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AFSSPDEVFKFIADEKVEYVDVRFCDLPGVVQHFSIPASAFDQSVFDDGLAFDGSSVRGFQSIHESDMLL LPDISTARVDPFRAAKTLNINFFVHDPFTREAYSRDPRNVARKAEQYLASTGIADTCYFGAEAEFYIFDS VTFDSKMNGTFYEIDSESGWWNTGEPYEEDGSPNRGYKVRPKGGYFPVAPYDHYVDLRDEMSTNLINAGF TLERGHHEVGTAGQAEINYKFDTLLAAADDVLLFKYIIKNTAWANGKTVTFMPKPLFGDNGSGMHAHQSL WKDGKPLFHDEAGYAGLSDLARHYIGGILHHAPSLLAFTNPTVNSYKRLVPGYEAPINLVYSQRNRSACV RIPITGNNPKAKRLEFRCPDSSGNPYLAFAAMLMAGIDGIKNKIEPLAPVDKDLYELPPEEAAGIPQAPT SLATVIDNLEKDHEYLTEGGVFTSDLIETWISYKRENEIEPVNIRPHPYEFALYYDV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_1933c | - | - | 100% (478) | glutamine synthetase, type I (GlnA1) |
| M. abscessus ATCC 19977 | MAB_1920 | - | 1e-53 | 33.26% (430) | glutamine synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2244 | glnA1 | 0.0 | 85.44% (474) | glutamine synthetase GLNA1 (glutamine synthase) (GS-I) |
| M. gilvum PYR-GCK | Mflv_2928 | - | 0.0 | 90.59% (478) | glutamine synthetase, type I |
| M. tuberculosis H37Rv | Rv2220 | glnA1 | 0.0 | 85.44% (474) | glutamine synthetase GLNA1 (glutamine synthase) (GS-I) |
| M. leprae Br4923 | MLBr_00925 | glnA | 0.0 | 83.05% (472) | glutamine synthase class I |
| M. marinum M | MMAR_3289 | glnA1 | 0.0 | 84.14% (473) | glutamine synthetase GlnA1 |
| M. avium 104 | MAV_2267 | glnA | 0.0 | 83.58% (475) | glutamine synthetase, type I |
| M. smegmatis MC2 155 | MSMEG_4290 | glnA | 0.0 | 89.75% (478) | glutamine synthetase, type I |
| M. thermoresistible (build 8) | TH_3499 | - | 0.0 | 86.58% (477) | PUTATIVE L-glutamine synthetase |
| M. ulcerans Agy99 | MUL_1340 | glnA1 | 0.0 | 83.72% (473) | glutamine synthetase GlnA1 |
| M. vanbaalenii PYR-1 | Mvan_3585 | - | 0.0 | 91.42% (478) | glutamine synthetase, type I |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2928|M.gilvum_PYR-GCK MAEQTADDIIKLIKDESVEYVDIRFCDLPGVVQHFSIPASAFDESVFEDG
MSMEG_4290|M.smegmatis_MC2_155 MAEKTSDDIFKLIKDENVEYVDIRFCDLPGVVQHFSIPASAFDESVFEDG
Mvan_3585|M.vanbaalenii_PYR-1 MAEKTADDIIKLIKDEQVEYVDIRFCDLPGVVQHFSIPASAFDESVFEDG
TH_3499|M.thermoresistible__bu VAEKTADDILKLIKDENVEYVDIRFCDLPGVVQHFTVPASAFTADVFEDG
