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MNLRDQVVFITGAGSGIGRATALAFARGGAKVIATDRNLASAEQTAELVHVSRGVCEPVLLDVADPLAWE SALARVEEHHGIPRVLVNNAGYTTAGRFLDHSADDWADLVAVNVRGAVTGSRLCARRMVDAGIRGQIINV ASGAAYTPLTVSSPYCTTKAAVMMFSEAFRLELRPHGIGVTAICPGAINTGFYTAARHLGSDAAVNTQRR DLSAGAIARFGSGPDAVAKAIVRSVRANRAIQPVTTEAYLGYALWRLSPTVMKVIARLSGEGTLRYVENT SLVRTAMGWLKERTK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_1381 | - | - | 100% (295) | putative oxidoreductase EphD |
| M. abscessus ATCC 19977 | MAB_4022c | - | 2e-54 | 43.02% (265) | oxidoreductase |
| M. abscessus ATCC 19977 | MAB_0514 | - | 3e-54 | 44.27% (262) | oxidoreductase EphD |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2237c | ephD | 3e-55 | 44.36% (266) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_2937 | - | 7e-54 | 45.49% (266) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv2214c | ephD | 3e-55 | 44.36% (266) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_00862 | ephD | 8e-53 | 42.70% (267) | short chain dehydrogenase |
| M. marinum M | MMAR_1932 | ephD_1 | 5e-55 | 41.95% (267) | short-chain dehydrogenase EphD_1 |
| M. avium 104 | MAV_3670 | - | 2e-55 | 42.86% (266) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4280 | - | 6e-52 | 43.98% (266) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_4323 | - | 5e-55 | 45.69% (267) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_3574 | ephD | 1e-54 | 44.19% (267) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_3576 | - | 3e-57 | 46.82% (267) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2237c|M.bovis_AF2122/97 MPATQ---QMSR-LVDSPDGVRIAVYHEG--NPDGPTVVLVHGFPDSHVL
Rv2214c|M.tuberculosis_H37Rv MPATQ---QMSR-LVDSPDGVRIAVYHEG--NPDGPTVVLVHGFPDSHVL
MUL_3574|M.ulcerans_Agy99 MPATK---QAPQQFVDSAGGVRIAVYEEG--NPDSPTVVLVHGFPDSHVL
MLBr_00862|M.leprae_Br4923 MPATQSIHKVPHQFVESPDGVRLAIYQSG--QPEGPAIVLVHGFPDSHVL
TH_4323|M.thermoresistible__bu --------MATEHFIDSSGGVRIAAYEEG--NPDGPTVVLVHGWPDSHVV
MSMEG_4280|M.smegmatis_MC2_155 ----------MYTFVTSQDGTRIAVYQQG--DPERPTLVMAHGWPDSHVL
