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SVHRDAIRAARSLVVKVGTNALTTSSGVFDSSRLARLVDAIEARMKAGTDVVIVSSGAIAAGIEPLGLSL RPKDLATKQAAASVGQVALVNSWSAAFARYGRAVGQVLLTAQDISMRVQHTNAQRTLDRLRALHAVAIVN ENDTVATNEIRFGDNDRLSAVVAHLVGAEALVLLSDINGLYDSDPRKNTGARFVPEVTGSADLDGVVASR GSSLGTGGMVSKMSSALLAADAGVPVLLAAAADAATALTDASVGTVFAARPDRMSARRFWLRYAADSVGS LTLDEGAVWAVVQQRRSLLAAGITAVSGRFYGGDVVELRGPDATMVARGVVAYDATELAAMMGRSTSELP CELRRPAVHADDLVSI*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. leprae Br4923 | MLBr_01464 | proB | - | 100% (367) | gamma-glutamyl kinase |
| M. leprae Br4923 | MLBr_02323 | ask | 2e-05 | 24.60% (187) | aspartate kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2466c | proB | 1e-169 | 84.70% (366) | gamma-glutamyl kinase |
| M. gilvum PYR-GCK | Mflv_2638 | - | 1e-162 | 81.08% (370) | gamma-glutamyl kinase |
| M. tuberculosis H37Rv | Rv2439c | proB | 1e-169 | 84.43% (366) | gamma-glutamyl kinase |
| M. abscessus ATCC 19977 | MAB_1613 | - | 1e-149 | 76.24% (362) | gamma-glutamyl kinase |
| M. marinum M | MMAR_3764 | proB | 1e-171 | 85.79% (366) | glutamate 5-kinase protein ProB |
| M. avium 104 | MAV_1732 | proB | 1e-176 | 87.74% (367) | gamma-glutamyl kinase |
| M. smegmatis MC2 155 | MSMEG_4621 | proB | 1e-161 | 80.43% (368) | gamma-glutamyl kinase |
| M. thermoresistible (build 8) | TH_4011 | - | 2e-19 | 84.62% (52) | PUTATIVE glutamate 5-kinase |
| M. ulcerans Agy99 | MUL_3711 | proB | 1e-173 | 86.61% (366) | gamma-glutamyl kinase |
| M. vanbaalenii PYR-1 | Mvan_3943 | - | 1e-165 | 82.02% (367) | gamma-glutamyl kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2638|M.gilvum_PYR-GCK ---MSVHRDAIRGARSVVVKIGTTALTTPSGVFDRGRLHYLADAIEARMK
Mvan_3943|M.vanbaalenii_PYR-1 ---MSAHRDAIRTARSVVVKIGTTALTTPTGVFDTSRLQDLADAIEARMK
MSMEG_4621|M.smegmatis_MC2_155 ---MSEHREAVRTARSVVVKIGTTALTTPSGVFDANRLASLVEAIEGRMK
Mb2466c|M.bovis_AF2122/97 --MRSPHRDAIRTARGLVVKVGTTALTTPSGMFDAGRLAGLAEAVERRMK
Rv2439c|M.tuberculosis_H37Rv --MRSPHRDAIRTARGLVVKVGTTALTTPSGMFDAGRLAGLAEAVERRMK
MLBr_01464|M.leprae_Br4923 ---MSVHRDAIRAARSLVVKVGTNALTTSSGVFDSSRLARLVDAIEARMK
