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PFPYQRPRRLRATPAIRRLVAETTLAPRQLVLPMFVADGLTEPKAISSLPGVVQHSTESLRRAAEDAVKA GVGGLMLFGVPQEKDKDATGSAGLCADGILNRALSVLSADLGDATVLMADTCLDEFTDHGHCGVLDAAGR VDNDATLTQYVHMAVAQANSGARVVGPSGMMDGQVAAIRAGLDAAGHSDVIIMAYTAKYASAFFGPFREA VGSSLRGDRRTYQQDVANGREALRELELDVQEGADIVMVKPAMAYLDVLRQVADVSPVPVAAYQVSGEYA MICAAAQNNWIDLQAMALETLTSIRRAGADIVLTYWAAEAAGWLSD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_3990c | - | - | 100% (327) | delta-aminolevulinic acid dehydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0525 | hemB | 1e-139 | 75.62% (324) | delta-aminolevulinic acid dehydratase |
| M. gilvum PYR-GCK | Mflv_0064 | - | 1e-137 | 72.84% (324) | delta-aminolevulinic acid dehydratase |
| M. tuberculosis H37Rv | Rv0512 | hemB | 1e-139 | 75.93% (324) | delta-aminolevulinic acid dehydratase |
| M. leprae Br4923 | MLBr_02419 | hemB | 1e-137 | 73.46% (324) | delta-aminolevulinic acid dehydratase |
| M. marinum M | MMAR_0845 | hemB | 1e-139 | 75.00% (324) | delta-aminolevulinic acid dehydratase HemB |
| M. avium 104 | MAV_4637 | hemB | 1e-128 | 76.61% (295) | delta-aminolevulinic acid dehydratase |
| M. smegmatis MC2 155 | MSMEG_0956 | hemB | 1e-142 | 75.62% (324) | delta-aminolevulinic acid dehydratase |
| M. thermoresistible (build 8) | TH_2257 | hemB | 1e-134 | 77.02% (309) | PROBABLE DELTA-AMINOLEVULINIC ACID DEHYDRATASE HEMB |
| M. ulcerans Agy99 | MUL_4601 | hemB | 1e-137 | 74.07% (324) | delta-aminolevulinic acid dehydratase |
| M. vanbaalenii PYR-1 | Mvan_0847 | - | 1e-139 | 73.62% (326) | delta-aminolevulinic acid dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0845|M.marinum_M --MGAYPRQRPRRLRSTAAMRRLVAQTSLEPRHLVLPMFVADGIEEPRPI
MUL_4601|M.ulcerans_Agy99 --MGAYPRQRPRRLRSTAAMRRLVAQTSLEPRHLVLPMFVADGIEEPRPI
MAV_4637|M.avium_104 ----------------------------------MLPMFVADGIDEPRPI
Mb0525|M.bovis_AF2122/97 MSMSSYPRQRPRRLRSTVAMRRLVAQTSLEPRHLVLPMFVADGIDEPRPI
Rv0512|M.tuberculosis_H37Rv MSMSSYPRQRPRRLRSTVAMRRLVAQTSLEPRHLVLPMFVADGIDEPRPI
MLBr_02419|M.leprae_Br4923 MSVSGYPRHRPRRLRSTPAMRRLVAQTSLEPRNLVLPMFVADGIDELRPI
Mflv_0064|M.gilvum_PYR-GCK ---MGFPRHRPRRLRTTPAMRRLVSETSLEPRHLVLPMFVADGLDEPRDI
Mvan_0847|M.vanbaalenii_PYR-1 ---MAFPRHRPRRLRTTPAMRRLVAQTSLEPRHLVLPMFVADGIEEPRDI
MSMEG_0956|M.smegmatis_MC2_155 ---MAFPRHRPRRLRTTPAMRRLVAQTSLEPRHLILPMFVADGIDEPRPI
TH_2257|M.thermoresistible__bu -------------------MRRLVAQTSLEPRHLVLPMFVADGIDEPRPI
MAB_3990c|M.abscessus_ATCC_199 ---MPFPYQRPRRLRATPAIRRLVAETTLAPRQLVLPMFVADGLTEPKAI
:********: * : *
MMAR_0845|M.marinum_M ASMPGVMQHTRDSLRSAAADAVSAGVGGLMLFGVPRDTSKDPVGSAGTDP