Mflv_2937|M.gilvum_PYR-GCK --------MSSQRFVVSRDGVRIAVYEEG--AADGPTVVLVHGHADTHEA
Mvan_3576|M.vanbaalenii_PYR-1 --------MSTQRFVESSDGVRIAVSEQG--NPDGPTLVLVHGLRDTHRV
MAB_1381|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1932|M.marinum_M ------MNTASRTGITASDGATLAVYHYTPLDPQRPTILAIHGWPDNHHL
MAV_3670|M.avium_104 ------MTVTS--TITADDGVTLAVHRYTDIDPARPTILAIHGFPDNHHV
Mb2237c|M.bovis_AF2122/97 WDGVV-PLLAERFRIVRYDNRGVGRSSVPKPISAYTMAHFADDFDAVIGE
Rv2214c|M.tuberculosis_H37Rv WDGVV-PLLAERFRIVRYDNRGVGRSSVPKPISAYTMAHFADDFDAVIGE
MUL_3574|M.ulcerans_Agy99 WDGVV-PRLAERFRILRYDNRGVGLSSAPKAVSAYTTACLADDFAAVIEA
MLBr_00862|M.leprae_Br4923 WDGVV-PLLAKRFRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVIDE
TH_4323|M.thermoresistible__bu WDSVA-PLLADRFRIIRYDNRGVGRTTAPRRVADHTMARYADDFGAVIDA
MSMEG_4280|M.smegmatis_MC2_155 WDGVV-GELGDRYRIVRYDNRGAGASDVPKATSAYTMERFADDFSAVIDA
Mflv_2937|M.gilvum_PYR-GCK WDAVV-ALLAARFRIVRYDTRGAGRSAAPQRTSGFRLERYADDLAAVLDA
Mvan_3576|M.vanbaalenii_PYR-1 WDPVV-ALLADRFRIVAYDTRGAGNSGAPKQTSAYTVDRFADDFAAVAAA
MAB_1381|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1932|M.marinum_M WDPVA-ELLGDRYNVVAYDVRGSGESSCPASRSGYRLEQLVSDTGAVIDS
MAV_3670|M.avium_104 WDGVADELTGAPYNFVAYDVRGAGESSCPATRSGYGFAQLARDMGAVIDS
Mb2237c|M.bovis_AF2122/97 LSPGEPVHVLAHDWGSVGVWEYLR-----RPGASDRVASFTSVSGPSQDH
Rv2214c|M.tuberculosis_H37Rv LSPGEPVHVLAHDWGSVGVWEYLR-----RPGASDRVASFTSVSGPSQDH
MUL_3574|M.ulcerans_Agy99 LSPGQPVHVLGHDWGSVAIWDYLT-----RSGAADRVASFTSVSGPSQDQ
MLBr_00862|M.leprae_Br4923 LSPDRPVHVLAHDWGSVGVWEYLS-----RSGASDRVASFTSVSGPSQDQ
TH_4323|M.thermoresistible__bu LAPGQRVHVLAHDWGSAGVWEYLA-----RPEAEDRIASFTSVSGPSGDH
MSMEG_4280|M.smegmatis_MC2_155 VSPDAPVHVLAHDWGSVGIWEYLS-----RQGSAARMVSFTSVSGPSTDH
Mflv_2937|M.gilvum_PYR-GCK VSAEAPVHVLAHDRGSAGVWRYLA-----RPESRGRLASFTSVSGPAPEH
Mvan_3576|M.vanbaalenii_PYR-1 VGGDTPVHVLAHGWGAAGVWQYLK-----RADAPERVASLTSVSGPSPEH
MAB_1381|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1932|M.marinum_M LGVDR-VHLLAHDWGSIQGWAAVT-----ADSVMEKVASFTSISGPHLQY
MAV_3670|M.avium_104 LGVGR-VHLLAHDWGSIQAWAAVTDQAIMGESVMDKVASFTSISGPHLNY
