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PEGDTVWHTAARLRQYLAGKTLTRCDIRVPRFATVDLTGQVVEQVQSRGKHLFIRTALVSIHSHLKMDGS WRVGDRPPRVDHHARIILEANDIRAVGVDLGVLELLERDNEGAVVAHLGPDLLGEDWDPHIAAANLAADP HRCIAEALLDQRVLAGIGNVYCNELCFVSGHLPTAPVSDVAKPLRLVTRAREMLWANRLRWNRTTTGDTR AGRQLWVYGRAGQPCRRCATGIERQGPDGSSERVRYWCPACQR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1237 | nei | - | 100% (254) | endonuclease VIII Nei |
| M. marinum M | MMAR_3812 | - | 4e-16 | 30.04% (283) | formamidopyrimidine-DNA glycosylase |
| M. marinum M | MMAR_1783 | fpg | 3e-11 | 27.36% (296) | formamidopyrimidine-DNA glycosylase Fpg |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3325 | nei | 1e-114 | 77.91% (258) | endonuclease VIII |
| M. gilvum PYR-GCK | Mflv_4811 | - | 3e-90 | 63.39% (254) | formamidopyrimidine-DNA glycolase |
| M. tuberculosis H37Rv | Rv3297 | nei | 1e-114 | 77.91% (258) | endonuclease VIII |
| M. leprae Br4923 | MLBr_01658 | fpg | 3e-14 | 28.17% (284) | formamidopyrimidine-DNA glycosylase |
| M. abscessus ATCC 19977 | MAB_4728c | - | 5e-81 | 58.37% (257) | putative DNA glycosylase Nei |
| M. avium 104 | MAV_1708 | - | 7e-19 | 31.29% (278) | endonuclease VIII and DNA n-glycosylase with an AP lyase |
| M. smegmatis MC2 155 | MSMEG_1756 | - | 1e-101 | 67.98% (253) | endonuclease VIII and DNA n-glycosylase with an AP lyase |
| M. thermoresistible (build 8) | TH_1221 | nei | 1e-100 | 67.42% (264) | PROBABLE ENDONUCLEASE VIII NEI |
| M. ulcerans Agy99 | MUL_2650 | nei | 1e-151 | 99.61% (254) | endonuclease VIII Nei |
| M. vanbaalenii PYR-1 | Mvan_1631 | - | 4e-90 | 62.99% (254) | DNA-formamidopyrimidine glycosylase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1237|M.marinum_M MPEGDTVWHTAARLRQYLAGKTLTRCDIR----------VPRFATVDLTG
MUL_2650|M.ulcerans_Agy99 MPEGDTVWHTAARLRQYLAGKTLTRCDIR----------VPRFATVDLTG
Mb3325|M.bovis_AF2122/97 MPEGDTVWHTAATLRRHLAGRTLTRCDIR----------VPRFAAVDLTG
Rv3297|M.tuberculosis_H37Rv MPEGDTVWHTAATLRRHLAGRTLTRCDIR----------VPRFAAVDLTG
Mflv_4811|M.gilvum_PYR-GCK MPEGDTVYRTAAKLRDALEGRELTRCDIR----------VPRYAAVDLSG
Mvan_1631|M.vanbaalenii_PYR-1 MPEGDTVYRTAAKLREALEGRELTRCDVR----------VPRYAAVDLSG
MSMEG_1756|M.smegmatis_MC2_155 MPEGDTVFHTAAALRAALEGKTLTRCDVR----------VPRYATVDLSG
TH_1221|M.thermoresistible__bu MPEGDTVWRTAEMLRVGLTGKTLTRCDIR----------VPRYATVDLAG
MAB_4728c|M.abscessus_ATCC_199 MPEGDTVFRTAKLLDDALGGRILTGCDIR----------VPRFATVDLSG
MAV_1708|M.avium_104 MPEGHTLHRLARLHQRRYAGAPVAVTSPQG---------RFAEAAAVVDG
