4259|M.marinum_M --------------------------------------------------
MAV_1325|M.avium_104 --------------------------------------------------
Mb1317|M.bovis_AF2122/97 AFPPMAVSVRLADDIDISRGDMIARTHNQPRITQEFDATVCWMADNAVLE
Rv1286|M.tuberculosis_H37Rv AFPPMAVSVRLADDIDISRGDMIARTHNQPRITQEFDATVCWMADNAVLE
MUL_3995|M.ulcerans_Agy99 AFPPMAVSLSLADEIDISRGDMIARTNNQPRVAQDFDATVCWMADSGVLE
Mflv_2272|M.gilvum_PYR-GCK AFPPMAVSVSLADDIDISRGDMIARPNNQPRIAQDFDATVCWMADEESLE
Mvan_4422|M.vanbaalenii_PYR-1 AFPPMAVSVSLADDIDISRGDMIARPNNQPRVAQDFDATVCWMADAESLE
MSMEG_4978|M.smegmatis_MC2_155 AFPPMAVSISLADDIDISRGDMIARPGNQPRVTQDFDATVCWMADDASLE
TH_2244|M.thermoresistible__bu AFPPMAISITLADDIDISRGDMITRSDNRPQMTQDFDATVCWMADESALE
MAB_4182|M.abscessus_ATCC_1997 AFAGSAVSVQLADQLDLGRGDMLCRPNNRPLVGAQIDAMVCWFTDVSTLS
MMAR_4259|M.marinum_M ------------------------------------------MNSN----
MAV_1325|M.avium_104 ------------------------------------------MSNN----
: .
Mb1317|M.bovis_AF2122/97 PGRDYVVKHTTRTVRARIAGLDYRLDVNTLHRDKTATALKLNELGRVSLR
Rv1286|M.tuberculosis_H37Rv PGRDYVVKHTTRTVRARIAGLDYRLDVNTLHRDKTATALKLNELGRVSLR
MUL_3995|M.ulcerans_Agy99 PGRDYVIKHTTRTTRARVTALDYRLDVNTLHRDKTATALKLNELGRISLR
Mflv_2272|M.gilvum_PYR-GCK PGRDYIIKHTTRTTRVRVTGLDYRLDVNTLHRDKSATALKLNELGRISLR
Mvan_4422|M.vanbaalenii_PYR-1 PGRDYVIKHTTRTTRVKVTGLDYRLDVNTLHRDKSATALKLNELGRISLR
MSMEG_4978|M.smegmatis_MC2_155 PGREYLIKHTTRTTRAKVVDLDYRLDVNTLHRDKSATALKLNELGRISLR
TH_2244|M.thermoresistible__bu PGRDYILKHTTRTTRVRITDLDYRLDVNTLERDKSATALKLNELGRISLR
MAB_4182|M.abscessus_ATCC_1997 EGSRFVMQHANSTVKAAIAGLDYRLDVNSLHRDQEAKELKLNEIGRVQLR
MMAR_4259|M.marinum_M -----ITWHSHSVTRV----------------------------------
MAV_1325|M.avium_104 -----ITWHEHKISRG----------------------------------
: * :
Mb1317|M.bovis_AF2122/97 TQVPLLLDEYTRNASTGSFILIDPDTNGTVAAGMVLRDVSARTPSPNTVR
Rv1286|M.tuberculosis_H37Rv TQVPLLLDEYTRNASTGSFILIDPDTNGTVAAGMVLRDVSARTPSPNTVR
MUL_3995|M.ulcerans_Agy99 TQVPLLLDEYTRNSSTGSFILIDPDTNGTVAAGMVLRDVSTHTPSPNTVR
