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MARLTVIATGGTISTGTGADGVHRPCYRGADLTAPFRADHDVEVVDLLAVDSSELTLADWDRMRGAVTAA LDGGADGVVILHGTDTMEETALWLDLTYDGPAPVVLTGAMRSADAPDADGPGNVRDALAVAAHPAARGLG VLLCFAGRVLQPLGLSKVATEDLSGFAGRLVGTVAGDVALTGPKTRPYLGDLGAAAAPRVDIVAAYLGSD AVALDACVAAGARAVVLEALGSGNAGPAVVDAVRRHCGTGVVIAVSTRVPGGRVGASYGPGHEMAAAGAV PVPTLRPPQARVLLIAALAAGLPAADVLGRWG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3233 | - | - | 100% (312) | L-asparaginase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1565c | ansA | 1e-122 | 73.02% (315) | L-aparaginase ansA |
| M. gilvum PYR-GCK | Mflv_3641 | - | 1e-104 | 62.94% (313) | asparaginase/glutaminase |
| M. tuberculosis H37Rv | Rv1538c | ansA | 1e-122 | 73.02% (315) | L-aparaginase ansA |
| M. leprae Br4923 | MLBr_01198 | ansA | 1e-123 | 72.76% (312) | L-asparaginase/L-glutaminase |
| M. abscessus ATCC 19977 | MAB_2701 | - | 3e-74 | 49.20% (311) | L-asparaginase |
| M. marinum M | MMAR_2360 | ansA | 1e-123 | 71.38% (318) | L-aparaginase AnsA |
| M. smegmatis MC2 155 | MSMEG_3173 | - | 1e-102 | 62.97% (316) | L-asparaginase |
| M. thermoresistible (build 8) | TH_1295 | ansA | 1e-67 | 64.11% (209) | Probable L-aparaginase ansA |
| M. ulcerans Agy99 | MUL_1536 | ansA | 1e-122 | 71.07% (318) | L-aparaginase AnsA |
| M. vanbaalenii PYR-1 | Mvan_2772 | - | 1e-107 | 65.38% (312) | asparaginase/glutaminase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1565c|M.bovis_AF2122/97 ---MGANHVRNDPIMARLTVITTGGTISTTAGPDGVLRPTHCGATLIAGL
Rv1538c|M.tuberculosis_H37Rv ---MGANHVRNDPIMARLTVITTGGTISTTAGPDGVLRPTHCGATLIAGL
MMAR_2360|M.marinum_M --------------MARLTVITTGGTISTSTGTDGVRRPSRNGAQLTAAV
MUL_1536|M.ulcerans_Agy99 ---MPMTWVRDDPTMARLTVITTGGTISTSTGTDGVRRPSRNGAQLTAAV
MLBr_01198|M.leprae_Br4923 --------------MSRLTVIATGGTISTSTDHDGVRRPAYSGTELTAHV
MAV_3233|M.avium_104 --------------MARLTVIATGGTISTGTGADGVHRPCYRGADLTAPF
Mflv_3641|M.gilvum_PYR-GCK --------------MGRLVVIATGGTISTSSDADGVKRPTRSGADLTAG-
Mvan_2772|M.vanbaalenii_PYR-1 --------------MDRLVVIATGGTIATSTGTDGVKRPARSGTELTEG-
MSMEG_3173|M.smegmatis_MC2_155 -----------MNPSAQVVLITTGGTISTSTDNAGVRRPTRRGAQLTAAL
TH_1295|M.thermoresistible__bu ---------------VSLVVLATGGTIATSTDADGVRRPTRTGADLTAGL
MAB_2701|M.abscessus_ATCC_1997 MIAAVPAALRPNDSSPALVLLTTGGTIATEVGADGIARHASSGGDLLAAS
:.:::*****:* . *: * * *
Mb1565c|M.bovis_AF2122/97 DM---DSDIEVVDLMALDSSKLTPADWDRIGAAVQEAFRGGAD------G
Rv1538c|M.tuberculosis_H37Rv DM---DSDIEVVDLMALDSSKLTPADWDRIGAAVQEAFRGGAD------G
MMAR_2360|M.marinum_M SG---DLDVEIVDLMALDSSQLVPADWDRIRAALHAITGRGADRPNGPDG
MUL_1536|M.ulcerans_Agy99 SG---DLDVEIVDLMALDSSQLVPADWDRIRAALHAITGRGADRPNGPDG
MLBr_01198|M.leprae_Br4923 AV---D--VDVVDLMTVDSSQLIPTDWDRIRAAVHTATRNGAR------G
MAV_3233|M.avium_104 RA---DHDVEVVDLLAVDSSELTLADWDRMRGAVTAALDGGAD------G
Mflv_3641|M.gilvum_PYR-GCK ------LDVEVVDALSVDSSALTPSDWDLISAAVRQAASAETTD-----G
Mvan_2772|M.vanbaalenii_PYR-1 ------LDVEVVDALAVDSSMLTPPDWDRIGAAVLAAATSGAS------G