TH_4011|M.thermoresistible__bu --------------------------------------------------
MAV_1732|M.avium_104 ---MTAHRDAIRTARSLVVKVGTNALTTPAGVFDAGRLAGLADAIEARMK
MMAR_3764|M.marinum_M --MGSPHREAIRTARSVVVKVGTTALTTPSGVFDAGRLAELADAIESRMK
MUL_3711|M.ulcerans_Agy99 --MGSPHREAIRTARSVVVKVGTTALTTPSGVFDAGRLAELADAIESRMK
MAB_1613|M.abscessus_ATCC_1997 MNPGAQAREAIRSARTVVVKVGTAALTDETGTFSADRMEYLVEVIEGRMK
Mflv_2638|M.gilvum_PYR-GCK AGSDVVIVSSGAIAAGIEPLKLTKRPADLATKQAAASVGQVALVNSWSAA
Mvan_3943|M.vanbaalenii_PYR-1 AGSDVVIVSSGAIAAGIEPLGLTKRPTDLATKQAAASVGQVALVNTWSSA
MSMEG_4621|M.smegmatis_MC2_155 AGSDVVIVSSGAIAAGIEPLGLSKRPTDLATKQAAASVGQVALVNAWSAA
Mb2466c|M.bovis_AF2122/97 AGSDVVIVSSGAIAAGIEPLGLSRRPKDLATKQAAASVGQVALVNSWSAA
Rv2439c|M.tuberculosis_H37Rv AGSDVVIVSSGAIAAGIEPLGLSRRPKDLATKQAAASVGQVALVNSWSAA
MLBr_01464|M.leprae_Br4923 AGTDVVIVSSGAIAAGIEPLGLSLRPKDLATKQAAASVGQVALVNSWSAA
TH_4011|M.thermoresistible__bu --------------------------------------------------
MAV_1732|M.avium_104 AGTDVVIVSSGAIAAGIEPLGLSRRPRDLATKQAAASVGQVALVNSWSAA
MMAR_3764|M.marinum_M AGTDVVIVSSGAIAAGIEPLGLSRRPKDLATKQAAASVGQVALVNSWSAA
MUL_3711|M.ulcerans_Agy99 AGTDVVIVSSGAIAAGIEPLGLSRRPKDLATKQAAASVGQVALVNSWSAA
MAB_1613|M.abscessus_ATCC_1997 AGSDVVIVSSGAIAAGMVPLGLTKRPTDLATKQAAASAGQVALIGAWSAA
Mflv_2638|M.gilvum_PYR-GCK FGRYDRTVGQVLLTAHDISMRVQHNNAQRTLDRLRALHAVAIVNENDTVA
Mvan_3943|M.vanbaalenii_PYR-1 FGRYHRTVGQVLLTAHDISMRVQHTNAQRTLDRLRALHAVAIVNENDTVA
MSMEG_4621|M.smegmatis_MC2_155 FAVYNRTVGQVLLTAHDISMRVQHNNAQRTLDRLRALHAVAIVNENDTVA
Mb2466c|M.bovis_AF2122/97 FARYGRTVGQVLLTAHDISMRVQHTNAQRTLDRLRALHAVAIVNENDTVA
Rv2439c|M.tuberculosis_H37Rv FARYGRTVGQVLLTAHDISMRVQHTNAQRTLDRLRALHAVAIVNENDTVA
MLBr_01464|M.leprae_Br4923 FARYGRAVGQVLLTAQDISMRVQHTNAQRTLDRLRALHAVAIVNENDTVA
TH_4011|M.thermoresistible__bu --------------------------------------------------
MAV_1732|M.avium_104 FARYGRTVGQVLLSAHDISMRAQHTNAQRTLDRLRALHAVAIVNENDTVA
MMAR_3764|M.marinum_M FARYGRTVGQVLLTAHDIAMRVQHSNAQRTLDRLRALHAVGIVNENDTVA
MUL_3711|M.ulcerans_Agy99 FARYGRTVGQVLLTAHDIAMRVQHTNAQRTLDRLRALHAVGIVNENDTVA
MAB_1613|M.abscessus_ATCC_1997 FARYERTVGQVLLTAHDISMRVHHTNAQRTLDRLTALHAVAIVNENDTVA