Mflv_2272|M.gilvum_PYR-GCK SQVPLLLDEYSRNAATGSFILIDPNTNRTIAAGMVLPYVAGRTSTPNTVR
Mvan_4422|M.vanbaalenii_PYR-1 SQVPLLLDEYSRNSATGSFILIDPNTNGTVAAGMILPFVSARTASPNTVR
MSMEG_4978|M.smegmatis_MC2_155 TRTPLLLDEYSRNPATGSFILIDPHTNGTVGAGMVLRDARNESASPNTVR
TH_2244|M.thermoresistible__bu SQAPLLLDEYTRNPATGSFILIDPVTNGTVGAGMVLRGRR-QTASPDTVR
MAB_4182|M.abscessus_ATCC_1997 LQRPIMFDPYRRNRTTGSFILVDEATNNTVAAGMIS---GPTLHQSKVVW
MMAR_4259|M.marinum_M ----------ERERLNG---------------------------------
MAV_1325|M.avium_104 ----------EREQLNG---------------------------------
*: .*
Mb1317|M.bovis_AF2122/97 HRSLVTAQDRPPRGKTVWFTGLSGSGKSSVAMLVERKLLEKGISAYVLDG
Rv1286|M.tuberculosis_H37Rv HRSLVTAQDRPPRGKTVWFTGLSGSGKSSVAMLVERKLLEKGISAYVLDG
MUL_3995|M.ulcerans_Agy99 HQSLVTTTERP-RGRTVWLTGLSGAGKSSVAMLVERKLLEEGVAAYVLDG
Mflv_2272|M.gilvum_PYR-GCK HESLCTAEDRLSKGRTVWFTGLSGSGKSSVAVRVERKLLEKGVPAYVLDG
Mvan_4422|M.vanbaalenii_PYR-1 HESLCTSEDRLTKGRTVWFTGLSGSGKSSVAMLVEQKLLEKGIPAYVLDG
MSMEG_4978|M.smegmatis_MC2_155 HENLITAEDRLTRGRTVWFTGLSGSGKSSVAMLVEQKLLGKGVPAYVLDG
TH_2244|M.thermoresistible__bu HQSLVTAADRLSRGCTVWFTGLSGAGKSSVAMLVERKLLERGRPAYVLDG
MAB_4182|M.abscessus_ATCC_1997 HSSAVSRDERSTKGGTIWITGLSASGKSTVAVELERRLVARGIPAYRLDG
MMAR_4259|M.marinum_M -----------HRGCVIWFTGLSASGKSTIANLVDQKLCEREVRTYLLDG
MAV_1325|M.avium_104 -----------HKGCVIWFTGLSGSGKSTVANVVEQKLYERGIRSYLLDG
:* .:*:****.:***::* ::::* . :* ***
Mb1317|M.bovis_AF2122/97 DNLRHGLNA-----------------DLGFSMADRAENLRRLSHVATLLA
Rv1286|M.tuberculosis_H37Rv DNLRHGLNA-----------------DLGFSMADRAENLRRLSHVATLLA
MUL_3995|M.ulcerans_Agy99 DNLRHGLNA-----------------DLGFSMADRAENLRRLAHVAVLLA
Mflv_2272|M.gilvum_PYR-GCK DNLRHGLNA-----------------DLGFSMDDRAENQRRLAYVAAILA
Mvan_4422|M.vanbaalenii_PYR-1 DNLRHGLNS-----------------DLGFSMADRAENQRRLAYVASILA
MSMEG_4978|M.smegmatis_MC2_155 DNLRHGLNA-----------------DLGFSMADRAENLRRLAHVASLLA
TH_2244|M.thermoresistible__bu DNLRHGLNS-----------------DLGFSMADRAENLRRLAHIATLLA
