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VLIAIEGVDGAGKRTLSEELRQAFEATGKSVATLAFPRYRQSVAADIAAEALHGQHGDLASSVYAMALLF AFDRAGAVEDIEALDRNHDIVILDRYVASNAAYSAARLHEDCSGRAVAWVQRIEYQRLRLPSPDWQVLLA VSVELAGKRSRYRARTDPDRLRDSYERDDGLQQRTGAVYAGLAAADWGGRWLVVDADIDSGWLVATLMGC
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. leprae Br4923 | MLBr_00772 | tmk | - | 100% (210) | thymidylate kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3275c | tmk | 2e-86 | 77.78% (207) | thymidylate kinase |
| M. gilvum PYR-GCK | Mflv_4714 | - | 6e-75 | 67.46% (209) | thymidylate kinase |
| M. tuberculosis H37Rv | Rv3247c | tmk | 2e-86 | 77.78% (207) | thymidylate kinase |
| M. abscessus ATCC 19977 | MAB_3594c | - | 2e-63 | 60.82% (194) | thymidylate kinase |
| M. marinum M | MMAR_1298 | tmk | 6e-88 | 77.88% (208) | thymidylate kinase Tmk |
| M. avium 104 | MAV_4210 | - | 9e-86 | 76.33% (207) | thymidylate kinase |
| M. smegmatis MC2 155 | MSMEG_1873 | - | 1e-75 | 69.00% (200) | thymidylate kinase |
| M. thermoresistible (build 8) | TH_0464 | tmk | 9e-74 | 65.87% (208) | PROBABLE THYMIDYLATE KINASE TMK (dTMP KINASE) (THYMIDYLIC |
| M. ulcerans Agy99 | MUL_2583 | tmk | 4e-88 | 77.88% (208) | thymidylate kinase |
| M. vanbaalenii PYR-1 | Mvan_1750 | - | 3e-74 | 66.83% (208) | thymidylate kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4714|M.gilvum_PYR-GCK --MLIVIEGVDGAGKRTLTNGLRAAFESGGRSVATLAFPRYGVSVPADVA
Mvan_1750|M.vanbaalenii_PYR-1 --MLIVIEGVDGAGKRTLTNGLRAAFESDGRSVATLAFPRYGVSVPADLA
MSMEG_1873|M.smegmatis_MC2_155 --MLIAIEGVDGAGKRTLTNGLRAAFETNHKSVASLAFPRYHQSVPADLA
TH_0464|M.thermoresistible__bu --VLIAIEGVDGAGKRTLTDGLRAALVSSHRSVADLAFPRYGRSITADLA
Mb3275c|M.bovis_AF2122/97 --MLIAIEGVDGAGKRTLVEKLSGAFRAAGRSVATLAFPRYGQSVAADIA
Rv3247c|M.tuberculosis_H37Rv --MLIAIEGVDGAGKRTLVEKLSGAFRAAGRSVATLAFPRYGQSVAADIA
MLBr_00772|M.leprae_Br4923 --MLIAIEGVDGAGKRTLSEELRQAFEATGKSVATLAFPRYRQSVAADIA
MMAR_1298|M.marinum_M --MLIAIEGVDGAGKRTLSEGLRKEFEAAGRSVATLAFPRYGNSVTADIA
MUL_2583|M.ulcerans_Agy99 --MLIAIEGVDGAGKRTLSEGLRKEFEAAGRSVATLAFPRYGNSVTADIA
MAV_4210|M.avium_104 --MLIAIEGVDGAGKRTLAEGLRKAFEAAGQSVATLAFPRYGRSVTADIA
MAB_3594c|M.abscessus_ATCC_199 MGQLIAIEGVDGAGKRTLTEKLIARGNSQGLSVATLDFPRYGRSVHADLA
**.************ : * : *** * **** *: **:*
Mflv_4714|M.gilvum_PYR-GCK AEALHGQHGDLADSVYAMAMLFAMDRAGARDEIGHLTSAYSVVILDRYVA
Mvan_1750|M.vanbaalenii_PYR-1 AEALHGAHGDLAESVYAMAVLFAMDRAGARDEIDHLKSAYDVVLLDRYVA
MSMEG_1873|M.smegmatis_MC2_155 AEALRGSHGDLAESVYAMATLFALDRAGAREQIEHLQAAYDVVILDRYVA
TH_0464|M.thermoresistible__bu AEALHGQHGDLASSVYAMAVLFAIDRAGARDHITELLATHDVVILDRYVA
Mb3275c|M.bovis_AF2122/97 AEALHGEHGDLASSVYAMATLFALDRAGAVHTIQGLCRGYDVVILDRYVA
Rv3247c|M.tuberculosis_H37Rv AEALHGEHGDLASSVYAMATLFALDRAGAVHTIQGLCRGYDVVILDRYVA
MLBr_00772|M.leprae_Br4923 AEALHGQHGDLASSVYAMALLFAFDRAGAVEDIEALDRNHDIVILDRYVA