Mb2237c|M.bovis_AF2122/97 LVNYVYGGLRRPWRPRTFLRAISQTLRLSYMALFSVPVVAPLLLRVAL-S
Rv2214c|M.tuberculosis_H37Rv LVNYVYGGLRRPWRPRTFLRAISQTLRLSYMALFSVPVVAPLLLRVAL-S
MUL_3574|M.ulcerans_Agy99 LVNYIFGGLRQPWRPKTFARALTQALRLSYMALFSVPVLAPLVLRATL-S
MLBr_00862|M.leprae_Br4923 LVDYILSGLRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIAL-S
TH_4323|M.thermoresistible__bu LARYVLDGLAAPYRPRRFLRSLTQLLRLSYMGFFSIPVLAPLLVRGVL-S
MSMEG_4280|M.smegmatis_MC2_155 YGAYVRRGLARPYRPVQFARAVNLASRFSYWIPFSIPVLAPALMR----R
Mflv_2937|M.gilvum_PYR-GCK VARYLRDTLARPQHPARFAGGLGHLARL---------------------A
Mvan_3576|M.vanbaalenii_PYR-1 VAGYVRAALTSPR---RFVRGAGQLVRL---------------------A
MAB_1381|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1932|M.marinum_M AGAFLRS----GRTPRSVAQVARQLASSGYIGFFLCPVVPELFFRSGIGV
MAV_3670|M.avium_104 AGAFLRS----ARTPRAVARVVRQLIASGYIGFFLCPGAAELSFRAGIGV
Mb2237c|M.bovis_AF2122/97 SAAVR-RNMVGDIPVDQIHHSETLARDAAHSVKTYPANYFRSFSSSRRGR
Rv2214c|M.tuberculosis_H37Rv SAAVR-RNMVGDIPVDQIHHSETLARDAAHSVKTYPANYFRSFSSSRRGR
MUL_3574|M.ulcerans_Agy99 RASVR-RNMVDNLPLDQIHHSDNLASDAANSVKTYPANYFRAFSRQSRTR
MLBr_00862|M.leprae_Br4923 SATIR-RTMVDNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGK
TH_4323|M.thermoresistible__bu KALRRSLRLRDGVPADRLHHSDTFAADAARSIKVYGANFLRTLRHARTDH
MSMEG_4280|M.smegmatis_MC2_155 GAARR---LQAIDTPGPKFQSENLDIDAANSLKIYRANAIRSFTHVRRDH
Mflv_2937|M.gilvum_PYR-GCK AAAPR-----------------------AVTDKTLRAN----LFPVSSGG
Mvan_3576|M.vanbaalenii_PYR-1 AAAPR-----------------------AATAKPYRAN----LRPAAPAG
MAB_1381|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1932|M.marinum_M KLVGAFERIGQSSTRSQRGQTPRSIGDYVNALNLYRANMPAGFVTD--GS
MAV_3670|M.avium_104 KVIAALERIGHTSTRSQRRDTQRSLRDYLNGLQLYRQNMPAPMLAP--GP
Mb2237c|M.bovis_AF2122/97 AIPIVDVPVQLIVNSQDPYVRPYGYDQTARWVPRLWRRDIKAGHFSPMSH
Rv2214c|M.tuberculosis_H37Rv AIPIVDVPVQLIVNSQDPYVRPYGYDQTARWVPRLWRRDIKAGHFSPMSH
MUL_3574|M.ulcerans_Agy99 GVPVIDVPVQLIVNTKDPYVRPYGYDETARWVPRLWRRDIKAGHFSPMSH
MLBr_00862|M.leprae_Br4923 GVPVVNVPVQLIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSH
TH_4323|M.thermoresistible__bu ---FVRVPVQLIVNTRDPYVRPHVYDETDRWVSRLWRRDIKAGHWSPMSH