MAB_1933c|M.abscessus_ATCC_199 MAFSSPDEVFKFIADEKVEYVDVRFCDLPGVVQHFSIPASAFDQSVFDDG
Mb2244|M.bovis_AF2122/97 MTEKTPDDVFKLAKDEKVEYVDVRFCDLPGIMQHFTIPASAFDKSVFDDG
Rv2220|M.tuberculosis_H37Rv MTEKTPDDVFKLAKDEKVEYVDVRFCDLPGIMQHFTIPASAFDKSVFDDG
MLBr_00925|M.leprae_Br4923 MTEKTSDDVLKLAKDENIEFVDVQFCDLPGIMQHFTIPASAFDKSVFEDG
MMAR_3289|M.marinum_M MTDKTPDDVFKLAKDESVEFVDVRFCDLPGVMQHFTIPISFFDEAVFEEG
MUL_1340|M.ulcerans_Agy99 MTDKTPDDVFKLAKDDGVEFVDVRFCDLPGVMQHFTIPISFFDEAVFEDG
MAV_2267|M.avium_104 MTETTPDDVFKLAKDEKVEFVDVRFCDLPGIMQHFTIPVSFFDESVFEDG
:: :.*:::*: *: :*:**::******::***::* * * **::*
Mflv_2928|M.gilvum_PYR-GCK LAFDGSSVRGFQSIHESDMMLLPDPATARIDPFRAAKTLNMNFFVHDPFT
MSMEG_4290|M.smegmatis_MC2_155 LAFDGSSVRGFQSIHESDMMLLPDPNTARIDPFRAAKTLNMNFFVHDPFT
Mvan_3585|M.vanbaalenii_PYR-1 LAFDGSSVRGFQSIHESDMMLLPDPETARIDPFRAAKTLNLNFFVHDPFT
TH_3499|M.thermoresistible__bu LAFDGSSVRGFQSIHESDMMLLPDPNTAGIDPFRAAKTLNMNFFVHDPFT
MAB_1933c|M.abscessus_ATCC_199 LAFDGSSVRGFQSIHESDMLLLPDISTARVDPFRAAKTLNINFFVHDPFT
Mb2244|M.bovis_AF2122/97 LAFDGSSIRGFQSIHESDMLLLPDPETARIDPFRAAKTLNINFFVHDPFT
Rv2220|M.tuberculosis_H37Rv LAFDGSSIRGFQSIHESDMLLLPDPETARIDPFRAAKTLNINFFVHDPFT
MLBr_00925|M.leprae_Br4923 LAFDGSSIRGFQSIHESDMLLFPDPDTARIDPFRAAKTLNVNFFVHDPFT
MMAR_3289|M.marinum_M LAFDGSSIRGFQSIHESDMLLLPDPDTAIIDQFREAKTLNLNFFVHDPFT
MUL_1340|M.ulcerans_Agy99 LAFDGSSIRGFQSIHESDMLLLPDPDTAIIDQFREAKTLNLNFFVHDPFT
MAV_2267|M.avium_104 LAFDGSSIRGFQSIHESDMLLLPDPATAQIDLFREAKTLNLNFFVHDPFT
*******:***********:*:** ** :* ** *****:*********
Mflv_2928|M.gilvum_PYR-GCK REAYSRDPRNVARKAENYLASTGIADTCFFGAEAEFYIFDSVTFDSKING
MSMEG_4290|M.smegmatis_MC2_155 REAYSRDPRNVARKAENYLASTGIADTAFFGAEAEFYIFDSVSFDSKING
Mvan_3585|M.vanbaalenii_PYR-1 REAYSRDPRNVARKAENYLASTGIADTAYFGAEAEFYIFDSVSFDSRING
TH_3499|M.thermoresistible__bu REAYSRDPRNVARKAENYLISTGIADTAYFGAEAEFYIFDSVSFDSRMNG
MAB_1933c|M.abscessus_ATCC_199 REAYSRDPRNVARKAEQYLASTGIADTCYFGAEAEFYIFDSVTFDSKMNG
Mb2244|M.bovis_AF2122/97 LEPYSRDPRNIARKAENYLISTGIADTAYFGAEAEFYIFDSVSFDSRANG
Rv2220|M.tuberculosis_H37Rv LEPYSRDPRNIARKAENYLISTGIADTAYFGAEAEFYIFDSVSFDSRANG
MLBr_00925|M.leprae_Br4923 LEPYSRDPRNIARKAENYLISTGIADTVYFGAEAEFYIFDSVSFDSRSNG
