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MTIETLSTQSKAQVLAEALPWLKQLHGRVVVIKYGGNAMTDDTLRQAFAADMAFLRNCGIHPVVVHGGGP QITAMLGKLGIEGDFKGGFRVTTPEVLDVARMVLFGQVGRELVNLINAHGPYAVGVTGEDAQLFTAVRRS VNVDGVATDIGLVGDVDHVNAAALMDLIAAHRIPVISTLAPDAEGVVHNINADTAAAALAEALGAEKLLM LTDVEGLYTSWPERDSLVREIDTAALEQLLPRLEAGMIPKVEACLRAVTGGVPSAHVIDGRVEHCVLVEL FTNAGTGTKVVSA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2464 | argB | - | 100% (293) | acetylglutamate kinase ArgB |
| M. marinum M | MMAR_5222 | ask | 1e-06 | 26.09% (230) | aspartate kinase Ask |
| M. marinum M | MMAR_3764 | proB | 6e-05 | 26.88% (253) | glutamate 5-kinase protein ProB |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1682 | argB | 1e-146 | 87.89% (289) | acetylglutamate kinase |
| M. gilvum PYR-GCK | Mflv_3528 | - | 1e-133 | 80.49% (287) | acetylglutamate kinase |
| M. tuberculosis H37Rv | Rv1654 | argB | 1e-146 | 87.89% (289) | acetylglutamate kinase |
| M. leprae Br4923 | MLBr_01408 | argB | 1e-146 | 88.28% (290) | acetylglutamate kinase |
| M. abscessus ATCC 19977 | MAB_2338 | - | 1e-129 | 77.43% (288) | acetylglutamate kinase |
| M. avium 104 | MAV_3116 | argB | 1e-148 | 90.34% (290) | acetylglutamate kinase |
| M. smegmatis MC2 155 | MSMEG_3774 | argB | 1e-142 | 84.25% (292) | acetylglutamate kinase |
| M. thermoresistible (build 8) | TH_1595 | argB | 1e-136 | 83.39% (283) | Probable Acetylglutamate kinase argB |
| M. ulcerans Agy99 | MUL_1646 | argB | 1e-163 | 98.63% (293) | acetylglutamate kinase |
| M. vanbaalenii PYR-1 | Mvan_3312 | - | 1e-133 | 80.28% (289) | acetylglutamate kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3528|M.gilvum_PYR-GCK ---------------MSLTTPDKAQVLADALPWLTALNGKIVVVKYGGNA
Mvan_3312|M.vanbaalenii_PYR-1 ---------------MTLTTSDKAAVLADALPWLTALNDKIVVVKYGGNA
MMAR_2464|M.marinum_M ----MTI--------ETLSTQSKAQVLAEALPWLKQLHGRVVVIKYGGNA
MUL_1646|M.ulcerans_Agy99 ----MTI--------ETLSTQSKAQVLAEALRWLKQLHGRVVVIKYGGNA
MLBr_01408|M.leprae_Br4923 ----MTVLMNRTGDDETLSTQVKAEVLAEALPWLKQLHGKVVVVKYSGNA
MAV_3116|M.avium_104 ----MTP------STEALPTAVKAQVLAEALPWLKQLHGKIVVIKYGGNA
Mb1682|M.bovis_AF2122/97 ----MSR-------IEALPTHIKAQVLAEALPWLKQLHGKVVVVKYGGNA
Rv1654|M.tuberculosis_H37Rv ----MSR-------IEALPTHIKAQVLAEALPWLKQLHGKVVVVKYGGNA
MSMEG_3774|M.smegmatis_MC2_155 ----MST--------PSIDRGFKADVLASALPWLKQLHGKIVVVKYGGNA
TH_1595|M.thermoresistible__bu MSDVVEP--------LMVDRKVKASVLSAALPWLKQLHGKIVVVKYGGNA
MAB_2338|M.abscessus_ATCC_1997 MKA-------------TKKATKKAAVLAGALPWLKKLHGTIVVIKYGGNA