MSMEG_3173|M.smegmatis_MC2_155 TAPT-APTVSVVDLMTTDSSHLTPSDWDAIREAVAKATDGPGGP----DG
TH_1295|M.thermoresistible__bu TPDAGIHDVEIKDLMAVDSSALTPADWDRIATAVADAADRGAT------G
MAB_2701|M.abscessus_ATCC_1997 GQ----GNVLVEDLMTIDSAEMTPQRWQQIAASVRGHVAAGAT------G
: : * :: **: : *: : :: *
Mb1565c|M.bovis_AF2122/97 VVITHGTDTLEETALWLDLTYAGSRPVVLTGAMLSADAPGADGPANLRDA
Rv1538c|M.tuberculosis_H37Rv VVITHGTDTLEETALWLDLTYAGSRPVVLTGAMLSADAPGADGPANLRDA
MMAR_2360|M.marinum_M VVITHGTDTLEETALWLDLTYSGSTPVVLTGAMRSSDAADADGPANLRDA
MUL_1536|M.ulcerans_Agy99 VVITHGTDTLEETALWLDLTYSGSTPVVLTGAMRSSDAADADGPANLRDA
MLBr_01198|M.leprae_Br4923 VVVTHGTDTMEETALWLDLTYAGNVPVVLTGAMRSADAPNADGPTNLREA
MAV_3233|M.avium_104 VVILHGTDTMEETALWLDLTYDGPAPVVLTGAMRSADAPDADGPGNVRDA
Mflv_3641|M.gilvum_PYR-GCK IVVLHGTDTMEETALWLELTYDGAPPVVLTGAQRSADDPDGDGPANLRDA
Mvan_2772|M.vanbaalenii_PYR-1 IVVTHGTDTMEETALWLELTYDGEVPVVLTGAQRSADADDADGPANLRDA
MSMEG_3173|M.smegmatis_MC2_155 VVITHGTDSLEETALWLELTHTGDTPVVITGAQRSSDAPEADGPRNLADA
TH_1295|M.thermoresistible__bu VVVTHGTDTLEETALWLELTYSGSVPVVVTGAQRSADAPDADGPRNLRDA
MAB_2701|M.abscessus_ATCC_1997 IVIAHGTDTLEETALWLALTCAVPVPVVLTGAQRSGDHPESDGPGNLRDA
:*: ****::******* ** ***:*** *.* .*** *: :*
Mb1565c|M.bovis_AF2122/97 LAVAADPAARDLGVLVSFGGRVLQPLGLHKVANPDLCGFAGES-LGFTSG
Rv1538c|M.tuberculosis_H37Rv LAVAADPAARDLGVLVSFGGRVLQPLGLHKVANPDLCGFAGES-LGFTSG
MMAR_2360|M.marinum_M LIVAGDPAVRDCGVLVCFAGRVLEPLGLRKAATDDLSGFAGEL-LGTVTD
MUL_1536|M.ulcerans_Agy99 LIVAGDPAVRDCGVLVCFARRVLEPLGLRKAATDDLSGFAGEL-LGTVTD
MLBr_01198|M.leprae_Br4923 LAVAASPAARGVGVLVSFAGRVLQPLGLRKAATQDLSGFAGEL-LGTSSS
MAV_3233|M.avium_104 LAVAAHPAARGLGVLLCFAGRVLQPLGLSKVATEDLSGFAGRL-VGTVAG
Mflv_3641|M.gilvum_PYR-GCK LTLAALPELRGAGVVVSFAGAVFEALGVHKVATTDPQSFAGR--------
Mvan_2772|M.vanbaalenii_PYR-1 LAVAARPESRGLGVVVSFAGAVFEALGLNKVATSDLQSFTGR--------
MSMEG_3173|M.smegmatis_MC2_155 IAVAASPDARGLGVLVCFAGTVRAPLGLHKRHTQELDAFSGTA-LGTVAD
TH_1295|M.thermoresistible__bu LTVAASPDADGLGVLVSFAGTVFAPLGLSKIAGAGLQSFAGSV-VGNVGD
MAB_2701|M.abscessus_ATCC_1997 LTVAASGEA--LGVVVCFAGQVFPAAGIRKVDLTATAGFAGAPPVGQIRD
: :*. **::.*. * . *: * .*:*
Mb1565c|M.bovis_AF2122/97 -GVRLTRTKTRPYLGDLGAAVAPRVDIVAVYPGSDAVAMDACVAAGARAV
Rv1538c|M.tuberculosis_H37Rv -GVRLTRTKTRPYLGDLGAAVAPRVDIVAVYPGSDAVAMDACVAAGARAV
MMAR_2360|M.marinum_M -EVTLRRAKSRPYLGDVLAADAPRVDIVAVYPGSDAVALDACVAAGARAI
MUL_1536|M.ulcerans_Agy99 -EVTLRRAKSRPYLGDVLAADAPRVDIVAVYPGSDAVALDACVAAGARAI
MLBr_01198|M.leprae_Br4923 -GFALTAAKTRPYLGDLCAADAPRVDIVAAYLGSDSVALDAYVSTGARGI
MAV_3233|M.avium_104 -DVALTGPKTRPYLGDLGAAAAPRVDIVAAYLGSDAVALDACVAAGARAV
Mflv_3641|M.gilvum_PYR-GCK ---RLTGHRTRPYLGRVDAASAPRVDIVAAYPGANTAALDACVAAGARGI
Mvan_2772|M.vanbaalenii_PYR-1 ---VVDGGRRRPYLGALRAADAPRVDIVAAYPGADTAALDACVAAGARGI
MSMEG_3173|M.smegmatis_MC2_155 GTVELTEDKTRPVLGALSAAAAPRVDIVAGYPGADAAALDACVAAGARGV
TH_1295|M.thermoresistible__bu GRCVLSDPGVRPQLGPVSAGSAPRVDIIAAYPGGX---------------
MAB_2701|M.abscessus_ATCC_1997 GAFVRTAQASSSFLGTVTRPALPRVDVVSLYPGADAVALDAFARAGAQGL
. ** : ****::: * *.