MLBr_01658|M.leprae_Br4923 MPELPEVEVVRRGLQDYIVGKTITAVRVHHPRAVRRHVAGPTDLTNRLLG
*** : * :: : : : *
MMAR_1237|M.marinum_M QVVEQVQSRGKHLFIR-TALVSIHSHLKMDGSWRVG--DRPPRVD-HHAR
MUL_2650|M.ulcerans_Agy99 QVVEEVQSRGKHLFIR-TALVSIHSHLKMDGSWRVG--DRPPRVD-HHAR
Mb3325|M.bovis_AF2122/97 EVVDEVISRGKHLFIR-TGTASIHSHLQMDGSWRVG--NRPVRVD-HRAR
Rv3297|M.tuberculosis_H37Rv EVVDEVISRGKHLFIR-TGTASIHSHLQMDGSWRVG--NRPVRVD-HRAR
Mflv_4811|M.gilvum_PYR-GCK QVVDEVLSRGKHLFIR-VGQASIHSHLKMDGAWVIGRVRVPT----YKIR
Mvan_1631|M.vanbaalenii_PYR-1 QTVDEVLSRGKHLFIR-VGQASIHSHLKMDGAWVIGRVRVPS----YKIR
MSMEG_1756|M.smegmatis_MC2_155 AVVDEVLSRGKHLFIR-AGSASIHSHLKMEGAWRIGHTKVAP----HRIR
TH_1221|M.thermoresistible__bu LRVDEVLSRGKHLFIR-VADASIHSHLKMDGSWRVHPLNRPSRAG-HRIR
MAB_4728c|M.abscessus_ATCC_199 QRVEGVIARGKHLFIR-VGGASIHSHLKMDGSWRIMPAGRPGPTWNHRIR
MAV_1708|M.avium_104 RVLRRTSAWGKHLFHHYAGGPIVHVHLGLYGSFSEWERPGDGPLPDPVGQ
MLBr_01658|M.leprae_Br4923 TRINGIDRRGKYLWFLLDTDIALVVHLGMSGQMLLGTVPRVDHVR---IS
: **:*: : ** : *
MMAR_1237|M.marinum_M IILEAN--------DIRAVGVDLG---VLELLERDNEGAVVAHLGPDLLG
MUL_2650|M.ulcerans_Agy99 IILEAN--------DIRAVGVDLG---VLELLERDNEGAVVAHLGPDLLG
Mb3325|M.bovis_AF2122/97 IILEANQQE----QAIRVVGVDLG---LLEVIDRHNDGAVVAHLGPDLLA
Rv3297|M.tuberculosis_H37Rv IILEANQQE----QAIRVVGVDLG---LLEVIDRHNDGAVVAHLGPDLLA
Mflv_4811|M.gilvum_PYR-GCK IVLETAN--------SRASGVDLG---VLEVLDRATDMEAVEHLGPDLLG
Mvan_1631|M.vanbaalenii_PYR-1 IVLETAR--------SRASGVDLG---VLEILDRATDMEAVAHLGPDLLG
MSMEG_1756|M.smegmatis_MC2_155 IVLETAD--------TRAIGIDLG---ILEVLDRGTDMDAVAYLGPDLLG
TH_1221|M.thermoresistible__bu ILLEAAGGPGSDIEPVQAVGIDLG---VLQVLDRRHDMDVVAHLGPDLLG
MAB_4728c|M.abscessus_ATCC_199 AVLTTDD--------SVAVGTSLG---ILDVVDRRREGDVVGHLGPDLLG
MAV_1708|M.avium_104 VRMRMVG---------ASHGTDLRGPTVCEVIDEGQVSDVLARLGPDPLR
MLBr_01658|M.leprae_Br4923 ALFDDGTVLN--FTDQRTLGGWLLAD--LMTVDGSVLPVPVAHLARDPFD
: * * :: : *. * :
MMAR_1237|M.marinum_M EDWDPHIAAANLAADPHRCIAEALLDQRVLAGIGNVYCNELCFVSGHLPT
MUL_2650|M.ulcerans_Agy99 EDWDPHIAAANLAADPHRCIAEALLDQRVLAGIGNVYCNELCFVSGHLPT
Mb3325|M.bovis_AF2122/97 DDWDPQRAAANLIVAPDRPIAEALLDQRVLAGIGNVYCNELCFVSGVLPT
Rv3297|M.tuberculosis_H37Rv DDWDPQRAAANLIVAPDRPIAEALLDQRVLAGIGNVYCNELCFVSGVLPT
Mflv_4811|M.gilvum_PYR-GCK EDWSAEVAAANLVADPERPLAETLLDQRVMAGVGNVFANELSFVFGLRPG
Mvan_1631|M.vanbaalenii_PYR-1 PDWSAPLAAANLVADPSRPVAEALLDQRVMAGVGNVYANELCFVFGLRPG
MSMEG_1756|M.smegmatis_MC2_155 PDWEPRVAADNLAADPDRPLAQALLDQRVMAGVGNVYCNELCFVFGRLPT