** **: ** **. *:. :**:**.***
Mflv_3528|M.gilvum_PYR-GCK MTDDRLKAAFAADMVFLRNCGIHPVVVHGGGPQISAMLKKLGIAGDFKGG
Mvan_3312|M.vanbaalenii_PYR-1 MTDDRLKAAFAADMVFLRNCGIHPVVVHGGGPQISAMLKKLGIAGDFKGG
MMAR_2464|M.marinum_M MTDDTLRQAFAADMAFLRNCGIHPVVVHGGGPQITAMLGKLGIEGDFKGG
MUL_1646|M.ulcerans_Agy99 MTDDTLRQAFAADMAFLRNCGIHPVVVHGGGPQITAMLGKLGIEGDFKGG
MLBr_01408|M.leprae_Br4923 MTDDMLRRAFAADMAFLRNCGIHPVVVHGGGPQITAMLRRLGIADDFKGG
MAV_3116|M.avium_104 MTDDTLRRAFAADMAFLRNCGIHPVVVHGGGPQITAMLRRLGIPGDFKGG
Mb1682|M.bovis_AF2122/97 MTDDTLRRAFAADMAFLRNCGIHPVVVHGGGPQITAMLRRLGIEGDFKGG
Rv1654|M.tuberculosis_H37Rv MTDDTLRRAFAADMAFLRNCGIHPVVVHGGGPQITAMLRRLGIEGDFKGG
MSMEG_3774|M.smegmatis_MC2_155 MTDDVLKAAFAADMVFLRNCGIHPVVVHGGGPQISAMLKRLGIEGDFKGG
TH_1595|M.thermoresistible__bu MTDDTLREAFAEDMVFLRNCGIYPVVVHGGGPQISAMLQRLGIEGDFKGG
MAB_2338|M.abscessus_ATCC_1997 MTDDALKNAFAEDMVFLRNCGIHPVVVHGGGPQISAMLKKLGVDGEFKGG
**** *: *** **.*******:***********:*** :**: .:****
Mflv_3528|M.gilvum_PYR-GCK FRVTTPEVLEVARMVLFGQVGRELVNLINAYGPYAVGITGEDAHLFTAVR
Mvan_3312|M.vanbaalenii_PYR-1 FRVTTPEVLDVARMVLFGQVGRELVNLINAYGPYAVGITGEDAHLFTAVR
MMAR_2464|M.marinum_M FRVTTPEVLDVARMVLFGQVGRELVNLINAHGPYAVGVTGEDAQLFTAVR
MUL_1646|M.ulcerans_Agy99 FRVTTPEVLDVARMVLFGQVGRELVNLINAHGPYAVGVTGEDAQLFTAVR
MLBr_01408|M.leprae_Br4923 FRVTTPEVLDVARMVLFGQVGRELVNLINAHGPYAVGITGEDAQLFTAGR
MAV_3116|M.avium_104 FRVTTPEVLDVARMVLFGQVGRELVNLINAHGPYAVGITGEDAQLFTAVR
Mb1682|M.bovis_AF2122/97 FRVTTPEVLDVARMVLFGQVGRELVNLINAHGPYAVGITGEDAQLFTAVR
Rv1654|M.tuberculosis_H37Rv FRVTTPEVLDVARMVLFGQVGRELVNLINAHGPYAVGITGEDAQLFTAVR
MSMEG_3774|M.smegmatis_MC2_155 FRVTTPEVLDVARMVLFGQVGRELVNLINAHGPYAVGVTGEDAQLFTAVR
TH_1595|M.thermoresistible__bu FRVTTPEVLDVARMVLFGQVGRQLVNLINAHGPYAVGITGEDAQLFTAVR
MAB_2338|M.abscessus_ATCC_1997 FRVTTPEVLDIARMVLFGQVGRELVGLINSHGPYAVGITGEDAQLFTAVR
*********::***********:**.***::******:*****:**** *
Mflv_3528|M.gilvum_PYR-GCK RTVMVDGVATDIGLVGDVERVNTDAVLDLIDAGRIPVVSTIAPDTAGLVY
Mvan_3312|M.vanbaalenii_PYR-1 RTVMVDGVATDIGLVGDVERVNTDAVLDLIDAGRIPVVSTIAPDTDGLVY
MMAR_2464|M.marinum_M RSVNVDGVATDIGLVGDVDHVNAAALMDLIAAHRIPVISTLAPDAEGVVH
MUL_1646|M.ulcerans_Agy99 RSVNVDGVATDIGLVGDVDHVNAAALMDLIAAHRIPVISTLAPDAEGVVH
MLBr_01408|M.leprae_Br4923 RSATVDGMATDIGLVGDVDQVNIAAVLDLISAHRIPVVSTLAPDRDGVVH
MAV_3116|M.avium_104 RSVTVDGVTTDIGLVGDVERVNAAAVLDLIAARRIPVVSTLAPDAEGVVH
Mb1682|M.bovis_AF2122/97 RSVTVDGVATDIGLVGDVDQVNTAAMLDLVAAGRIPVVSTLAPDADGVVH
Rv1654|M.tuberculosis_H37Rv RSVTVDGVATDIGLVGDVDQVNTAAMLDLVAAGRIPVVSTLAPDADGVVH
MSMEG_3774|M.smegmatis_MC2_155 RNVTVDGVATDIGLVGDVEHVNAGSLLDLIAAGRIPVVSTIAPDADGVVH
