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MIDITARLVEIVGNNNVLTGDAIPEDYSHDEELTQVPQRPAYVVKPTTAEEVSRLLSAASEYRVPVTARG SGCGLSGAACPREGGLLISFERMNQVLEVDTDNQVAVVQPGVTLSQLDEATHDRGLGYMVHPGELSSSVG GNVGTNAGGMRAVKYGIARNNVLGLQAVLPTGEIIRTGGKIAKVSTGYDLTQLIVGSEGTLALATEVIVK LHPQLTHNASVLAPFADFDQIMAAVPKILATGLAPYILEYIDNMTMAALVYTQNLELGIPDQVRDNCQAY LLVALEDRTADRLLEDVEATGELLAELGAMDAYVLEGASARKLIEAREKAFWAAKAAGADDLIDTVVPRA SMPKFLSTAKGLASAAGGTAIGCGHAGDGNVHLAIICKDPAKKKQLMTDIFALAMELGGAISGEHGVGRA KTPYFLELEDPAKIALMSRIKQSFDPAGILNPDVLFTTIQS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3413 | - | - | 100% (461) | oxidoreductase |
| M. marinum M | MMAR_4183 | - | 1e-64 | 35.59% (458) | oxidoreductase |
| M. marinum M | MMAR_0388 | - | 3e-50 | 30.31% (452) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2301 | - | 0.0 | 82.46% (456) | dehydrogenase |
| M. gilvum PYR-GCK | Mflv_2230 | - | 2e-63 | 35.16% (455) | FAD linked oxidase domain-containing protein |
| M. tuberculosis H37Rv | Rv2280 | - | 0.0 | 82.46% (456) | dehydrogenase |
| M. leprae Br4923 | MLBr_01103 | - | 1e-63 | 34.92% (461) | putative oxidoreductase subunit |
| M. abscessus ATCC 19977 | MAB_1407c | - | 1e-63 | 34.13% (460) | oxidoreductase |
| M. avium 104 | MAV_1405 | - | 3e-64 | 35.16% (455) | oxidoreductase, FAD-binding |
| M. smegmatis MC2 155 | MSMEG_5037 | - | 4e-63 | 35.60% (455) | oxidoreductase, FAD-binding |
| M. thermoresistible (build 8) | TH_3358 | - | 9e-66 | 36.11% (457) | PUTATIVE FAD linked oxidase domain protein |
| M. ulcerans Agy99 | MUL_4485 | - | 8e-64 | 35.37% (458) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_4464 | - | 6e-62 | 35.24% (454) | FAD linked oxidase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2230|M.gilvum_PYR-GCK --MQPLASLIADLPDGTVVTDPDILESYRQDRAADPAAGTPLAVVRPRRT
Mvan_4464|M.vanbaalenii_PYR-1 --MQPLASLIAELPDGTVVTDPDIVASYRQDRAADPSAGTPIAVVRPRRT
MSMEG_5037|M.smegmatis_MC2_155 MTNAALAELVTELPEGTVVTDPDILASYRQDRAADPNAGMPLAVVRPHRT
TH_3358|M.thermoresistible__bu -VSAALSALIAELPDGTVVTDPDILASYRQDRARDPDAGTPLAVVRPRRT
MAV_1405|M.avium_104 MSSEALASLIADLPDGTVVTDPTVTEGYRQDRAFDPSAGKPLAVVRPRRT
MUL_4485|M.ulcerans_Agy99 MNADVLASLIAGLPDGMAVTDPTVTEGYRQDRALDPSAGKPLAVVRPRCT
MLBr_01103|M.leprae_Br4923 --MGVLTSLIAGLPDGMVVTDSAVTDGYRHDRALDPSAGKPLAVVQPRRT
MAB_1407c|M.abscessus_ATCC_199 MSRDALHALTAVLGEGAVITDPDITASYRQDRAFDPDAGMPLAVVRPRST
Mb2301|M.bovis_AF2122/97 -MSEMTARFSEIVGNANLLTGDAIPEDYAHDEELTGPPQKPAYAAKPATP
Rv2280|M.tuberculosis_H37Rv -MSEMTARFSEIVGNANLLTGDAIPEDYAHDEELTGPPQKPAYAAKPATP
MMAR_3413|M.marinum_M -MIDITARLVEIVGNNNVLTGDAIPEDYSHDEELTQVPQRPAYVVKPTTA
: : : :*. : .* :*. . * ..:* .