MUL_4601|M.ulcerans_Agy99 ASMPGVMQHTRDSLRSAAADAVSAGVGGLMLFGVPRDTSKDPVGSAGTDP
MAV_4637|M.avium_104 ASMPKVVQHTRDSLRAAAASAVAAGVGGLMLFGVPRDEEKDPIGSAGTDP
Mb0525|M.bovis_AF2122/97 TSMPGVVQHTRDSLRRAAAAAVAAGVGGLMLFGVPRDQDKDGVGSAGIDP
Rv0512|M.tuberculosis_H37Rv TSMPGVVQHTRDSLRRAAAAAVAAGVGGLMLFGVPRDQDKDGVGSAGIDP
MLBr_02419|M.leprae_Br4923 ASMPGVVQHTRDSLRRAAVAAVDAGVGGLNLFGVPRDQDKDATGSAGVDP
Mflv_0064|M.gilvum_PYR-GCK ASMPGVVQHTRESLRRAAAEAVEAGVGGLMLFGVPRDEDKDATGSIGVDP
Mvan_0847|M.vanbaalenii_PYR-1 TSMPGVVQHTRDSLRRAAADAVAAGVGGLMLFGVPRDEDKDPTGSVGVDP
MSMEG_0956|M.smegmatis_MC2_155 NSMPGVVQHTRDSLRRAAADAVAAGVGGLMLFGVPLDEDKDATGSVGVDP
TH_2257|M.thermoresistible__bu GSMPGVVQHTRESLRRAAAEAVGAGVGGLMLFGVPQEADKDATGSIGADE
MAB_3990c|M.abscessus_ATCC_199 SSLPGVVQHSTESLRRAAEDAVKAGVGGLMLFGVPQEKDKDATGSAGLCA
*:* *:**: :*** ** ** ****** ***** : .** ** *
MMAR_0845|M.marinum_M DGILNAALRDLAKDLGDATVLMADTCLDEFTDHGHCGVLDDRGRVDNDAT
MUL_4601|M.ulcerans_Agy99 DGILNAALRDLAKDLGDATVLMAETCLDEFTDHGHCGVLDDRGRVDNDAT
MAV_4637|M.avium_104 DGILNVALRDLAKDLGDATVLMADTCLDEFTDHGHCGVLDDRGRVDNDAT
Mb0525|M.bovis_AF2122/97 DGILNVALRDLAKDLGEATVLMADTCLDEFTDHGHCGVLDDRGRVDNDAT
Rv0512|M.tuberculosis_H37Rv DGILNVALRDLAKDLGEATVLMADTCLDEFTDHGHCGVLDDRGRVDNDAT
MLBr_02419|M.leprae_Br4923 DGILNVALRDLAEDLGDATVLMADTCLDEFTDHGHCGVLDGQGRVDNDAT
Mflv_0064|M.gilvum_PYR-GCK DGILNRALRDLTRDLGDDTVLMADTCLDEFTDHGHCGVVDPTGRVDNDLT
Mvan_0847|M.vanbaalenii_PYR-1 DGILNRALRDLAKDLGDSTVLMADTCLDEFTDHGHCGVLDPTGRVDNDLT
MSMEG_0956|M.smegmatis_MC2_155 DGILNVALRDLAKDLGDSTVLMADTCLDEFTDHGHCGVLDAHGRVDNDAT
TH_2257|M.thermoresistible__bu HGILNAALRDLTADLGDDTVLMADTCLDEFTDHGHCGVLDARGRVDNDAT
MAB_3990c|M.abscessus_ATCC_199 DGILNRALSVLSADLGDATVLMADTCLDEFTDHGHCGVLDAAGRVDNDAT
.**** ** *: ***: *****:**************:* ****** *
MMAR_0845|M.marinum_M VARYVELAVAQAQAGAHVVGPSGMMDGQVGAIRDGLDEAGHADVVILAYA
MUL_4601|M.ulcerans_Agy99 VARYVELAVAQAQAGAHVVGPSGMMDGQVGAIRDGLDEAGYADVVILAYA
MAV_4637|M.avium_104 VARYVNLAVAQAESGAHVVGPSGMMDGQVGAIRDGLDAAGFTDVVILAYA
Mb0525|M.bovis_AF2122/97 VARYVELAVAQAESGAHVVGPSGMMDGQVAAIRDGLDAAGYIDVVILAYA
Rv0512|M.tuberculosis_H37Rv VARYVELAVAQAESGAHVVGPSGMMDGQVAAIRDGLDAAGYIDVVILAYA
MLBr_02419|M.leprae_Br4923 VARYVELAVAQAESGANVVGPSGMMDGQIGALRDGLDSAGYADVAILAYA
Mflv_0064|M.gilvum_PYR-GCK NRRYVELAVAQANSGAQVVSPSGMMDGQVAAIRDGLDVAGYTHTAILAYS
Mvan_0847|M.vanbaalenii_PYR-1 NRRYVELAVAQANSGAHMVGPSGMMDGQVAAIRDGLDAAGYSETAILAYA
MSMEG_0956|M.smegmatis_MC2_155 NLRYVELAVAQADSGAHVVGPSGMMDGQVAAIRDGLDAAGHTDVAILAYS
TH_2257|M.thermoresistible__bu NARYVELAVAQAEAGAQVVSPSGMMDGQVAAIRAGLDAAGHTDVAILAYA
MAB_3990c|M.abscessus_ATCC_199 LTQYVHMAVAQANSGARVVGPSGMMDGQVAAIRAGLDAAGHSDVIIMAYT
:**.:*****::**.:*.********:.*:* *** **. .. *:**:
MMAR_0845|M.marinum_M AKFASAFYGPFREAVSCSLSGDRRTYQQEPGNMREALREVELDLDEGADI
MUL_4601|M.ulcerans_Agy99 AKFASAFYGPFREAVSCSLSGDRRTYQQEPGNMREALREVELDLDEGADI
MAV_4637|M.avium_104 AKFASAFYGPFREAVSSSLSGDRRTYQQETGNSREALREIRLDLDEGADI
Mb0525|M.bovis_AF2122/97 AKFASAFYGPFREAVSSSLSGDRRTYQQEPGNAAEALREIELDLDGGADI
Rv0512|M.tuberculosis_H37Rv AKFASAFYGPFREAVSSSLSGDRRTYQQEPGNAAEALREIELDLDEGADI
MLBr_02419|M.leprae_Br4923 AKFSSAFYGPFREAVSCSLSGDRRTYQQEPGNAREALREIKLDLDEGADI
Mflv_0064|M.gilvum_PYR-GCK AKFASGFYGPFREAVGSSLEGDRRTYQQDPGNGREALHEVRLDIEEGADI
Mvan_0847|M.vanbaalenii_PYR-1 AKFASGFYGPFREAVGSSLQGDRRTYQQDPGNAREALHEIQLDIDEGADI
MSMEG_0956|M.smegmatis_MC2_155 AKFASAFYGPFREAVSSSLTGDRRTYQQDAGNIREAVREIELDIDEGADM
TH_2257|M.thermoresistible__bu AKFASGFYGPFREAVASSLSGDRRTYQQDPGNAREALLEVRLDIDEGADM
MAB_3990c|M.abscessus_ATCC_199 AKYASAFFGPFREAVGSSLRGDRRTYQQDVANGREALRELELDVQEGADI
**::*.*:*******..** ********: .* **: *:.**:: ***:
MMAR_0845|M.marinum_M VMIKPALGYLDVVAAAADISPVPVAAYQVSGEYAMICAAAANSWIDQRAA
MUL_4601|M.ulcerans_Agy99 VMIKPALGYLDVVAAAADISPVPVAAYQVSGEYAMICAAAANSRIDQRAA
MAV_4637|M.avium_104 VMVKPAMSYLDVVAAAAEVSPVPVAAYQVSGEYAMICAAAANNWIDERAA
Mb0525|M.bovis_AF2122/97 VMVKPAMGYLDVVAAAADVSPVPVAAYQVSGEYAMIRAAAANNWIDERAA
Rv0512|M.tuberculosis_H37Rv VMVKPAMGYLDVVAAAADVSPVPVAAYQVSGEYAMIRAAAANNWIDERAA
MLBr_02419|M.leprae_Br4923 IMIKPASGYLDVVATAAGVSPVPVAAYQVSGEYAMICAAAANNWIDERAA
Mflv_0064|M.gilvum_PYR-GCK VMVKPAMSYLDVVRATAEICPLPLAAYQVSGEYSMIAAAAEKGWIDLPTV
Mvan_0847|M.vanbaalenii_PYR-1 VMVKPAMAYLDVVRAAAEISPVPVAAYQVSGEYSMIAAAGEKGWIDLPAV
MSMEG_0956|M.smegmatis_MC2_155 VMVKPAMSYLDVVRAAAEISPVPVAAYQISGEYSMISAAAANGWIDLQTA
TH_2257|M.thermoresistible__bu VMIKPALGYLDVVRAAADISPVPVAAYQVSGEYAMISAAAANGWIDGPAV
MAB_3990c|M.abscessus_ATCC_199 VMVKPAMAYLDVLRQVADVSPVPVAAYQVSGEYAMICAAAQNNWIDLQAM
:*:*** .****: .* :.*:*:****:****:** **. :. ** :
MMAR_0845|M.marinum_M ALESLTSIRRAGADIVLTYWAADAASWLS-
MUL_4601|M.ulcerans_Agy99 ALESLTSIRRAGADIVLTYWAADAASWLS-
MAV_4637|M.avium_104 ALESLTSIRRAGADIVLSYWAADAAGWLS-
Mb0525|M.bovis_AF2122/97 VLESLTGIRRAGADIVLTYWAVDAAGWLT-
Rv0512|M.tuberculosis_H37Rv VLESLTGIRRAGADIVLTYWAVDAAGWLT-
MLBr_02419|M.leprae_Br4923 VLESLTSIRRAGADIVFTYWAADVACWLS-
Mflv_0064|M.gilvum_PYR-GCK VLESLVGIRRAGADIVLSYWAVDVARWLT-
Mvan_0847|M.vanbaalenii_PYR-1 VLESLEGIRRAGADIALSYWAVDVAHWLS-
MSMEG_0956|M.smegmatis_MC2_155 ALESLVGIRRAGADLILTYWAADVAGWLA-
TH_2257|M.thermoresistible__bu ALEALTGIRRAGADIVLTYWAVEAAGWLG-
MAB_3990c|M.abscessus_ATCC_199 ALETLTSIRRAGADIVLTYWAAEAAGWLSD
.**:* .*******: ::***.:.* **