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MLCIGITGGIGAGKSLLSSTFSQCGGIVVDGDVLAREVVQPGTKGLSSLVDAFGQDILLPGGALDRRALA VKAFRDDAARNVLNGIVHPLVANRRAEIIAAISEDAVVVEDIPLLVESGMAHLFPLVVVVHADVELRVRR LVEQRGVAETDARARIAAQASDEERRAVADVWLDNSSTPEVLVQRARDLWYHRILPFAYNLSQRQAVYAP AGLVTSDPIWLGQAKRIVARLKTTCGHKALRVDHIGSTAVPHYPGFPDFQAKDIIDIQITVESLAMADEL ADPLLSAGYPRLEHVTGDAAKTNARSTVDRYEHSSDPNLWHKRFHASADPGRPTYVHIRVAGWPNQQFGL LFVDWLKANPGVRADYLDVKRTADRLAAGDMGRYADAKEPWLLDAYRRAWEWADSTGWRL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. leprae Br4923 | MLBr_01383 | coaE | - | 100% (410) | dephospho-CoA kinase/protein folding accessory domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1657 | coaE | 0.0 | 77.51% (409) | dephospho-CoA kinase/unknown domain fusion protein |
| M. gilvum PYR-GCK | Mflv_3559 | coaE | 1e-146 | 63.37% (415) | fused dephospho-CoA kinase/unknown domain-containing protein |
| M. tuberculosis H37Rv | Rv1631 | coaE | 0.0 | 77.51% (409) | dephospho-CoA kinase/unknown domain fusion protein |
| M. abscessus ATCC 19977 | MAB_2298 | coaE | 1e-127 | 56.45% (411) | dephospho-CoA kinase/unknown domain fusion protein |
| M. marinum M | MMAR_2434 | coaE | 1e-175 | 73.61% (413) | dephospho-CoA kinase CoaE |
| M. avium 104 | MAV_3151 | coaE | 1e-173 | 72.37% (409) | fused dephospho-CoA kinase/unknown domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_2076 | - | 1e-10 | 28.42% (190) | hypothetical protein MSMEG_2076 |
| M. thermoresistible (build 8) | TH_0576 | - | 1e-146 | 62.10% (409) | Probable dephospho-CoA kinase coaE (dephosphocoenzyme A kinase) |
| M. ulcerans Agy99 | MUL_1613 | coaE | 1e-173 | 73.54% (412) | dephospho-CoA kinase/unknown domain fusion protein |
| M. vanbaalenii PYR-1 | Mvan_3353 | coaE | 1e-142 | 63.57% (409) | fused dephospho-CoA kinase/unknown domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3559|M.gilvum_PYR-GCK MLRIGLTGGIGAGKSTVSATFSELGAVVVDGDVIAREVVEPGTEGLAKLV
Mvan_3353|M.vanbaalenii_PYR-1 MLRIGLTGGIGAGKSTVSATFSDLGGIVIDGDVIAREVVEPGTPGLASLV
Mb1657|M.bovis_AF2122/97 MLRIGLTGGIGAGKSLLSTTFSQCGGIVVDGDVLAREVVQPGTEGLASLV
Rv1631|M.tuberculosis_H37Rv MLRIGLTGGIGAGKSLLSTTFSQCGGIVVDGDVLAREVVQPGTEGLASLV
MLBr_01383|M.leprae_Br4923 MLCIGITGGIGAGKSLLSSTFSQCGGIVVDGDVLAREVVQPGTKGLSSLV
MMAR_2434|M.marinum_M MLRIGLTGGIGAGKSALSATFAECGGIIVDGDVLAREVVEPGTEGLAALV
MUL_1613|M.ulcerans_Agy99 MLRIGLTGGIGAGKSALSATFAQCGGIIVDGDVLAREVVEPGTEGLAALV
MAV_3151|M.avium_104 MLRIGLTGGIGAGKSALSSAFAQCGAVIVDGDVIAREVVRPGTEGLAALV
TH_0576|M.thermoresistible__bu MIRIGLTGGIGAGKSTVAATFAECGGIIVDGDVIAREVVQPGTEGLAKLV
MAB_2298|M.abscessus_ATCC_1997 MLRIGLTGGIGAGKSTVSRTLAGCGAFIVDSDVIAREVVEPGTPGLAALV