Mflv_2230|M.gilvum_PYR-GCK EEVQTVLRWAGTHRIAVVPRGMGTGLSGGATALDGGIVLSTEKMR-DITV
Mvan_4464|M.vanbaalenii_PYR-1 EEVQATLRWATAHRIAVVPRGMGTGLSGGATALDGGIVLSTEKMR-DITV
MSMEG_5037|M.smegmatis_MC2_155 EEVQAVMRWASANKVPVVPRGAGTGLSGGATAIDGGLVLSTEKMR-DISV
TH_3358|M.thermoresistible__bu EEVQTVLRWANAHRVPVVPRGAGTGLSGGASALDGGIVLSTEKMR-DITV
MAV_1405|M.avium_104 EEVQTVLRWASAHGVPVVTRGAGSGLSGGATALDNGIVLSTEKMR-DITV
MUL_4485|M.ulcerans_Agy99 EEVQTILRWAGANRVAVVTRGAGSGLSGGATALDGGIVLSTEKMR-DITI
MLBr_01103|M.leprae_Br4923 DEVQTVLRWASANRVPVVARGAGSGLSGGATALDDGIVLSTEKMR-DITV
MAB_1407c|M.abscessus_ATCC_199 EEVSATLKWASAHHISVVPRGAGTGLSGGSTAQDGAVVLSTERMR-TITI
Mb2301|M.bovis_AF2122/97 EEVAQLLKAASENGVPVTARGSGCGLSGAARPVEGGLLISFDRMNKVLEV
Rv2280|M.tuberculosis_H37Rv EEVAQLLKAASENGVPVTARGSGCGLSGAARPVEGGLLISFDRMNKVLEV
MMAR_3413|M.marinum_M EEVSRLLSAASEYRVPVTARGSGCGLSGAACPREGGLLISFERMNQVLEV
:** : * :.*..** * ****.: . :..:::* ::*. : :
Mflv_2230|M.gilvum_PYR-GCK DPVTRTAVVQPGLLNAEVKKVVAEHGLWYPPDPSSFEICSIGGNIATNAG
Mvan_4464|M.vanbaalenii_PYR-1 DPVTRTAVAQPGLLNAEVKKAVAEYGLWYPPDPSSFEICSIGGNIATNAG
MSMEG_5037|M.smegmatis_MC2_155 DTVTRTAVVQPGLLNAEVKKAVAEHGLWYPPDPSSFEICSIGGNIATNAG
TH_3358|M.thermoresistible__bu DPVTRTAVVQPGLLNAEVKQAAAEHGLWYPPDPSSFEICSIGGNIATNAG
MAV_1405|M.avium_104 DPVTRTAVCQPGLFNAEVKKAAAEHGLWYPPDPSSFEICSIGGNIATNAG
MUL_4485|M.ulcerans_Agy99 DPVTRTAVCQPGLFNAEVKKAAAEHGLWYPPDPSSFEICSIGGNIATNAG
MLBr_01103|M.leprae_Br4923 DPVTRTAVCQPGLFNAEVKKAAAEHGLWYPPDPSSFEICSIGGNVATNAG
MAB_1407c|M.abscessus_ATCC_199 DTATRVAITQPGALNAEVKAAAAAQGLWYPPDPSSFEICSIGGNIATNAG
Mb2301|M.bovis_AF2122/97 DTANQVAVVQPGVALTDLDAATADTGLRYTVYPGELSSS-VGGNVGTNAG
Rv2280|M.tuberculosis_H37Rv DTANQVAVVQPGVALTDLDAATADTGLRYTVYPGELSSS-VGGNVGTNAG
MMAR_3413|M.marinum_M DTDNQVAVVQPGVTLSQLDEATHDRGLGYMVHPGELSSS-VGGNVGTNAG
*. .:.*: *** :::. .. ** * *..:. . :***:.****
Mflv_2230|M.gilvum_PYR-GCK GLCCVKYGVTTDYVLGLQVVLADGTAVRLGGPRLKDVAGLSLTKLFVGSE
Mvan_4464|M.vanbaalenii_PYR-1 GLCCVKYGVTTDYVLGLQVVLADGTAVRLGGPRLKDVAGLSLTKLFVGSE