MSMEG_4280|M.smegmatis_MC2_155 ---YVQVPVQLICNRKDPVVRGEGYRDESKWVPLLWRRDLDAGHWAPFSH
Mflv_2937|M.gilvum_PYR-GCK DAHDVDIPVQLIVGSADPYPDPHLFEDRAGRPARLWRRDVKAGHVTPTSH
Mvan_3576|M.vanbaalenii_PYR-1 --VPVDVPVQLIVPDHDPHVGPHVYDGMSASVSRLWRRDIKTGDLSPGSH
MAB_1381|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1932|M.marinum_M SLPQTSVPVQVLVPRKDMFVTPALQRFTGAIPGGGRVVPIEGGHWVVTSR
MAV_3670|M.avium_104 RLPETTVPVQTLVPRRDVFVTPALQRFTGAIPQRARVIEIEGGHWVVTSR
Mb2237c|M.bovis_AF2122/97 PQVMAAAVHDFADLADGKQPSRALLRAQVGRPRG--YFGDTLVSVTGAGS
Rv2214c|M.tuberculosis_H37Rv PQVMAAAVHDFADLADGKQPSRALLRAQVGRPRG--YFGDTLVSVTGAGS
MUL_3574|M.ulcerans_Agy99 PQVMAAAVHDFADLVDGKPPSRALLRAQVGRPRK--YFGDTLVAVTGAGS
MLBr_00862|M.leprae_Br4923 PQVMAAAVHDLADLVDGKQPSRALLRAQVGRSRD--TFGDTLVSVTGAGS
TH_4323|M.thermoresistible__bu PQVLATAVTELADHLAGAPAGRALLRAQVGRPRE--YFGDMLVAITGAGG
MSMEG_4280|M.smegmatis_MC2_155 PRAIAQAVGEFVDHMEGAPPARALRRAEVARPRK--AFSDMLVSVTGAAS
Mflv_2937|M.gilvum_PYR-GCK PGILARALTQLVDHLDGAPAARELLRAQVGRPRK--AFGDTLVAVTGAAS
Mvan_3576|M.vanbaalenii_PYR-1 PQVLARAVDQLVDHLGGAPAPRELLRAQVGRARK--VFGDTLVSVTGAAS
MAB_1381|M.abscessus_ATCC_1997 ---------------------------------M--NLRDQVVFITGAGS
MMAR_1932|M.marinum_M PDVVARLTADWVDRVVAGTGDAAATVVR-AGPGE---VRGQLALVTGAGA
MAV_3670|M.avium_104 PDVIARLTTEWVDLQSAGAVAPQLTGERRELPGERREVRGRLALVTGAGA
. . :. :***..
Mb2237c|M.bovis_AF2122/97 GIGRETALAFAREGA-EIVISDIDEATVKDTAAEIAARGGIAYPYVLDVS
Rv2214c|M.tuberculosis_H37Rv GIGRETALAFAREGA-EIVISDIDEATVKDTAAEIAARGGIAYPYVLDVS
MUL_3574|M.ulcerans_Agy99 GIGRETALAFAREGA-EVVLSDIDEATVKDTAAEIAARGGVAHPYVLDVS
MLBr_00862|M.leprae_Br4923 GIGRETALALARRGA-EVVVSDIDEAAAKNTAAQIVASGGVAYAYALDVS
TH_4323|M.thermoresistible__bu GIGRETALAFAREGA-EVIVSDIDEATAKDTAAEIAARGGVAHAYQLDVS
MSMEG_4280|M.smegmatis_MC2_155 GIGRATALEFARLGA-EIVVSDIDEAGAKATATAIDEAGGVAHAYGLDVA
Mflv_2937|M.gilvum_PYR-GCK GIGRATALAFAHHGA-DVVISDVNAAGLDETARLVTSAGVHAYPYTVDVA
Mvan_3576|M.vanbaalenii_PYR-1 GIGRETALAFARAGA-DVVISDVDEAGLEQTARLVTAAGAAAHSYTVDVA
MAB_1381|M.abscessus_ATCC_1997 GIGRATALAFARGGA-KVIATDRNLASAEQTAELVHVSRGVCEPVLLDVA