MSMEG_2076|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_3559|M.gilvum_PYR-GCK EAFGDGILRSDGSLDRPALAAIAFSDDEKRTTLNGIVHPLVAQRRSDLIA
Mvan_3353|M.vanbaalenii_PYR-1 DAFGEAILLPDGALNRPALAAIAFSDEEKRATLNGIVHPLVAHRRSELID
Mb1657|M.bovis_AF2122/97 DAFGRDILLADGALDRQALAAKAFRDDESRGVLNGIVHPLVARRRSEIIA
Rv1631|M.tuberculosis_H37Rv DAFGRDILLADGALDRQALAAKAFRDDESRGVLNGIVHPLVARRRSEIIA
MLBr_01383|M.leprae_Br4923 DAFGQDILLPGGALDRRALAVKAFRDDAARNVLNGIVHPLVANRRAEIIA
MMAR_2434|M.marinum_M DAFGHDILLPGGALDRPGLAAKAFRDEASRSKLNGIVHPLVARRRAEIIA
MUL_1613|M.ulcerans_Agy99 DAFGHDILLPDGALDRPGLAAKAFRDEASRSKLNGIVHPLVARRRAEIIA
MAV_3151|M.avium_104 EAFGRDILLADGSLDRPALAAKAFADDAARQTLNGIVHPLVGARRAEIIA
TH_0576|M.thermoresistible__bu ETFGEDILLPDGSLDRPALAAKAFADDEQRAKLNAIVHPLVGRRREEIIA
MAB_2298|M.abscessus_ATCC_1997 EAFGETILRADGALDRPALAAIAFQDDEHRATLNGIVHPLVGARRAELIA
MSMEG_2076|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_3559|M.gilvum_PYR-GCK AAREAAENPVIVEDIPLLVESQMAPMFPLVIIVHADPEVRVKRLIEHRNF
Mvan_3353|M.vanbaalenii_PYR-1 AA---DEEAVIVEDIPLLVESQMAPMFPLVVIVHADEEVRVKRLIEYRHF
Mb1657|M.bovis_AF2122/97 AVS---GDAVVVEDIPLLVESGMAPLFPLVVVVHADVELRVRRLVEQRGM
Rv1631|M.tuberculosis_H37Rv AVS---GDAVVVEDIPLLVESGMAPLFPLVVVVHADVELRVRRLVEQRGM
MLBr_01383|M.leprae_Br4923 AIS---EDAVVVEDIPLLVESGMAHLFPLVVVVHADVELRVRRLVEQRGV
MMAR_2434|M.marinum_M AVS---DDAVVVEDIPLLVESGMAPLFPLVVVVHADMEVRLRRLVHQRGM
MUL_1613|M.ulcerans_Agy99 AVS---DDAVVVEDIPLLVESGMAPLFPLVVVVHADMEVRLRRLVHQRGM
MAV_3151|M.avium_104 SVP---ADSVVVEDIPLLVESGMAPLFPLVVIVYADVEVRLRRLVEQRGM
TH_0576|M.thermoresistible__bu AVP---DDAVVVEDIPLLVETGMAPTFPLVVVVYADAEVRVKRLVEIRGM
MAB_2298|M.abscessus_ATCC_1997 AAG---EEAVVVEDIPLLTENSLAPFYHLVLVVHADIETRVTRLVTHRGM
MSMEG_2076|M.smegmatis_MC2_155 -------------------------------------------------M
.
Mflv_3559|M.gilvum_PYR-GCK SEEDARARIAAQATEEQRRAVADVWLDNSGSAGELVEKARDLWHGRIRPF
Mvan_3353|M.vanbaalenii_PYR-1 TEEDARARIAAQAGEEQRRAVADVWLDNSGSAGELVEKARALWHERIQPF
Mb1657|M.bovis_AF2122/97 AEADARARIAAQASDQQRRAVADVWLDNSGSPEDLVRRARDVWNTRVQPF
Rv1631|M.tuberculosis_H37Rv AEADARARIAAQASDQQRRAVADVWLDNSGSPEDLVRRARDVWNTRVQPF
MLBr_01383|M.leprae_Br4923 AETDARARIAAQASDEERRAVADVWLDNSSTPEVLVQRARDLWYHRILPF
MMAR_2434|M.marinum_M SEDDARARIAAQASDEQRRAIADVWLDNSGSLDALVERARDVWNNRILPF
MUL_1613|M.ulcerans_Agy99 SEDDACARIAAQASDEQRRAVADVWLDNSGSLDALVERARDVWNNRILPF
MAV_3151|M.avium_104 AEADARARIAAQASDEQRRAVADIWLDNSGSPAELVQRAQQVWNERIVPF
TH_0576|M.thermoresistible__bu SEQDARARIAAQATDEQRAAIADVLLDNSGTQQEIVDKARALWEQRVLPL
MAB_2298|M.abscessus_ATCC_1997 NEQDARSRVAAQASDEQRRAIADVWLDNSGDTEVLAHAVRDLWASRLLPY
MSMEG_2076|M.smegmatis_MC2_155 ERVPTRHEITRHHDPD---PVESPWVDGPPPDE-----------------
. : .:: : : .: . :*..
