For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
LTTVPPPQLRAFSEGLSFALDPFQVRACTALENGHGVLVCAPTGAGKTIVGEFAVHLALAAGRKCFYTTP IKALSNQKHNDLVSVYGPEKVGLLTGDSSINSDAPVVVMTTEVLRNMLYADSPALHGLSYVVMDEVHFLA DRFRGAVWEEVILHLPEDVALASLSATVSNAEEFGGWIKTVRGDTTVVVDETRPVPLWQHVMVGRRLFDL FDGDEPLGRRASGGTGNPSRVDPGLTRYIAQRRQADRFADFDRPRRRGPQQRTSRPPTLYRPPSRPEVIT RLDEDGLLPAITFIFSRAGCDGAVAQCLRSRLRLTTEEERREIIAIIDRRTEGLPEADLDVLGYWQWREG LLRGIAAHHAGMLPVFRHTVEELFTKGLVKAVFATETLALGINMPARTVVLERLVKFNGEQHAALTPGEY TQLTGRAGRRGIDVEGHAVVLWTPEVEPTEIAGLASTRTFPLRSSFAPSYNMTINLVHRMGPDPARELLE RSFAQYQADRSVVGLVRGIERGRKMLDEIAGELDGHDGSVLQYVRLRAGLTERERAAARASRLERRGAAN DALAALKRGDVIAIPHGRRNGVAVVLEPAHDDEDPRPLVLTEHRWAGRISSADYSGGAEPLGSIALPKRV EHRQPKVRRDVASALRSALDEGRVRRPQPGKRRTDGRHGDADADLERLRREIREHPVHHAPNREELARTG ERYLRIERDNAQLQKKVAAATNSLARTFDRILALLAERGYVEDSAELGMKVTQDGMLLARIYSESDLLVA ECLRRGLWAGLKPAELAAVASAVLYESRGDTVSATGEAPTAALRGALAETHRALARLRRDEQQHHLSPTR EIDEGFVAAVYRWATTGDLAASLEAAGDTGTALPAGDFVRWCRQVVDLLDQIHKAAPDAEVRSAAKAAVG DVRRGVVAVDGT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2189 | - | - | 100% (922) | ATP-dependent DNA helicase HelY |
| M. abscessus ATCC 19977 | MAB_3651 | - | 2e-06 | 28.29% (205) | ATP-dependent helicase Lhr |
| M. abscessus ATCC 19977 | MAB_3278c | - | 6e-05 | 26.95% (141) | ATP-dependent DNA helicase RecG |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2119c | helY | 0.0 | 70.48% (918) | ATP-dependent DNA helicase HelY |
| M. gilvum PYR-GCK | Mflv_3095 | - | 0.0 | 69.19% (925) | DEAD/DEAH box helicase domain-containing protein |
| M. tuberculosis H37Rv | Rv2092c | helY | 0.0 | 70.59% (918) | ATP-dependent DNA helicase HelY |
| M. leprae Br4923 | MLBr_01333 | helY | 0.0 | 66.88% (930) | putative helicase, Ski2 subfamily |
| M. marinum M | MMAR_3078 | helY | 0.0 | 69.73% (925) | ATP-dependent DNA helicase HelY |
| M. avium 104 | MAV_4267 | - | 7e-09 | 30.05% (203) | DEAD/DEAH box helicase |
| M. smegmatis MC2 155 | MSMEG_3885 | - | 0.0 | 72.03% (926) | DEAD/DEAH box helicase |
| M. thermoresistible (build 8) | TH_0503 | helY | 0.0 | 75.19% (657) | PROBABLE ATP-DEPENDENT DNA HELICASE HELY |
| M. ulcerans Agy99 | MUL_2324 | helY | 0.0 | 69.59% (924) | ATP-dependent DNA helicase HelY |
| M. vanbaalenii PYR-1 | Mvan_3440 | - | 0.0 | 69.48% (937) | DEAD/DEAH box helicase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2119c|M.bovis_AF2122/97 ---------MTELAELDRFTAELP----FSLDDFQQRACSALERGHGVLV
Rv2092c|M.tuberculosis_H37Rv ---------MTELAELDRFTAELP----FSLDDFQQRACSALERGHGVLV
MLBr_01333|M.leprae_Br4923 ---------MTDLAELARFTAELP----FSLDDFQQRACAALERGHGVLV
MMAR_3078|M.marinum_M ---------MTELVELARFTADLP----FALDDFQRRACAALEGGHGVLV
MUL_2324|M.ulcerans_Agy99 ---------MTELVELARFTADLP----FALDDFQRRACAALEGGHGVLV
Mflv_3095|M.gilvum_PYR-GCK --MTNPPDP--APESLTAFTALLP----FSLDGFQRRACEALAQGHGVLV
Mvan_3440|M.vanbaalenii_PYR-1 --MTTQPDPGTATESVAAFTALLP----FELDDFQRRACEALAQGHGVLV
MSMEG_3885|M.smegmatis_MC2_155 ----MPPEG--RPDQLTAFTAQLP----FTLDDFQVRACQALENGHGVLV
TH_0503|M.thermoresistible__bu -------MTTSPDGALAEFAGQLD----FELDDFQRRACEALENGHGVLV
MAB_2189|M.abscessus_ATCC_1997 -------MTTVPPPQLRAFSEGLS----FALDPFQVRACTALENGHGVLV
MAV_4267|M.avium_104 MSTRAEPRPSDPLGRFSAITREWFTSTFAAPTTAQAQAWSAIADGHNTLV
. :: * :* *: **..**
Mb2119c|M.bovis_AF2122/97 CAPTGAGKTVVG------EFAVHLALAAGSKCFYTTPLKALSNQKHTDLT
Rv2092c|M.tuberculosis_H37Rv CAPTGAGKTVVG------EFAVHLALAAGSKCFYTTPLKALSNQKHTDLT
MLBr_01333|M.leprae_Br4923 CAPTGAGKTVVG------EFAVHLALAAGGKCFYTTPLKALSNQKYTDLT
MMAR_3078|M.marinum_M CAPTGAGKTVVG------EFAVHLALASGGKCFYTTPLKALSNQKHTDLT
MUL_2324|M.ulcerans_Agy99 CAPTGAGKTVVG------EFAVHLALASGGKCFYTTPLKALSNQKHTDLT
Mflv_3095|M.gilvum_PYR-GCK CAPTGAGKTVVG------EFAVHLALEAGRKCFYTTPIKALSNQKHNDLV
Mvan_3440|M.vanbaalenii_PYR-1 CAPTGAGKTVVG------EFAVHLALAAGRKCFYTTPIKALSNQKHNDLV
MSMEG_3885|M.smegmatis_MC2_155 CAPTGAGKTIVG------EFAVHLALASGGKCFYTTPIKALSNQKHNDLV
TH_0503|M.thermoresistible__bu CAPTGAGKTVVG------EFAVHLALAAGRKCFYTTPIKALSNQKHHDLV
MAB_2189|M.abscessus_ATCC_1997 CAPTGAGKTIVG------EFAVHLALAAGRKCFYTTPIKALSNQKHNDLV
MAV_4267|M.avium_104 IAPTGSGKTLAAFLWALDSLAGQAERAPGTRVLYVSPLKALAVDVERNLR
****:***:.. .:* : .* : :*.:*:***: : :*
Mb2119c|M.bovis_AF2122/97 ARYG--------------RDQIGLLTGDLS-------VNGNAPVVVMTTE
Rv2092c|M.tuberculosis_H37Rv ARYG--------------RDQIGLLTGDLS-------VNGNAPVVVMTTE
MLBr_01333|M.leprae_Br4923 ARYG--------------RNRIGLLTGDQS-------VNGDSPVVVMTTE
MMAR_3078|M.marinum_M ARYG--------------RDKIGLLTGDLA-------VNANAPVVVMTTE
MUL_2324|M.ulcerans_Agy99 ARYG--------------RDKTGLLTGDLA-------VNANAPVVVMTTE
Mflv_3095|M.gilvum_PYR-GCK RRYG--------------PERIGLLTGDQA-------INGDADIVVMTTE
Mvan_3440|M.vanbaalenii_PYR-1 LRYG--------------PKRIGLLTGDQA-------INGDADVVVMTTE
MSMEG_3885|M.smegmatis_MC2_155 ARYG--------------AEKIGLLTGDQS-------INGDADVVVMTTE
TH_0503|M.thermoresistible__bu ARYG--------------PERIGLLTGDQS-------INGDAPIVVMTTE
MAB_2189|M.abscessus_ATCC_1997 SVYG--------------PEKVGLLTGDSS-------INSDAPVVVMTTE
MAV_4267|M.avium_104 TPLAGLTRIAERAGLPAPDISVGVRSGDTPPAVRRQLINRPPDVLITTPE
. *: :** . :* . ::: *.*
Mb2119c|M.bovis_AF2122/97 VLRNMLYADS-PALQGLSYVVMDEVHFLADRMRGPVWEEVILQLP-----
Rv2092c|M.tuberculosis_H37Rv VLRNMLYADS-PALQGLSYVVMDEVHFLADRMRGPVWEEVILQLP-----
MLBr_01333|M.leprae_Br4923 VLRNMLYADS-FALQGLSHVVMDEVHFIADRMRGPVWEEVILHLP-----
MMAR_3078|M.marinum_M VLRNMLYADS-PALPGLSYVVMDEVHFLADRMRGPVWEEVILHLP-----
MUL_2324|M.ulcerans_Agy99 VLRNMLYADS-PALPGLSYVVMDEVHFLADRMRGPVWEEVILHLP-----
Mflv_3095|M.gilvum_PYR-GCK VLRNMLYADS-PALHGLSHVVMDEVHFLADRMRGAVWEEVILHLP-----
Mvan_3440|M.vanbaalenii_PYR-1 VLRNMLYADS-RALQGLSYVVMDEVHFLADRMRGAVWEEVILHLP-----
MSMEG_3885|M.smegmatis_MC2_155 VLRNMLYANS-QALHGLSYVVMDEVHFLADRMRGAVWEEVILHLP-----
TH_0503|M.thermoresistible__bu VLRNMLYAGS-PTLEGLAYVVMDEVHFLADRMRGAVWEEVILHLP-----
MAB_2189|M.abscessus_ATCC_1997 VLRNMLYADS-PALHGLSYVVMDEVHFLADRFRGAVWEEVILHLP-----
MAV_4267|M.avium_104 SLFLMLTSAARETLAGVQTVIVDEIHAIAGGKRGAHLALSLERLDALREG
* ** : : :* *: *::**:* :*. **. : :*
Mb2119c|M.bovis_AF2122/97 DDVRVVSLSATVSNAEEFGGWIQMVRG-----------DTTVVVDEHRPV
Rv2092c|M.tuberculosis_H37Rv DDVRVVSLSATVSNAEEFGGWIQTVRG-----------DTTVVVDEHRPV
MLBr_01333|M.leprae_Br4923 DDVRMVSLSATVSNAEEFGGWVQTVRG-----------DTTVVVDEHRPV
MMAR_3078|M.marinum_M DEVRVVSLSATVSNAEEFGGWIQTVRG-----------DTTVVVDEHRPV
MUL_2324|M.ulcerans_Agy99 DEVRVVSLSATVSNAEEFGGWIQTVRG-----------DTAVVVDEHRPV
Mflv_3095|M.gilvum_PYR-GCK EEVRLVSLSATVSNAEEFGGWIKTVRG-----------DTTVVVDEHRPV
Mvan_3440|M.vanbaalenii_PYR-1 EEVRLVSLSATVSNAEEFGGWIKTVRG-----------DTTVVVDEHRPV
MSMEG_3885|M.smegmatis_MC2_155 DEVLLVSLSATVSNAEEFGGWIQTVRG-----------DTTVVVDEHRPV
TH_0503|M.thermoresistible__bu EEVRLVSLSATVSNAEEFGGWMQTVRG-----------DTTVVVDEHRPV
MAB_2189|M.abscessus_ATCC_1997 EDVALASLSATVSNAEEFGGWIKTVRG-----------DTTVVVDETRPV
MAV_4267|M.avium_104 RPAQRIGLSATVRPPDELARFLSGAAPGTRTTVVAPPSAKTVELSVQVPV
. .***** .:*:. ::. . .:* :. **
Mb2119c|M.bovis_AF2122/97 PLWQHVLVG-------KRMFDLFD--------------------------
Rv2092c|M.tuberculosis_H37Rv PLWQHVLVG-------KRMFDLFD--------------------------
MLBr_01333|M.leprae_Br4923 PLWQHVLVG-------KRLFDLFD--------------------------
MMAR_3078|M.marinum_M PLWQHVLVG-------KRLFDLFD--------------------------
MUL_2324|M.ulcerans_Agy99 PLWQHVLVG-------KRLFDLFD--------------------------
Mflv_3095|M.gilvum_PYR-GCK PLWQHVMVG-------RRLLDLFD--------------------------
Mvan_3440|M.vanbaalenii_PYR-1 PLWQHVMVG-------KRLLDLFD--------------------------
MSMEG_3885|M.smegmatis_MC2_155 PLSQHMMVG-------KRLFDLFE--------------------------
TH_0503|M.thermoresistible__bu PLWQHVMVG-------RRLFDLFD--------------------------
MAB_2189|M.abscessus_ATCC_1997 PLWQHVMVG-------RRLFDLFDGD------------------------
MAV_4267|M.avium_104 PDMANLANNTIWPDVENRLVDLIEAHGSTIVFANSRRLAERLTARLNEIH
* :: . .*:.**::
Mb2119c|M.bovis_AF2122/97 --------------------------------------YRIGEAEG---Q
Rv2092c|M.tuberculosis_H37Rv --------------------------------------YRIGEAEG---Q
MLBr_01333|M.leprae_Br4923 --------------------------------------YDSNVD-----Q
MMAR_3078|M.marinum_M --------------------------------------YQADKPAVSSRQ
MUL_2324|M.ulcerans_Agy99 --------------------------------------YQADKPAGSSRQ
Mflv_3095|M.gilvum_PYR-GCK --------------------------------------YRGSGPSG--RD
Mvan_3440|M.vanbaalenii_PYR-1 --------------------------------------YRASGPAG--RN
MSMEG_3885|M.smegmatis_MC2_155 --------------------------------------RSSS--------
TH_0503|M.thermoresistible__bu --------------------------------------YRAAKSGG---E
MAB_2189|M.abscessus_ATCC_1997 ----------------------------------EPLGRRASGGTG--NP
MAV_4267|M.avium_104 AERSGVELSATANPKVAGGAPAHIMASGQTYGVEPILARAHHGSVSKEQR
Mb2119c|M.bovis_AF2122/97 PQVNRELLR-----------------------------------------
Rv2092c|M.tuberculosis_H37Rv PQVNRELLR-----------------------------------------
MLBr_01333|M.leprae_Br4923 SPVNPNLLR-----------------------------------------
MMAR_3078|M.marinum_M ARVNPDLLR-----------------------------------------
MUL_2324|M.ulcerans_Agy99 ARVNPDLLR-----------------------------------------
Mflv_3095|M.gilvum_PYR-GCK LLVDPELLR-----------------------------------------
Mvan_3440|M.vanbaalenii_PYR-1 LLVDPELLR-----------------------------------------
MSMEG_3885|M.smegmatis_MC2_155 TLVDPELLR-----------------------------------------
TH_0503|M.thermoresistible__bu PVVDRNLLR-----------------------------------------
MAB_2189|M.abscessus_ATCC_1997 SRVDPGLTR-----------------------------------------
MAV_4267|M.avium_104 ALVEEDLKRGLLKAVVATSSLELGIDMGAVDLVIQVEAPPSVASGLQRIG
*: * *
Mb2119c|M.bovis_AF2122/97 -----------------------------------HIAHRREADRMADWQ
Rv2092c|M.tuberculosis_H37Rv -----------------------------------HIAHRREADRMADWQ
MLBr_01333|M.leprae_Br4923 -----------------------------------HIAHCREADRMSDWR
MMAR_3078|M.marinum_M -----------------------------------HIAHRREADRMSDWE
MUL_2324|M.ulcerans_Agy99 -----------------------------------HIAHRREADRMSDWE
Mflv_3095|M.gilvum_PYR-GCK -----------------------------------HIAHRREAERLVDWQ
Mvan_3440|M.vanbaalenii_PYR-1 -----------------------------------HIAHRREAERLTDWQ
MSMEG_3885|M.smegmatis_MC2_155 -----------------------------------HISHRREADRLMDWQ
TH_0503|M.thermoresistible__bu -----------------------------------HIEHRREAERLVDWQ
MAB_2189|M.abscessus_ATCC_1997 -----------------------------------YIAQRRQADRFADFD
MAV_4267|M.avium_104 RAGHQVGEVSRGVLFPKHRTDLIGCAVTVQRMLAGQIETMRVPANPLDIL
* * . . *
Mb2119c|M.bovis_AF2122/97 -PRR-----RGSG-RPGFYRPPGRPEVIAKLDA----------EGLLPAI
Rv2092c|M.tuberculosis_H37Rv -PRR-----RGSG-RPGFYRPPGRPEVIAKLDA----------EGLLPAI
MLBr_01333|M.leprae_Br4923 NPRRRA--GRGSGVRPRFYRSLARPEVIAILDA----------EGLLPAI
MMAR_3078|M.marinum_M -PRRSGRGGYGRGGRPRFYRPPPRPDVIATLDS----------AGLLPAI
MUL_2324|M.ulcerans_Agy99 -PRRSGRGEYGRGRRPRFYRPPPRPDVIATLDS----------AGLLPAI
Mflv_3095|M.gilvum_PYR-GCK -PRGR--GRDRQGRQPSLYRTPGRAEVIGVLEQ----------SRLLPAI
Mvan_3440|M.vanbaalenii_PYR-1 -PRGR--GRS--GRPSGLYRTPGRAEVINVLAQ----------DNLLPAI
MSMEG_3885|M.smegmatis_MC2_155 -PRGR--GRG--GRPQ-FYRPPGRPEVITALDD----------AGLLPAI
TH_0503|M.thermoresistible__bu -PRGR---GRPPRGRPGLYRPPTRPEVIATLDA----------EGLLPAI
MAB_2189|M.abscessus_ATCC_1997 RPRRRG-PQQRTSRPPTLYRPPSRPEVITRLDE----------DGLLPAI
MAV_4267|M.avium_104 AQQTVAAAALEPLDADRWFDTVRRAAPFATLPRSIYEATLDLLSGKYPST
: : . *. : * *:
Mb2119c|M.bovis_AF2122/97 TFVFSR-----------------------AGCDAAVTQCLRSPLRLTSEE
Rv2092c|M.tuberculosis_H37Rv TFVFSR-----------------------AGCDAAVTQCLRSPLRLTSEE
MLBr_01333|M.leprae_Br4923 TFVFSR-----------------------FGCDAAVQQCLRSPLRLTSEE
MMAR_3078|M.marinum_M TFVFSR-----------------------AGCDAAVQQCLRSPLRLTSEE
MUL_2324|M.ulcerans_Agy99 TFVFSR-----------------------AGCDAAVQQCLRSPLRLTSEE
Mflv_3095|M.gilvum_PYR-GCK TFIFSR-----------------------AGCDAAVKQCLRSSLRLTTNE
Mvan_3440|M.vanbaalenii_PYR-1 TFIFSR-----------------------AGCDAAVKQCLRSSLRLTTDE
MSMEG_3885|M.smegmatis_MC2_155 TFVFSR-----------------------AGCDAAVKQCLRSSLRLTTRE
TH_0503|M.thermoresistible__bu TFVFSR-----------------------AGCDAAVKQCLRSPLRLTSAE
MAB_2189|M.abscessus_ATCC_1997 TFIFSR-----------------------AGCDGAVAQCLRSRLRLTTEE
MAV_4267|M.avium_104 EFAELRPRLVYDRNTGTLTARPGAQRLAVTSGGAIPDRGLFTVYLASEAE
* * . .. : * : : *
Mb2119c|M.bovis_AF2122/97 ERARIAEVIDHRCGDLADSDLAVLGYYEWREGLLR---------------
Rv2092c|M.tuberculosis_H37Rv ERARIAEVIDHRCGDLADSDLAVLGYYEWREGLLR---------------
MLBr_01333|M.leprae_Br4923 ERAQIAEVIDHRCGDLADADLAVLGYYEWREGLLR---------------
MMAR_3078|M.marinum_M ERAQIAEVIDHRCGDLEDDDLAVLGYYEWREGLLR---------------
MUL_2324|M.ulcerans_Agy99 ERAQIAEVIDHRCGDLEDDDLAVLGYYEWREGLLR---------------
Mflv_3095|M.gilvum_PYR-GCK ERARIAEIVDRRTADLNDTDLVVLDFHQWREGLLR---------------
Mvan_3440|M.vanbaalenii_PYR-1 ERARIADIVDRRTADLNDSDLIVLDFHEWREGLLR---------------
MSMEG_3885|M.smegmatis_MC2_155 ERARIAEIVDRRCSDLNESDLIVLDYHEWREGLLR---------------
TH_0503|M.thermoresistible__bu ERRQIAEIVDRRCADLSDADLIVLGYHEWREGLLR---------------
MAB_2189|M.abscessus_ATCC_1997 ERREIIAIIDRRTEGLPEADLDVLGYWQWREGLLR---------------
MAV_4267|M.avium_104 KPSRVGELEEEMVYESRPGDVISLGATSWRITEITHDRVLVIPAPGQPAR
: .: : :. *: *. .** :
Mb2119c|M.bovis_AF2122/97 ---------GLAAHHAGMLPAFRHTVEEL----------------FTAGL
Rv2092c|M.tuberculosis_H37Rv ---------GLAAHHAGMLPAFRHTVEEL----------------FTAGL
MLBr_01333|M.leprae_Br4923 ---------GLAAHHAGMLPAFRHAVEEL----------------FTAGL
MMAR_3078|M.marinum_M ---------GLAAHHAGMLPAFRHTVEEL----------------FTAGL
MUL_2324|M.ulcerans_Agy99 ---------GLAAHHAGMLPAFRHTVEEL----------------FTAGL
Mflv_3095|M.gilvum_PYR-GCK ---------GIAAHHAGMLPTFRHTVEEL----------------FTAGL
Mvan_3440|M.vanbaalenii_PYR-1 ---------GLAAHHAGMLPVFRHTVEEL----------------FTAGL
MSMEG_3885|M.smegmatis_MC2_155 ---------GLAAHHAGMLPTFRHTVEEL----------------FTAGL
TH_0503|M.thermoresistible__bu ---------GLAAHHAGMLPTFRHTVEEL----------------FTAGL
MAB_2189|M.abscessus_ATCC_1997 ---------GIAAHHAGMLPVFRHTVEEL----------------FTKGL
MAV_4267|M.avium_104 LPFWRGDGVGRPAELGAALGAFTGELAGLSREEFDSRCAALGFDAYAVDN
* .*. .. * .* : * :: .
Mb2119c|M.bovis_AF2122/97 VKAVFATETLALGINMPARTVVLERLVKFNGEQHMPLTP-------GEYT
Rv2092c|M.tuberculosis_H37Rv VKAVFATETLALGINMPARTVVLERLVKFNGEQHMPLTP-------GEYT
MLBr_01333|M.leprae_Br4923 VKAVFATETLALGINMPARTVVLERLVKFNGKQHVPLTP-------GEYT
MMAR_3078|M.marinum_M VKAVFATETLALGINMPARTVVLERLVKFNGEQHVPLTP-------GEYT
MUL_2324|M.ulcerans_Agy99 VKAVFATETLALGINMPARTVVLERLVKFNGEQHVPLTP-------GEYT
Mflv_3095|M.gilvum_PYR-GCK VKAVFATETLALGINMPARTVVLERLVKYNGEQHMPLTP-------GEYT
Mvan_3440|M.vanbaalenii_PYR-1 VKAVFATETLALGINMPARTVVLEKLVKFNGEQHMPLTP-------GEYT
MSMEG_3885|M.smegmatis_MC2_155 VKAVFATETLALGINMPARTVVLERLVKFNGEQHLPLTP-------GEYT
TH_0503|M.thermoresistible__bu VKAVFATETLALGINMPARTVVLERLXKFDGEQHKPLTP-------GEYT
MAB_2189|M.abscessus_ATCC_1997 VKAVFATETLALGINMPARTVVLERLVKFNGEQHAALTP-------GEYT
MAV_4267|M.avium_104 LYGLFDEQRTAAGVVPTDTTLLVERFRDELGDWRVILHSPYGLGVNGPLA
: .:* : * *: . *:::*:: . *. : * . * :
Mb2119c|M.bovis_AF2122/97 QLTGRAGRRGIDVEG----------------------------HAVVIWH
Rv2092c|M.tuberculosis_H37Rv QLTGRAGRRGIDVEG----------------------------HAVVIWH
MLBr_01333|M.leprae_Br4923 QLTGRAGRRGIDVEG----------------------------HAVVIWH
MMAR_3078|M.marinum_M QLTGRAGRRGIDVEG----------------------------HAVVLWH
MUL_2324|M.ulcerans_Agy99 QLTGRAGRRGIDVEG----------------------------HAVVLWH
Mflv_3095|M.gilvum_PYR-GCK QLTGRAGRRGIDVEG----------------------------HAVVLWN
Mvan_3440|M.vanbaalenii_PYR-1 QLTGRAGRRGIDVEG----------------------------HAVVLWN
MSMEG_3885|M.smegmatis_MC2_155 QLTGRAGRRGIDVEG----------------------------HAVVLWR
TH_0503|M.thermoresistible__bu QLTGRAGRRGIDVEG----------------------------HAVVLWH
MAB_2189|M.abscessus_ATCC_1997 QLTGRAGRRGIDVEG----------------------------HAVVLWT
MAV_4267|M.avium_104 LAVGRRLRERYGIDEKPTASDDGVVVRLPDTVSDFASDGGDTPPGAELFV
.** *. .:: .. ::
Mb2119c|M.bovis_AF2122/97 PEIE---PSEVAGLASTRTFP-----------------------------
Rv2092c|M.tuberculosis_H37Rv PEIE---PSEVAGLASTRTFP-----------------------------
MLBr_01333|M.leprae_Br4923 PSEDTSGPSAVAGLASARTFP-----------------------------
MMAR_3078|M.marinum_M PTDENADPSAVAGLASTRTFP-----------------------------
MUL_2324|M.ulcerans_Agy99 PTDENADPSAVAGLASTRTFP-----------------------------
Mflv_3095|M.gilvum_PYR-GCK PD---VDPAEVAGLASTRTFP-----------------------------
Mvan_3440|M.vanbaalenii_PYR-1 PD---VDPAEVAGLASTRTFP-----------------------------
MSMEG_3885|M.smegmatis_MC2_155 PDDSTAEPAEVAGLASTRTFP-----------------------------
TH_0503|M.thermoresistible__bu PD---LDPVEIAGLASTRTFP-----------------------------
MAB_2189|M.abscessus_ATCC_1997 PE---VEPTEIAGLASTRTFP-----------------------------
MAV_4267|M.avium_104 FDADEIDPIVTAEVGGSALFASRFRECAARALLLPRRHPGRRSPLWQQRQ
* * :..: *.
Mb2119c|M.bovis_AF2122/97 ---------------------LRSSFAPSYNMTINLVHRMGPQQ------
Rv2092c|M.tuberculosis_H37Rv ---------------------LRSSFAPSYNMTINLVHRMGPQQ------
MLBr_01333|M.leprae_Br4923 ---------------------LRSSFVPSYNMTINLVHWMSPER------
MMAR_3078|M.marinum_M ---------------------LRSSFAPSYNMTINLVQHMGPEQ------
MUL_2324|M.ulcerans_Agy99 ---------------------LRSSFAPSYNMTINLVQHMGPEQ------
Mflv_3095|M.gilvum_PYR-GCK ---------------------LRSSFAPTYNMTINLVHQMGPAQ------
Mvan_3440|M.vanbaalenii_PYR-1 ---------------------LRSSFAPTYNMTINLVHQMGPAQ------
MSMEG_3885|M.smegmatis_MC2_155 ---------------------LRSSFAPSYNMTINLVQHMGPQQ------
TH_0503|M.thermoresistible__bu ---------------------LRSSFSPSYNMTINLVQQMTPEA------
MAB_2189|M.abscessus_ATCC_1997 ---------------------LRSSFAPSYNMTINLVHRMGPDP------
MAV_4267|M.avium_104 RAAQLLEVARKYPDFPVVLETVRECLQDVYDVPALVALMAGIAQRRVRVL
:*..: *::. :.
Mb2119c|M.bovis_AF2122/97 --------------------------AHRLLEQSFAQYQADRSVVGLVRG
Rv2092c|M.tuberculosis_H37Rv --------------------------AHRLLEQSFAQYQADRSVVGLVRG
MLBr_01333|M.leprae_Br4923 --------------------------AHALLEQSFAQYQADRSVVGLVRG
MMAR_3078|M.marinum_M --------------------------AHRLLEQSFAQYQADRSVVGLVRG
MUL_2324|M.ulcerans_Agy99 --------------------------AHRLLEQSFAQYQADRSVVGLVRG
Mflv_3095|M.gilvum_PYR-GCK --------------------------AHRLLERSFAQYQADRSVVGLVRG
Mvan_3440|M.vanbaalenii_PYR-1 --------------------------AHQLLERSFAQYQADRSVVGLVRG
MSMEG_3885|M.smegmatis_MC2_155 --------------------------AHELLERSFAQYQADRSVVGLVRG
TH_0503|M.thermoresistible__bu --------------------------AHRLLEQSFAQYQADRSVVGLVRG
MAB_2189|M.abscessus_ATCC_1997 --------------------------ARELLERSFAQYQADRSVVGLVRG
MAV_4267|M.avium_104 EVETQRPSPFAASLLFGYVGAFMYEGDSPLAERRAAALSLDSTLLAELLG
* *: * . * :::. : *
Mb2119c|M.bovis_AF2122/97 ------------IERGNRILGEIAAELGGS---------DAPILEYARLR
Rv2092c|M.tuberculosis_H37Rv ------------IERGNRILGEIAAELGGS---------DAPILEYARLR
MLBr_01333|M.leprae_Br4923 ------------IERCTQVLGDISSELGGP---------DAPILEYARLR
MMAR_3078|M.marinum_M ------------IERGKEMLDELAAELGGP---------DAPILDYARMR
MUL_2324|M.ulcerans_Agy99 ------------IERGREMLDELAAELGGP---------DAPILDYARMR
Mflv_3095|M.gilvum_PYR-GCK ------------AERGERMLAELAAEMGGP---------DAPILDYVRLR
Mvan_3440|M.vanbaalenii_PYR-1 ------------VERGERMLGELAAEMGGP---------DSAILDYVRLR
MSMEG_3885|M.smegmatis_MC2_155 ------------IRRGERMLGELAAEIGGK---------DSAVIDYARLR
TH_0503|M.thermoresistible__bu ------------IERGRRMLAEIAAELGDHSQNGGKNRRESPILEYARLR
MAB_2189|M.abscessus_ATCC_1997 ------------IERGRKMLDEIAGELDGH---------DGSVLQYVRLR
MAV_4267|M.avium_104 RVELRELLDPEVVAATARALQHLAPERAAR--------DAEAVADLLRLL
. * .:: * .: : *:
Mb2119c|M.bovis_AF2122/97 ARVSELERAQAR--------ASRLQRRQAATDALAALRRG--------DI
Rv2092c|M.tuberculosis_H37Rv ARVSELERAQAR--------ASRLQRRQAATDALAALRRG--------DI
MLBr_01333|M.leprae_Br4923 ARIAEMERAQSF--------VFRLQRKQAANDVLAALRRG--------DI
MMAR_3078|M.marinum_M ARVTEMERSQAR--------ASRLQRRQEASEALAALRKG--------DI
MUL_2324|M.ulcerans_Agy99 ARVTEMERSQAR--------ASRLQRRQEASEALAALRKG--------DI
Mflv_3095|M.gilvum_PYR-GCK AQISERERAQSR--------ASRLQRRQAINDALAALRRG--------DI
Mvan_3440|M.vanbaalenii_PYR-1 AQISQRERAQSR--------ASRLQRRQATNEALAALRPG--------DI
MSMEG_3885|M.smegmatis_MC2_155 AKIGERERAQSR--------ASRLQRRRAATDALADLRKG--------DI
TH_0503|M.thermoresistible__bu AKISERERAQSR--------ASRLHRRQAANEALAKLRRG--------DI
MAB_2189|M.abscessus_ATCC_1997 AGLTERERAAAR--------ASRLERRGAANDALAALKRG--------DV
MAV_4267|M.avium_104 GPLTEDEVVARAGGADAVEVRGWLEGLRAARRAVPVSFAGRSWWVAIEDI
. : : * *. .:. * *:
Mb2119c|M.bovis_AF2122/97 ITITHGRRGGLAVVLESARDRDDPRPLVLTEHRWAGRISSADYSG-TTPV
Rv2092c|M.tuberculosis_H37Rv ITITHGRRGGLAVVLESARDRDDPRPLVLTEHRWAGRISSADYSG-TTPV
MLBr_01333|M.leprae_Br4923 ITITHGRHGGLAVVLESARDSSNPRPLVLTEHRWAGRISSADYMGAAAPV
MMAR_3078|M.marinum_M ITITHGRRGGLAVVLESARDSSDPRPLVLTENRWAGRISSADYTGESPPV
MUL_2324|M.ulcerans_Agy99 ITITHGRRGGLAVVLESARDSSDPRPLVLTENRWAGRISSADYTGESPPV
Mflv_3095|M.gilvum_PYR-GCK VTISQGKHGGLAVVLEPARDADDPRPLVLSEHRWAGRISSADYGAAAGPI
Mvan_3440|M.vanbaalenii_PYR-1 ITITAGRRGGLAVVLEPARDDEDPRPLVLSEHRWAGRISSADYTGAPGPL
MSMEG_3885|M.smegmatis_MC2_155 ITITHGRRGGLAVVLEAAQDRDDPRPLVLTEHKWAGRISSADYSGASAPL
TH_0503|M.thermoresistible__bu IAITHGRRAGLAVVLEPARDADDPRPLVLNEHRWAGRISNADYPGAAAPL
MAB_2189|M.abscessus_ATCC_1997 IAIPHGRRNGVAVVLEPAHDDEDPRPLVLTEHRWAGRISSADYSGGAEPL
MAV_4267|M.avium_104 GRLRDGLGIAVPLGVPAAFTEEVADPLGELLGRYARTHTPFSTAEAAARF
: * .:.: : .* . . ** ::* : . . .
Mb2119c|M.bovis_AF2122/97 GS-----------MTLPKRVEHRQPR------------------------
Rv2092c|M.tuberculosis_H37Rv GS-----------MTLPKRVEHRQPR------------------------
MLBr_01333|M.leprae_Br4923 GS-----------MTLPKRVEHRQQR------------------------
MMAR_3078|M.marinum_M GS-----------MTLPKRVEHRQPR------------------------
MUL_2324|M.ulcerans_Agy99 GS-----------MTLPKRVEHRQPR------------------------
Mflv_3095|M.gilvum_PYR-GCK GK-----------MTLPKHVEHRNPR------------------------
Mvan_3440|M.vanbaalenii_PYR-1 GK-----------MSLPKRIEHRNPR------------------------
MSMEG_3885|M.smegmatis_MC2_155 GS-----------MSLPKRVEHRQPR------------------------
TH_0503|M.thermoresistible__bu GR-----------MTLPRRVEHRQPK------------------------
MAB_2189|M.abscessus_ATCC_1997 GS-----------IALPKRVEHRQPK------------------------
MAV_4267|M.avium_104 GLGLRVTADVLGRLADPSTSQGRLVRGDFVAARPSEPGGVLGAEQWCDAD
* :: * : * :
Mb2119c|M.bovis_AF2122/97 ----VRRDLASALRSAAAGLVIPAARR-VS---------EAGGFHDPELE
Rv2092c|M.tuberculosis_H37Rv ----VRRDLASALRSAAAGLVIPAARR-VS---------EAGGFHDPELE
MLBr_01333|M.leprae_Br4923 ----VRRDLASALRSAATRLSVPDIGDGVDGDKIG---FNDGVLHDPELA
MMAR_3078|M.marinum_M ----VRRDLASALRSAAAGMTAPAARR-----------EKTRAPHDPDLA
MUL_2324|M.ulcerans_Agy99 ----VRRDLASALRSAAAGMTAPAARR-----------EKTRAPHDPDLA
Mflv_3095|M.gilvum_PYR-GCK ----ARRDLASALRSAAATLDVPSAQRRRGRGP-------VDGDVDPELI
Mvan_3440|M.vanbaalenii_PYR-1 ----VRRDLASALRSAAARLDVPSVRASRRSGPP------PEHDVDPELN
MSMEG_3885|M.smegmatis_MC2_155 ----VRKDLASALRSAAAGL-VPSRRSNR-GAP--------ERDVDPELA
TH_0503|M.thermoresistible__bu ----VRRDLASALQSAAARLXXX---------------------------
MAB_2189|M.abscessus_ATCC_1997 ----VRRDVASALRSALDEGRVRRPQPGKRRTDG------RHGDADADLE
MAV_4267|M.avium_104 VLRILRRRSLAALRAQVEPVSTAAYGRFLPAWHRVGAAESSRAPGHSGLD
*: :**::
Mb2119c|M.bovis_AF2122/97 SSREQLRRHPVHTSPGLEDQ------------------------------
Rv2092c|M.tuberculosis_H37Rv SSREQLRRHPVHTSPGLEDQ------------------------------
MLBr_01333|M.leprae_Br4923 SLRAQLRRHRSNNAPGLDTQ------------------------------
MMAR_3078|M.marinum_M SLREKLRRHPCHNAPGVESQ------------------------------
MUL_2324|M.ulcerans_Agy99 SLREKLRRHPCHNAPGVESR------------------------------
Mflv_3095|M.gilvum_PYR-GCK SLRNRLRAHSAHSLDDREER------------------------------
Mvan_3440|M.vanbaalenii_PYR-1 VLRDRMRAHRAHGLPDREKL------------------------------
MSMEG_3885|M.smegmatis_MC2_155 GLRERLRSHPVHKLPDREEQ------------------------------
TH_0503|M.thermoresistible__bu -----WRSPPAAPPAHPRTR------------------------------
MAB_2189|M.abscessus_ATCC_1997 RLRREIREHPVHHAPNREEL------------------------------
MAV_4267|M.avium_104 GLMSVIEQLAGVRLPASALEPLVLAPRVRDYSPALLDELLATGEVTWSGA
.
Mb2119c|M.bovis_AF2122/97 --IRQAERYLRIERDNAQLERKVAAATNSLARTFDRFVGLLTE-------
Rv2092c|M.tuberculosis_H37Rv --IRQAERYLRIERDNAQLERKVAAATNSLARTFDRFVGLLTE-------
MLBr_01333|M.leprae_Br4923 --LQQAERYLRIERYNAQLQRKVAAATNSLARTFDRIVGLLIE-------
MMAR_3078|M.marinum_M --IRQAERYLRIERDNAQLENKVAAATNSLARTFDRIVGLLTE-------
MUL_2324|M.ulcerans_Agy99 --IRQAEHYLRIERDNAQLENKVAAATNSLARTFDRIVGLLTE-------
Mflv_3095|M.gilvum_PYR-GCK --ARVAERYLRIERDNEQLRKKIASATNSLAVTFDRIVVLLTE-------
Mvan_3440|M.vanbaalenii_PYR-1 --ARVAERYLRIEEDNEQLRKKIAAATNSLAQTFDRIVVLLTD-------
MSMEG_3885|M.smegmatis_MC2_155 --VRIAERYLRIERDNLQIQQKVNAATNSLARTFDRIVALLSE-------
TH_0503|M.thermoresistible__bu --AVRAARCSR---------------------------------------
MAB_2189|M.abscessus_ATCC_1997 --ARTGERYLRIERDNAQLQKKVAAATNSLARTFDRILALLAE-------
MAV_4267|M.avium_104 GSISGSDGWIALHPSESAPLTLQGPADIELGEAHRAILDVLAGGGGYFFR
.
Mb2119c|M.bovis_AF2122/97 ---------------------REFIDGP------------------ATDP
Rv2092c|M.tuberculosis_H37Rv ---------------------REFIDGP------------------ATDP
MLBr_01333|M.leprae_Br4923 ---------------------RDFIRGP------------------ADDP
MMAR_3078|M.marinum_M ---------------------REYIHGP------------------ADDP
MUL_2324|M.ulcerans_Agy99 ---------------------REYIHGP------------------ADDP
Mflv_3095|M.gilvum_PYR-GCK ---------------------RGFIAPG-------------------DTP
Mvan_3440|M.vanbaalenii_PYR-1 ---------------------RGFITVDGVDET---------TTVEQDTP
MSMEG_3885|M.smegmatis_MC2_155 ---------------------RGYIEAGDGGD--------------AGQP
TH_0503|M.thermoresistible__bu --------------------------------------------------
MAB_2189|M.abscessus_ATCC_1997 ---------------------RGYVEDS-----------------AELGM
MAV_4267|M.avium_104 QLATDGVSDAELKAALWELVWAGWITGDTFAPVRALLGGGGTRRRSAPAH
Mb2119c|M.bovis_AF2122/97 VVTDDGRLLARIYSESDLLVAECLRTGAWEGLKPAELAGVVSAVVYETRG
Rv2092c|M.tuberculosis_H37Rv VVTDDGRLLARIYSESDLLVAECLRTGAWEGLKPAELAGVVSAVVYETRG
MLBr_01333|M.leprae_Br4923 QVTDDGRLLARIYSESDLLVAECLRTGAWAGLRPAELAAVVSAVLYETRG
MMAR_3078|M.marinum_M RVTDDGRLLARIYSESDLLVAECLRTGAWAGLKPPELAAVVSCVLYETRG
MUL_2324|M.ulcerans_Agy99 RVTDDGRLLARIYSESDLLVAECLRTGAWAGLKPPELAAVVSCVLYETRG
Mflv_3095|M.gilvum_PYR-GCK TVTEDGRLLSRIYSESDLLVAECLRAGVWEELDAAELVAALSSVLYESRR
Mvan_3440|M.vanbaalenii_PYR-1 AVTDDGRLLARIYSESDLLVAECLRAGVWEGLDSAELAAALSAVLYESRR
MSMEG_3885|M.smegmatis_MC2_155 RVTDAGRLLARIYSESDLLVAECLRAGAWDGLEPAELAGVLSAVLYESRG
TH_0503|M.thermoresistible__bu --------------------------------------------------
MAB_2189|M.abscessus_ATCC_1997 KVTQDGMLLARIYSESDLLVAECLRRGLWAGLKPAELAAVASAVLYESRG
MAV_4267|M.avium_104 RAQRPPRLSRYSVAHPQARPADTTVAGRWSVLPPPEPDSTVRAHFQAELL
Mb2119c|M.bovis_AF2122/97 GDGQGAPFGADVPTPRLRQALTQTSRLSTTLRADEQAHR-----------
Rv2092c|M.tuberculosis_H37Rv GDGQGAPFGADVPTPRLRQALTQTSRLSTTLRADEQAHR-----------
MLBr_01333|M.leprae_Br4923 DDGPGGPVDAEAPTPRLRQALQHTSRLSATLRADEQRHR-----------
MMAR_3078|M.marinum_M SDGGGGRPGVEAPTPRLRQALIQTSRLSVALRADEQAHR-----------
MUL_2324|M.ulcerans_Agy99 SDGGGGRPGVEAPTPRLRQALIQTSRLSVALRADEQAHR-----------
Mflv_3095|M.gilvum_PYR-GCK -DGQGPGDGSDIPTGRLRRALNRTRALWADLRTDEQRHR-----------
Mvan_3440|M.vanbaalenii_PYR-1 -EGHGPGDGSDIPTGRLRRALNQTRRLWSELRADEQRHR-----------
MSMEG_3885|M.smegmatis_MC2_155 -DAQGVPAGTDVPTAGLRQALVRTRRLSAALRSDEQRHR-----------
TH_0503|M.thermoresistible__bu --------------------------------------------------
MAB_2189|M.abscessus_ATCC_1997 DTVSATG---EAPTAALRGALAETHRALARLRRDEQQHH-----------
MAV_4267|M.avium_104 LGRHGVLTRGAVAAEGVAGGFATLYKVLSTFEDAGRCQRGYFIESLGGAQ
Mb2119c|M.bovis_AF2122/97 --ITPSREPDDGFVR-----------VIYRWSRTGDLAAALAA---ADVN
Rv2092c|M.tuberculosis_H37Rv --ITPSREPDDGFVR-----------VIYRWSRTGDLAAALAA---ADVN
MLBr_01333|M.leprae_Br4923 --IALSREPDDGFVG-----------VIYCWARTGDLAAVLAA---ADAS
MMAR_3078|M.marinum_M --IGQSREPDDGFVN-----------VVYRWARTGDLSAALAA---ADIE
MUL_2324|M.ulcerans_Agy99 --IGQSREPDDGFVN-----------VVYRWARTGDLSAALAA---ADIE
Mflv_3095|M.gilvum_PYR-GCK --ITYSREPDTGFVA-----------VIHRWASTGDLASALAAGAASAAG
Mvan_3440|M.vanbaalenii_PYR-1 --LPPSREPDDGFVA-----------AVHRWASTGDLASALTA---SDHA
MSMEG_3885|M.smegmatis_MC2_155 --IAPGREPDEGFVT-----------AVYRWATTGDLASALAA---SDIT
TH_0503|M.thermoresistible__bu --------------------------------------------------
MAB_2189|M.abscessus_ATCC_1997 --LSPTREIDEGFVA-----------AVYRWATTGDLAASLEA-----AG
MAV_4267|M.avium_104 FAVASTVDRLRGFADGVDPQRPEYRAIVLAAADPANPYGAALPWPASSAD
Mb2119c|M.bovis_AF2122/97 GSGSPLLAGDFVRWCR---------QVLDLLDQVRNAAPNPELRATAKRA
Rv2092c|M.tuberculosis_H37Rv GSGSPLLAGDFVRWCR---------QVLDLLDQVRNAAPNPELRATAKRA
MLBr_01333|M.leprae_Br4923 GNGAPLSAGDFVRWCR---------QVLDLLDQLRNAAPEPDLRATAKRA
MMAR_3078|M.marinum_M GPGSPLSAGDFVRWCR---------QVLDLLDQVRNAAPDPEVRAAAKRA
MUL_2324|M.ulcerans_Agy99 GPGSPLSAGDFVRWCR---------QVLDLLDQVRNAAPDPEVRAAAKRA
Mflv_3095|M.gilvum_PYR-GCK GTASSMSAGDFVRWCR---------QVLDLADQVRNAAPSPALRATAKRA
Mvan_3440|M.vanbaalenii_PYR-1 GTGASMSAGDFVRWCR---------QVLDLADQVRNAAPSAALRATAKRA
MSMEG_3885|M.smegmatis_MC2_155 GTGSPLSAGDFVRWCR---------QVLDLLDQVRNAAPTPSLRNTAKRA
TH_0503|M.thermoresistible__bu --------------------------------------------------
MAB_2189|M.abscessus_ATCC_1997 DTGTALPAGDFVRWCR---------QVVDLLDQIHKAAPDAEVRSAAKAA
MAV_4267|M.avium_104 GARPGRKAGALVVLVDGELAWFLERGGRSLLTFTDDPAAQHAAAAALAGL
Mb2119c|M.bovis_AF2122/97 IGDIRRGVVAVDAG------------------------------------
Rv2092c|M.tuberculosis_H37Rv IGDIRRGVVAVDAG------------------------------------
MLBr_01333|M.leprae_Br4923 INDVRRGVVAVDAG------------------------------------
MMAR_3078|M.marinum_M INDIRRGVVAVDAG------------------------------------
MUL_2324|M.ulcerans_Agy99 INDIRRGVVAVDAG------------------------------------
Mflv_3095|M.gilvum_PYR-GCK IADVRRGVVAVDAG------------------------------------
Mvan_3440|M.vanbaalenii_PYR-1 INDVRRGVVAVDAG------------------------------------
MSMEG_3885|M.smegmatis_MC2_155 INDVRRGVVAVDAG------------------------------------
TH_0503|M.thermoresistible__bu --------------------------------------------------
MAB_2189|M.abscessus_ATCC_1997 VGDVRRGVVAVDGT------------------------------------
MAV_4267|M.avium_104 VSARRVAAILVERIDGVPALAPRGDGAAGNDALTALADAGFARTPRGMRL
Mb2119c|M.bovis_AF2122/97 -
Rv2092c|M.tuberculosis_H37Rv -
MLBr_01333|M.leprae_Br4923 -
MMAR_3078|M.marinum_M -
MUL_2324|M.ulcerans_Agy99 -
Mflv_3095|M.gilvum_PYR-GCK -
Mvan_3440|M.vanbaalenii_PYR-1 -
MSMEG_3885|M.smegmatis_MC2_155 -
TH_0503|M.thermoresistible__bu -
MAB_2189|M.abscessus_ATCC_1997 -
MAV_4267|M.avium_104 R