MMAR_1298|M.marinum_M AEALHGEHGDLASSVFAMATLFALDRAAAVDEIHGLCLAYEVVILDRYVA
MUL_2583|M.ulcerans_Agy99 AEALHGEHGDLASSVFAMATLFALDRAAAVDEIHGLCLAYEVVILDRYVA
MAV_4210|M.avium_104 AEALHGEHGDLASSVYAMAMLFALDRAAAVGDIEGLRRDHDVVIMDRYVA
MAB_3594c|M.abscessus_ATCC_199 AESLKGGHGDVVSSAYAMGLLFALDRRDARDELAGLTRSHDLVILDRWVA
**:*:* ***:..*.:**. ***:** * : * :.:*::**:**
Mflv_4714|M.gilvum_PYR-GCK SNAAYSAARLHQGADGDVVAWVRDLEYGRLKLPVPTWQVLLDVPTELAAQ
Mvan_1750|M.vanbaalenii_PYR-1 SNAAYSAARLHQGVDGDVAAWVGDLEYGRLRLPKPDWQVLLDVPTELAAQ
MSMEG_1873|M.smegmatis_MC2_155 SNAAYSAARLHQGVDGEVVTWVHELEFGRLHLPVPDWQVLLNVPTELAAQ
TH_0464|M.thermoresistible__bu SNAAYSAARLHQGVDGEVVEWVRALEFDRLQLPRPDRQILLDVPAELAAE
Mb3275c|M.bovis_AF2122/97 SNAAYSAARLHENAAGKAAAWVQRIEFARLGLPKPDWQVLLAVSAELAGE
Rv3247c|M.tuberculosis_H37Rv SNAAYSAARLHENAAGKAAAWVQRIEFARLGLPKPDWQVLLAVSAELAGE
MLBr_00772|M.leprae_Br4923 SNAAYSAARLHEDCSGRAVAWVQRIEYQRLRLPSPDWQVLLAVSVELAGK
MMAR_1298|M.marinum_M SNAAYSAARLHQDSAGEAVAWVGRMEYERFGLPEPDWQVLLAVPVELAGE
MUL_2583|M.ulcerans_Agy99 SNAAYSAARLHQDSAGEAVAWVGRMEYERFGLPEPDWQVLLAVPVELAGE
MAV_4210|M.avium_104 SNAAYTAARLHQDADGPAVAWVHTLEYGRLKLPAPDRQVLLAVSAELAAE
MAB_3594c|M.abscessus_ATCC_199 SNAAYGAARLHQDGGGDMARWVHQLEYERFGLPHPDWQVFLDVSPELAQQ
***** *****:. * . ** :*: *: ** * *::* *. *** :
Mflv_4714|M.gilvum_PYR-GCK RAVNRAAEDAARARDAYERDDGLQRRTGAVYAELAAAQWGGPWAVIPPDV
Mvan_1750|M.vanbaalenii_PYR-1 RAVSRAAREADRARDAYERDDGLQRRTSAVYAELAAANWGGPWVVVPPDV
MSMEG_1873|M.smegmatis_MC2_155 RAEHRANTEADRAKDAYERDDGLQRRTGEVYAALAAADWGGRWAIAGPDV
TH_0464|M.thermoresistible__bu RAERRAEQEVDRARDAYERDDGLQRRTAAVYTALAAAEWGGRWSVVGPDV
Mb3275c|M.bovis_AF2122/97 RSRGRAQRDPGRARDNYERDAELQQRTGAVYAELAAQGWGGRWLVVGADV
Rv3247c|M.tuberculosis_H37Rv RSRGRAQRDPGRARDNYERDAELQQRTGAVYAELAAQGWGGRWLVVGADV
MLBr_00772|M.leprae_Br4923 RSRYRARTDPDRLRDSYERDDGLQQRTGAVYAGLAAADWGGRWLVVDADI
MMAR_1298|M.marinum_M RSRGRARSDPGRPRDSYERDDGLQQRTGSVYAELAAAGWGGRWLVVDADV
MUL_2583|M.ulcerans_Agy99 RSRGRARSDPGRPRDSYERDDGLQQRTGSVYAELAAAGWGGRWLVVDADV
MAV_4210|M.avium_104 RARSRAESDPGRARDSYERDDGLQQRTGAVYAQLAAAGWGGAWRVVDADV
MAB_3594c|M.abscessus_ATCC_199 RARQREQQESDRARDTYERDSDLQQRVSAAYADLAQRDWGGPWMITDG-V
*: * : * :* **** **:*.. .*: ** *** * : :
Mflv_4714|M.gilvum_PYR-GCK DAAELAARLLG-------------
Mvan_1750|M.vanbaalenii_PYR-1 DAAALADRLVSSR-----------
MSMEG_1873|M.smegmatis_MC2_155 DATALADRLSSG------------
TH_0464|M.thermoresistible__bu DPAALAATLVDG------------
Mb3275c|M.bovis_AF2122/97 DPGRLAATLAPPDVPS--------
Rv3247c|M.tuberculosis_H37Rv DPGRLAATLAPPDVPS--------
MLBr_00772|M.leprae_Br4923 DSGWLVATLMGC------------
MMAR_1298|M.marinum_M DPGALAATLMSPTAPEG---GN--
MUL_2583|M.ulcerans_Agy99 DPGALAATLMSPTAPEGEIEGYLP
MAV_4210|M.avium_104 DPARLAADLAAE------------
MAB_3594c|M.abscessus_ATCC_199 EPEALAAQLLRRA-----------
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