Mflv_3559|M.gilvum_PYR-GCK AHNLAAGEPARADARPVPADPQWAAQAQRILARLRTACGHRAVRVDHIGS
Mvan_3353|M.vanbaalenii_PYR-1 ARNLEAGTPAKSEARLVPSDPSWPAQAQRILARLRTACGHRASRIDHIGS
Mb1657|M.bovis_AF2122/97 AHNLAQRQIARAPARLVPADPSWPDQARRIVNRLKIACGHKALRVDHIGS
Rv1631|M.tuberculosis_H37Rv AHNLAQRQIARAPARLVPADPSWPDQARRIVNRLKIACGHKALRVDHIGS
MLBr_01383|M.leprae_Br4923 AYNLSQRQAVYAPAGLVTSDPIWLGQAKRIVARLKTTCGHKALRVDHIGS
MMAR_2434|M.marinum_M AHNLSVGQIARFPARVVPADPSWPEQAQRIVARLKTTCGHKASRVDHIGS
MUL_1613|M.ulcerans_Agy99 AHNLSVGQIARFPARVVPADPSWPEQAQRIVARLKTTCGHKASRVDHIGS
MAV_3151|M.avium_104 AHNLSTRQIARAPVRLVPPDPEWPAQAQRIVNRLKTASGHRALRVDHVGS
TH_0576|M.thermoresistible__bu AENIRTGRCVTPALELVAPQPHWRADAARIIARIQMACGAKALRVDHIGS
MAB_2298|M.abscessus_ATCC_1997 AHNLRMRQRAPWRPELMPADPTWPVQAQRVINRLAVACGSRALRIDHIGS
MSMEG_2076|M.smegmatis_MC2_155 ------------PVAIVAPDPRWPARYRRLAEQIRAALGPVVLDLDHVGS
:..:* * *: :: : * . :**:**
Mflv_3559|M.gilvum_PYR-GCK TAVPD------LDAKDVIDVQVTVESLDVADELTDALQAAGYVR-TQITG
Mvan_3353|M.vanbaalenii_PYR-1 TAVPG------LDAKDVIDVQVTVASLEVADGLADALLGAGYVR-TPVTT
Mb1657|M.bovis_AF2122/97 TAVS---GFPDFLAKDVIDIQVTVESLDVADELAEPLLAAGYPRLEHITQ
Rv1631|M.tuberculosis_H37Rv TAVS---GFPDFLAKDVIDIQVTVESLDVADELAEPLLAAGYPRLEHITQ
MLBr_01383|M.leprae_Br4923 TAVPHYPGFPDFQAKDIIDIQITVESLAMADELADPLLSAGYPRLEHVTG
MMAR_2434|M.marinum_M TAVAG------FDAKDVIDIQVTVESLAVADELAEGLRSAGYPRLEHITQ
MUL_1613|M.ulcerans_Agy99 TAVAG------FDAKDVIDIQVTVESLAVADELAEGLRSASYPRLEHITQ
MAV_3151|M.avium_104 TALPG---DPDFAAKDVIDIQITVESLAAADELVEPLLAAGYPRLEHITA
TH_0576|M.thermoresistible__bu TAVDG------LSAKDVIDIQVTVGSLDAADEIAEPLARVGYPRRAEITS
MAB_2298|M.abscessus_ATCC_1997 TAVPG------LDAKDVIDIQVTVESLAVADTLADPLAGIGLPSIPGITT
MSMEG_2076|M.smegmatis_MC2_155 TSVPG------LAAKDVIDIDLTVGDPRDESAYVPALQNLGYRLTVREP-
*:: : ***:**:::** . . . * . .