MSMEG_5037|M.smegmatis_MC2_155 GLCCVKYGVTTDYVLGLQVVLADGTAVRLGGPRLKDVAGLSLTKLFVGSE
TH_3358|M.thermoresistible__bu GLCCVKYGVTTDYVMGLQVVLADGTAVRLGGPRIKDVAGLPLTKLFVGSE
MAV_1405|M.avium_104 GLCCVKYGVTTDYVLGMQVVLADGTAVRLGGPRLKDVAGLSLTKLFVGSE
MUL_4485|M.ulcerans_Agy99 GLCCVKYGVTTDYVLGMQVVLADGTAVRLGGPRLKDVAGLSLTKLFVGSE
MLBr_01103|M.leprae_Br4923 GLCCVKYGVTGDYVLGIQVVLADGTAVRLGGPRLKDVAGLSLTKLFVGSE
MAB_1407c|M.abscessus_ATCC_199 GLCCVKYGVTTDYVLGMQVVLADGTVLKLGGPRLKDVAGLSLTKLFVGSE
Mb2301|M.bovis_AF2122/97 GMRAVKYGVARHNVLGLQAVLPTGEIIRTGGRMAKVSTGYDLTQLIIGSE
Rv2280|M.tuberculosis_H37Rv GMRAVKYGVARHNVLGLQAVLPTGEIIRTGGRMAKVSTGYDLTQLIIGSE
MMAR_3413|M.marinum_M GMRAVKYGIARNNVLGLQAVLPTGEIIRTGGKIAKVSTGYDLTQLIVGSE
*: .****:: . *:*:*.**. * :: ** * :* **:*::***
Mflv_2230|M.gilvum_PYR-GCK GTLGVVTEVTLKLLPAQHPACTVVATFDSVESAADAVVEITGR-IRPSML
Mvan_4464|M.vanbaalenii_PYR-1 GTLGVVTEVTLKLLPAQSGACTVVATFDSVEDAANAVVTITGK-IRPSML
MSMEG_5037|M.smegmatis_MC2_155 GTLGVVTEVTLRLLPPQNSPCTVVATFDSVEAAANAVVTITGK-IRPSML
TH_3358|M.thermoresistible__bu GTLGVVTEVTLRLLPPQHQASTVVATFASVEAAAESVLAITAR-IRPSML
MAV_1405|M.avium_104 GTLGVITEVTLRLVPKQNTSSVVVASFATVEDAVGAVLGVTGR-LRPSML
MUL_4485|M.ulcerans_Agy99 GTLGVITEVTLRLLPAQNAAAVVVASFASVESAVDAVLGVSAR-IRPSML
MLBr_01103|M.leprae_Br4923 GTLGIITEVTLRLLPTQNTSSIVVATFASVQAAVDAVLGVAAR-LRPAML
MAB_1407c|M.abscessus_ATCC_199 GTLGVITEVTLRLLPCQPTPCTVVATFSSVHDATDAVLAITAQ-IRPSML
Mb2301|M.bovis_AF2122/97 GTLALVTEVIVKLHPRLDHNASVLAPFADFDQVMAAVPKILASGLAPDIL
Rv2280|M.tuberculosis_H37Rv GTLALVTEVIVKLHPRLDHNASVLAPFADFDQVMAAVPKILASGLAPDIL
MMAR_3413|M.marinum_M GTLALATEVIVKLHPQLTHNASVLAPFADFDQIMAAVPKILATGLAPYIL
***.: *** ::* * . *:*.* .. :* : . : * :*
Mflv_2230|M.gilvum_PYR-GCK EFMDSTAINAVEDKLKMGL-------DRDAAAMMVAASDDRGAAGAQDAE
Mvan_4464|M.vanbaalenii_PYR-1 EFMDSAAINAVEDKLKMGL-------DRSAAAMMVAASDDRGPSGAQDAE
MSMEG_5037|M.smegmatis_MC2_155 EFMDSVAINAVEDKLKMGL-------DRNAAAMMVAASDDRGAAGADDTE