Mflv_2638|M.gilvum_PYR-GCK TNEIRFGDNDRLSALVAHLVGADALILLSDIDGLYDGDPRKAPEDNPARF
Mvan_3943|M.vanbaalenii_PYR-1 TNEIRFGDNDRLSALVAHLVGADALILLSDVDGLYDSDPRKGN----ARF
MSMEG_4621|M.smegmatis_MC2_155 TNEIRFGDNDRLSALVAHLVGADALILLSDIDGLYDGDPRKATPDKPARF
Mb2466c|M.bovis_AF2122/97 TNEIRFGDNDRLSALVAHLVGADALVLLSDIDGLYDCDPRKTAD---ATF
Rv2439c|M.tuberculosis_H37Rv TNEIRFGDNDRLSALVAHLVGADALVLLSDIDGLYDCDPRKTAD---ATF
MLBr_01464|M.leprae_Br4923 TNEIRFGDNDRLSAVVAHLVGAEALVLLSDINGLYDSDPRKNTG---ARF
TH_4011|M.thermoresistible__bu --------------------------------------------------
MAV_1732|M.avium_104 TNEIRFGDNDRLSALVAHLVGAEALVLLSDIDGLYDSDPRKTKG---AKF
MMAR_3764|M.marinum_M TNEIRFGDNDRLSALVAHLVGADALVLLSDIDGLYDADPGKFQN---ARF
MUL_3711|M.ulcerans_Agy99 TNEIRFGDNDRLSALVAHLVGADALVLLSDIDGLYDADPRKFQN---ARF
MAB_1613|M.abscessus_ATCC_1997 TNEIRFGDNDRLSALVAHLVGADALVLLSDIDGLYDSDPRKGN----ARF
Mflv_2638|M.gilvum_PYR-GCK ISEVSGPDDLADVTAGRGSHLGTGGMVSKLSSALLAADAGVPVLLAAAAD
Mvan_3943|M.vanbaalenii_PYR-1 IPEVDGPDDLEGVTAGRGSHLGTGGMVSKLSSALLAADAGVPVLLAAASD
MSMEG_4621|M.smegmatis_MC2_155 IPEVAAQGDLDGVVAGRGSSLGTGGMASKLSSALLAADAGVPVLLAAAAD
Mb2466c|M.bovis_AF2122/97 IPEVSGPADLDGVVAGRSSHLGTGGMASKVSAALLAADAGVPVLLAPAAD
Rv2439c|M.tuberculosis_H37Rv IPEVSGPADLDGVVAGRSSHLGTGGMASKVAAALLAADAGVPVLLAPAAD
MLBr_01464|M.leprae_Br4923 VPEVTGSADLDGVVASRGSSLGTGGMVSKMSSALLAADAGVPVLLAAAAD
TH_4011|M.thermoresistible__bu --------------------------------------------------
MAV_1732|M.avium_104 IPEVTGAEDLAGVVAGPGSDLGTGGMTSKMSSALLAADAGVPVLLAAAAD
MMAR_3764|M.marinum_M IPEVSGPADLDGVVAGQGSHLGTGGMASKMSSALLAADAGVPVLLAPAAD
MUL_3711|M.ulcerans_Agy99 IPEVSGPADLDGVVAGQGSHLGTGGMASKMSSALLAADAGVPVLLAPAAD
MAB_1613|M.abscessus_ATCC_1997 ISEVSGPEDLADVIAGPGGSRGTGGMASKLSSALLASDAGVPVLLASATE
Mflv_2638|M.gilvum_PYR-GCK AASALGDASVGTVFAPRPERMSARRFWVRYAAEASGTLTLDDGAVRAVVQ
Mvan_3943|M.vanbaalenii_PYR-1 AAAALDGASVGTVFAPRKERMSARRFWVRYAAEASGALTLDDGAVKAVVR
MSMEG_4621|M.smegmatis_MC2_155 AGRALDDASVGTVFAPRPERMSARKFWMRYAAESAGALTLDDGAVRAVIK
Mb2466c|M.bovis_AF2122/97 AATALADASVGTVFAARPARLSARRFWVRYAAEATGALTLDAGAVRAVVR