Mflv_3559|M.gilvum_PYR-GCK DVAKPDARSTASPFDHSDDAAHWAKRLFCSADPGRPTNVHVRVDGWPNQQ
Mvan_3353|M.vanbaalenii_PYR-1 DISKPDPRSTVAEFDH-EGGDGWLKRLYCSADPGRPTNVHVRVDGRPGQQ
Mb1657|M.bovis_AF2122/97 DTEKTDARSTVGRYDHTDSAALWHKRVHASADPGRPTNVHLRVHGWPNQQ
Rv1631|M.tuberculosis_H37Rv DTEKTDARSTVGRYDHTDSAALWHKRVHASADPGRPTNVHLRVHGWPNQQ
MLBr_01383|M.leprae_Br4923 DAAKTNARSTVDRYEHSSDPNLWHKRFHASADPGRPTYVHIRVAGWPNQQ
MMAR_2434|M.marinum_M DNPKEDPRSLIDHYDHGRDPALWHKRFHASADPGRPTNVHIRVDGWPNQQ
MUL_1613|M.ulcerans_Agy99 DNPKEDPRSLIDHYDHGRDPALWHKRFHASADPGRPTNVHIRVDGWPNQQ
MAV_3151|M.avium_104 DVAKPDARSTVERYDHTDDPALWHKRIHASADPGRPTNVHIRVDGWPGQQ
TH_0576|M.thermoresistible__bu DVAKPDARSTVAEFDHSADASLWRKRLHGAADPGRPANIHIRVDGWPNQQ
MAB_2298|M.abscessus_ATCC_1997 DDP------------HDSDTAHWGKRIHAAADPGRAVLVHVRVDGWPGQR
MSMEG_2076|M.smegmatis_MC2_155 ---------------------GWHQHRCLRLDVPR-ANLHVFGPDCPEVV
* :: * * . :*: . *
Mflv_3559|M.gilvum_PYR-GCK FALLFVDWLTDNPAVRTEYADLKRRVAAEDH----PTTGAYADAKEPWFL
Mvan_3353|M.vanbaalenii_PYR-1 FALLFVAWLNANPAVRAEYLDVKRRVAAQEH----AMTGAYAEAKEPWFL
Mb1657|M.bovis_AF2122/97 FALLFVDWLAANPGAREDYLTVKCDADRRAD----GELARYVTAKEPWFL
Rv1631|M.tuberculosis_H37Rv FALLFVDWLAANPGAREDYLTVKCDADRRAD----GELARYVTAKEPWFL
MLBr_01383|M.leprae_Br4923 FGLLFVDWLKANPGVRADYLDVKRTADRLAA----GDMGRYADAKEPWLL
MMAR_2434|M.marinum_M FALLFVDWLRANPGARADYLAIKRDAEKQAALAGGGGVEHYVTTKEPWFL
MUL_1613|M.ulcerans_Agy99 FALLFVDWLRANPGARADYLAIKRDAEKQAALAGGG-VEHYVTTKEPWFL
MAV_3151|M.avium_104 FALLFVDWLTADPDARADYLAVKRSAEQQAD----GDIDAYVAVKEPWFR
TH_0576|M.thermoresistible__bu FALLFADWLNAEPAVRDEYLSVKQRAVSTGD------LDAYTEAKEPWFA
MAB_2298|M.abscessus_ATCC_1997 FALIFRDWLRSDHQACAEYLSIKQAAERAAAAAG-GDPGAYVDAKEPWFA
MSMEG_2076|M.smegmatis_MC2_155 RHRMFRDWLRSHPDDRESYENAKRAAVPGGG-----HVMDYNARKQPVIR
:* ** . .* * . * *:* :
Mflv_3559|M.gilvum_PYR-GCK DAYRRAWQWADTTGWRPAGPR-------
Mvan_3353|M.vanbaalenii_PYR-1 DAYRRAWEWADTTGWRP-----------
Mb1657|M.bovis_AF2122/97 DAYQRAWEWADAVHWRP-----------
Rv1631|M.tuberculosis_H37Rv DAYQRAWEWADAVHWRP-----------
MLBr_01383|M.leprae_Br4923 DAYRRAWEWADSTGWRL-----------
MMAR_2434|M.marinum_M DAYRRAWEWADSTGWRP-----------
MUL_1613|M.ulcerans_Agy99 DAYRRAWEWADSTGWRP-----------
MAV_3151|M.avium_104 DAYRRAWDWADSTGWKP-----------
TH_0576|M.thermoresistible__bu EAYRRAWDWADRTGWRXRASSVTSGSST
MAB_2298|M.abscessus_ATCC_1997 QAYTRALDWANASQWTP-----------
MSMEG_2076|M.smegmatis_MC2_155 EIYDRMFRAEGLL---------------
: * * .