MAB_4182|M.abscessus_ATCC_1997 DNLRHGLNA-----------------DLGFSAADRAENVRRVGAVAQILS
MMAR_4259|M.marinum_M DNVRYGLNASPDTLQQRHGREFASRFGLGFSAEDREENIRRIGAVAKLFS
MAV_1325|M.avium_104 DNVRYGLNAGPDLLEERHGPEFAQRFGLGFSAQDREENIRRIGAVAKLFC
**:*:***: .**** ** ** **:. :* ::.
Mb1317|M.bovis_AF2122/97 DCGHLVLVPAISPLAEHRALARKVHADAGIDFFEVFCDTPLQDCERRDPK
Rv1286|M.tuberculosis_H37Rv DCGHLVLVPAISPLAEHRALARKVHADAGIDFFEVFCDTPLQDCERRDPK
MUL_3995|M.ulcerans_Agy99 DCGHVVLVPAISPLPEHRELARKVHTDAGFDFVEVFCDTPLADCERRDPK
Mflv_2272|M.gilvum_PYR-GCK DAGQVVLVPAISPLAEHRALARKVATEQGLEFFEVFCDTPLDDCERRDPK
Mvan_4422|M.vanbaalenii_PYR-1 DSGQVVLVPAISPLAEHRALARKVATDQGLDFFEVFCDTPLEDCERRDPK
MSMEG_4978|M.smegmatis_MC2_155 DSGQIVLVPAISPLEEHRELARRVSTESGVEFFEVFCDTPLADCEARDPK
TH_2244|M.thermoresistible__bu DSGQVVLVPAISPLEEHRQLARQIHAEAGFEFFEVFCDTPLEDCERRDPK
MAB_4182|M.abscessus_ATCC_1997 DSGVVAVAALISPYRADRDKIRAQHEKAGLPFVEVFVDTPVEICEQRDPK
MMAR_4259|M.marinum_M EAGVVALTAFISPYRRDRDGVRATLADG--DFLEIFIDTPIEICEQRDPK
MAV_1325|M.avium_104 EAGIIALTAFISPYVRDRDAIRATLDDG--DFQEIFIDTPIEICEKRDPK
:.* :.:.. *** .* * . * *:* ***: ** ****
Mb1317|M.bovis_AF2122/97 GLYAKARAGEITHFTGIDSPYQRPKNPDLRLTPDR-SIDEQAQEVIDLLE
Rv1286|M.tuberculosis_H37Rv GLYAKARAGEITHFTGIDSPYQRPKNPDLRLTPDR-SIDEQAQEVIDLLE
MUL_3995|M.ulcerans_Agy99 GLYAKARAGEITHFTGIDSPYQRPKHPDLRLTPAR-SLDQQAQDVIDLLE
Mflv_2272|M.gilvum_PYR-GCK GLYAKARAGEITHFTGIDSPYQRPKNPDLRLTPDL-TPDEHADAVIELLE
Mvan_4422|M.vanbaalenii_PYR-1 GLYAKARAGEITHFTGIDSPYQRPRNPDLRLTPDR-TPEEHADAVIELLE
MSMEG_4978|M.smegmatis_MC2_155 GLYAKARAGEITHFTGIDSPYQRPKHPDLRLTPEH-SLDELADMVIEMLE
TH_2244|M.thermoresistible__bu GLYAKARAGLITHFTGIDSPYQRPKNPDLRLTPEH-SLDELAQMVIDLLG
MAB_4182|M.abscessus_ATCC_1997 GMYAKARAGEISDFTGVNAPYEAPENAELVLRPEEGDPEQQAATILDYWL
MMAR_4259|M.marinum_M GLYKKVRAGEIKGFTGIDDPYEAPVAPELRLEGGTKDAETLADEVISYLE
MAV_1325|M.avium_104 GLYKKARAGEIKGFTGIDDPYEAPPRPELRLDGAAKDAETLAEEVIAHLE
*:* *.*** *. ***:: **: * .:* * : * ::
Mb1317|M.bovis_AF2122/97 SSS----------------------
Rv1286|M.tuberculosis_H37Rv SSS----------------------
MUL_3995|M.ulcerans_Agy99 LRP----------------------
Mflv_2272|M.gilvum_PYR-GCK SRES---------------------
Mvan_4422|M.vanbaalenii_PYR-1 SRER---------------------
MSMEG_4978|M.smegmatis_MC2_155 TRR----------------------
TH_2244|M.thermoresistible__bu ERV----------------------
MAB_4182|M.abscessus_ATCC_1997 SV-----------------------
MMAR_4259|M.marinum_M KVGVIPALARCGTAREGSVEVQQVS
MAV_1325|M.avium_104 RVGVIATDGLAHTR--GRDEVTA--