MMAR_1932|M.marinum_M GIGRATAVELARQGARMVIIADRDLAAANESATQVRAAGAAAAVYQVDVS
MAV_3670|M.avium_104 GIGRATAVELARQGARKVVIVDRDRAAADQTADAVRAAGAGAAVYQVDVS
**** **: :*: ** :: * : * . :* : . :**:
Mb2237c|M.bovis_AF2122/97 DAEAVEAFAERVSAEHGVPDIVVNNAGIGQAGRFLDTPAEQFDRVLAVNL
Rv2214c|M.tuberculosis_H37Rv DAEAVEAFAERVSAEHGVPDIVVNNAGIGQAGRFLDTPAEQFDRVLAVNL
MUL_3574|M.ulcerans_Agy99 DTEAVEAFADQVSATHGLPDIVVNNAGVGQAGRFLDTPAEQFDRVLDVNL
MLBr_00862|M.leprae_Br4923 DAAAVEAFAEQVSAKHGVPDIVVNNAGIGQAGRFLDTPPEEFDRVLAVNL
TH_4323|M.thermoresistible__bu DAAAVDRFADEVCARHGVPDIVVNNAGIGHAGRFLDTPRDQWDRVLEVNL
MSMEG_4280|M.smegmatis_MC2_155 DPDAVQRFVDDVCATHGVPDIVVNNAGIGHAGNFLDTPADQYERVLEVNF
Mflv_2937|M.gilvum_PYR-GCK DAAAVEAFAEQVCAEHGVPDVVVNNAGVGHAGFFLDTPAEEFDRVLDINF
Mvan_3576|M.vanbaalenii_PYR-1 DAAAVEAMAELVCAAHGVPDIVVNNAGVGHAGFFLDTPAEEFDRVLGINF
MAB_1381|M.abscessus_ATCC_1997 DPLAWESALARVEEHHGIPRVLVNNAGYTTAGRFLDHSADDWADLVAVNV
MMAR_1932|M.marinum_M DETAMNDLAAQVLDEHGVVDILVNNAGIGMAGRFLETTPQHWDAILGINV
MAV_3670|M.avium_104 DEAAMNDLAAQVRNEHGVVDILVNNAGIGMAGRFLETSPANWDAIMGVNV
* * : * **: ::***** ** **: . .: :: :*.
Mb2237c|M.bovis_AF2122/97 GGVVNGCRAFGQRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYM
Rv2214c|M.tuberculosis_H37Rv GGVVNGCRAFGQRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYM
MUL_3574|M.ulcerans_Agy99 GGVVNGCRAFGQRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATFM
MLBr_00862|M.leprae_Br4923 GGVVNCCRAFGQRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYM
TH_4323|M.thermoresistible__bu GGVVNGCRAFAPRLVERGTGGHIVNIASMASYAPLQSLNAYCTSKAAVYM
MSMEG_4280|M.smegmatis_MC2_155 GGVVNCCRAFGRRLVEQGTGGHIVNVASMAAYSPAGSMNAYATSKAAVFM
Mflv_2937|M.gilvum_PYR-GCK GGVVNGCRSFGKRLADRGVGGHIVNVASMASYTPVNVMNAYCTSKAAVFM
Mvan_3576|M.vanbaalenii_PYR-1 GGVVNGCRSWGRRLVDRGTGGHIVNVASMASYTPVNVMNAYCTSKAAVFM
MAB_1381|M.abscessus_ATCC_1997 RGAVTGSRLCARRMVDAGIRGQIINVASGAAYTPLTVSSPYCTTKAAVMM
MMAR_1932|M.marinum_M GGVISGSRAFGAQMVERGQGGTIINIASAAAYLPSKSMVAYSTTKAAVLG
MAV_3670|M.avium_104 RGVIWGSRAFGAQMVERGQGGTIINVASAAAYLPSKSMVAYGTTKAAVLA
*.: .* . ::.: * * *:*::* *:* * .* *:***.