Rv2439c|M.tuberculosis_H37Rv AATALADASVGTVFAARPARLSARRFWVRYAAEATGALTLDAGAVRAVVR
MLBr_01464|M.leprae_Br4923 AATALTDASVGTVFAARPDRMSARRFWLRYAADSVGSLTLDEGAVWAVVQ
TH_4011|M.thermoresistible__bu --------------------------------------------------
MAV_1732|M.avium_104 AASALTDASVGTVFAARPVRMSARRFWVRYAAEAAGALTLDEGAVRAVVH
MMAR_3764|M.marinum_M AAAALTDASVGTVFAARSERMSARRFWVRYAAESAGSLTLDEGAVRAVVG
MUL_3711|M.ulcerans_Agy99 AAAALTDASVGTVFAARSERMSARRFWVRYAAESAGSLTLDEGAVRAVVG
MAB_1613|M.abscessus_ATCC_1997 AAAALGDGSCGTVFAARPQRMSARKFWVRYAAEATGSLTLDAGAVRAVVA
Mflv_2638|M.gilvum_PYR-GCK QRRSLLPAGISAVSGRFFGGDVVELRDQENAMVARGVVAYDKAELATMLG
Mvan_3943|M.vanbaalenii_PYR-1 QRRSLLPAGITALSGRFYGGDVVELRNQDATMVARGVVAYDAAELATMLG
MSMEG_4621|M.smegmatis_MC2_155 QRRSLLPAGITSVTGRFHGGDVVDLRALDGHTVARGVVAYDQAELASIIG
Mb2466c|M.bovis_AF2122/97 QRRSLLAAGITAVSGRFCGGDVVELRAPDAAMVARGVVAYDASELATMVG
Rv2439c|M.tuberculosis_H37Rv QRRSLLAAGITAVSGRFCGGDVVELRAPDAAMVARGVVAYDASELATMVG
MLBr_01464|M.leprae_Br4923 QRRSLLAAGITAVSGRFYGGDVVELRGPDATMVARGVVAYDATELAAMMG
TH_4011|M.thermoresistible__bu ---------------------VVELRGPDSTMVARGVVAYDATELAKMTG
MAV_1732|M.avium_104 QRRSLLPAGITAVSGRFYAGDVVELRGPDAVPVARGVVAYDATELATMMG
MMAR_3764|M.marinum_M HRRSLLPAGITAVAGKFFGGDVVDLCGPDATMVARGVVAYDATELATMMG
MUL_3711|M.ulcerans_Agy99 HRRSLLPAGITAVAGKFFGGDVVDLCGPDATMVARGVVAYDATELAAMMG
MAB_1613|M.abscessus_ATCC_1997 SRRSLLPAGITGVSGRFHGGDVVELRDADGTMVGRGVVAYDVAELATMLG
**:* : *.******* :*** : *
Mflv_2638|M.gilvum_PYR-GCK RSTSDLPAEMRRPAVHADDLVAV--------
Mvan_3943|M.vanbaalenii_PYR-1 RSTSDLPAEMRRPAVHADDLVAV--------
MSMEG_4621|M.smegmatis_MC2_155 RSTHELPVEMRRPAVHADDLVRT--------
Mb2466c|M.bovis_AF2122/97 RSTSELPGELRRPVVHADDLVAVSAKQAKQV
Rv2439c|M.tuberculosis_H37Rv RSTSELPGELRRPVVHADDLVAVSAKQAKQV
MLBr_01464|M.leprae_Br4923 RSTSELPCELRRPAVHADDLVSI--------
TH_4011|M.thermoresistible__bu RSTSELPPDMRRPAVHADDLVAV--------
MAV_1732|M.avium_104 RSTSELPGELRRPAVHADDLVAV--------
MMAR_3764|M.marinum_M RSTSELPGELRRPAVHADDLVAV--------
MUL_3711|M.ulcerans_Agy99 RSTSELPGELRRPAVHADDLVAV--------
MAB_1613|M.abscessus_ATCC_1997 RSTNELPEDLRRPAVHADDLVT---------
*** :** ::***.*******