For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. avium 104 MAV_1543 (mce)

annotation: methylmalonyl-CoA epimerase
coordinates: 1500839 - 1501303
length: 154

TTDQVDARQVLATALVTAIDHVGIAVADLDAAIAWYHDHLGMILVHEEVNEEQGIREAMLAVRGAPAGTA
QLQLMAPIDDSSTIAKFLDKRGPGIQQMAMRVSDLDTLIERLREQGVRLIYDAPRRGTANSRINFIHPKD
AGGVLIELVEPAA*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. avium 104MAV_1543mce-100% (154)methylmalonyl-CoA epimerase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1357c-7e-6678.43% (153) hypothetical protein Mb1357c
M. gilvum PYR-GCKMflv_2339-1e-7283.12% (154) glyoxalase/bleomycin resistance protein/dioxygenase
M. tuberculosis H37Rv-----
M. leprae Br4923MLBr_01157-1e-6777.92% (154) hypothetical protein MLBr_01157
M. abscessus ATCC 19977MAB_1462c-7e-5766.89% (151) hypothetical protein MAB_1462c
M. marinum MMMAR_4076gloA_11e-6579.08% (153) glyoxalase, GloA_1
M. smegmatis MC2 155MSMEG_4921mce7e-6877.78% (153) methylmalonyl-CoA epimerase
M. thermoresistible (build 8)TH_1535-5e-6979.74% (153) CONSERVED HYPOTHETICAL PROTEIN
M. ulcerans Agy99MUL_3939gloA_17e-6679.08% (153) glyoxalase, GloA_1
M. vanbaalenii PYR-1Mvan_4306-7e-7080.39% (153) glyoxalase/bleomycin resistance protein/dioxygenase

CLUSTAL 2.0.9 multiple sequence alignment


MMAR_4076|M.marinum_M               -------MTTDQVDARQILETSLVTGLDHVGIAVADLDAAIEWYHDHLGL
MUL_3939|M.ulcerans_Agy99           -------MTTDQVDARQILETSLVTGLDHVGIAVADLDAAIKWYHDHLGL
Mb1357c|M.bovis_AF2122/97           ------MMTTDQVHARHMLATSLVTGLDHVGIAVADLDVAIEWYHDHLGM
MLBr_01157|M.leprae_Br4923          ------MMTTDQINTCQLLATTLVITIDHVGIAVADLNAAISWYHDHLGM
MAV_1543|M.avium_104                -------MTTDQVDARQVLATALVTAIDHVGIAVADLDAAIAWYHDHLGM
Mflv_2339|M.gilvum_PYR-GCK          MLGYVFFMTAEQTDARPVLATALVTAIDHVGIAVPDLDAAIKWYHDHLGM
Mvan_4306|M.vanbaalenii_PYR-1       -------MTAEQTDARPVLATALVTAIDHVGIAVPDLDAAIKWYHDHLGM
MSMEG_4921|M.smegmatis_MC2_155      -------MTTEHVDARPALASALVTAIDHVGIAVPDLDAAAKWYHDHLGM
TH_1535|M.thermoresistible__bu      -------MTTDQVDARPLLPTALVTAVDHVGIAVADLDAAIKWYHDNLGM
MAB_1462c|M.abscessus_ATCC_199      ------MTTSSPLDVPAILSTGLVTAIDHVGIAVPDLDVAIEWYHEHLGM
                                            *:.  ..   * : **  :*******.**:.*  ***::**:

MMAR_4076|M.marinum_M               ILVHEEVNDDQGIREAMLAVPSAPE-TTQIQLMAPIDESSVIAKFLHKRG
MUL_3939|M.ulcerans_Agy99           ILVHEEVNDDQGIREAMLAVPSAPE-TTQIQLMAPIDESSVIAKFLQKRG
Mb1357c|M.bovis_AF2122/97           ILVHEEINDDQGIREALLAVPGS---AAQIQLMAPLDESSVIAKFLDKRG
MLBr_01157|M.leprae_Br4923          ILVHEEVNDDQGIREAMLSAHGAPIGTTQIQLMAPINESSPIAKFLDKHG
MAV_1543|M.avium_104                ILVHEEVNEEQGIREAMLAVRGAPAGTAQLQLMAPIDDSSTIAKFLDKRG
Mflv_2339|M.gilvum_PYR-GCK          IVLHEEVNEEQGVREAMLSVRGAPVGSAQIQLMAPLDETSTIAKFLDKRG
Mvan_4306|M.vanbaalenii_PYR-1       IVLHEEVNEEQGVREAMLTVRGAAVGSAQIQLMSPLDETSTIAKFIDKRG
MSMEG_4921|M.smegmatis_MC2_155      IVLHEEINEEQGVREAMLSVRGAPKGSAQIQLLAPIDEKSTIAKFIDTRG
TH_1535|M.thermoresistible__bu      IVLHEEVNEEQGVREAMLSVRGAPVGSTQIQLMAPLGPDSTIAKFLDKRG
MAB_1462c|M.abscessus_ATCC_199      ILVHEEINEGQGVREAMLSFPGAEPGSAQIQLMSPLHASSPIGKFLDTKG
                                    *::***:*: **:***:*:  .:   ::*:**::*:   * *.**:..:*

MMAR_4076|M.marinum_M               PGIQQFACRVRNLEKLSEQLRAQGIRLVYETPRRGTADSRINFIHPKDAG
MUL_3939|M.ulcerans_Agy99           PGIQQFACRVRNLEKLSEQLRAQGIRLVYETPRRGTADSRINFIHPKDAG
Mb1357c|M.bovis_AF2122/97           PGIQQLACRVSDLDAMCRRLRSQGVRLVYETARRGTANSRINFIHPKDAG
MLBr_01157|M.leprae_Br4923          PGIQQLACRVSDLDRLTKRLRAQGVRLVYDTPRQGTSNARINFIHPKDAG
MAV_1543|M.avium_104                PGIQQMAMRVSDLDTLIERLREQGVRLIYDAPRRGTANSRINFIHPKDAG
Mflv_2339|M.gilvum_PYR-GCK          PGLQQLAYRTSDIDTLSERLREQGVRLLYDAPRRGTSNSRINFIHPKDGG
Mvan_4306|M.vanbaalenii_PYR-1       PGLQQLAYRTSDIDALSERLREQGVRLLYDTPRRGTADSRINFVHPKDAG
MSMEG_4921|M.smegmatis_MC2_155      PGLQQLAYRTSDIDALSDRLRADGVRLLYDAPKRGTANSRINFIHPKDAG
TH_1535|M.thermoresistible__bu      PGLQQLAYRVRDIEAISEGLREQGIRLLYDEPRRGTANSRINFIHPKDAG
MAB_1462c|M.abscessus_ATCC_199      PGLQQLAYRVTDIDALTDQLRAAGVRVLYDEPRIGTANSRINFLHPKDTG
                                    **:**:* *. ::: :   **  *:*::*: .: **:::****:**** *

MMAR_4076|M.marinum_M               GVLIELVEPARRV-----
MUL_3939|M.ulcerans_Agy99           GVLIELVEPARRV-----
Mb1357c|M.bovis_AF2122/97           GVLIELVEPAP-------
MLBr_01157|M.leprae_Br4923          GVLIELVEPAS-------
MAV_1543|M.avium_104                GVLIELVEPAA-------
Mflv_2339|M.gilvum_PYR-GCK          GVLIELVEPASDGSGSAH
Mvan_4306|M.vanbaalenii_PYR-1       GVLIELVEPAKDSGEGSH
MSMEG_4921|M.smegmatis_MC2_155      GVLIELVEPSPE----EH
TH_1535|M.thermoresistible__bu      GVLIELVEPAPNG--SDH
MAB_1462c|M.abscessus_ATCC_199      GVLIELVQPTESH-----
                                    *******:*: