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TETAELTAATDADVLAVAREQVLEQGVGLTQEQVLRVLQLPDDRLEELLALAHEVRMRWCGPEVEVEGII SLKTGGCPEDCHFCSQSGLFASPVRSAWLDIPSLVEAAKQTAKSGATEFCIVAAVRGPDERLLAQVAAGI EAIRNEVDIQIACSLGMLTQEQVDRLSAMGVHRYNHNLETAKSHFPNVVTTHSWEERWDTLKMVREAGME VCCGGILGMGETLEQRAEFAANLAELEPDEVPLNFLNPRPGTPFGDLEVLPASDALRAVAAFRLALPRTM LRFAGGREITLGDLGAKQGILGGINAVIVGNYLTTLGRPAEADLELLDDLQMPIKALNSSL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2684c | - | - | 100% (342) | biotin synthase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1615 | bioB | 1e-172 | 86.80% (341) | biotin synthase |
| M. gilvum PYR-GCK | Mflv_3624 | - | 1e-174 | 90.91% (330) | biotin synthase |
| M. tuberculosis H37Rv | Rv1589 | bioB | 1e-172 | 86.80% (341) | biotin synthase |
| M. leprae Br4923 | MLBr_01220 | bioB | 1e-166 | 85.80% (331) | biotin synthase |
| M. marinum M | MMAR_2387 | bioB | 1e-173 | 88.86% (332) | biotin synthase BioB |
| M. avium 104 | MAV_3196 | bioB | 1e-171 | 87.61% (339) | biotin synthase |
| M. smegmatis MC2 155 | MSMEG_3194 | bioB | 1e-175 | 90.12% (334) | biotin synthase |
| M. thermoresistible (build 8) | TH_0655 | bioB | 1e-170 | 87.84% (329) | PROBABLE BIOTIN SYNTHETASE BIOB |
| M. ulcerans Agy99 | MUL_1563 | bioB | 1e-172 | 88.55% (332) | biotin synthase |
| M. vanbaalenii PYR-1 | Mvan_2793 | - | 1e-175 | 91.79% (329) | biotin synthase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1615|M.bovis_AF2122/97 ----MTQAATRPTNDAGQDGGNNSDILVVARQQVLQRGEGLNQDQVLAVL
Rv1589|M.tuberculosis_H37Rv ----MTQAATRPTNDAGQDGGNNSDILVVARQQVLQRGEGLNQDQVLAVL
MMAR_2387|M.marinum_M ----MTQAATRPSNDAGQDGVTEPDILAVARQQVLERGEGLNQEQVLQVL
MUL_1563|M.ulcerans_Agy99 ---MVTQAATRPSNDAGQDGVTEPDILAVARQQVLERGEGLNQEQVLQVL
MAV_3196|M.avium_104 ----MTQAATRPTAETGND----EDILAVARRQVLEGGQGLSRDQVLQVL
Mflv_3624|M.gilvum_PYR-GCK ----------------------MSDILAVAREQVLERGVGLDQDQTLQVL
Mvan_2793|M.vanbaalenii_PYR-1 ----------------------MTDILAVAREQVLVRGEGLDQDQTLQVL
MSMEG_3194|M.smegmatis_MC2_155 MFEVFRDLFNPQEDGVTQAAINGTDVLDVAREQVLERGVGLDQAQTLQVL
MAB_2684c|M.abscessus_ATCC_199 -----------MTETAELTAATDADVLAVAREQVLEQGVGLTQEQVLRVL
TH_0655|M.thermoresistible__bu ----------------------VTDILQEAREQVLERGVGLDKEQTLRVL
MLBr_01220|M.leprae_Br4923 ----MTQAGTRSTNGDTEN----TDILAQARQQVLERGEGLSRDQVLQML
*:* **.*** * ** : *.* :*
Mb1615|M.bovis_AF2122/97 QLPDDRLEELLALAHEVRMRWCGPEVEVEGIISLKTGGCPEDCHFCSQSG
Rv1589|M.tuberculosis_H37Rv QLPDDRLEELLALAHEVRMRWCGPEVEVEGIISLKTGGCPEDCHFCSQSG
MMAR_2387|M.marinum_M QLSEDRLEELLALAHDVRMRWCGPEVEVEGIISLKTGGCPEDCHFCSQSG
MUL_1563|M.ulcerans_Agy99 QLSEDRLEELLVLAHDVRMRWCGPEVEVEGIISLKTGGCPEDCHFCSQSG
MAV_3196|M.avium_104 RLPDDRLDDLLALAHEVRMRWCGPEVEVEGIISLKTGGCPEDCHFCSQSG
Mflv_3624|M.gilvum_PYR-GCK QLPDDRLDELLALAHEVRMAHCGPDVEVEGIISLKTGGCPEDCHFCSQSG
Mvan_2793|M.vanbaalenii_PYR-1 QLPDDRLDDLLALAHEVRMAWCGPDVEVEGIISLKTGGCPEDCHFCSQSG
MSMEG_3194|M.smegmatis_MC2_155 QLPDERLDDLLSLAHEVRMRWCGPDVEVEGIISLKTGGCPEDCHFCSQSG
MAB_2684c|M.abscessus_ATCC_199 QLPDDRLEELLALAHEVRMRWCGPEVEVEGIISLKTGGCPEDCHFCSQSG
TH_0655|M.thermoresistible__bu QLPDDRLDELLELGHEVRMRWCGPDVEVEGIISLKTGGCPEDCHFCSQSG
MLBr_01220|M.leprae_Br4923 WLPDDRLEELLALAHDVRMRWCGPEVEIEGIISLKTGGCPEDCHFCSQSG
*.::**::** *.*:*** ***:**:**********************
Mb1615|M.bovis_AF2122/97 LFASPVRSAWLDIPSLVEAAKQTAKSGATEFCIVAAVRGPDERLMAQVAA
Rv1589|M.tuberculosis_H37Rv LFASPVRSAWLDIPSLVEAAKQTAKSGATEFCIVAAVRGPDERLMAQVAA
MMAR_2387|M.marinum_M LFSSPVRSAWLDIPSLVEAAKQTAKSGATEFCIVAAVRGPDARLLSQVAA
MUL_1563|M.ulcerans_Agy99 LFSSPVRSAWLDIPSLVEAAKQTAKSGATEFCIVAAVRGPDARLLSQVAA
MAV_3196|M.avium_104 LFASPVRSARLDIPSLVEAAKQTAKSGATEFCIVAAVRGPDERLLAQVAA
Mflv_3624|M.gilvum_PYR-GCK LFASPVRSAWLDVPSLVEAAKQTAKTGATEFCIVAAVRGPDERLLAQVAA
Mvan_2793|M.vanbaalenii_PYR-1 LFASPVRSAWLDIPSLVEAAKQTAKTGATEFCIVAAVRGPDERLLAQVAA
MSMEG_3194|M.smegmatis_MC2_155 LFASPVRSAWLDVPSLVEAAKQTAKTGATEFCIVAAVRGPDERLLAQVAA
MAB_2684c|M.abscessus_ATCC_199 LFASPVRSAWLDIPSLVEAAKQTAKSGATEFCIVAAVRGPDERLLAQVAA
TH_0655|M.thermoresistible__bu LFASPVRSAWLDIDNLVEAAKQTAKTGATEFCIVAAVRGPDERLMAQVAA
MLBr_01220|M.leprae_Br4923 LFMSPVRSAWLDIRSLVEAAKQTAKSGATEFCIVAAVRGPDERLMSQVAA
** ****** **: .**********:*************** **::****
Mb1615|M.bovis_AF2122/97 GIEAIRNEVEINIACSLGMLTAEQVDQLAARGVHRYNHNLETARSFFANV
Rv1589|M.tuberculosis_H37Rv GIEAIRNEVEINIACSLGMLTAEQVDQLAARGVHRYNHNLETARSFFANV
MMAR_2387|M.marinum_M GIEAIRNEVEINVACSLGMLTAEQVEQLAAMGVHRYNHNLETARSYFTNV
MUL_1563|M.ulcerans_Agy99 GIEAIRNEVEINVACSLGMLTAEQVEQLAAMGVHRYNHNLETARSYFTNV
MAV_3196|M.avium_104 GIEAIRNEVEINIACSLGMLTAEQVEQLAEMGVHRYNHNLETARSFFPNV
Mflv_3624|M.gilvum_PYR-GCK GIEAIRNEVDIQIACSLGMLTQDQVERLSAMGVHRYNHNLETARSFFTNV
Mvan_2793|M.vanbaalenii_PYR-1 GIEAIRNEVDIQIACSLGMLTQDQVERLSEMGVHRYNHNLETARSFFTNV
MSMEG_3194|M.smegmatis_MC2_155 GIEAIRNEVDIQIACSLGMLTEEQVQRLADMGVHRYNHNLETARSFFPNV
MAB_2684c|M.abscessus_ATCC_199 GIEAIRNEVDIQIACSLGMLTQEQVDRLSAMGVHRYNHNLETAKSHFPNV
TH_0655|M.thermoresistible__bu GIEAIRSEVDIQIACSLGMLTKEQVEQLAEMGVHRYNHNLETARSFFPNV
MLBr_01220|M.leprae_Br4923 GIEAIRNEVEINIACSLGMLTVEQVEQLSGIGVHRYNHNLETARSFFTNV
******.**:*::******** :**::*: ************:*.*.**
Mb1615|M.bovis_AF2122/97 VTTHTWEERWQTLSMVRDAGMEVCCGGILGMGETLQQRAEFAAELAELGP
Rv1589|M.tuberculosis_H37Rv VTTHTWEERWQTLSMVRDAGMEVCCGGILGMGETLQQRAEFAAELAELGP
MMAR_2387|M.marinum_M VTTHTWEERWQTLTMVRDAGMEVCCGGILGMGETLEQRAEFAANLAELDP
MUL_1563|M.ulcerans_Agy99 VTTHTWEERWQTLTMVRDAGMEVCCGGILGMGETLEQRAEFAANLAELDP
MAV_3196|M.avium_104 VTTHTWEERWDTLSMVRDAGMEVCCGGILGMGETLEQRAEFAAELAELGP
Mflv_3624|M.gilvum_PYR-GCK VTTHSWEERWETLQMVREAGMEVCCGGILGMGESLGQRAEFAANLAELDP
Mvan_2793|M.vanbaalenii_PYR-1 VTTHSWEERWDTLQMVREAGMEVCCGGILGMGETLEQRAEFAANLAELDP
MSMEG_3194|M.smegmatis_MC2_155 VTTHTWEERWDTLNMVREAGMEVCCGGILGMGETLEQRAEFAANLAELNP
MAB_2684c|M.abscessus_ATCC_199 VTTHSWEERWDTLKMVREAGMEVCCGGILGMGETLEQRAEFAANLAELEP
TH_0655|M.thermoresistible__bu VTTHTWEERWETLQMVHEAGMEVCCGGILGMGETVEQRAEFAAELAELDP
MLBr_01220|M.leprae_Br4923 VTTHTWEERWQTLSMVRDAGMEVCCGGILGMGETVEQRAEFALELAELGP
****:*****:** **::***************:: ****** :**** *
Mb1615|M.bovis_AF2122/97 DEVPLNFLNPRPGTPFADLEVMPVGDALKAVAAFRLALPRTMLRFAGGRE
Rv1589|M.tuberculosis_H37Rv DEVPLNFLNPRPGTPFADLEVMPVGDALKAVAAFRLALPRTMLRFAGGRE
MMAR_2387|M.marinum_M DEVPLNFLNPRPGTPFGDLEVLPAGEALKAVGAFRLALPRTMLRFAGGRE
MUL_1563|M.ulcerans_Agy99 DEVPLNFLNPRPGTPFGDLEVLPAGEALKAVGAFRLALPRTMLRFAGGRE
MAV_3196|M.avium_104 DEVPLNFLNPRPGTPFGDLEVMPATEALKSVAAFRLALPRTMLRFAGGRE
Mflv_3624|M.gilvum_PYR-GCK HEVPLNFLNPRPGTPFGDLEVLPATEALKAVAAFRLALPRTMLRFAGGRE
Mvan_2793|M.vanbaalenii_PYR-1 HEVPLNFLNPRPGTPFGDLEVLPASEALKAVAAFRLALPRTMLRFAGGRE
MSMEG_3194|M.smegmatis_MC2_155 HEVPLNFLNPRPGTPFGDLEVLPASEALKAVAAFRLALPRTMLRFAGGRE
MAB_2684c|M.abscessus_ATCC_199 DEVPLNFLNPRPGTPFGDLEVLPASDALRAVAAFRLALPRTMLRFAGGRE
TH_0655|M.thermoresistible__bu HEVPLNFLNPRPGTPFGDLEVLPATEALKAVAAFRLALPRTMLRFAGGRE
MLBr_01220|M.leprae_Br4923 DEVPLNFLNPRPGTPFGALEVMPPSEALKSVAAFRLALPRTILRFAGGRE
.***************. ***:* :**::*.*********:********
Mb1615|M.bovis_AF2122/97 ITLGDLGAKRGILGGINAVIVGNYLTTLGRPAEADLELLDELQMPLKALN
Rv1589|M.tuberculosis_H37Rv ITLGDLGAKRGILGGINAVIVGNYLTTLGRPAEADLELLDELQMPLKALN
MMAR_2387|M.marinum_M ITLGDLGAKRGILGGINAVIVGNYLTTLGRPAEADLELLEDLQMPLKALN
MUL_1563|M.ulcerans_Agy99 ITLGDLGAKRGILGGINAVIVGNYLTTLGRPAEADLELLEDLQMPLKALN
MAV_3196|M.avium_104 ITLGDLGAKKGILGGINAVIVGNYLTTLGRPAESDLELLDDLQMPLKGLN
Mflv_3624|M.gilvum_PYR-GCK ITLGDLGAKQGILGGINAVIVGNYLTTLGRPAEADLQLLDDLQMPIKALN
Mvan_2793|M.vanbaalenii_PYR-1 ITLGDLGAKQGILGGINAVIVGNYLTTLGRPAEADLQLLDDLQMPIKALN
MSMEG_3194|M.smegmatis_MC2_155 ITLGDLGAKKGILGGINAVIVGNYLTTLGRPAEADLQLLDDLQMPIKALN
MAB_2684c|M.abscessus_ATCC_199 ITLGDLGAKQGILGGINAVIVGNYLTTLGRPAEADLELLDDLQMPIKALN
TH_0655|M.thermoresistible__bu ITLGDLGAKKGMLGGINAVIVGNYLTTLGRPAESDLELLEDLQMPIKALN
MLBr_01220|M.leprae_Br4923 ITLGDLGAKQGMLGGINAVIVGNYLTTLGRPAEADLRLLDDLQMPIKALN
*********:*:*********************:**.**::****:*.**
Mb1615|M.bovis_AF2122/97 ASL
Rv1589|M.tuberculosis_H37Rv ASL
MMAR_2387|M.marinum_M ASL
MUL_1563|M.ulcerans_Agy99 ASL
MAV_3196|M.avium_104 ASL
Mflv_3624|M.gilvum_PYR-GCK ATL
Mvan_2793|M.vanbaalenii_PYR-1 ATL
MSMEG_3194|M.smegmatis_MC2_155 ATL
MAB_2684c|M.abscessus_ATCC_199 SSL
TH_0655|M.thermoresistible__bu ATL
MLBr_01220|M.leprae_Br4923 ASL
::*