Mb2237c|M.bovis_AF2122/97 FSDCLRAELDAAGVGLTTICPGVIDTNIVATTGFHAP-GTDEEKIDGRRG
Rv2214c|M.tuberculosis_H37Rv FSDCLRAELDAAGVGLTTICPGVIDTNIVATTGFHAP-GTDEEKIDGRRG
MUL_3574|M.ulcerans_Agy99 FSDCLRAELDAADVGLTTICPGVINTNIVNTTRFDAPPGKGGDQLDGRRG
MLBr_00862|M.leprae_Br4923 FSDCLRAELDAVGVGLTTICPGVIDTNIIQSTRIDTP-TAKQERVRDRRG
TH_4323|M.thermoresistible__bu FSDCLRAELDSAGIMLTTICPSTVNTNIIGSTRFNAP-DGLDDVVDTRRE
MSMEG_4280|M.smegmatis_MC2_155 FSDCLRAELAHAGIGVTTLCPGMIDTGIVDTTRFDVP-AHKAGQVEARRA
Mflv_2937|M.gilvum_PYR-GCK FSDCLRAELDSFGIGLTTICPGFISTNIVDTTRFSLA-QGRDDDVDVLRG
Mvan_3576|M.vanbaalenii_PYR-1 FSDCLRAELDSAGIGVTTICPGVIGTNIVDTTRFSLP-EARRDDAESIRR
MAB_1381|M.abscessus_ATCC_1997 FSEAFRLELRPHGIGVTAICPGAINTGFYTAARHLGS----DAAVNTQRR
MMAR_1932|M.marinum_M FSEALRADLADEGISVTAVCPGFVNTNIAKSTVYAGM---STEQQERARQ
MAV_3670|M.avium_104 LSESLRADFADEGITVTAVCPGFVNTNIAKSTIYAGM---SAQQQERARD
:*:.:* :: .: :*::**. :.*.: :: *
Mb2237c|M.bovis_AF2122/97 QIDKMFALRS-YGPDKVADAIVSAVKKKKPIRPVAPEAYALYGISRVLPQ
Rv2214c|M.tuberculosis_H37Rv QIDKMFALRS-YGPDKVADAIVSAVKKKKPIRPVAPEAYALYGISRVLPQ
MUL_3574|M.ulcerans_Agy99 QIDKMFALRS-YGPDKVAKAIVSAVKKNKPIRPVAPEAYALYGISRVLPP
MLBr_00862|M.leprae_Br4923 QLDMMFRLRR-YGPDKVADTILSAIKKNKPIRPVAPEAYALYGISRVLPQ
TH_4323|M.thermoresistible__bu QLQKLFALRR-FGPDKAAKAIVSAVKQNKPIRPVMPEAYFVYGVSRVLPQ
MSMEG_4280|M.smegmatis_MC2_155 QVKKTFQARR-YGPEKVAKAVTSAVSRNQALRPVTPEAYVAYGVSRLFPA
Mflv_2937|M.gilvum_PYR-GCK RAQKGFSARK-YGPEKVADAIVDAVRTNKAIRPVAPEARFVYGVAHALPQ
Mvan_3576|M.vanbaalenii_PYR-1 RARQGFAVRR-VGPDKVAKAIVAAVQKNKPVRPVTTEAYLVYGVAHALPQ
MAB_1381|M.abscessus_ATCC_1997 DLSAGAIARFGSGPDAVAKAIVRSVRANRAIQPVTTEAYLGYALWRLSPT
MMAR_1932|M.marinum_M KADAAYRRRN-FTPEATARAIVKAIRSGPAVLPVAAESKVGYAMRRISPS
MAV_3670|M.avium_104 RADAAYRRRN-FTPEATAKAIVKAIKTGPAVVPIAAESRIGYALRRISPG
* *: .* :: :: .: *: .*: *.: : *
Mb2237c|M.bovis_AF2122/97 ALRSTARL---RVI---------------------
Rv2214c|M.tuberculosis_H37Rv ALRSTARL---RVI---------------------
MUL_3574|M.ulcerans_Agy99 ALRSTARM---RVI---------------------
MLBr_00862|M.leprae_Br4923 VLRSTARI---RVI---------------------
TH_4323|M.thermoresistible__bu ALRSTARG---RVL---------------------
MSMEG_4280|M.smegmatis_MC2_155 ALRRAARS---QVL---------------------
Mflv_2937|M.gilvum_PYR-GCK VLRSTARG---GNFV--------------------
Mvan_3576|M.vanbaalenii_PYR-1 AMRSAARG---GNIM--------------------
MAB_1381|M.abscessus_ATCC_1997 VMKVIARLSGEGTLRYVENTSLVRTAMGWLKERTK
MMAR_1932|M.marinum_M MIRMFARLDIRQR----------------------
MAV_3670|M.avium_104 AIRLLARWDIRQT----------------------
:: **