Mb1565c|M.bovis_AF2122/97 VLEALGSGNAGAAVIEGVRRHCRDGSDPVVIAVSTRVAGARVGAGYGPGH
Rv1538c|M.tuberculosis_H37Rv VLEALGSGNAGAAVIEGVRRHCRDGSDPVVIAVSTRVAGARVGAGYGPGH
MMAR_2360|M.marinum_M VLEALGSGNAGAAVIDGVRRHCGNG---VVIAVSTRVAGARVGAGYGPGH
MUL_1536|M.ulcerans_Agy99 VLEALGSGNAGAAVIDGVRRHCGNG---VVIAVSTRVAGARVGAGYGPGH
MLBr_01198|M.leprae_Br4923 VLEALGSGNAGAAVVDGVRRHCHNG---IVIAVSTRVPEGHVSAGYGPGH
MAV_3233|M.avium_104 VLEALGSGNAGPAVVDAVRRHCGTG---VVIAVSTRVPGGRVGASYGPGH
Mflv_3641|M.gilvum_PYR-GCK VLQAMGSGNAGRELIDGVRRHCRAG---VAVVVSTRVPGGPVRPGYGPGR
Mvan_2772|M.vanbaalenii_PYR-1 VLEGLGSGNAGAALIAGVRRHCRDG---VAVAVSTRVAGGRVSAGYGPGR
MSMEG_3173|M.smegmatis_MC2_155 VLEAMGSGNLGAALTEGVERHLRAG---VEIVVSTRVPGGVIAPDYGPGR
TH_1295|M.thermoresistible__bu ---------------------XXGG------------VGGHVASSRRFRV
MAB_2701|M.abscessus_ATCC_1997 VLESMGAGNANDAVTEAVSRHIENG---IHVVVTTRVPGGLLSPGYAPGQ
* . : ..
Mb1565c|M.bovis_AF2122/97 DLVEAGAVMVPRLPPSQARVLLMAALAANSPVADVIDRWG
Rv1538c|M.tuberculosis_H37Rv DLVEAGAVMVPRLPPSQARVLLMAALAANSPVADVIDRWG
MMAR_2360|M.marinum_M DLVAAGAVMVPRLPPSQARVLLMAALTAELPIVEVIDRWG
MUL_1536|M.ulcerans_Agy99 DLVAAGAVMVPRLPPSQARVLLMAALTAELPIVEVIDRWG
MLBr_01198|M.leprae_Br4923 DLVEAGAVLVPWLRPSQVRVLLMAALAANLPIADVIERWG
MAV_3233|M.avium_104 EMAAAGAVPVPTLRPPQARVLLIAALAAGLPAADVLGRWG
Mflv_3641|M.gilvum_PYR-GCK DLVDAGAVVAPSLRPPQARVLLMAALATGAPIGDTFTRWG
Mvan_2772|M.vanbaalenii_PYR-1 ELVDGDAFVVPRLRPPQARVLLMAALAAGAAPGQVFARWG
MSMEG_3173|M.smegmatis_MC2_155 RLADAGAVVAPRLRPPQARVLLMAALAAQRPVREVFSSWG
TH_1295|M.thermoresistible__bu DLVDTDPVRSRNSSP--TRRTLIA----------------
MAB_2701|M.abscessus_ATCC_1997 KLIDAGAVVAPRLRAGQARVLLMAALATGSDLVAVIDRLG
: ... . .* *:*