TH_3358|M.thermoresistible__bu EFMDAVAINAVEDKLRMGL-------DRSAAAMMVAASDDRGPAGAEDAE
MAV_1405|M.avium_104 EFMDSVAINAVEDTLRMDL-------DRGAAAMLVAGSDERGRAGSEDAE
MUL_4485|M.ulcerans_Agy99 EFMDSVAINAVEDTLRMDL-------DRGAAAMLVASSDERGQADRDDAE
MLBr_01103|M.leprae_Br4923 EFMDSVAINAVEDTFRMGL-------DREAAAMLVAGSDELGHAGTDEAK
MAB_1407c|M.abscessus_ATCC_199 EFMDSVAINAVEDKLKMGL-------DRAAGAMLVARSDERGHTSTEDAE
Mb2301|M.bovis_AF2122/97 EYIDNTSMAALISTQNLELGIPDQIRDSCEAYLLVALENRIADRLFEDIQ
Rv2280|M.tuberculosis_H37Rv EYIDNTSMAALISTQNLELGIPDQIRDSCEAYLLVALENRIADRLFEDIQ
MMAR_3413|M.marinum_M EYIDNMTMAALVYTQNLELGIPDQVRDNCQAYLLVALEDRTADRLLEDVE
*::* :: *: . .: * * . ::** .: . :: :
Mflv_2230|M.gilvum_PYR-GCK YMARVFTEHGATEVFSTSDPDEGDAFVAARRFAIPAVESKGSLLLEDVGV
Mvan_4464|M.vanbaalenii_PYR-1 FMAGVFTEHGAREVFSTSDPDEGEAFVAARRFAIPAVEARGALLLEDVGV
MSMEG_5037|M.smegmatis_MC2_155 FMARVFSEAGATEVFSTSDPDEGEAFVAARRFAIPAVEAKGSLLLEDVGV
TH_3358|M.thermoresistible__bu FMAQVFTEHGATEVFSTADPDEGEAFVAARRFAIPAVEAKGALLLEDVGV
MAV_1405|M.avium_104 IMAKVFAENAATEVFSTDDPDEGEAFVVARRFCIPAVEAKGSLLLEDVGV
MUL_4485|M.ulcerans_Agy99 LMAAVFAEHGATEVFSTTDPDEGEPFVAARRFCIPAVEAKGSLLLEDVGV
MLBr_01103|M.leprae_Br4923 LIGAVFAENGATQVSSTNDPDEGEAFVAARRFCIPAVESKGSLLLEDVGV
MAB_1407c|M.abscessus_ATCC_199 LIARIFTDHHAAEVFSTDDEEEGEAFVAARRFAIPAVEAKGSLLLEDVGV
Mb2301|M.bovis_AF2122/97 TVGEMLMELGAVDAYVLEG-GSARKLIEAREKAFWAAKALGADDIIDTVV
Rv2280|M.tuberculosis_H37Rv TVGEMLMELGAVDAYVLEG-GSARKLIEAREKAFWAAKALGADDIIDTVV
MMAR_3413|M.marinum_M ATGELLAELGAMDAYVLEG-ASARKLIEAREKAFWAAKAAGADDLIDTVV
. :: : * :. . .. :: **. .: *.:: *: : *. *
Mflv_2230|M.gilvum_PYR-GCK PLPALAELVGGVEKIAAARDVMISVIAHAGDGNTHPLIVFDPSDTAMEQR
Mvan_4464|M.vanbaalenii_PYR-1 PLPALAELVGGVEKIAGHHELMISVIAHAGDGNTHPLIVFDPDDPDMERR
MSMEG_5037|M.smegmatis_MC2_155 PLPALADLVSGVEKIAAQREVMISVIAHAGDGNTHPLIVFDPADEAMTAR
TH_3358|M.thermoresistible__bu PLPALADLVGGVARLADHHELTISVIAHAGDGNTHPLIVYDPADAAMAER
MAV_1405|M.avium_104 PLPALGRLVTGIAAIAAERDLMISVIAHAGDGNTHPLIVYDPADADMTER