TH_1221|M.thermoresistible__bu PDWDAEVAAANLTADPDRPLAEALLDQRVLAGVGNVYCNELCFVTGHLPT
MAB_4728c|M.abscessus_ATCC_199 TDWDPDVAVERLIARSDEALSAALLDQRVMAGIGNVYSNELCFLAGLLPT
MAV_1708|M.avium_104 DDADPSWAWQRIAK-SRRPIGALLMDQTVMAGVGNVYRSELLFRHGIDPY
MLBr_01658|M.leprae_Br4923 PRFDVEAVVK-VLRCKHSELKRQLLDQQTVSGIGNIYADEALWRAEVHGA
. . : : *:** .::*:**:: .* :
MMAR_1237|M.marinum_M APVSDVAK-----------PLRLVTRAREMLWANRLR--------WNRTT
MUL_2650|M.ulcerans_Agy99 APVSDVAK-----------PLRLVTRAREMLWANRLR--------WNRTT
Mb3325|M.bovis_AF2122/97 APVSAVAD-----------PRRLVTRARDMLWVNRFR--------WNRCT
Rv3297|M.tuberculosis_H37Rv APVSAVAD-----------PRRLVTRARDMLWVNRFR--------WNRCT
Mflv_4811|M.gilvum_PYR-GCK TPVGELTD-----------PLRVANRAQQMLWLNRLR--------VNRTT
Mvan_1631|M.vanbaalenii_PYR-1 TAVGELAD-----------PVRVASRAQQMLWLNRLR--------VNRTT
MSMEG_1756|M.smegmatis_MC2_155 APVGTLKD-----------PLRVVQRARDMLWLNRSR--------WNRTT
TH_1221|M.thermoresistible__bu TAAGAVTD-----------PVRMMQRARDMLWLNRTR--------WNRTT
MAB_4728c|M.abscessus_ATCC_199 TAVGRLGD-----------PAGLVERAHTLMHANKDS--------YRRTT
MAV_1708|M.avium_104 RAGRDVGEAEFDAAWTDLVALMKVGLRRGKIIVVRPE--------HDRGA
MLBr_01658|M.leprae_Br4923 RIAATLTRR---------QLAAVLDAAADVMRDSLAKGGTSFDSLYVNVN
: : .
MMAR_1237|M.marinum_M TGDTRAGRQLWVYGRAGQPCRRCATGIERQGPDGSSERVRYWCPACQR--
MUL_2650|M.ulcerans_Agy99 TGDTRAGRQLWVYGRAGQPCRRCATGIERQGPDGSSERVRYWCPACQR--
Mb3325|M.bovis_AF2122/97 TGDTRAGRRLWVYGRAGQGCRRCGTLIAY---DTTDERVRYWCPACQR--
Rv3297|M.tuberculosis_H37Rv TGDTRAGRRLWVYGRAGQGCRRCGTLIAY---DTTDERVRYWCPACQR--
Mflv_4811|M.gilvum_PYR-GCK TGNTRPGQDVWVYGRAGLPCRRCGTPIET---DKNTERVTYWCPTCQR--
Mvan_1631|M.vanbaalenii_PYR-1 TGNTRPGQDVWVYGRAGLPCRRCGTPIET---DKGGDRVTYWCPTCQR--
MSMEG_1756|M.smegmatis_MC2_155 TGDTRNGRQLWVYGRAGEPCRRCGTLIQT---DRGGERVTYWCPVCQTAS
TH_1221|M.thermoresistible__bu TGDTRQGRDLWVYGRGGKPCRRCGTLIAR---DAGGERVSYWCPHCQR--
MAB_4728c|M.abscessus_ATCC_199 TGDPRSGRELWVYGRHGKPCRRCGTPIAR---DQGLPRVAYWCPNCQR--
MAV_1708|M.avium_104 PSYRPDRPRTYVYRRAGEACRVCGEPVRT---AVLEGRNVFWCPTCQK--
MLBr_01658|M.leprae_Br4923 GESGYFDRSLDAYGREGEGCRRCGAVMHR---EKFMNRSSFYCPRCQPRP
.* * * ** *. : * ::** **
MMAR_1237|M.marinum_M --
MUL_2650|M.ulcerans_Agy99 --
Mb3325|M.bovis_AF2122/97 --
Rv3297|M.tuberculosis_H37Rv --
Mflv_4811|M.gilvum_PYR-GCK --
Mvan_1631|M.vanbaalenii_PYR-1 --
MSMEG_1756|M.smegmatis_MC2_155 --
TH_1221|M.thermoresistible__bu --
MAB_4728c|M.abscessus_ATCC_199 --
MAV_1708|M.avium_104 --
MLBr_01658|M.leprae_Br4923 RR