MMAR_3289|M.marinum_M LEPYSRDPRNVARKAENYLISTGIADTAYFGAEAEFYIFDSVAFDSRTNG
MUL_1340|M.ulcerans_Agy99 LEPYSRDPRNVARKAENYLISTGIADTAYFGAEAEFYIFDSVAFDSRTNG
MAV_2267|M.avium_104 LEPYSRDPRNIARKAENYLISTGVADTAYFGAEAEFYIFDSVSFDSRTNG
*.*******:*****:** ***:*** :*************:***: **
Mflv_2928|M.gilvum_PYR-GCK TFYEVDSESGWWNTGEPFEADGSANRGYKVRPKGGYFPVAPYDHYVDLRD
MSMEG_4290|M.smegmatis_MC2_155 TFYEVDSESGWWNTGEPFESDGSANRGYKVRPKGGYFPVAPYDHYVDLRD
Mvan_3585|M.vanbaalenii_PYR-1 TFYEVDSESGWWNTGEPLEADGSPNRGYKVRPKGGYFPVAPYDHYVDLRD
TH_3499|M.thermoresistible__bu TFYEVDSEAGWWNSGEPAEADGRPNRGYKVRPKGGYFPVAPYDHYVDLRD
MAB_1933c|M.abscessus_ATCC_199 TFYEIDSESGWWNTGEPYEEDGSPNRGYKVRPKGGYFPVAPYDHYVDLRD
Mb2244|M.bovis_AF2122/97 SFYEVDAISGWWNTGAATEADGSPNRGYKVRHKGGYFPVAPNDQYVDLRD
Rv2220|M.tuberculosis_H37Rv SFYEVDAISGWWNTGAATEADGSPNRGYKVRHKGGYFPVAPNDQYVDLRD
MLBr_00925|M.leprae_Br4923 SFYQVDAISGWWNTGAATESDGSPNRGYKVRHKGGYFPVAPNDQYVDLRD
MMAR_3289|M.marinum_M SFYEVDAISGWWNTGAANEADGGPNLGYKVRPKGGYFPVAPVDHYVDLRD
MUL_1340|M.ulcerans_Agy99 SFYEVDAISGWWNTGAANEADGGPNLGYKVRPKGGYFPVAPVDHYVDLRD
MAV_2267|M.avium_104 SFYEIDAISGWWNTGSPNELDGSPNRGYKVRPKGGYFPVAPVDHYVDLRD
:**::*: :****:* . * ** .* ***** ********* *:******
Mflv_2928|M.gilvum_PYR-GCK EMATNLQNAGFVLERGHHEVGTAGQAEINYKFNTLLHAADDVLLFKYIIK
MSMEG_4290|M.smegmatis_MC2_155 QMATNLQNAGFTLERGHHEVGTAGQAEINYKFNTLLAAADDVLLFKYIIK
Mvan_3585|M.vanbaalenii_PYR-1 EMSTNLINAGFTLERGHHEVGTAGQAEINYKFNTLLHAADDVLLFKYIIK
TH_3499|M.thermoresistible__bu QMCTNLINAGFELERGHHEVGTGGQAEINYKFNTMLHAADDVLLFKYIVK
MAB_1933c|M.abscessus_ATCC_199 EMSTNLINAGFTLERGHHEVGTAGQAEINYKFDTLLAAADDVLLFKYIIK
Mb2244|M.bovis_AF2122/97 KMLTNLINSGFILEKGHHEVGSGGQAEINYQFNSLLHAADDMQLYKYIIK
Rv2220|M.tuberculosis_H37Rv KMLTNLINSGFILEKGHHEVGSGGQAEINYQFNSLLHAADDMQLYKYIIK
MLBr_00925|M.leprae_Br4923 KMLTNLTNAGFVLEKGHHEVGTGGQGEINYQFNTLLHAADDMQLYKYIVK
MMAR_3289|M.marinum_M KMLTNLINAGFSLEKGHHEVGTGGQAEINYKFNTLLHAADDMQLYKYIVK
MUL_1340|M.ulcerans_Agy99 KMLTNLINAGFSLEKGHHEVGTGGQAEINYKFNTLLHAADDMQLYKYIVK
MAV_2267|M.avium_104 QMLSNLIKAGFSLEKGHHEVGTGGQAEINYKFNTLLHAADDMMLYKYIVK
:* :** ::** **:******:.**.****:*:::* ****: *:***:*
Mflv_2928|M.gilvum_PYR-GCK NTAWQNGKTVTFMPKPLFGDNGSGMHAHQSLWKDGKPLFHDESGYAGLSD
MSMEG_4290|M.smegmatis_MC2_155 NTAWQAGKTVTFMPKPLFGDNGSGMHAHQSLWKDGQPLFHDESGYAGLSD
Mvan_3585|M.vanbaalenii_PYR-1 NTAWQNGKTVTFMPKPLFGDNGSGMHAHQSLWKDGKPLFHDESGYAGLSD
TH_3499|M.thermoresistible__bu NTAWQAGKTVTFMPKPLFGDNGSGMHVHQSLWKDGKPLFHDESGYAGLSD
MAB_1933c|M.abscessus_ATCC_199 NTAWANGKTVTFMPKPLFGDNGSGMHAHQSLWKDGKPLFHDEAGYAGLSD
Mb2244|M.bovis_AF2122/97 NTAWQNGKTVTFMPKPLFGDNGSGMHCHQSLWKDGAPLMYDETGYAGLSD
Rv2220|M.tuberculosis_H37Rv NTAWQNGKTVTFMPKPLFGDNGSGMHCHQSLWKDGAPLMYDETGYAGLSD
MLBr_00925|M.leprae_Br4923 NTAWQNGKTVTFMPKPLFGDNGSGMHTHQSLWKGGTPLMYDEIGYAGLSD
MMAR_3289|M.marinum_M QTAWQAGKTVTFMPKPLFGDNGSGMHTHQSLWKDGSPMMYDETGYAGLSD
MUL_1340|M.ulcerans_Agy99 QTAWQAGKTVTFMPKPLFGDNGSGMHTHQSLWKDDTPMMYDETGYAGLSD
MAV_2267|M.avium_104 NTAWQNGKTVTFMPKPLFGDNGSGMHTHQSLWKDGSPLMYDETGYAGLSD
:*** ******************** ******.. *:::** *******
Mflv_2928|M.gilvum_PYR-GCK MARHYIGGILHHAPSLLAFTNPTVNSYKRLVPGYEAPINLVYSQRNRSAC
MSMEG_4290|M.smegmatis_MC2_155 IARHYIGGILHHAPSLLAFTNPTVNSYKRLVPGYEAPINLVYSQRNRSAC
Mvan_3585|M.vanbaalenii_PYR-1 LARHYIGGILHHAPSLLAFTNPTVNSYKRLVPGYEAPINLVYSQRNRSAC
TH_3499|M.thermoresistible__bu IARHYIGGILHHAPSLLAFTNPTVNSYKRLVPGYEAPINLVYSQRNRSAC
MAB_1933c|M.abscessus_ATCC_199 LARHYIGGILHHAPSLLAFTNPTVNSYKRLVPGYEAPINLVYSQRNRSAC
Mb2244|M.bovis_AF2122/97 TARHYIGGLLHHAPSLLAFTNPTVNSYKRLVPGYEAPINLVYSQRNRSAC
Rv2220|M.tuberculosis_H37Rv TARHYIGGLLHHAPSLLAFTNPTVNSYKRLVPGYEAPINLVYSQRNRSAC
MLBr_00925|M.leprae_Br4923 TARHYIGGLLHHAPSLLAFTNPTVNSYKRLVPGYEAPIKLVYSQRNRSAC
MMAR_3289|M.marinum_M TARHYIGGLLHHAPSLLAFTNPTVNSYKRLVPGYEAPINLVYSQRNRSAC
MUL_1340|M.ulcerans_Agy99 TARHYIGGLLHHAPSLLSFTNPTVNSYKRLVPGYEAPINLVYSQRNRSAC
MAV_2267|M.avium_104 TARHYIGGLLHHAPSLLAFTNPTTNSYKRLVPGFEAPINLVYSQRNRSAC
*******:********:*****.*********:****:***********
Mflv_2928|M.gilvum_PYR-GCK VRIPITGNNPKAKRLEFRCPDSSGNPYLAFAAMLMAGIDGIKKKIEPLAP
MSMEG_4290|M.smegmatis_MC2_155 VRIPITGNNPKAKRLEFRCPDSSGNPYLAFAAMLMAGIDGIKKKIEPLQP
Mvan_3585|M.vanbaalenii_PYR-1 VRIPITGNNPKAKRLEFRCPDSSGNPYLAFAAMLMAGIDGIKKKIEPLAP
TH_3499|M.thermoresistible__bu VRIPITGNNPKAKRLEFRCPDSSGNPYLAFAAMLMAGIDGIKKKMEPAAP
MAB_1933c|M.abscessus_ATCC_199 VRIPITGNNPKAKRLEFRCPDSSGNPYLAFAAMLMAGIDGIKNKIEPLAP
Mb2244|M.bovis_AF2122/97 VRIPITGSNPKAKRLEFRSPDSSGNPYLAFSAMLMAGLDGIKNKIEPQAP
Rv2220|M.tuberculosis_H37Rv VRIPITGSNPKAKRLEFRSPDSSGNPYLAFSAMLMAGLDGIKNKIEPQAP
MLBr_00925|M.leprae_Br4923 VRIPITGKNPKAKRLEFRCPDASGNPYLAFSAMLMAGLDGIKNKIEPQAP
MMAR_3289|M.marinum_M VRIPITGSNPKAKRLEFRCPDSSGNPYLAFAAMLMAGLDGIKNKIEPQAP
MUL_1340|M.ulcerans_Agy99 VRIPITGSNPKAKRLEFRCPDSSGNPYLAFAAMLMAGLDGIKNKIEPQAP
MAV_2267|M.avium_104 VRIPITGTNPKAKRLEFRCPDSSGNPYLAFSAMLMAGLDGIKNKIEPQAP
*******.**********.**:********:******:****:*:** *
Mflv_2928|M.gilvum_PYR-GCK VDKDLYELPPEEAANIPQAPTSLSAVIDKLEQDHEYLTEGGVFTTDLIET
MSMEG_4290|M.smegmatis_MC2_155 VDKDLYELPPDEAAAIPQAPTSLSAVIDKLEEDHEYLTEGGVFTEDLIET
Mvan_3585|M.vanbaalenii_PYR-1 VDKDLYELPPEEAANIPQAPTSLASVIDRLEEDHEYLTEGGVFTTDLIET
TH_3499|M.thermoresistible__bu IDKDLYELPPDEAANIPQAPTSLSAVIDNLEADHDYLTEGGVFTEDLIET
MAB_1933c|M.abscessus_ATCC_199 VDKDLYELPPEEAAGIPQAPTSLATVIDNLEKDHEYLTEGGVFTSDLIET
Mb2244|M.bovis_AF2122/97 VDKDLYELPPEEAASIPQTPTQLSDVIDRLEADHEYLTEGGVFTNDLIET
Rv2220|M.tuberculosis_H37Rv VDKDLYELPPEEAASIPQTPTQLSDVIDRLEADHEYLTEGGVFTNDLIET
MLBr_00925|M.leprae_Br4923 VDKDLYELPPEEAADIPQAPTQLAAVIDRLEEDHDYLTEGSVFTPDLIET
MMAR_3289|M.marinum_M VDKDLYELPPEEAANIPQAPTQLAAVIDRLEADHEYLTEGGVFTPDLIET
MUL_1340|M.ulcerans_Agy99 VDKDLYELPPEEAANIPQAPTQLAAVIDRLEADHEYLTEGGVFTPDLIET
MAV_2267|M.avium_104 VDKDLYELPPEEAANIPQAPTQLSAVIDRLEEDHEYLTEGGVFTPDLIET
:*********:*** ***:**.*: ***.** **:*****.*** *****
Mflv_2928|M.gilvum_PYR-GCK WISYKRENEIMPIQIRPHPYEFSLYYDV
MSMEG_4290|M.smegmatis_MC2_155 WISYKRENEIMPIQIRPHPYEFSLYYDV
Mvan_3585|M.vanbaalenii_PYR-1 WISYKRENEIMPIQIRPHPYEFSLYYDV
TH_3499|M.thermoresistible__bu WIAYKRENEILPVQIRPHPYEVALYFDC
MAB_1933c|M.abscessus_ATCC_199 WISYKRENEIEPVNIRPHPYEFALYYDV
Mb2244|M.bovis_AF2122/97 WISFKRENEIEPVNIRPHPYEFALYYDV
Rv2220|M.tuberculosis_H37Rv WISFKRENEIEPVNIRPHPYEFALYYDV
MLBr_00925|M.leprae_Br4923 WINFKRENEIEPVNIRPHPYEFALYYDV
MMAR_3289|M.marinum_M WISFKRENEIEPVNLRPHPYEFALYYDC
MUL_1340|M.ulcerans_Agy99 WISVKRENEIEPVNLRPHPYEFALYYDC
MAV_2267|M.avium_104 WISFKRETEILPVQVRPHPYEFALYYDV
** ***.** *:::******.:**:*