MUL_4485|M.ulcerans_Agy99 PLPNLRKLVTGIARIAQERDLMISVIAHAGDGNTHPLLVYDPSDAAMAER
MLBr_01103|M.leprae_Br4923 PLPALGKLVTGIAHISTERNLMISVIAHAGDGNTHPLIVYNPADATMTER
MAB_1407c|M.abscessus_ATCC_199 PLPKLAQLVEGVEAIAAQHRLLISVIAHAGDGNTHPLIVHDPTDPDESRR
Mb2301|M.bovis_AF2122/97 PRASMPKFLSTARGLAAAADGAAVGCGHAGDGNVHMAIACKDP-----EK
Rv2280|M.tuberculosis_H37Rv PRASMPKFLSTARGLAAAADGAAVGCGHAGDGNVHMAIACKDP-----EK
MMAR_3413|M.marinum_M PRASMPKFLSTAKGLASAAGGTAIGCGHAGDGNVHLAIICKDP-----AK
* . : :: :: .******.* : . :
Mflv_2230|M.gilvum_PYR-GCK AQQAFGEIMDLAVSLGGTITGEHGVGRLKRPWLAGQLGPEAMELNRRIKQ
Mvan_4464|M.vanbaalenii_PYR-1 AQQAFGEIMDLAIGLGGTITGEHGVGRLKRPWLAGQLGPEAMELNRRIKQ
MSMEG_5037|M.smegmatis_MC2_155 AQLAFGEIMELAVGLGGTITGEHGVGRLKRPWLANQIGPDAMELNHRIKR
TH_3358|M.thermoresistible__bu AAQAFGEIMELAIDLGGTITGEHGVGRLKRPWLADQIGPEAMELHRRIKD
MAV_1405|M.avium_104 AHLAFGEIMDLAVGLGGTITGEHGVGRLKRPWLAGYLGPEVMDLNRRIKQ
MUL_4485|M.ulcerans_Agy99 AQLAYGEIMDLAVGLGGTITGEHGVGRLKRPWLEGYLGPDVMDLNRRIKQ
MLBr_01103|M.leprae_Br4923 AHRAFGEIMDMAVGLGGTITGEHGVGRLKRPWLDDYLGPDVMELNQRIKH
MAB_1407c|M.abscessus_ATCC_199 AQTAFGQIMDLAISLGGTITGEHGVGRLKKPWLGDQVGPEVLEVNRRIKQ
Mb2301|M.bovis_AF2122/97 KKKLMTDIFALAMELGGAISGEHGVGRAKTGYFLELEDPVKISLMRRIKQ
Rv2280|M.tuberculosis_H37Rv KKKLMTDIFALAMELGGAISGEHGVGRAKTGYFLELEDPVKISLMRRIKQ
MMAR_3413|M.marinum_M KKQLMTDIFALAMELGGAISGEHGVGRAKTPYFLELEDPAKIALMSRIKQ
:*: :*: ***:*:******* * :: .* : : ***
Mflv_2230|M.gilvum_PYR-GCK ALDPDGILNPGAAI-----
Mvan_4464|M.vanbaalenii_PYR-1 ALDPDGILNPGAAI-----
MSMEG_5037|M.smegmatis_MC2_155 ALDPDNILNPGAAI-----
TH_3358|M.thermoresistible__bu ALDPNGILNPGAGF-----
MAV_1405|M.avium_104 ALDPQGILNPGSGI-----
MUL_4485|M.ulcerans_Agy99 ALDPLDILNPGSGI-----
MLBr_01103|M.leprae_Br4923 ALDPYGILNPGAAI-----
MAB_1407c|M.abscessus_ATCC_199 ALDPDGILNPGTLI-----
Mb2301|M.bovis_AF2122/97 SFDPAGILNPGVVFGDT--
Rv2280|M.tuberculosis_H37Rv SFDPAGILNPGVVFGDT--
MMAR_3413|M.marinum_M SFDPAGILNPDVLFTTIQS
::** .****. :