TH_1595|M.thermoresistible__bu RSVTVDGVATDIGLVGDVEKVSTDAVLDLIGAGRIPVVSSLAPDTDGVVY
MAB_2338|M.abscessus_ATCC_1997 RTATVDGVETDIGLVGDVAQVSPEAILDLIDAGRIPVVSTVAPDADGVVH
*.. ***: ********* :*. :::**: * ****:*::*** *:*:
Mflv_3528|M.gilvum_PYR-GCK NINADTAAAALAEALGAEKLLMLTDVEGLYTDWPDRGSLVNQINSDALAE
Mvan_3312|M.vanbaalenii_PYR-1 NINADTAAAALAEALSAEKLLMLTDVEGLYTRWPDRDSLVSQIDSDALAE
MMAR_2464|M.marinum_M NINADTAAAALAEALGAEKLLMLTDVEGLYTSWPERDSLVREIDTAALEQ
MUL_1646|M.ulcerans_Agy99 NINADTAAAAVAEALGAEKLLMLTDVEGLYTSWPDRDSLVREIDTAALEQ
MLBr_01408|M.leprae_Br4923 NINADTAAAALAETLGAEKLLMLTNVEGLYTRWPERDSLVNEIDSAALAQ
MAV_3116|M.avium_104 NINADTAAAALAEALGAEKLLMLTDVEGLYTSWPNRDSLVSEIDTATLSQ
Mb1682|M.bovis_AF2122/97 NINADTAAAAVAEALGAEKLLMLTDIDGLYTRWPDRDSLVSEIDTGTLAQ
Rv1654|M.tuberculosis_H37Rv NINADTAAAAVAEALGAEKLLMLTDIDGLYTRWPDRDSLVSEIDTGTLAQ
MSMEG_3774|M.smegmatis_MC2_155 NINADTAAAALAEALGAEKLVMLTDVEGLYTDWPDRTSLVSEIDTGALTQ
TH_1595|M.thermoresistible__bu NINADTAAAALAAALRAEKLVMLTDIEGLYTDWPNRESLVSEIDTAELEK
MAB_2338|M.abscessus_ATCC_1997 NLNADTAAGALAEALGAERLLMLTDIEGLYTDWPDRESLVTEIAAEDLRS
*:******.*:* :* **:*:***:::**** **:* *** :* : * .
Mflv_3528|M.gilvum_PYR-GCK LLPTLEEGMVPKIEACLRAIDGGVPSAHVIDGRVEHCVLVELFTNEGAGT
Mvan_3312|M.vanbaalenii_PYR-1 LLPTLEAGMVPKIEACLRAIDGGVPSAHVIDGRVEHCVLVELFTDEGAGT
MMAR_2464|M.marinum_M LLPRLEAGMIPKVEACLRAVTGGVPSAHVIDGRVEHCVLVELFTNAGTGT
MUL_1646|M.ulcerans_Agy99 LLPRLEAGMIPKVEGCLRAVTGGVPSAHVIDGRVEHCVLVELFTNAGTGT
MLBr_01408|M.leprae_Br4923 LLPTLEAGMIPKVEACLRAVTGGVPSAHVIDGRVKHCVLVELLTNEGTGT
MAV_3116|M.avium_104 LLPTLEAGMIPKVEACLRAVSAGVPSAHVIDGRVEHCVLVELFTDAGTGT
Mb1682|M.bovis_AF2122/97 LLPTLESGMVPKVEACLRAVIGGVPSAHIIDGRVTHCVLVELFTDAGTGT
Rv1654|M.tuberculosis_H37Rv LLPTLESGMVPKVEACLRAVIGGVPSAHIIDGRVTHCVLVELFTDAGTGT
MSMEG_3774|M.smegmatis_MC2_155 LLPKLESGMVPKIEACLRAVNGGVPSAHVIDGRVEHCVLVELFTDEGTGT
TH_1595|M.thermoresistible__bu LLPGLESGMVPKIEACLRAVNGGVPSAHVIDGRVEHCVLVELFTDEGTGT
MAB_2338|M.abscessus_ATCC_1997 LLPKLESGMIPKIEACLRAVDGGVPSAHIIDGRVEHCVLVELFTDEGVGT
*** ** **:**:*.****: .******:***** *******:*: *.**
Mflv_3528|M.gilvum_PYR-GCK KVVRS-
Mvan_3312|M.vanbaalenii_PYR-1 KVVQST
MMAR_2464|M.marinum_M KVVSA-
MUL_1646|M.ulcerans_Agy99 KVVSA-
MLBr_01408|M.leprae_Br4923 KVVSA-
MAV_3116|M.avium_104 KVVSS-
Mb1682|M.bovis_AF2122/97 KVVRG-
Rv1654|M.tuberculosis_H37Rv KVVRG-
MSMEG_3774|M.smegmatis_MC2_155 KVVAQ-
TH_1595|M.thermoresistible__bu KVVSA-
MAB_2338|M.abscessus_ATCC_1997 IIRSKS
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